ATE242260T1 - Sulfonatfreie cyaninfarbstoffe zur markierung von nukleosiden und nukleotiden - Google Patents
Sulfonatfreie cyaninfarbstoffe zur markierung von nukleosiden und nukleotidenInfo
- Publication number
- ATE242260T1 ATE242260T1 AT98930319T AT98930319T ATE242260T1 AT E242260 T1 ATE242260 T1 AT E242260T1 AT 98930319 T AT98930319 T AT 98930319T AT 98930319 T AT98930319 T AT 98930319T AT E242260 T1 ATE242260 T1 AT E242260T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- integer
- nucleosides
- nucleotides
- sulfonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/879,596 US5986086A (en) | 1997-06-20 | 1997-06-20 | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
PCT/US1998/012593 WO1998058942A1 (en) | 1997-06-20 | 1998-06-16 | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE242260T1 true ATE242260T1 (de) | 2003-06-15 |
Family
ID=25374472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98930319T ATE242260T1 (de) | 1997-06-20 | 1998-06-16 | Sulfonatfreie cyaninfarbstoffe zur markierung von nukleosiden und nukleotiden |
Country Status (7)
Country | Link |
---|---|
US (1) | US5986086A (de) |
EP (1) | EP0989990B1 (de) |
JP (1) | JP2002507203A (de) |
AT (1) | ATE242260T1 (de) |
CA (1) | CA2294979A1 (de) |
DE (1) | DE69815342T2 (de) |
WO (1) | WO1998058942A1 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4306960B2 (ja) * | 1998-02-04 | 2009-08-05 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | ジデオキシ色素ターミネーター |
US6114350A (en) * | 1999-04-19 | 2000-09-05 | Nen Life Science Products, Inc. | Cyanine dyes and synthesis methods thereof |
US6271360B1 (en) * | 1999-08-27 | 2001-08-07 | Valigen (Us), Inc. | Single-stranded oligodeoxynucleotide mutational vectors |
CA2382063A1 (en) * | 1999-09-17 | 2001-03-22 | Shiv Kumar | Charge-modified nucleic acid terminators |
EP1088559A3 (de) * | 1999-09-29 | 2002-10-02 | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN | Galenische Formulierungen |
EP1106621B1 (de) * | 1999-12-07 | 2003-11-19 | Fuji Photo Film Co., Ltd. | Fluoreszente materialen |
US7115589B2 (en) * | 1999-12-17 | 2006-10-03 | Ariad Pharmaceuticals, Inc. | Purine derivatives |
AU2277201A (en) * | 1999-12-17 | 2001-06-25 | Ariad Pharmaceuticals, Inc. | Novel purines |
JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
DE10046215B4 (de) * | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
EP1322710B2 (de) | 2000-09-29 | 2015-02-18 | Life Technologies Corporation | Modifizierte carbocyaninfarbstoffe und deren konjugate |
JP4741170B2 (ja) * | 2000-10-11 | 2011-08-03 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | アニオン性リンカーを有する蛍光核酸塩基結合体 |
NO20006130D0 (no) * | 2000-12-01 | 2000-12-01 | Erling Sundrehagen | Reagens og analysemetode |
WO2002068537A2 (en) * | 2001-02-28 | 2002-09-06 | Stratagene | Fluorescent dye |
JP4676654B2 (ja) * | 2001-07-19 | 2011-04-27 | 富士フイルム株式会社 | 蛍光ヌクレオチド及びそれを用いた標識法 |
US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
US8569516B2 (en) * | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
IL146142A0 (en) * | 2001-10-24 | 2002-07-25 | Univ Bar Ilan | 2-substituted-5'-o-(1-boranotriphosphate adenosine derivatives and pharmaceutical compositions comprising them for treatment of type 2 diabetes |
US6838289B2 (en) * | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
CA2490961A1 (en) * | 2002-07-01 | 2004-01-08 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
US20040265870A1 (en) * | 2003-04-09 | 2004-12-30 | Invitrogen Corporation | Methods of synthesizing and labeling nucleic acid molecules |
WO2005009348A2 (en) * | 2003-06-25 | 2005-02-03 | Ariad Pharmaceuticals, Inc. | Substituted purine derivatives |
US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
US20060029948A1 (en) * | 2003-09-19 | 2006-02-09 | Gary Lim | Sealing cover and dye compatibility selection |
WO2005040357A2 (en) * | 2003-10-24 | 2005-05-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
US7705150B2 (en) | 2004-02-04 | 2010-04-27 | Biosearch Technologies, Inc. | Cyanine dyes |
WO2005077125A2 (en) * | 2004-02-11 | 2005-08-25 | Applera Corporation | Methods and compositions for detecting nucleic acids |
US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
EP1781675B1 (de) | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Fluoreszierende phosphonatfarbstoffe und konjugate |
EP2312317A3 (de) | 2005-05-03 | 2011-06-08 | Life Technologies Corporation | Fluoreszentes Erkennungssystem und Farbstoffsatz zur Verwendung damit |
US7781187B2 (en) * | 2005-12-30 | 2010-08-24 | Corning Incorporated | Fluorescent dyes |
