JP2002504511A - 癌処置のためのエポチロンの使用 - Google Patents
癌処置のためのエポチロンの使用Info
- Publication number
- JP2002504511A JP2002504511A JP2000533117A JP2000533117A JP2002504511A JP 2002504511 A JP2002504511 A JP 2002504511A JP 2000533117 A JP2000533117 A JP 2000533117A JP 2000533117 A JP2000533117 A JP 2000533117A JP 2002504511 A JP2002504511 A JP 2002504511A
- Authority
- JP
- Japan
- Prior art keywords
- epothilone
- treatment
- tumor
- proliferative disease
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9803907.6A GB9803907D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
| GBGB9803905.0A GB9803905D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
| GBGB9805937.1A GB9805937D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
| GBGB9805936.3A GB9805936D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
| US9803905.0 | 1999-01-19 | ||
| US9805937.1 | 1999-01-19 | ||
| US09/233,993 | 1999-01-19 | ||
| US09/233,993 US6302838B1 (en) | 1998-02-25 | 1999-01-19 | Cancer treatment with epothilones |
| US9805936.3 | 1999-01-19 | ||
| US9803907.6 | 1999-01-19 | ||
| PCT/EP1999/001147 WO1999043320A1 (en) | 1998-02-25 | 1999-02-23 | Use of epothilones for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128592A Division JP2011173928A (ja) | 1998-02-25 | 2011-06-08 | 癌処置のためのエポチロンの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002504511A true JP2002504511A (ja) | 2002-02-12 |
| JP2002504511A5 JP2002504511A5 (https=) | 2010-08-19 |
Family
ID=27517450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533117A Withdrawn JP2002504511A (ja) | 1998-02-25 | 1999-02-23 | 癌処置のためのエポチロンの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6635666B2 (https=) |
| EP (1) | EP1056453B1 (https=) |
| JP (1) | JP2002504511A (https=) |
| AU (1) | AU755944B2 (https=) |
| BE (1) | BE1011980A5 (https=) |
| CA (1) | CA2319752A1 (https=) |
| FR (1) | FR2775187B1 (https=) |
| IT (1) | ITMI990375A1 (https=) |
| NZ (1) | NZ506187A (https=) |
| WO (1) | WO1999043320A1 (https=) |
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| JP2005525360A (ja) * | 2002-03-01 | 2005-08-25 | シエーリング アクチエンゲゼルシャフト | 増殖過程に関連する脳疾患の処理へのエポチロンの使用 |
| JP2005538044A (ja) * | 2002-04-15 | 2005-12-15 | プロテオジス アクチェンゲゼルシャフト | 腫瘍の治療のための物質の使用 |
| JP2006504727A (ja) * | 2002-10-11 | 2006-02-09 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 多発性骨髄腫の処置のためのラクトン誘導体 |
| JP2008514569A (ja) * | 2004-09-24 | 2008-05-08 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 骨転移の治療へのエポチロンの使用 |
| JP2009513486A (ja) * | 2003-06-27 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | エポチロンでの癌処置 |
| JP2009536153A (ja) * | 2006-04-05 | 2009-10-08 | ノバルティス アクチエンゲゼルシャフト | 癌を処置するための治療剤の組合せ |
| JP2019522989A (ja) * | 2016-06-28 | 2019-08-22 | アルマ マータ ステューディオラム — ユニバーシタ ディ ボローニャ | ＴＡＴκ−ＣＤＫＬ５融合タンパク質、組成物、製剤、及びそれらの使用 |
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| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
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| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
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| NZ511722A (en) | 1998-11-20 | 2004-05-28 | Kosan Biosciences Inc | Recombinant methods and materials for producing epothilone and epothilone derivatives |
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| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| AU3606700A (en) * | 1999-02-26 | 2000-09-14 | Napro Biotherapeutics, Inc. | Treatment regimen for hormone-sensitive cancers |
