ATE339688T1 - Diagnostische tests und kits für clostridium difficile - Google Patents

Diagnostische tests und kits für clostridium difficile

Info

Publication number
ATE339688T1
ATE339688T1 AT98918009T AT98918009T ATE339688T1 AT E339688 T1 ATE339688 T1 AT E339688T1 AT 98918009 T AT98918009 T AT 98918009T AT 98918009 T AT98918009 T AT 98918009T AT E339688 T1 ATE339688 T1 AT E339688T1
Authority
AT
Austria
Prior art keywords
toxin
difficile
kits
provides methods
clostridium difficile
Prior art date
Application number
AT98918009T
Other languages
German (de)
English (en)
Inventor
Gunars E Valkirs
Original Assignee
Biosite Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Inc filed Critical Biosite Inc
Application granted granted Critical
Publication of ATE339688T1 publication Critical patent/ATE339688T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
AT98918009T 1997-04-04 1998-04-03 Diagnostische tests und kits für clostridium difficile ATE339688T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/832,935 US5965375A (en) 1997-04-04 1997-04-04 Diagnostic tests and kits for Clostridium difficile

Publications (1)

Publication Number Publication Date
ATE339688T1 true ATE339688T1 (de) 2006-10-15

Family

ID=25262976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98918009T ATE339688T1 (de) 1997-04-04 1998-04-03 Diagnostische tests und kits für clostridium difficile

Country Status (7)

Country Link
US (2) US5965375A (https=)
EP (1) EP1019724B1 (https=)
JP (1) JP2002510385A (https=)
AT (1) ATE339688T1 (https=)
CA (1) CA2285919C (https=)
DE (1) DE69835893T2 (https=)
WO (1) WO1998045706A1 (https=)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179611B2 (en) * 1997-02-10 2007-02-20 Bd Lee Laboratories Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile
EP1116030A4 (en) * 1998-09-21 2004-04-14 Biosite Inc DIAGNOSTIC ASSAY FOR DETECTING $ i (GIARDIA LAMBLIA)
HK1038794A1 (zh) * 1998-12-29 2002-03-28 Inverness Medical - Biostar Inc. 提供用於测试方法的、含液体和固体组分的样品的方法
RU2165622C2 (ru) * 1999-02-11 2001-04-20 Центр Государственного санитарно-эпидемиологического надзора в Красноярском крае Способ регистрирования титра противодифтерийного антитоксина у взрослого населения крайнего севера
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
US7371584B2 (en) * 1999-10-15 2008-05-13 Wavesence, Inc. Multi-functional and configurable assay
US7390675B2 (en) * 1999-10-15 2008-06-24 Christopher Feistel Multi-functional and configurable assay
AU2001251340A1 (en) * 2000-04-06 2001-10-23 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US20060257399A1 (en) * 2000-06-28 2006-11-16 Glycofi, Inc. Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform
US20060029604A1 (en) * 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
US20060024304A1 (en) * 2000-06-28 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform
US20060034830A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
JP2004511808A (ja) * 2000-10-17 2004-04-15 ベッスト−テスト　アンパーツゼルスカブ 体液サンプル中の生物学的細胞の直接的検出のためのアッセイ
WO2002062379A2 (en) * 2001-02-09 2002-08-15 The Provost, Fellows And Scholars Of The College Of The Holy And Unidivided Trinity Of Queen Elizabeth Clostridium difficile vaccine
US6811549B2 (en) 2001-02-16 2004-11-02 William H. Fleming Administration of therapeutic or diagnostic agents using interlabial pad
US20060034829A1 (en) * 2001-12-27 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform
US20060024292A1 (en) * 2001-12-27 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Gal2GlcNAc2Man3GlcNAc2 glycoform
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US20030186463A1 (en) * 2002-03-18 2003-10-02 Robert Hudak Method for clearing color and debris from or adding adjuvants or reactants to a selected portion of a chromatographic strip alone or in combination with a cell lysing step
GB0214947D0 (en) * 2002-06-28 2002-08-07 Secr Defence Assay
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
JP4667874B2 (ja) * 2002-12-26 2011-04-13 メソ スケール テクノロジーズ エルエルシー バイオマーカーを抽出するための方法、組成物およびキット
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
AU2004288132A1 (en) * 2003-08-12 2005-05-19 Massachusetts Institute Of Technology Sample preparation methods and devices
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
US20050164238A1 (en) * 2003-09-29 2005-07-28 Biosite, Inc. Methods and compositions for the diagnosis of sepsis
US20050196817A1 (en) * 2004-01-20 2005-09-08 Molecular Staging Inc. Biomarkers for sepsis
JP2008511816A (ja) * 2004-08-03 2008-04-17 ベクトン・ディキンソン・アンド・カンパニー サンプルを分別するための磁性材料の使用
PL1824991T3 (pl) * 2004-11-24 2016-08-31 Techlab Inc Urządzenie oraz sposób do wykrywania analitów
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
CA2531616A1 (en) * 2004-12-28 2006-06-28 Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.) High strength thin steel sheet having high hydrogen embrittlement resisting property and high workability
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2007044091A2 (en) * 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070020699A1 (en) * 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
JP2009504659A (ja) * 2005-08-08 2009-02-05 オンコノン・リミテッド・ライアビリティ・カンパニー 抗体組成物、腫瘍性疾患の処置方法、および受胎能の調節方法
EP1937305A4 (en) * 2005-09-09 2008-10-08 Glycofi Inc IMMUNOGLOBULIN CONTAINING PRESENTLY A MAN7GLCNAC2, MAN8GLCNAC2 GLYCOFORM
AU2006299417A1 (en) * 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in Systemic Inflammatory Response Syndromes
WO2007117330A2 (en) * 2005-12-22 2007-10-18 Biosite Incorporated Latent protein c assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes
KR20090029184A (ko) * 2006-04-07 2009-03-20 더 가브먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 항체 조성물 및 신생물성 질병의 치료 방법
US8398606B2 (en) * 2007-02-28 2013-03-19 QuantrRx Biomedical Corporation Folded perineal pad
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8268638B2 (en) * 2007-07-18 2012-09-18 Advantageous Systems, Llc Methods and apparatuses for detecting analytes in biological fluid of an animal
BRPI0906060A2 (pt) 2008-02-28 2015-12-01 3M Innovative Properties Co anticorpos isolados, métodos de preparo de um anticorpo anti-clostridium difficile, composição e método para a detecção da presença de um esporo de clostridium difficile em uma amostra
US20090263905A1 (en) * 2008-04-18 2009-10-22 Kim Scheuringer Detection test assembly for detecting the presence of a substance in a sample
US8206940B2 (en) 2008-05-15 2012-06-26 Tufts University Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US20110287965A1 (en) * 2008-11-26 2011-11-24 Tzam Diagnostics Llc Methods and compositions to detect clostridium difficile
AU2009350614B2 (en) * 2009-07-27 2013-04-04 Biodics Gmbh Method for detecting and identifying a variant C. difficile strain in a sample
US8765399B2 (en) 2010-05-18 2014-07-01 Montefiore Medical Center Cultures and protocols for diagnosis of toxigenic Clostridium difficile
US9186668B1 (en) 2010-06-04 2015-11-17 Sandia Corporation Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