WO2008111485A1 (ja) * | 2007-03-09 | 2008-09-18 | Riken | モノヌクレオシドまたはモノヌクレオチドから誘導される構造を有する化合物、核酸、標識物質、核酸検出方法およびキット |
FR2913424B1 (fr) * | 2007-03-09 | 2009-07-24 | Cis Bio Internat Sa | Derives de cyanine, conjuges fluorescents les contenant et leur utilisation |
CA2622649C (en) * | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
US20110262354A1 (en) | 2007-07-13 | 2011-10-27 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
US20110085974A1 (en) * | 2008-06-13 | 2011-04-14 | Cedars-Sinai Medical Center | Small molecule ligand-drug conjugates for targeted cancer therapy |
JP4621926B2 (ja) * | 2008-07-24 | 2011-02-02 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
JP5146785B2 (ja) * | 2008-07-24 | 2013-02-20 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸誘導体 |
JP5704481B2 (ja) * | 2010-01-22 | 2015-04-22 | 国立大学法人九州大学 | 核酸検出用キット |
US8889886B2 (en) | 2010-08-25 | 2014-11-18 | Pacific Biosciences, Inc. | Cyanine dyes |
WO2012088007A1 (en) | 2010-12-21 | 2012-06-28 | Pierce Biotechnology, Inc. | Fluorescent compounds |
EP2658998B1 (de) | 2010-12-29 | 2015-04-22 | Life Technologies Corporation | Ddao-verbindungen als fluorezenzreferenzstandards |
DK2714939T3 (en) | 2011-05-24 | 2015-06-29 | Elitech Holding Bv | DETECTION OF METHICILLIN-RESISTENT STAPHYLOCOCCUS AUREUS |
US8889884B1 (en) | 2011-07-14 | 2014-11-18 | Pierce Biotechnology, Inc. | Phosphine derivatives of fluorescent compounds |
US9249307B2 (en) | 2011-08-16 | 2016-02-02 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
US9751868B2 (en) | 2012-02-28 | 2017-09-05 | Pierce Biotechnology, Inc. | Benzocyanine compounds |
US20140072515A9 (en) | 2012-03-02 | 2014-03-13 | Greg Hermanson | Cyanine compounds |
EP2850086B1 (de) | 2012-05-18 | 2023-07-05 | Pacific Biosciences Of California, Inc. | Heteroarylcyaninfarbstoffe |
US9315864B2 (en) | 2012-05-18 | 2016-04-19 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes with sulfonic acid substituents |
JP5509440B2 (ja) | 2012-06-22 | 2014-06-04 | 国立大学法人九州大学 | タンパク質−核酸複合体の製造方法および標的物の検出方法 |
US9676787B2 (en) | 2012-08-28 | 2017-06-13 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
US10294261B2 (en) | 2012-09-04 | 2019-05-21 | Kabushiki Kaisha Dnaform | Compound, nucleic acid, labeling substance, and detection method |
JP2016510991A (ja) | 2013-03-11 | 2016-04-14 | エリテックグループ・ベスローテン・フェンノートシャップElitechgroup B.V. | 正確な鎖置換型等温増幅のための方法 |
EP2997161B1 (de) | 2013-05-13 | 2017-09-27 | Elitechgroup B.V. | Digitale tröpfchen -pcr mit kurzen sonden mit kleineren rillen |
US10266903B2 (en) | 2014-12-12 | 2019-04-23 | Elitechgroup, Inc. | Methods and compositions for detecting antibiotic resistant bacteria |
EP3230468B1 (de) | 2014-12-12 | 2020-09-16 | ELITechGroup, Inc. | Verfahren und kits zum nachweis von antibiotikaresistenten bakterien |
WO2021080629A1 (en) | 2019-10-23 | 2021-04-29 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
CN115181049B (zh) * | 2022-06-01 | 2023-12-19 | 郑州玛特瑞斯生物科技有限公司 | 一种荧光化合物及其制备方法、荧光修饰核苷酸、测序试剂 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5569587A (en) * | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
US5627027A (en) * | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
US4981977A (en) * | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
GB9009980D0 (en) * | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
US5556959A (en) * | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
DE4326466A1 (de) * | 1993-08-06 | 1995-02-09 | Boehringer Mannheim Gmbh | Infrarot-Farbstoff-markierte Nucleotide und ihre Verwendung in der Nucleinsäure-Detektion |
US5808043A (en) * | 1995-01-18 | 1998-09-15 | Pharmacia Biotech Inc. | Composition for stabilization of labelled nucleoside triphosphates and methods for using same |
-
1997
- 1997-06-20 US US08/879,596 patent/US5986086A/en not_active Expired - Fee Related
-
1998
- 1998-06-16 DE DE69815342T patent/DE69815342T2/de not_active Expired - Fee Related
- 1998-06-16 JP JP50473699A patent/JP2002507203A/ja not_active Ceased
- 1998-06-16 EP EP98930319A patent/EP0989990B1/de not_active Expired - Lifetime
- 1998-06-16 AT AT98930319T patent/ATE242260T1/de not_active IP Right Cessation
- 1998-06-16 WO PCT/US1998/012593 patent/WO1998058942A1/en active IP Right Grant
- 1998-06-16 CA CA002294979A patent/CA2294979A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998058942A1 (en) | 1998-12-30 |
JP2002507203A (ja) | 2002-03-05 |
DE69815342T2 (de) | 2004-04-29 |
EP0989990B1 (de) | 2003-06-04 |
EP0989990A1 (de) | 2000-04-05 |
CA2294979A1 (en) | 1998-12-30 |
US5986086A (en) | 1999-11-16 |
DE69815342D1 (de) | 2003-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |