JP2002507203A - ヌクレオシドおよびヌクレオチド標識のための非スルホン化シアニン色素 - Google Patents
ヌクレオシドおよびヌクレオチド標識のための非スルホン化シアニン色素Info
- Publication number
- JP2002507203A JP2002507203A JP50473699A JP50473699A JP2002507203A JP 2002507203 A JP2002507203 A JP 2002507203A JP 50473699 A JP50473699 A JP 50473699A JP 50473699 A JP50473699 A JP 50473699A JP 2002507203 A JP2002507203 A JP 2002507203A
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- dye
- propyl
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下の式の化学化合物: 〔式中、 R1はアルキル、アラルキルおよび置換アルキルからなる群から選択される; R3はH、PO3 -2;P2O6 -3;P3O9 -4、α−チオホスフェート;およびαB H3 -ホスフェートからなる群から選択される: R4はH、低級アルキル、アシル、(CH2)pCOO(CH2)qCH3(式中、pは 0から4の整数およびqは0から4の整数)および5,6;6,7;または7,8− ブタジエニルからなる群から選択される; R5はH、低級アルキル、アシル、(CH2)pCOO(CH2)qCH3(式中、pは 0から4の整数およびqは0から4の整数)および5,6;6,7;または7,8− ブタジエニルからなる群から選択される; rは1、2または3; XおよびYはO、S、C(R6)2、N(R6)(式中、R6はCH3または低級アルキ ル)である; およびR3−O−Sugar−Baseはヌクレオチドまたはヌクレオシドである。〕 2.Rが置換基がOR2、COOR2、NR2R2またはSR2(式中、R2はH、 除去可能な保護基、または低級アルキル基である)、置換アルキル鎖からなる群 から選択される、請求項1記載の化合物。 3.R2がH、除去可能な保護基、または低級アルキル基からなる群から選択 される、請求項2記載の化合物。 4.Rが(CH2)3OHである、請求項1記載の化合物。 5.Rが(CH2)5COOH、(CH2)3NH2およびC2H5からなる群から選択 される、請求項1記載の化合物。 6.R3がPO3 -2、P2O6 -3およびP3O9 -4からなる群から選択される、請求 項1記載の化合物。 7.リンカーがプロピル−O−PO2−O−ヘキシル、プロピル−O2C−エチ ル−CO、プロピル−O2C−エチル−CONH−ヘキシルおよびプロピル−O2 C−エチル−CONH−プロピニルからなる群から選択される、請求項1記載の 化合物。 8.リンカーが3から25原子の長さである、請求項1記載の化合物。 9.XおよびYがC(CH3)2である、請求項1記載の化合物。 10.R3−O−Sugar−Baseにより形成されるヌクレオチドまたはヌクレオシ ドがIDC-rCTP、IDC-dCTP、IDC-ddCTP、ITC-ddCTP、ITC-ddATP、IDC-dATP、IMC-c 7-ddGTPおよびOMC-ddCTPからなる群から選択される、請求項1記載の化合物。 11.R3がPO2 -2、P2O5 -3およびP3O8 -4からなる群から選択される、請 求項1記載の化合物。 12.R3がP(BH3)O2 -2、P2(BH3)O5 -3およびP3(BH3)O8 -4からな る群から選択される、請求項1記載の化合物。 13.ヌクレオチドまたはヌクレオシドに結合した非スルホン化カルボシアニ ン色素。 14.色素がインドカルボシアニン色素である、請求項13記載の色素。 15.請求項1記載の化合物を核酸鎖に挿入させる段階を含む、核酸分子の標 識法。 16.更に分子の核酸配列の決定の段階を含む、請求項15記載の方法。 17.請求項13記載の化合物を核酸鎖に挿入させる段階を含む、核酸分子の 標識法。 18.更に分子の核酸配列の決定の段階を含む、請求項17記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/879,596 US5986086A (en) | 1997-06-20 | 1997-06-20 | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
US08/879,596 | 1997-06-20 | ||
PCT/US1998/012593 WO1998058942A1 (en) | 1997-06-20 | 1998-06-16 | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002507203A true JP2002507203A (ja) | 2002-03-05 |
Family
ID=25374472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50473699A Ceased JP2002507203A (ja) | 1997-06-20 | 1998-06-16 | ヌクレオシドおよびヌクレオチド標識のための非スルホン化シアニン色素 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5986086A (ja) |
EP (1) | EP0989990B1 (ja) |
JP (1) | JP2002507203A (ja) |
AT (1) | ATE242260T1 (ja) |
CA (1) | CA2294979A1 (ja) |
DE (1) | DE69815342T2 (ja) |
WO (1) | WO1998058942A1 (ja) |
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JP2011026324A (ja) * | 2008-07-24 | 2011-02-10 | Kyushu Univ | 酵素基質修飾ヌクレオシド三リン酸誘導体 |
JP2011169878A (ja) * | 2010-01-22 | 2011-09-01 | Kyushu Univ | 核酸検出用キット |
WO2013191265A1 (ja) * | 2012-06-22 | 2013-12-27 | 国立大学法人九州大学 | タンパク質-核酸複合体の製造方法および標的物の検出方法 |
WO2014038561A1 (ja) * | 2012-09-04 | 2014-03-13 | 株式会社ダナフォーム | 化合物、核酸、標識物質および検出方法 |
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JP4306960B2 (ja) * | 1998-02-04 | 2009-08-05 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | ジデオキシ色素ターミネーター |
US6114350A (en) * | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
US6271360B1 (en) * | 1999-08-27 | 2001-08-07 | Valigen (Us), Inc. | Single-stranded oligodeoxynucleotide mutational vectors |
CA2382063A1 (en) * | 1999-09-17 | 2001-03-22 | Shiv Kumar | Charge-modified nucleic acid terminators |
EP1088559A3 (de) * | 1999-09-29 | 2002-10-02 | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN | Galenische Formulierungen |
EP1106621B1 (en) * | 1999-12-07 | 2003-11-19 | Fuji Photo Film Co., Ltd. | Fluorescent substances |
US7115589B2 (en) * | 1999-12-17 | 2006-10-03 | Ariad Pharmaceuticals, Inc. | Purine derivatives |
AU2277201A (en) * | 1999-12-17 | 2001-06-25 | Ariad Pharmaceuticals, Inc. | Novel purines |
JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
DE10046215B4 (de) * | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
EP1322710B2 (en) | 2000-09-29 | 2015-02-18 | Life Technologies Corporation | Modified carbocyanine dyes and their conjugates |
JP4741170B2 (ja) * | 2000-10-11 | 2011-08-03 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | アニオン性リンカーを有する蛍光核酸塩基結合体 |
NO20006130D0 (no) * | 2000-12-01 | 2000-12-01 | Erling Sundrehagen | Reagens og analysemetode |
WO2002068537A2 (en) * | 2001-02-28 | 2002-09-06 | Stratagene | Fluorescent dye |
JP4676654B2 (ja) * | 2001-07-19 | 2011-04-27 | 富士フイルム株式会社 | 蛍光ヌクレオチド及びそれを用いた標識法 |
US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
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US6838289B2 (en) * | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
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US20040265870A1 (en) * | 2003-04-09 | 2004-12-30 | Invitrogen Corporation | Methods of synthesizing and labeling nucleic acid molecules |
WO2005009348A2 (en) * | 2003-06-25 | 2005-02-03 | Ariad Pharmaceuticals, Inc. | Substituted purine derivatives |
US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
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US20060029948A1 (en) * | 2003-09-19 | 2006-02-09 | Gary Lim | Sealing cover and dye compatibility selection |
WO2005040357A2 (en) * | 2003-10-24 | 2005-05-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
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WO2005077125A2 (en) * | 2004-02-11 | 2005-08-25 | Applera Corporation | Methods and compositions for detecting nucleic acids |
US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
EP1781675B1 (en) | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
EP2312317A3 (en) | 2005-05-03 | 2011-06-08 | Life Technologies Corporation | Fluorescent detection system and dye set for use therewith |
US7781187B2 (en) * | 2005-12-30 | 2010-08-24 | Corning Incorporated | Fluorescent dyes |
WO2008111485A1 (ja) * | 2007-03-09 | 2008-09-18 | Riken | モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット |
FR2913424B1 (fr) * | 2007-03-09 | 2009-07-24 | Cis Bio Internat Sa | Derives de cyanine, conjuges fluorescents les contenant et leur utilisation |
CA2622649C (en) * | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
US20110262354A1 (en) | 2007-07-13 | 2011-10-27 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
US20110085974A1 (en) * | 2008-06-13 | 2011-04-14 | Cedars-Sinai Medical Center | Small molecule ligand-drug conjugates for targeted cancer therapy |
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-
1997
- 1997-06-20 US US08/879,596 patent/US5986086A/en not_active Expired - Fee Related
-
1998
- 1998-06-16 DE DE69815342T patent/DE69815342T2/de not_active Expired - Fee Related
- 1998-06-16 JP JP50473699A patent/JP2002507203A/ja not_active Ceased
- 1998-06-16 EP EP98930319A patent/EP0989990B1/en not_active Expired - Lifetime
- 1998-06-16 AT AT98930319T patent/ATE242260T1/de not_active IP Right Cessation
- 1998-06-16 WO PCT/US1998/012593 patent/WO1998058942A1/en active IP Right Grant
- 1998-06-16 CA CA002294979A patent/CA2294979A1/en not_active Abandoned
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US8198418B2 (en) | 2008-07-24 | 2012-06-12 | Kyushu University, National University Corporation | Nucleoside triphosphate derivative, nucleic acid probe, multilabeled nucleic acid probe, method for production of multilabeled nucleic acid probe, and method for detection of target nucleic acid |
JP2011169878A (ja) * | 2010-01-22 | 2011-09-01 | Kyushu Univ | 核酸検出用キット |
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WO2014038561A1 (ja) * | 2012-09-04 | 2014-03-13 | 株式会社ダナフォーム | 化合物、核酸、標識物質および検出方法 |
JPWO2014038561A1 (ja) * | 2012-09-04 | 2016-08-12 | 株式会社ダナフォーム | 化合物、核酸、標識物質および検出方法 |
US10294261B2 (en) | 2012-09-04 | 2019-05-21 | Kabushiki Kaisha Dnaform | Compound, nucleic acid, labeling substance, and detection method |
EA034342B1 (ru) * | 2012-09-04 | 2020-01-29 | КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ | Соединение, нуклеиновая кислота, вещество, несущее метку, и способ обнаружения |
Also Published As
Publication number | Publication date |
---|---|
WO1998058942A1 (en) | 1998-12-30 |
DE69815342T2 (de) | 2004-04-29 |
ATE242260T1 (de) | 2003-06-15 |
EP0989990B1 (en) | 2003-06-04 |
EP0989990A1 (en) | 2000-04-05 |
CA2294979A1 (en) | 1998-12-30 |
US5986086A (en) | 1999-11-16 |
DE69815342D1 (de) | 2003-07-10 |
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