JP2002510385A - クロストリジウム・ディフィシル用診断テストおよび診断キット - Google Patents

クロストリジウム・ディフィシル用診断テストおよび診断キット

Info

Publication number
JP2002510385A
JP2002510385A JP54295998A JP54295998A JP2002510385A JP 2002510385 A JP2002510385 A JP 2002510385A JP 54295998 A JP54295998 A JP 54295998A JP 54295998 A JP54295998 A JP 54295998A JP 2002510385 A JP2002510385 A JP 2002510385A
Authority
JP
Japan
Prior art keywords
toxin
clostridium difficile
binding
binding site
site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP54295998A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002510385A5 (https=
Inventor
ヴァルキルス,グナース・イー
Original Assignee
バイオサイト・ダイアグノスティクス・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオサイト・ダイアグノスティクス・インコーポレーテッド filed Critical バイオサイト・ダイアグノスティクス・インコーポレーテッド
Publication of JP2002510385A publication Critical patent/JP2002510385A/ja
Publication of JP2002510385A5 publication Critical patent/JP2002510385A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/811Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
JP54295998A 1997-04-04 1998-04-03 クロストリジウム・ディフィシル用診断テストおよび診断キット Pending JP2002510385A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/832,935 1997-04-04
US08/832,935 US5965375A (en) 1997-04-04 1997-04-04 Diagnostic tests and kits for Clostridium difficile
PCT/US1998/006702 WO1998045706A1 (en) 1997-04-04 1998-04-03 DIAGNOSTIC TESTS AND KITS FOR $i(CLOSTRIDIUM DIFFICILE)

Publications (2)

Publication Number Publication Date
JP2002510385A true JP2002510385A (ja) 2002-04-02
JP2002510385A5 JP2002510385A5 (https=) 2005-11-24

Family

ID=25262976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54295998A Pending JP2002510385A (ja) 1997-04-04 1998-04-03 クロストリジウム・ディフィシル用診断テストおよび診断キット

Country Status (7)

Country Link
US (2) US5965375A (https=)
EP (1) EP1019724B1 (https=)
JP (1) JP2002510385A (https=)
AT (1) ATE339688T1 (https=)
CA (1) CA2285919C (https=)
DE (1) DE69835893T2 (https=)
WO (1) WO1998045706A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008511816A (ja) * 2004-08-03 2008-04-17 ベクトン・ディキンソン・アンド・カンパニー サンプルを分別するための磁性材料の使用
JP2008522165A (ja) * 2004-11-24 2008-06-26 テクラブ インコーポレイテッド 分析物を検出するための装置および方法
JP2012211914A (ja) * 2000-04-06 2012-11-01 Caliper Life Sciences Inc 保護層を組み込んだミクロ流体装置及びシステム
JP2013500479A (ja) * 2009-07-27 2013-01-07 バイオディクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中における変異したc.ディフィシル菌株を検出および同定するための方法
JP2015515634A (ja) * 2012-04-26 2015-05-28 テックラブ,インコーポレーテッド バイオマーカーとしてのクロストリジウム・ディフィシル(Clostridiumdifficile)・デヒドロゲナーゼおよび毒素
JP2015517658A (ja) * 2012-05-11 2015-06-22 テックラブ,インコーポレーテッド クロストリジウム・ディフィシル(Clostridiumdifficile)・リボタイプ027の診断マーカーとしての細胞壁タンパク質CwpV(CD0514)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
CA2344589A1 (en) * 1998-09-21 2000-03-30 Biosite Diagnostics Diagnostic assays for detection of giardia lamblia
EP1141707A4 (en) * 1998-12-29 2005-01-12 Thermo Biostar Inc METHODS FOR PRESENTING LIQUID AND SOLID COMPONENTS OF A SAMPLE FOR ANALYTICAL METHODS
RU2165622C2 (ru) * 1999-02-11 2001-04-20 Центр Государственного санитарно-эпидемиологического надзора в Красноярском крае Способ регистрирования титра противодифтерийного антитоксина у взрослого населения крайнего севера
US7371584B2 (en) * 1999-10-15 2008-05-13 Wavesence, Inc. Multi-functional and configurable assay
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US7390675B2 (en) * 1999-10-15 2008-06-24 Christopher Feistel Multi-functional and configurable assay
US20060029604A1 (en) * 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
US20060257399A1 (en) * 2000-06-28 2006-11-16 Glycofi, Inc. Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform
US20060024304A1 (en) * 2000-06-28 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform
US20060034830A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
JP2004511808A (ja) * 2000-10-17 2004-04-15 ベッスト−テスト アンパーツゼルスカブ 体液サンプル中の生物学的細胞の直接的検出のためのアッセイ
WO2002062379A2 (en) * 2001-02-09 2002-08-15 The Provost, Fellows And Scholars Of The College Of The Holy And Unidivided Trinity Of Queen Elizabeth Clostridium difficile vaccine
US6811549B2 (en) 2001-02-16 2004-11-02 William H. Fleming Administration of therapeutic or diagnostic agents using interlabial pad
US20060034829A1 (en) * 2001-12-27 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform
US20060024292A1 (en) * 2001-12-27 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US20030186463A1 (en) * 2002-03-18 2003-10-02 Robert Hudak Method for clearing color and debris from or adding adjuvants or reactants to a selected portion of a chromatographic strip alone or in combination with a cell lysing step
GB0214947D0 (en) * 2002-06-28 2002-08-07 Secr Defence Assay
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
AU2003293562A1 (en) * 2002-12-26 2004-07-22 Meso Scale Technologies, Llc Methods, compositions and kits for biomarker extraction
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
CA2535153A1 (en) * 2003-08-12 2005-05-19 Massachusetts Institute Of Technology Sample preparation methods and devices
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
JP2007518062A (ja) * 2003-09-29 2007-07-05 バイオサイト インコーポレイテッド 敗血症を診断する方法および診断するための組成物
US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
US20050196817A1 (en) * 2004-01-20 2005-09-08 Molecular Staging Inc. Biomarkers for sepsis
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
CA2531616A1 (en) * 2004-12-28 2006-06-28 Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.) High strength thin steel sheet having high hydrogen embrittlement resisting property and high workability
US7189522B2 (en) * 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
EP2477029A1 (en) * 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070020699A1 (en) * 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
CA2615460A1 (en) * 2005-08-08 2007-02-15 Onconon, Llc Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility
JP2009507482A (ja) * 2005-09-09 2009-02-26 グライコフィ, インコーポレイテッド 主にman7glcnac2、man8glcnac2グリコフォームを含むイムノグロブリン
WO2007041623A2 (en) * 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7655428B2 (en) * 2005-12-22 2010-02-02 Biosite, Inc. Latent protein C assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes
KR20090029184A (ko) * 2006-04-07 2009-03-20 더 가브먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 항체 조성물 및 신생물성 질병의 치료 방법
CA2679725C (en) * 2007-02-28 2015-07-07 Quantrx Biomedical Corporation Folded perineal pad
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8268638B2 (en) * 2007-07-18 2012-09-18 Advantageous Systems, Llc Methods and apparatuses for detecting analytes in biological fluid of an animal
WO2009108652A1 (en) 2008-02-28 2009-09-03 3M Innovative Properties Company Antibodies to clostridium difficile spores and uses thereof
US20090263905A1 (en) 2008-04-18 2009-10-22 Kim Scheuringer Detection test assembly for detecting the presence of a substance in a sample
EP2288719A4 (en) * 2008-05-15 2012-01-11 Univ Tufts METHOD FOR DIAGNOSIS OF CLOSTRIDIUM DIFFICILE AND METHOD AND VECTORS FOR RECOMBINANT TOXINEXPRESSION
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US20110287965A1 (en) * 2008-11-26 2011-11-24 Tzam Diagnostics Llc Methods and compositions to detect clostridium difficile
US8765399B2 (en) 2010-05-18 2014-07-01 Montefiore Medical Center Cultures and protocols for diagnosis of toxigenic Clostridium difficile
US9186668B1 (en) 2010-06-04 2015-11-17 Sandia Corporation Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
US9795961B1 (en) 2010-07-08 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Devices, systems, and methods for detecting nucleic acids using sedimentation
US8962346B2 (en) 2010-07-08 2015-02-24 Sandia Corporation Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
US20120276060A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for treating infection in patients with clostridium difficile disease
WO2013043773A2 (en) 2011-09-20 2013-03-28 Avery Dennison Corporation Embossed thermoplastic label
US9244065B1 (en) 2012-03-16 2016-01-26 Sandia Corporation Systems, devices, and methods for agglutination assays using sedimentation
EP2852682B1 (en) 2012-05-21 2017-10-04 Fluidigm Corporation Single-particle analysis of particle populations
ES2385625B2 (es) 2012-05-29 2013-09-25 Certest Biotec, S.L. Dispositivo para el diagnóstico rápido de enfermedades causadas por Clostridium difficile en muestras fecales
KR101955329B1 (ko) * 2012-06-08 2019-03-07 삼성전자주식회사 클로스트리디움 디피실리 균주 검출용 조성물과 키트 및 이를 이용한 검출 방법
WO2013192620A1 (en) 2012-06-22 2013-12-27 Quantrx Biomedical Corporation Method for obtaining fetal cells and fetal cellular components
US9903001B1 (en) 2012-07-19 2018-02-27 National Technology & Engineering Solutions Of Sandia, Llc Quantitative detection of pathogens in centrifugal microfluidic disks
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
US9304128B1 (en) * 2013-02-01 2016-04-05 Sandia Corporation Toxin activity assays, devices, methods and systems therefor
US9500579B1 (en) 2013-05-01 2016-11-22 Sandia Corporation System and method for detecting components of a mixture including tooth elements for alignment
US9803238B1 (en) 2013-11-26 2017-10-31 National Technology & Engineering Solutions Of Sandia, Llc Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
FR3014446B1 (fr) * 2013-12-10 2017-05-26 Biomerieux Sa Stabilisation de la gdh en solution aqueuse
DK3578635T3 (da) 2014-04-02 2022-02-07 Chembio Diagnostic Systems Inc Immunoassay, som anvender indfangningskonjugat
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
US9702871B1 (en) 2014-11-18 2017-07-11 National Technology & Engineering Solutions Of Sandia, Llc System and method for detecting components of a mixture including a valving scheme for competition assays
FI126289B (en) 2014-12-19 2016-09-15 Mobidiag Ltd Method for detecting the presence of a hypervirulent strain of Clostridium difficile
US10254298B1 (en) 2015-03-25 2019-04-09 National Technology & Engineering Solutions Of Sandia, Llc Detection of metabolites for controlled substances
JP6989927B2 (ja) 2015-08-25 2022-02-03 プロセナ バイオサイエンシーズ リミテッド リン酸化アルファ-シヌクレインを検出するための方法
CA3021914C (en) 2016-04-27 2024-04-30 Gen-Probe Incorporated Blood cell lysis reagent
US10981174B1 (en) 2016-08-04 2021-04-20 National Technology & Engineering Solutions Of Sandia, Llc Protein and nucleic acid detection for microfluidic devices
US10406528B1 (en) 2016-08-04 2019-09-10 National Technology & Engineering Solutions Of Sandia, Llc Non-contact temperature control system for microfluidic devices
US10786811B1 (en) 2016-10-24 2020-09-29 National Technology & Engineering Solutions Of Sandia, Llc Detection of active and latent infections with microfluidic devices and systems thereof
EP3706795A4 (en) 2017-11-09 2021-10-13 Pinteon Therapeutics Inc. METHODS AND COMPOSITIONS FOR GENERATING AND USING HUMANIZED CONFORMATION SPECIFIC PHOSPHORYLATED TAU ANTIBODIES
EP3765031A4 (en) 2018-03-14 2022-03-23 Memorial Sloan Kettering Cancer Center ANTI-POLYSIAL ACID ANTIBODIES AND USES THEREOF
EP3938400B1 (en) 2019-03-11 2025-07-30 Memorial Sloan Kettering Cancer Center Cd22 antibodies and methods of using the same
US11597961B2 (en) 2019-04-22 2023-03-07 Qualitic Biotechnology LLC Rapid colorimetric diagnostic test for C. difficile
CA3140406A1 (en) 2019-05-28 2020-12-03 Shanghaitech University Composition and methods to treat ectodermal dysplasia 2, clouston type
CN112661849B (zh) * 2020-12-17 2022-05-20 杭州贤至生物科技有限公司 一种艰难梭菌重组蛋白单克隆抗体的制备方法和应用
CN117700560B (zh) * 2023-12-08 2024-05-31 北京新兴四寰生物技术有限公司 抗艰难梭菌谷氨酸脱氢酶的单克隆抗体及其应用
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937201A (en) * 1982-06-10 1990-06-26 Mitsubishi Kasei Corporation Latex reagent for detection of the toxin of clostridium difficile
US4530833A (en) * 1982-09-13 1985-07-23 Wilkins Tracy D Toxins and antibodies of C. difficile
US4533630A (en) * 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
US4879218A (en) * 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4863852A (en) * 1985-07-03 1989-09-05 Virginia Tech Intellectual Properties, Inc. Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors
US5071759A (en) * 1986-05-30 1991-12-10 The United States Of America As Represented By The Secretary Of The Army Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B
US5231003A (en) * 1990-05-11 1993-07-27 Cambridge Bioscience Corporation Monoclonal antibodies specific for toxin b of clostridium difficile
JP3290988B2 (ja) * 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド 多重リガンドを同時検出する新規接合体及び検定法
US5610023A (en) * 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012211914A (ja) * 2000-04-06 2012-11-01 Caliper Life Sciences Inc 保護層を組み込んだミクロ流体装置及びシステム
JP2008511816A (ja) * 2004-08-03 2008-04-17 ベクトン・ディキンソン・アンド・カンパニー サンプルを分別するための磁性材料の使用
JP2008522165A (ja) * 2004-11-24 2008-06-26 テクラブ インコーポレイテッド 分析物を検出するための装置および方法
JP2013500479A (ja) * 2009-07-27 2013-01-07 バイオディクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中における変異したc.ディフィシル菌株を検出および同定するための方法
JP2015515634A (ja) * 2012-04-26 2015-05-28 テックラブ,インコーポレーテッド バイオマーカーとしてのクロストリジウム・ディフィシル(Clostridiumdifficile)・デヒドロゲナーゼおよび毒素
JP2015517658A (ja) * 2012-05-11 2015-06-22 テックラブ,インコーポレーテッド クロストリジウム・ディフィシル(Clostridiumdifficile)・リボタイプ027の診断マーカーとしての細胞壁タンパク質CwpV(CD0514)