| EP1154779A2 (en) * | 1999-02-26 | 2001-11-21 | Napro Biotherapeutics, Inc. | Treatment regimen for prostate cancer, initiated after androgen ablative therapy has started |
| US20050042275A1 (en) * | 1999-08-04 | 2005-02-24 | Jean-Claude Sonntag | Epothilone compositions |
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| HU229349B1 (en) * | 2001-01-25 | 2013-11-28 | Bristol Myers Squibb Co | Methods for preparation of pharmaceutical composition containing epothilone analogs useful for treatment of cancer |
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| IL156580A0 (en) | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
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- 1999-02-16 FR FR9901903A patent/FR2775187B1/fr not_active Expired - Fee Related
- 1999-02-23 EP EP99910257A patent/EP1056453B1/en not_active Expired - Lifetime
- 1999-02-23 WO PCT/EP1999/001147 patent/WO1999043320A1/en not_active Ceased
- 1999-02-23 JP JP2000533117A patent/JP2002504511A/ja not_active Withdrawn
- 1999-02-23 AU AU29279/99A patent/AU755944B2/en not_active Ceased
- 1999-02-23 CA CA002319752A patent/CA2319752A1/en not_active Withdrawn
- 1999-02-23 NZ NZ506187A patent/NZ506187A/en not_active IP Right Cessation
- 1999-02-24 IT IT99MI000375A patent/ITMI990375A1/it unknown
- 1999-02-25 BE BE9900126A patent/BE1011980A5/fr not_active IP Right Cessation
-
2001
- 2001-08-09 US US09/925,119 patent/US6635666B2/en not_active Expired - Fee Related
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2003
- 2003-08-01 US US10/633,114 patent/US20040024033A1/en not_active Abandoned
-
2005
- 2005-03-24 US US11/089,269 patent/US7091226B2/en not_active Expired - Fee Related
-
2006
- 2006-04-19 US US11/406,896 patent/US7875601B2/en not_active Expired - Fee Related
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005525360A (ja) * | 2002-03-01 | 2005-08-25 | シエーリング アクチエンゲゼルシャフト | 増殖過程に関連する脳疾患の処理へのエポチロンの使用 |
| JP2005538044A (ja) * | 2002-04-15 | 2005-12-15 | プロテオジス アクチェンゲゼルシャフト | 腫瘍の治療のための物質の使用 |
| JP2006504727A (ja) * | 2002-10-11 | 2006-02-09 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 多発性骨髄腫の処置のためのラクトン誘導体 |
| JP2009513486A (ja) * | 2003-06-27 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | エポチロンでの癌処置 |
| JP2008514569A (ja) * | 2004-09-24 | 2008-05-08 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 骨転移の治療へのエポチロンの使用 |
| JP2009536153A (ja) * | 2006-04-05 | 2009-10-08 | ノバルティス アクチエンゲゼルシャフト | 癌を処置するための治療剤の組合せ |
| JP2019522989A (ja) * | 2016-06-28 | 2019-08-22 | アルマ マータ ステューディオラム — ユニバーシタ ディ ボローニャ | ＴＡＴκ−ＣＤＫＬ５融合タンパク質、組成物、製剤、及びそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US6635666B2 (en) | 2003-10-21 |
| CA2319752A1 (en) | 1999-09-02 |
| ITMI990375A1 (it) | 1999-08-25 |
| FR2775187B1 (fr) | 2003-02-21 |
| EP1056453B1 (en) | 2010-10-06 |
| US20050165071A1 (en) | 2005-07-28 |
| EP1056453A1 (en) | 2000-12-06 |
| AU755944B2 (en) | 2003-01-02 |
| FR2775187A1 (fr) | 1999-08-27 |
| US7875601B2 (en) | 2011-01-25 |
| NZ506187A (en) | 2003-11-28 |
| WO1999043320A1 (en) | 1999-09-02 |
| US7091226B2 (en) | 2006-08-15 |
| US20040024033A1 (en) | 2004-02-05 |
| AU2927999A (en) | 1999-09-15 |
| US20020028839A1 (en) | 2002-03-07 |
| US20060223867A1 (en) | 2006-10-05 |
| BE1011980A5 (fr) | 2000-03-07 |
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