JP2002504520A5 - - Google Patents

Info

Publication number

JP2002504520A5

JP2002504520A5 JP2000533139A JP2000533139A JP2002504520A5 JP 2002504520 A5 JP2002504520 A5 JP 2002504520A5 JP 2000533139 A JP2000533139 A JP 2000533139A JP 2000533139 A JP2000533139 A JP 2000533139A JP 2002504520 A5 JP2002504520 A5 JP 2002504520A5

Authority

JP

Japan

Prior art keywords

kda

wound

active enamel

use according

amelogenin

Prior art date

1999-02-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000003298 dental enamel Anatomy 0.000 claims 33
• 208000027418 Wounds and injury Diseases 0.000 claims 30
• 206010052428 Wound Diseases 0.000 claims 28
• 239000000126 substance Substances 0.000 claims 26
• 238000000034 method Methods 0.000 claims 21
• 108010007570 Amelogenin Proteins 0.000 claims 17
• 102000007325 Amelogenin Human genes 0.000 claims 17
• 238000002360 preparation method Methods 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 9
• 241000894006 Bacteria Species 0.000 claims 8
• 208000014674 injury Diseases 0.000 claims 8
• 230000006378 damage Effects 0.000 claims 7
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 6
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 6
• 208000015181 infectious disease Diseases 0.000 claims 6
• 239000000463 material Substances 0.000 claims 6
• 210000004400 mucous membrane Anatomy 0.000 claims 6
• 101000797621 Rattus norvegicus Ameloblastin Proteins 0.000 claims 5
• 238000001962 electrophoresis Methods 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims 5
• 108010022248 tuftelin Proteins 0.000 claims 5
• 102000012344 tuftelin Human genes 0.000 claims 5
• 241000124008 Mammalia Species 0.000 claims 4
• 230000004968 inflammatory condition Effects 0.000 claims 4
• 210000000214 mouth Anatomy 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 238000001356 surgical procedure Methods 0.000 claims 4
• 230000008733 trauma Effects 0.000 claims 4
• 230000029663 wound healing Effects 0.000 claims 4
• 241000186046 Actinomyces Species 0.000 claims 3
• 208000035143 Bacterial infection Diseases 0.000 claims 3
• 241000191940 Staphylococcus Species 0.000 claims 3
• 230000001580 bacterial effect Effects 0.000 claims 3
• 208000022362 bacterial infectious disease Diseases 0.000 claims 3
• 239000002537 cosmetic Substances 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 210000001519 tissue Anatomy 0.000 claims 3
• 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 claims 2
• 206010001889 Alveolitis Diseases 0.000 claims 2
• 102100040409 Ameloblastin Human genes 0.000 claims 2
• 241000193830 Bacillus <bacterium> Species 0.000 claims 2
• 241000589876 Campylobacter Species 0.000 claims 2
• 208000034656 Contusions Diseases 0.000 claims 2
• 241001453172 Fusobacteria Species 0.000 claims 2
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 2
• 206010061216 Infarction Diseases 0.000 claims 2
• 208000035901 Ischaemic ulcer Diseases 0.000 claims 2
• 208000009893 Nonpenetrating Wounds Diseases 0.000 claims 2
• 208000009344 Penetrating Wounds Diseases 0.000 claims 2
• 241000605862 Porphyromonas gingivalis Species 0.000 claims 2
• 241001135221 Prevotella intermedia Species 0.000 claims 2
• 241000589970 Spirochaetales Species 0.000 claims 2
• 241000295644 Staphylococcaceae Species 0.000 claims 2
• 241000194019 Streptococcus mutans Species 0.000 claims 2
• 241001135235 Tannerella forsythia Species 0.000 claims 2
• 206010053615 Thermal burn Diseases 0.000 claims 2
• 230000009519 contusion Effects 0.000 claims 2
• 238000000605 extraction Methods 0.000 claims 2
• 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 2
• 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 2
• 230000007574 infarction Effects 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• 210000004877 mucosa Anatomy 0.000 claims 2
• 208000028169 periodontal disease Diseases 0.000 claims 2
• 230000003239 periodontal effect Effects 0.000 claims 2
• 230000008929 regeneration Effects 0.000 claims 2
• 238000011069 regeneration method Methods 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 230000037303 wrinkles Effects 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• 101710081264 Ameloblastin Proteins 0.000 claims 1
• 102000004506 Blood Proteins Human genes 0.000 claims 1
• 108010017384 Blood Proteins Proteins 0.000 claims 1
• 101000891247 Homo sapiens Ameloblastin Proteins 0.000 claims 1
• 206010048685 Oral infection Diseases 0.000 claims 1
• 241001464887 Parvimonas micra Species 0.000 claims 1
• HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical group OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims 1
• 206010041899 Stab wound Diseases 0.000 claims 1
• -1 ameline Proteins 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 208000002925 dental caries Diseases 0.000 claims 1
• 239000004053 dental implant Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 108010074702 enamel matrix proteins Proteins 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 244000005700 microbiome Species 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims 1
• 239000000770 propane-1,2-diol alginate Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 230000036575 thermal burns Effects 0.000 claims 1