Also Published As

Publication number Publication date
CA2285919A1 (en) 1998-10-15
EP1019724B1 (en) 2006-09-13
EP1019724A1 (en) 2000-07-19
EP1019724A4 (en) 2004-10-06
US5965375A (en) 1999-10-12
WO1998045706A1 (en) 1998-10-15
US6503722B1 (en) 2003-01-07
DE69835893D1 (de) 2006-10-26
CA2285919C (en) 2009-06-02
ATE339688T1 (de) 2006-10-15
DE69835893T2 (de) 2007-03-08

Similar Documents

Publication Publication Date Title
JP2002510385A (ja) クロストリジウム・ディフィシル用診断テストおよび診断キット
US6348318B1 (en) Methods for concentrating ligands using magnetic particles
AU2010200492B2 (en) Method and device for trichomonas detection
WO1998045684A9 (en) Methods for concentrating ligands using magnetic particles
CA2396696A1 (en) Assays for detection of bacillus anthracis
JPH11507130A (ja) 潰瘍性結腸炎、原発性硬化性胆管炎、および1型自己免疫性肝炎のための区別的アッセイ
EP0166623A2 (en) Antibody lectin sandwich assay
CN101435825A (zh) 夹心免疫检测法及用该法检测抗原的方法
KR100756117B1 (ko) 모노클로날 항체, 하이브리도마, 면역분석 방법 및 진단킷트
US6207395B1 (en) Diagnostic assays for detection of Entamoeba histolytica
JPS6097272A (ja) 免疫螢光法
CA2045673A1 (en) Detection of antibodies in body fluids for diagnostic testing
US6908739B2 (en) Diagnostic assays for detection of Giardia lamblia
US7052858B2 (en) Diagnostic assays for detection of Cryptosporidium parvum
JPH05508770A (ja) 膵臓エラスターゼ1特異性抗体、その獲得方法および該抗体を含有するテストキット
US4741999A (en) Monoclonal antibodies useful in the identification of microorganisms causing periodontal disease
AU625344B2 (en) Chlamydia half-sandwich immunoassay
JP3638731B2 (ja) 多剤耐性ブドウ球菌抗原の抽出方法
US5472848A (en) Methods to aid in the diagnosis of multiple sclerosis
JPH08333397A (ja) クラミジア・ニューモニエに特異的な標識化モノクローナル抗体、クラミジア・ニューモニエ検出・測定用試薬及びその試薬並びにクラミジア・ニューモニエ感染の診断薬
Finn Development of an enzyme immunoassay for the measurement of serum antibody of C. trachomatis
JP2002275199A (ja) 抗体作製方法及び抗酸菌の免疫学的検出方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050404

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050404

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060411

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060711

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20060828

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061011

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20061205