ES2166081T3 - Derivados de nucleosidos con grupos protectores fotolabiles. - Google Patents

Derivados de nucleosidos con grupos protectores fotolabiles.

Info

Publication number
ES2166081T3
ES2166081T3 ES97922946T ES97922946T ES2166081T3 ES 2166081 T3 ES2166081 T3 ES 2166081T3 ES 97922946 T ES97922946 T ES 97922946T ES 97922946 T ES97922946 T ES 97922946T ES 2166081 T3 ES2166081 T3 ES 2166081T3
Authority
ES
Spain
Prior art keywords
och3
halogen
atoms
protective groups
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97922946T
Other languages
English (en)
Inventor
Wolfgang Pfleiderer
Sigrid Buhler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2166081T3 publication Critical patent/ES2166081T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

LA INVENCION TRATA DE DERIVADOS DE NUCLEOSIDOS CON GRUPOS PROTECTORES FOTOLABILES DE FORMULA GENERAL (I), EN LA QUE R SUP,1 = H, NO 2 , CN, OCH 3 , HALOGENO, ALQUILO O ALCOX IALQUILO CON 1 A 4 ATOMOS DE C, R 2 = H, OCH 3 , R SUP,3 = H, F, CL, BR, NO 2 , O UN RADICAL ALIFATICO DE ACILO CON 2 A 5 ATOMOS DE C; R 4 = H, HALOGENO, OCH 3 , UN RADICAL ALQUILICO CON 1 A 4 ATOMOS DE C O UN RADICAL ARILICO OPCIONALMENTE SUSTITUIDO, R 5 = H O UN GRUPO FUNCIONAL USU AL PARA LA OBTENCION DE OLIGONUCLEOTIDOS, R 6 = H, OH, HALOGENO O XR 8 , SIENDO X = O O S Y R 8 ES UN GRUPO DE PROTECCION USUAL EN LA QUIMICA DE LOS NUCLEOTIDOS, B = ADENINA, CITOSINA, GUANINA, TIMINA, URACILO, 2, 6 - DIAMINOPURIN - 9 ILO, HIPOXANTINA - 9 - ILO, AMID - 1 - ILO DEL ACIDO 5 - AMINO - 4 - IMIDAZOLCARBOXILICO O AMID - 3 - ILO DEL ACIDO 5 - AMINO - 4 - IMIDAZOLCARBOXILICO, Y EN EL CASO DE QUE B = ADENINA, CITOSINA O GUANINA LA FUNCION DE AMINA PRIMARIA LLEVA OPCIONALMENTE UN GRUPO DE PROTECCION PERMANENTE. ESTOS DERIVADOS SE PUEDEN UTILIZAR PARA LA SINTESIS CONTROLADA POR LA LUZ DE OLIGONUCLEOTIDOS SOBRE UN CHIP DE DNA.
ES97922946T 1996-05-20 1997-05-02 Derivados de nucleosidos con grupos protectores fotolabiles. Expired - Lifetime ES2166081T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19620170A DE19620170A1 (de) 1996-05-20 1996-05-20 Nucleosid-Derivate mit photolabilen Schutzgruppen

Publications (1)

Publication Number Publication Date
ES2166081T3 true ES2166081T3 (es) 2002-04-01

Family

ID=7794741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97922946T Expired - Lifetime ES2166081T3 (es) 1996-05-20 1997-05-02 Derivados de nucleosidos con grupos protectores fotolabiles.

Country Status (10)

Country Link
US (1) US6153744A (es)
EP (1) EP0901501B1 (es)
JP (1) JP2000514404A (es)
AT (1) ATE207077T1 (es)
AU (1) AU711814B2 (es)
CA (1) CA2254065A1 (es)
DE (2) DE19620170A1 (es)
DK (1) DK0901501T3 (es)
ES (1) ES2166081T3 (es)
WO (1) WO1997044345A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
DE19858440A1 (de) * 1998-12-17 2000-06-21 Deutsches Krebsforsch Verfahren zur photolithografischen Biochip-Synthese
DE19952113A1 (de) 1999-10-29 2001-05-03 Nigu Chemie Gmbh Nucleosid-Derivate mit photolabilen Schutzgruppen
DE10105079A1 (de) * 2001-02-05 2002-08-08 Febit Ferrarius Biotech Gmbh Fotolabile Schutzgruppen für die Synthese von Biopolymeren
DE10105077A1 (de) * 2001-02-05 2002-08-08 Febit Ferrarius Biotech Gmbh Hybrid-Schutzgruppe
KR100464261B1 (ko) * 2002-01-24 2005-01-03 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
DE10209203A1 (de) 2002-03-04 2003-09-25 Ulrich Steiner Verfahren zur Abspaltung von labilen funktionellen Gruppen aus chemischen Verbindungen
KR100464264B1 (ko) * 2002-03-21 2005-01-03 주식회사 파나진 광분해 보호기를 갖는 신규한 ｐｎａ 단량체
AU2003298235A1 (en) * 2002-12-23 2004-07-22 Febit Ag Intramolecular triplet-sensitized o-nitrophenylethyl photoprotective groups
US7759513B2 (en) * 2003-02-21 2010-07-20 Nigu Chemie Gmbh Photolabile protective groups for improved processes to prepare oligonucleotide arrays
DE102004019098A1 (de) * 2004-04-20 2005-11-10 Chemogenix Gmbh Photolabile Schutzgruppen
PE20081692A1 (es) 2007-01-24 2008-12-18 Mochida Pharm Co Ltd Nuevo derivado de heterocicliden acetamida
US20110003708A1 (en) * 2007-12-27 2011-01-06 Compugen Ltd. Biomarkers for the prediction of renal injury
EP2311792B1 (de) 2009-10-13 2013-05-15 Roche Diagnostics GmbH Friedel-crafts-acylierung zur Synthese von Aryl- und Heteroaryl-(3-ethyl-4-nitro-phenyl)-Methanonen
WO2013019361A1 (en) 2011-07-07 2013-02-07 Life Technologies Corporation Sequencing methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3606394A1 (de) * 1986-02-27 1987-09-03 Wolfgang Prof Dr Dr Pfleiderer Neue ribonucleoside, verfahren zu deren herstellung und deren verwendung
DE3606395A1 (de) * 1986-02-27 1987-09-03 Wolfgang Prof Dr Dr Pfleiderer Neue nucleinsaeurebausteine, verfahren zu deren herstellung und deren verwendung
DE4444996A1 (de) * 1994-12-16 1996-06-20 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen

Also Published As

Publication number Publication date
JP2000514404A (ja) 2000-10-31
DK0901501T3 (da) 2002-02-11
AU711814B2 (en) 1999-10-21
US6153744A (en) 2000-11-28
WO1997044345A1 (de) 1997-11-27
EP0901501B1 (de) 2001-10-17
ATE207077T1 (de) 2001-11-15
DE59704973D1 (de) 2001-11-22
CA2254065A1 (en) 1997-11-27
EP0901501A1 (de) 1999-03-17
AU2890497A (en) 1997-12-09
DE19620170A1 (de) 1997-11-27

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