US9795961B1 (en) 2010-07-08 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Devices, systems, and methods for detecting nucleic acids using sedimentation
US8962346B2 (en) 2010-07-08 2015-02-24 Sandia Corporation Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
US10295535B2 (en) * 2011-04-29 2019-05-21 Techlab, Inc. Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease
US20120276059A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease
KR20140066770A (ko) 2011-09-20 2014-06-02 애버리 데니슨 코포레이션 양각 열가소성 라벨
US9244065B1 (en) 2012-03-16 2016-01-26 Sandia Corporation Systems, devices, and methods for agglutination assays using sedimentation
US9133527B2 (en) * 2012-05-11 2015-09-15 Techlab, Inc. Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
WO2013177206A2 (en) 2012-05-21 2013-11-28 Fluidigm Corporation Single-particle analysis of particle populations
ES2385625B2 (es) 2012-05-29 2013-09-25 Certest Biotec, S.L. Dispositivo para el diagnóstico rápido de enfermedades causadas por Clostridium difficile en muestras fecales
KR101955329B1 (ko) 2012-06-08 2019-03-07 삼성전자주식회사 클로스트리디움 디피실리 균주 검출용 조성물과 키트 및 이를 이용한 검출 방법
CA2876692C (en) 2012-06-22 2022-05-24 Quantrx Biomedical Corporation Method for obtaining fetal cells and fetal cellular components
US9903001B1 (en) 2012-07-19 2018-02-27 National Technology & Engineering Solutions Of Sandia, Llc Quantitative detection of pathogens in centrifugal microfluidic disks
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
US9304128B1 (en) * 2013-02-01 2016-04-05 Sandia Corporation Toxin activity assays, devices, methods and systems therefor
US9500579B1 (en) 2013-05-01 2016-11-22 Sandia Corporation System and method for detecting components of a mixture including tooth elements for alignment
US9803238B1 (en) 2013-11-26 2017-10-31 National Technology & Engineering Solutions Of Sandia, Llc Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
FR3014446B1 (fr) * 2013-12-10 2017-05-26 Biomerieux Sa Stabilisation de la gdh en solution aqueuse
SG11201608278WA (en) 2014-04-02 2016-10-28 Chembio Diagnostic Systems Inc Immunoassay utilizing trapping conjugate
US10093989B2 (en) 2014-10-20 2018-10-09 Gen-Probe Incorporated Red blood cell lysis solution
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
US9702871B1 (en) 2014-11-18 2017-07-11 National Technology & Engineering Solutions Of Sandia, Llc System and method for detecting components of a mixture including a valving scheme for competition assays
FI126289B (en) 2014-12-19 2016-09-15 Mobidiag Ltd Method for detecting the presence of a hypervirulent strain of Clostridium difficile
US10254298B1 (en) 2015-03-25 2019-04-09 National Technology & Engineering Solutions Of Sandia, Llc Detection of metabolites for controlled substances
EP3341725B1 (en) 2015-08-25 2021-08-18 Prothena Biosciences Limited Methods for detecting phosphorylated alpha-synuclein
EP3448998B1 (en) 2016-04-27 2020-06-03 Gen-Probe Incorporated Blood cell lysis reagent
US10406528B1 (en) 2016-08-04 2019-09-10 National Technology & Engineering Solutions Of Sandia, Llc Non-contact temperature control system for microfluidic devices
US10981174B1 (en) 2016-08-04 2021-04-20 National Technology & Engineering Solutions Of Sandia, Llc Protein and nucleic acid detection for microfluidic devices
US10786811B1 (en) 2016-10-24 2020-09-29 National Technology & Engineering Solutions Of Sandia, Llc Detection of active and latent infections with microfluidic devices and systems thereof
EP3706795A4 (en) 2017-11-09 2021-10-13 Pinteon Therapeutics Inc. METHODS AND COMPOSITIONS FOR GENERATING AND USING HUMANIZED CONFORMATION SPECIFIC PHOSPHORYLATED TAU ANTIBODIES
CN119930831A (zh) 2018-03-14 2025-05-06 纪念斯隆凯特琳癌症中心 抗聚唾液酸抗体及其用途
EP3938400B1 (en) 2019-03-11 2025-07-30 Memorial Sloan Kettering Cancer Center Cd22 antibodies and methods of using the same
US11597961B2 (en) 2019-04-22 2023-03-07 Qualitic Biotechnology LLC Rapid colorimetric diagnostic test for C. difficile
US20220251179A1 (en) 2019-05-28 2022-08-11 Shanghaitech University Composition and methods to treat ectodermal dysplasia 2, clouston type
CN112661849B (zh) * 2020-12-17 2022-05-20 杭州贤至生物科技有限公司 一种艰难梭菌重组蛋白单克隆抗体的制备方法和应用
CN117700560B (zh) * 2023-12-08 2024-05-31 北京新兴四寰生物技术有限公司 抗艰难梭菌谷氨酸脱氢酶的单克隆抗体及其应用
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937201A (en) * 1982-06-10 1990-06-26 Mitsubishi Kasei Corporation Latex reagent for detection of the toxin of clostridium difficile
US4530833A (en) * 1982-09-13 1985-07-23 Wilkins Tracy D Toxins and antibodies of C. difficile
US4879218A (en) * 1982-09-13 1989-11-07 Virginia Tech Intellectual Properties, Inc. Antibody for C.difficile
US4533630A (en) * 1982-09-13 1985-08-06 Wilkins Tracy D Toxins and antibodies of C. difficile
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4863852A (en) * 1985-07-03 1989-09-05 Virginia Tech Intellectual Properties, Inc. Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors
US5071759A (en) * 1986-05-30 1991-12-10 The United States Of America As Represented By The Secretary Of The Army Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B
US5231003A (en) * 1990-05-11 1993-07-27 Cambridge Bioscience Corporation Monoclonal antibodies specific for toxin b of clostridium difficile
EP0579767B1 (en) * 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Novel conjugates and assays for simultaneous detection of multiple ligands
US5610023A (en) * 1995-03-31 1997-03-11 Lee Laboratories, Inc. Method of purification of clostridium difficile toxin A and production of mono-specific antibodies
US5965375A (en) * 1997-04-04 1999-10-12 Biosite Diagnostics Diagnostic tests and kits for Clostridium difficile

Also Published As

Publication number Publication date
US6503722B1 (en) 2003-01-07
CA2285919C (en) 2009-06-02
EP1019724B1 (en) 2006-09-13
EP1019724A1 (en) 2000-07-19
US5965375A (en) 1999-10-12
DE69835893T2 (de) 2007-03-08
WO1998045706A1 (en) 1998-10-15
JP2002510385A (ja) 2002-04-02
EP1019724A4 (en) 2004-10-06
CA2285919A1 (en) 1998-10-15
DE69835893D1 (de) 2006-10-26

Similar Documents

Publication Publication Date Title
ATE339688T1 (de) Diagnostische tests und kits für clostridium difficile
TW326074B (en) Methods, kits and diagnostic systems for performing an affinity assay
DE60134957D1 (de) Methoden und testsätze für annäherungstest
WO2002097112A3 (en) Catalytic amplification of multiplexed assay signals
PL309211A1 (en) Heterogenous specific bond test used for detection or content determination of a given substance in a sample analysed, method of reducing non-specific bonding in pseudohomogenous tests and testing set for performing immunological test and those employing genetic probe
NZ306051A (en) Testing using electrochemiluminescence
ATE160876T1 (de) Verfahren und zusammensetzungen zum nachweis von serumproteasen, insbesondere für aktiviertes protein c
CY1107621T1 (el) Μεθοδος ανιχνευσης αντισωματων σε ενα δειγμα
GB9709821D0 (en) Allergy assay
ATE405832T1 (de) Verfahren zur erhöhung des dynamischen messbereichs von auf spezifischen bindereaktionen basierenden, insbesondere immunologischen testelementen
DE60333876D1 (de) Methoden zum Nachweis Analyten in Proben
DE69529691D1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
DE69725118D1 (en) Reagentien für tests für mycophenolsäure
JPS60501178A (ja) 抗原抗体検出剤
DE50203136D1 (de) Verfahren zum Nachweis von Analyten in Proben mittels Analysenelementen
GB9913819D0 (en) Assay
WO2004054431A3 (en) Tests for the rapid evaluation of ischemic states and kits
ATE278193T1 (de) Verfahren zum testen eines asialoglycoproteinrezeptors und testreagenz dafür
SE0003662D0 (sv) Assay method and kit therefor
ES2004066A6 (es) Metodo para analisis cualitativo y-o cuantitativo de antigenos,anticuerpos yno microorganismos u otras celulas y su correspondiente equipo
DE60216482D1 (de) Zusammensetzungen und verfahren zum bestimmen von aa4rp
Reiss et al. Recent advances in detection and identification of botulinum neurotoxins (BoNTs)
Durkee Development of amplified detection systems for protein blotting using a solid phase coagulation assay.
WO2005084404A3 (en) Microfluidic biosensor and methods of use

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties