JP2002504230A - 再構成エネルギーを使用した検体の検出 - Google Patents
再構成エネルギーを使用した検体の検出Info
- Publication number
- JP2002504230A JP2002504230A JP50318499A JP50318499A JP2002504230A JP 2002504230 A JP2002504230 A JP 2002504230A JP 50318499 A JP50318499 A JP 50318499A JP 50318499 A JP50318499 A JP 50318499A JP 2002504230 A JP2002504230 A JP 2002504230A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- transition metal
- electrode
- metal complex
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/873,977 | 1997-06-12 | ||
| US08/873,977 US6013459A (en) | 1997-06-12 | 1997-06-12 | Detection of analytes using reorganization energy |
| PCT/US1998/012082 WO1998057158A1 (en) | 1997-06-12 | 1998-06-12 | Detection of analytes using reorganization energy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009256449A Division JP4929337B2 (ja) | 1997-06-12 | 2009-11-09 | 再構成エネルギーを使用した検体の検出 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002504230A true JP2002504230A (ja) | 2002-02-05 |
| JP2002504230A5 JP2002504230A5 (enExample) | 2005-12-22 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50318499A Pending JP2002504230A (ja) | 1997-06-12 | 1998-06-12 | 再構成エネルギーを使用した検体の検出 |
| JP2009256449A Expired - Lifetime JP4929337B2 (ja) | 1997-06-12 | 2009-11-09 | 再構成エネルギーを使用した検体の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009256449A Expired - Lifetime JP4929337B2 (ja) | 1997-06-12 | 2009-11-09 | 再構成エネルギーを使用した検体の検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (11) | US6013459A (enExample) |
| EP (2) | EP2312304A1 (enExample) |
| JP (2) | JP2002504230A (enExample) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006098342A (ja) * | 2004-09-30 | 2006-04-13 | Kyushu Univ | 異常プリオンの電気化学的検出方法 |
| JP2008542762A (ja) * | 2005-06-03 | 2008-11-27 | ユニバーシティ オブ テキサス システム | 電気化学および単一ファラデー電極による電気化学発光 |
| JP2011501161A (ja) * | 2007-10-17 | 2011-01-06 | オームクス コーポレーション | バイオセンサーに用いる新しい化学 |
| JP2015529809A (ja) * | 2012-07-27 | 2015-10-08 | オームクス コーポレイション | 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 |
Families Citing this family (187)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620850A (en) * | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US7195871B2 (en) * | 1996-01-24 | 2007-03-27 | Third Wave Technologies, Inc | Methods and compositions for detecting target sequences |
| US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
| US7393645B2 (en) * | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US7381525B1 (en) * | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
| US6699667B2 (en) | 1997-05-14 | 2004-03-02 | Keensense, Inc. | Molecular wire injection sensors |
| US6060327A (en) | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
| US7220550B2 (en) * | 1997-05-14 | 2007-05-22 | Keensense, Inc. | Molecular wire injection sensors |
| EP0878711A1 (en) * | 1997-05-15 | 1998-11-18 | Interuniversitair Micro-Elektronica Centrum Vzw | Chemically sensitive sensor comprising arylene alkenylene oligomers |
| CA2293744A1 (en) | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
| US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| IL121312A (en) * | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| CN1598564B (zh) * | 1997-12-22 | 2010-04-21 | 罗赫诊断手术公司 | 测量仪 |
| US8071384B2 (en) | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
| US7390667B2 (en) * | 1997-12-22 | 2008-06-24 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC phase angle measurements |
| US7407811B2 (en) * | 1997-12-22 | 2008-08-05 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC excitation |
| US7494816B2 (en) | 1997-12-22 | 2009-02-24 | Roche Diagnostic Operations, Inc. | System and method for determining a temperature during analyte measurement |
| US7087148B1 (en) | 1998-06-23 | 2006-08-08 | Clinical Micro Sensors, Inc. | Binding acceleration techniques for the detection of analytes |
| US20050244954A1 (en) * | 1998-06-23 | 2005-11-03 | Blackburn Gary F | Binding acceleration techniques for the detection of analytes |
| US6761816B1 (en) * | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
| US6740518B1 (en) | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| US6541617B1 (en) * | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| US6432723B1 (en) | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US7312087B2 (en) * | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
| CA2370123C (en) | 1999-05-03 | 2010-09-14 | Gen-Probe Incorporated | Polynucleotide probes for detection and quantitation of actinomycetes |
| EP1177317B1 (en) | 1999-05-03 | 2006-08-09 | Gen-Probe Incorporated | POLYNUCLEOTIDE PROBES FOR exclusive DETECTION AND QUANTITATION OF STAPHYLOCOCCUS |
| US6821770B1 (en) | 1999-05-03 | 2004-11-23 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
| US6326486B1 (en) | 1999-05-03 | 2001-12-04 | Gen-Probe Incorporated | Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae |
| EP1925678B1 (en) | 1999-05-03 | 2009-07-22 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
| US6324091B1 (en) * | 2000-01-14 | 2001-11-27 | The Regents Of The University Of California | Tightly coupled porphyrin macrocycles for molecular memory storage |
| US6381169B1 (en) | 1999-07-01 | 2002-04-30 | The Regents Of The University Of California | High density non-volatile memory device |
| IL147119A0 (en) * | 1999-07-01 | 2002-08-14 | Univ | High density non-volatile memory device |
| KR100348786B1 (ko) * | 1999-10-01 | 2002-08-17 | 엘지전자주식회사 | 핵산검출방법, 및 핵산검출기와 이의 제조방법 |
| US6361958B1 (en) * | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
| US6824669B1 (en) * | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
| JP4382265B2 (ja) * | 2000-07-12 | 2009-12-09 | 日本電気株式会社 | 酸化シリコン膜の形成方法及びその形成装置 |
| US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
| US7435384B2 (en) * | 2001-01-08 | 2008-10-14 | Leonard Fish | Diagnostic instrument with movable electrode mounting member and methods for detecting analytes |
| WO2002077633A1 (en) | 2001-03-23 | 2002-10-03 | The Regents Of The University Of California | Open circuit potential amperometry and voltammetry |
| WO2003021247A1 (en) * | 2001-08-28 | 2003-03-13 | Duke University | Biosensor |
| US7074519B2 (en) * | 2001-10-26 | 2006-07-11 | The Regents Of The University Of California | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device |
| US7348206B2 (en) * | 2001-10-26 | 2008-03-25 | The Regents Of The University Of California | Formation of self-assembled monolayers of redox SAMs on silicon for molecular memory applications |
| US20030082560A1 (en) * | 2001-10-29 | 2003-05-01 | Yingjian Wang | Method of making interactive protein arrays |
| US6756223B2 (en) * | 2001-12-18 | 2004-06-29 | Motorola, Inc. | Electro-chemical analysis device with integrated thermal sensor and method for monitoring a sample using the device |
| US6728129B2 (en) | 2002-02-19 | 2004-04-27 | The Regents Of The University Of California | Multistate triple-decker dyads in three distinct architectures for information storage applications |
| GB0205455D0 (en) * | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| US20030198960A1 (en) * | 2002-04-01 | 2003-10-23 | Wenhong Fan | Signal amplifying targeted reporters for biological and chemical sensor applications |
| AU2003222676B2 (en) | 2002-05-10 | 2009-04-23 | Anteo Technologies Pty Ltd | Generation of surface coating diversity |
| EP1513958B1 (en) | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
| WO2004013606A2 (en) * | 2002-08-02 | 2004-02-12 | Stratatech Corporation | Species specific dna detection |
| JP4571499B2 (ja) * | 2002-10-16 | 2010-10-27 | デューク ユニバーシティ | バイオセンサ |
| EP3241915B1 (en) | 2002-10-16 | 2021-06-23 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| KR100475312B1 (ko) * | 2002-12-10 | 2005-03-10 | 한국전자통신연구원 | Dna 감지체 및 이를 이용한 dna 감지방법 |
| EP2361991A1 (en) | 2002-12-18 | 2011-08-31 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
| US8206904B2 (en) | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
| US7297780B2 (en) | 2003-01-06 | 2007-11-20 | Third Wave Technologies, Inc. | Reactive functional groups for preparation of modified nucleic acid |
| WO2005007806A2 (en) * | 2003-05-07 | 2005-01-27 | Duke University | Protein design for receptor-ligand recognition and binding |
| EP1631812A4 (en) * | 2003-05-14 | 2010-12-01 | Nantero Inc | SENSOR PLATFORM HAVING A HORIZONTAL NANOPHONE ELEMENT |
| US7718439B2 (en) | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
| US8148164B2 (en) | 2003-06-20 | 2012-04-03 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
| US7452457B2 (en) * | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
| US7645373B2 (en) * | 2003-06-20 | 2010-01-12 | Roche Diagnostic Operations, Inc. | System and method for coding information on a biosensor test strip |
| US8058077B2 (en) | 2003-06-20 | 2011-11-15 | Roche Diagnostics Operations, Inc. | Method for coding information on a biosensor test strip |
| US7597793B2 (en) * | 2003-06-20 | 2009-10-06 | Roche Operations Ltd. | System and method for analyte measurement employing maximum dosing time delay |
| US7604721B2 (en) | 2003-06-20 | 2009-10-20 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
| US8206565B2 (en) | 2003-06-20 | 2012-06-26 | Roche Diagnostics Operation, Inc. | System and method for coding information on a biosensor test strip |
| US7645421B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
| EP1700244A4 (en) * | 2003-12-12 | 2009-07-08 | Bio Layer Pty Ltd | PROCESS FOR THE PREPARATION OF SURFACES |
| EP1694871B1 (en) | 2003-12-19 | 2010-08-25 | Gen-Probe Incorporated | Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2 |
| RU2006132051A (ru) | 2004-02-06 | 2008-03-20 | БАЙЕР ХЕЛТКЭР ЭлЭлСи (US) | Окисляемые соединения в качестве внутреннего стандарта для биосенсоров и способ их применения |
| US7807043B2 (en) * | 2004-02-23 | 2010-10-05 | Oakville Hong Kong Company Limited | Microfluidic test device |
| US7462451B2 (en) * | 2004-04-26 | 2008-12-09 | Third Wave Technologies, Inc. | Compositions for modifying nucleic acids |
| US20060003382A1 (en) * | 2004-05-10 | 2006-01-05 | Amanda Eckermann | Compositions and methods for analyte detection |
| US7569126B2 (en) | 2004-06-18 | 2009-08-04 | Roche Diagnostics Operations, Inc. | System and method for quality assurance of a biosensor test strip |
| US7556723B2 (en) * | 2004-06-18 | 2009-07-07 | Roche Diagnostics Operations, Inc. | Electrode design for biosensor |
| AU2005259833B2 (en) * | 2004-07-02 | 2011-09-22 | Anteo Technologies Pty Ltd | Use of metal complexes |
| US8765488B2 (en) * | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
| US8471238B2 (en) * | 2004-09-16 | 2013-06-25 | Nantero Inc. | Light emitters using nanotubes and methods of making same |
| ES2759991T3 (es) | 2004-09-30 | 2020-05-12 | Gen Probe Inc | Ensayo para detectar y cuantificar el VIH-1 |
| US20060223080A1 (en) | 2004-11-09 | 2006-10-05 | Gen-Probe Incorporated | Compositions and methods for detecting group a streptococci |
| AU2006212754B2 (en) | 2005-02-07 | 2009-09-03 | Gen-Probe Incorporated | Compositions and methods for detecting Group B Streptococci |
| US20060238696A1 (en) * | 2005-04-20 | 2006-10-26 | Chien-Hui Wen | Method of aligning negative dielectric anisotropic liquid crystals |
| EP1913374B1 (en) | 2005-07-20 | 2019-01-09 | Ascensia Diabetes Care Holdings AG | Method for signalling the user to add additional sample to a test strip, method for measuring the temperature of a sample and methods for determining the concentration of an analyte based on gated amperometry |
| CN101273266B (zh) | 2005-09-30 | 2012-08-22 | 拜尔健康护理有限责任公司 | 门控伏特安培法 |
| US20070207455A1 (en) * | 2005-11-17 | 2007-09-06 | Third Wave Technologies, Inc. | Compositions and methods for detecting an HCV-1 subtype |
| US20090306342A1 (en) * | 2005-12-30 | 2009-12-10 | Bio-Layer Pty Limited | Binding of molecules |
| US20090036315A1 (en) * | 2006-02-07 | 2009-02-05 | Antara Biosciences Inc. | Device and methods for detecting and quantifying one or more target agents |
| US20080067056A1 (en) * | 2006-05-19 | 2008-03-20 | The Johns Hopkins University | Method and device for controlled release of biomolecules and nanoparticles |
| WO2007143097A1 (en) | 2006-06-01 | 2007-12-13 | Third Wave Technologies, Inc. | Detection of nucleic acids |
| US7892816B2 (en) * | 2006-09-28 | 2011-02-22 | Colorado State University Research Foundation | Electrochemical detection of substrates |
| JP4321599B2 (ja) * | 2007-02-06 | 2009-08-26 | セイコーエプソン株式会社 | 検出素子 |
| WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
| WO2009002447A1 (en) | 2007-06-21 | 2008-12-31 | Gen-Probe Incorporated | Instrument and receptacles for use in performing processes |
| GB0713183D0 (en) * | 2007-07-06 | 2007-08-15 | King S College London | Method |
| CA2697411C (en) * | 2007-09-07 | 2015-04-14 | Third Wave Technologies, Inc. | Methods and applications for target quantification |
| US8951400B2 (en) | 2007-10-17 | 2015-02-10 | Ohmx Corporation | Chemistry used in biosensors |
| WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
| CN102301000B (zh) * | 2008-03-15 | 2015-04-29 | 豪洛捷公司 | 核酸分子扩增反应的分析组分及方法 |
| WO2009117522A2 (en) * | 2008-03-18 | 2009-09-24 | Reinhart, Kevin | Nanopore and carbon nanotube based dna sequencer and a serial recognition sequencer |
| US8961757B2 (en) * | 2008-03-18 | 2015-02-24 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Nanopore and carbon nanotube based DNA sequencer |
| CA2721536A1 (en) | 2008-04-21 | 2009-10-29 | Gen-Probe Incorporated | Method for detecting chikungunya virus |
| US8968540B2 (en) | 2008-10-06 | 2015-03-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Trans-base tunnel reader for sequencing |
| AU2010208085B2 (en) | 2009-01-30 | 2014-02-06 | Gen-Probe Incorporated | Systems and methods for detecting a signal and applying thermal energy to a signal transmission element |
| US20110091931A1 (en) * | 2009-04-24 | 2011-04-21 | Colby Pharmaceutical Company | Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies |
| WO2011034668A1 (en) | 2009-08-07 | 2011-03-24 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| US9250234B2 (en) | 2011-01-19 | 2016-02-02 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay |
| WO2011084772A2 (en) | 2009-12-21 | 2011-07-14 | Northwestern University | Allelic disorders caused by mutations in trpv4 |
| US9140682B2 (en) | 2010-02-02 | 2015-09-22 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Controlled tunnel gap device for sequencing polymers |
| JP2013528379A (ja) | 2010-05-21 | 2013-07-11 | オームクス コーポレーション | Psa酵素活性アッセイによる癌の検出 |
| EP2588629B1 (en) | 2010-06-30 | 2017-05-17 | Gen-Probe Incorporated | Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals |
| EP2625297B1 (en) | 2010-10-04 | 2018-10-10 | Gen-Probe Prodesse, Inc. | Compositions, methods and kits to detect adenovirus nucleic acids |
| US20150225792A1 (en) | 2014-01-17 | 2015-08-13 | Northwestern University | Compositions and methods for identifying depressive disorders |
| US20150218639A1 (en) | 2014-01-17 | 2015-08-06 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
| US10093981B2 (en) | 2010-10-19 | 2018-10-09 | Northwestern University | Compositions and methods for identifying depressive disorders |
| US10233501B2 (en) | 2010-10-19 | 2019-03-19 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| EP2670893B1 (en) | 2011-02-02 | 2018-06-27 | Exact Sciences Development Company, LLC | Digital sequence analysis of dna methylation |
| WO2012145449A1 (en) * | 2011-04-22 | 2012-10-26 | International Park Of Creativity | Methods and devices for amplifying nucleic acids |
| CN104450680A (zh) | 2011-05-12 | 2015-03-25 | 精密科学公司 | 核酸的分离 |
| US8808990B2 (en) | 2011-05-12 | 2014-08-19 | Exact Sciences Corporation | Serial isolation of multiple DNA targets from stool |
| US8993341B2 (en) | 2011-05-12 | 2015-03-31 | Exact Sciences Corporation | Removal of PCR inhibitors |
| WO2013059293A1 (en) | 2011-10-17 | 2013-04-25 | Ohmx Corporation | Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
| US9340567B2 (en) | 2011-11-04 | 2016-05-17 | Ohmx Corporation | Chemistry used in biosensors |
| DE102011120550B4 (de) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren |
| WO2013096798A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Amplification of a sequence from a ribonucleic acid |
| CA2860739A1 (en) | 2012-01-09 | 2013-07-18 | Ohmx Corporation | Enzyme cascade methods for e-trace assay signal amplification |
| WO2013148344A1 (en) * | 2012-03-28 | 2013-10-03 | Arizona Board Of Regents | Method for improving the accuracy of chemical identification in a recognition-tunneling junction |
| AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
| US9044729B2 (en) | 2012-07-27 | 2015-06-02 | International Park Of Creativity | Methods and devices for electromagnetic amplification of nucleic acids |
| EP2877592B1 (en) | 2012-07-27 | 2016-09-21 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
| US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
| US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
| EP3919174A3 (en) | 2012-10-24 | 2022-03-09 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| EP4234721A3 (en) | 2013-03-14 | 2023-10-18 | Mayo Foundation for Medical Education and Research | Detecting neoplasm |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス, インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| WO2015042493A2 (en) | 2013-09-20 | 2015-03-26 | Ohmx Corporation | Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness |
| EP3047037B1 (en) | 2013-09-20 | 2019-11-27 | The Regents Of The University Of Michigan | Method for the analysis of radiosensitivity |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| WO2015089438A1 (en) | 2013-12-13 | 2015-06-18 | Northwestern University | Biomarkers for post-traumatic stress states |
| WO2015095689A1 (en) | 2013-12-19 | 2015-06-25 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| WO2015131073A1 (en) | 2014-02-27 | 2015-09-03 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Triazole-based reader molecules and methods for synthesizing and use thereof |
| US9880121B2 (en) | 2014-04-29 | 2018-01-30 | Ohmx Corporation | Bioelectronic binding assay using peak profiling |
| US20160041118A1 (en) | 2014-08-11 | 2016-02-11 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| WO2016077364A2 (en) | 2014-11-11 | 2016-05-19 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
| ES2879964T3 (es) | 2014-12-12 | 2021-11-23 | Exact Sciences Dev Co Llc | Composiciones y métodos para realizar ensayos de detección de metilación |
| CN107208135B (zh) | 2014-12-12 | 2021-10-15 | 精密科学公司 | 用于进行甲基化检测测定的组合物和方法 |
| US9506890B2 (en) | 2014-12-16 | 2016-11-29 | Eastman Chemical Company | Physical vapor deposited biosensor components |
| US20160178562A1 (en) | 2014-12-19 | 2016-06-23 | Ohmx Corporation | Competitive enzymatic assay |
| EP3054017A1 (en) | 2015-02-03 | 2016-08-10 | Johann Wolfgang Goethe-Universität, Frankfurt am Main | Circular RNA for the diagnosis and treatment of cardiovascular diseases |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CA3233310A1 (en) | 2015-10-30 | 2017-05-04 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay and isolation and detection of dna from plasma |
| KR102436270B1 (ko) | 2016-05-05 | 2022-08-25 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 폐 종양의 검출 |
| US20170321286A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Corporation | Detection of lung neoplasia by amplification of rna sequences |
| EP3472340B1 (en) | 2016-06-15 | 2023-08-16 | Eastman Chemical Company | Physical vapor deposited biosensor components |
| US11345949B2 (en) | 2016-07-19 | 2022-05-31 | Exact Sciences Corporation | Methylated control DNA |
| CA3029838A1 (en) | 2016-07-19 | 2018-01-25 | Exact Sciences Development Company, Llc | Nucleic acid control molecules from non-human organisms |
| CA3034903A1 (en) | 2016-09-02 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Detecting hepatocellular carcinoma |
| EP3512957B1 (en) | 2016-09-16 | 2022-03-09 | Eastman Chemical Company | Biosensor electrodes prepared by physical vapor deposition |
| JP7111698B2 (ja) | 2016-09-16 | 2022-08-02 | イーストマン ケミカル カンパニー | 物理蒸着によって製造されるバイオセンサー電極 |
| US11300578B2 (en) | 2016-09-19 | 2022-04-12 | Roche Molecular Systems, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| CA3049459A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
| AU2018229294B2 (en) | 2017-02-28 | 2024-06-13 | Exact Sciences Corporation | Detecting prostate cancer |
| CN110770575A (zh) | 2017-06-22 | 2020-02-07 | 伊士曼化工公司 | 用于电化学传感器的物理气相沉积电极 |
| US20190062809A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
| WO2019040769A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS |
| CN111655869B (zh) | 2017-11-30 | 2024-06-28 | 梅约医学教育与研究基金会 | 检测乳腺癌 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| EP4647508A2 (en) | 2018-04-02 | 2025-11-12 | Enumera Molecular, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| US11408030B2 (en) | 2018-09-10 | 2022-08-09 | Andy Madrid | Test for detecting Alzheimer's disease |
| EP3947718A4 (en) | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES |
| US20230046033A1 (en) | 2019-09-16 | 2023-02-16 | Exact Sciences Corporation | Structure and temperature-dependent flap endonuclease substrates |
| CA3154354A1 (en) | 2019-10-31 | 2021-05-06 | William R. Taylor | Detecting ovarian cancer |
| CA3174354A1 (en) | 2020-04-17 | 2021-10-21 | Robert F. Eisele | Ingestible sampling device |
| CN116670299A (zh) | 2020-08-19 | 2023-08-29 | 梅约医学教育与研究基金会 | 检测非霍奇金淋巴瘤 |
| AU2021345359A1 (en) | 2020-09-21 | 2023-05-11 | Enumera Molecular, Inc. | Compositions and methods for isolation of cell-free dna |
| WO2023011660A1 (en) | 2021-08-06 | 2023-02-09 | Sansure Biotech Inc. | Compositions for liquefying a viscous biological sample, combination products, liquefying agents, and kits thereof, and methods and application thereof |
| EP4538392A1 (en) | 2023-10-11 | 2025-04-16 | Pangaea Oncology, S.A | Genetic signature of lung cancer |
Family Cites Families (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| JPS5866048A (ja) * | 1981-10-15 | 1983-04-20 | Meidensha Electric Mfg Co Ltd | 硝酸イオン濃度自動測定装置 |
| US5241060A (en) * | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
| US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| GB8328520D0 (en) * | 1983-10-25 | 1983-11-23 | Serono Diagnostics Ltd | Methods of assay |
| WO1985002627A1 (en) * | 1983-12-16 | 1985-06-20 | Genetics International, Inc. | Assay for nucleic acids |
| US4849513A (en) * | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
| US4943523A (en) * | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
| US5175269A (en) * | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
| US5002885A (en) * | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
| US4952685A (en) * | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| US5013831A (en) * | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
| CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
| GB8417301D0 (en) | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
| US4755458A (en) * | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5112974A (en) * | 1985-01-18 | 1992-05-12 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents to DNA |
| GB8507706D0 (en) | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
| US5595908A (en) * | 1985-09-26 | 1997-01-21 | University Of Southern Mississipi | Piezoelectric device for detection of polynucleotide hybridization |
| CA1273552A (en) * | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
| US4868103A (en) * | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| CA1254945A (en) * | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
| US4704193A (en) * | 1986-05-14 | 1987-11-03 | Gte Laboratories Incorporated | Covalently coupled cofactor modified electrodes and methods of synthesis and use |
| JPS63238166A (ja) * | 1987-03-26 | 1988-10-04 | Mitsubishi Electric Corp | 有機電子素子材料 |
| GB8712582D0 (en) * | 1987-05-28 | 1987-07-01 | Neotronics Ltd | Acidic gas sensors |
| US5192507A (en) * | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
| US5082830A (en) * | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
| US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
| GB2217447A (en) * | 1988-04-21 | 1989-10-25 | Atomic Energy Authority Uk | Bonding to metal surfaces |
| US4920047A (en) * | 1988-05-20 | 1990-04-24 | General Electric Company | Electrical detection of the immune reaction |
| SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| US4952585A (en) * | 1988-12-15 | 1990-08-28 | Merrell Dow Pharmaceuticals Inc. | Castanospermine esters in the inhibition of tumor metastasis |
| US5089112A (en) | 1989-03-20 | 1992-02-18 | Associated Universities, Inc. | Electrochemical biosensor based on immobilized enzymes and redox polymers |
| CA2033692A1 (en) * | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
| DE69125441T2 (de) | 1990-09-28 | 1997-11-06 | Toshiba Kawasaki Kk | Verfahren zum Gennachweis |
| US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
| JPH04136751A (ja) * | 1990-09-28 | 1992-05-11 | Terumo Corp | 二酸化炭素濃度測定用電極 |
| DE4039677A1 (de) * | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | Universalbindefilm |
| US5180968A (en) | 1991-03-01 | 1993-01-19 | Research Foundation Of State University Of New York | Method and apparatus for compensation of double layer charging current in electrochemical cells |
| CA2050057A1 (en) | 1991-03-04 | 1992-09-05 | Adam Heller | Interferant eliminating biosensors |
| RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
| US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
| DE69231853T2 (de) | 1991-11-07 | 2001-09-13 | Nanotronics, Inc. | Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems |
| US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
| JP2788786B2 (ja) * | 1991-11-15 | 1998-08-20 | イゲン,インコーポレーテッド | 増幅生成物の迅速アッセイ |
| EP0569578A1 (en) | 1991-11-15 | 1993-11-18 | Amoco Corporation | Method of enhancing hybridization signals in growth media |
| US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5391272A (en) | 1992-03-06 | 1995-02-21 | Andcare, Inc. | Electrochemical immunoassay methods |
| EP0566751B1 (en) * | 1992-03-23 | 1996-01-10 | F. Hoffmann-La Roche Ag | DNA detection method |
| CA2094785A1 (en) * | 1992-05-08 | 1993-11-09 | Jean Gariepy | Metal chelating peptide |
| GB9212010D0 (en) * | 1992-06-05 | 1992-07-15 | Medisense Inc | Mediators to oxidoreductase enzymes |
| JPH0641183A (ja) * | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
| IL102930A (en) * | 1992-08-25 | 1997-03-18 | Yissum Res Dev Co | Electrobiochemical analytical method and electrodes |
| US5312527A (en) * | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
| US5472881A (en) * | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| DE69333991T2 (de) * | 1992-11-27 | 2006-12-14 | Canon K.K. | Verfahren und Sonde zum Nachweis von Nukleinsäuren |
| WO1994020841A1 (en) * | 1993-03-05 | 1994-09-15 | University Of Wollongong | Pulsed electrochemical detection using polymer electroactive electrodes |
| FR2703359B1 (fr) | 1993-03-31 | 1995-06-23 | Cis Bio Int | Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation . |
| RU2041262C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
| RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
| RU2041261C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ изготовления матрицы для детектирования мисматчей |
| US6331274B1 (en) | 1993-11-01 | 2001-12-18 | Nanogen, Inc. | Advanced active circuits and devices for molecular biological analysis and diagnostics |
| US6207373B1 (en) | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
| US5824473A (en) * | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| IL108726A (en) | 1994-02-22 | 1999-12-31 | Yissum Res Dev Co | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor |
| US5871918A (en) | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
| US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US5601982A (en) * | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| JPH11502617A (ja) | 1995-03-10 | 1999-03-02 | メソ スケール テクノロジーズ,エルエルシー | 多重アレイの多重特異的な電気化学発光試験 |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| US5679519A (en) | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
| US6127127A (en) | 1995-06-27 | 2000-10-03 | The University Of North Carolina At Chapel Hill | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
| EP1193315A1 (en) * | 1995-06-27 | 2002-04-03 | University of North Carolina at Chapel Hill et al. | Microelectronic device for electrochemical detection |
| US5795453A (en) * | 1996-01-23 | 1998-08-18 | Gilmartin; Markas A. T. | Electrodes and metallo isoindole ringed compounds |
| US5830341A (en) * | 1996-01-23 | 1998-11-03 | Gilmartin; Markas A. T. | Electrodes and metallo isoindole ringed compounds |
| US5861247A (en) | 1996-01-26 | 1999-01-19 | University Of Chicago | Rapid method to detect duplex formation in sequencing by hybridization methods |
| US5851772A (en) | 1996-01-29 | 1998-12-22 | University Of Chicago | Microchip method for the enrichment of specific DNA sequences |
| US6107080A (en) | 1996-04-25 | 2000-08-22 | Mcgill University | Biosensor device and method |
| JP2000513811A (ja) | 1996-05-22 | 2000-10-17 | オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート | 核酸センサー |
| US5874046A (en) | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
| JP4072206B2 (ja) * | 1996-11-05 | 2008-04-09 | クリニカル・マイクロ・センサーズ・インコーポレイテッド | 導電性オリゴマーを介して核酸に連結させた電極 |
| US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
| US7381525B1 (en) | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7045285B1 (en) * | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
| US7160678B1 (en) * | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
| US5942397A (en) | 1996-12-11 | 1999-08-24 | Tarlov; Michael J. | Surface immobilization of biopolymers |
| US5905024A (en) | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
| EP0951569A2 (en) | 1996-12-23 | 1999-10-27 | University Of Chicago | Customized oligonucleotide microchips as multiple biosensors |
| US6306584B1 (en) | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
| KR20000070821A (ko) | 1997-02-06 | 2000-11-25 | 프란시스 제이 메이어 | 특이적 결합의 전기화학적 검출 |
| US6060327A (en) | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
| CA2293744A1 (en) | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
| US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| SE9703314D0 (sv) | 1997-09-15 | 1997-09-15 | Sangtec Medical Ab | Capacity affinity sensor |
| US6060023A (en) | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
| DE69939464D1 (de) * | 1998-05-06 | 2008-10-16 | Clinical Micro Sensors Inc | Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten |
| US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| US6761816B1 (en) * | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
| US20050244954A1 (en) * | 1998-06-23 | 2005-11-03 | Blackburn Gary F | Binding acceleration techniques for the detection of analytes |
| US6740518B1 (en) * | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
| US6541617B1 (en) * | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
| US7018532B2 (en) * | 2004-01-27 | 2006-03-28 | Kaufman Michael J | Aeration and mixing trough |
-
1997
- 1997-06-12 US US08/873,977 patent/US6013459A/en not_active Expired - Lifetime
-
1998
- 1998-06-12 WO PCT/US1998/012082 patent/WO1998057158A1/en not_active Ceased
- 1998-06-12 EP EP10180837A patent/EP2312304A1/en not_active Withdrawn
- 1998-06-12 JP JP50318499A patent/JP2002504230A/ja active Pending
- 1998-06-12 CA CA002292696A patent/CA2292696A1/en not_active Abandoned
- 1998-06-12 US US09/096,504 patent/US6013170A/en not_active Expired - Lifetime
- 1998-06-12 AU AU78355/98A patent/AU747345B2/en not_active Ceased
- 1998-06-12 EP EP98926542.6A patent/EP0988532B1/en not_active Expired - Lifetime
-
1999
- 1999-10-13 US US09/417,988 patent/US6248229B1/en not_active Expired - Lifetime
-
2001
- 2001-04-24 US US09/841,809 patent/US7018523B2/en not_active Expired - Lifetime
-
2005
- 2005-11-18 US US11/283,233 patent/US7267939B2/en not_active Expired - Fee Related
-
2007
- 2007-08-02 US US11/832,792 patent/US7514228B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,971 patent/US7579145B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/980,203 patent/US7595153B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,930 patent/US7582419B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,931 patent/US7566534B2/en not_active Expired - Fee Related
-
2009
- 2009-08-20 US US12/544,682 patent/US20100038262A1/en not_active Abandoned
- 2009-11-09 JP JP2009256449A patent/JP4929337B2/ja not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006098342A (ja) * | 2004-09-30 | 2006-04-13 | Kyushu Univ | 異常プリオンの電気化学的検出方法 |
| JP2008542762A (ja) * | 2005-06-03 | 2008-11-27 | ユニバーシティ オブ テキサス システム | 電気化学および単一ファラデー電極による電気化学発光 |
| JP2011501161A (ja) * | 2007-10-17 | 2011-01-06 | オームクス コーポレーション | バイオセンサーに用いる新しい化学 |
| JP2011502245A (ja) * | 2007-10-17 | 2011-01-20 | オームクス コーポレーション | 酵素検出のための電気化学的検定方法 |
| JP2015529809A (ja) * | 2012-07-27 | 2015-10-08 | オームクス コーポレイション | 酵素及び他の標的分析物の存在及び活性の切断前検出後の単分子層の電気測定 |
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| US7566534B2 (en) | 2009-07-28 |
| US20080173554A1 (en) | 2008-07-24 |
| US7595153B2 (en) | 2009-09-29 |
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| US20080173553A1 (en) | 2008-07-24 |
| AU7835598A (en) | 1998-12-30 |
| EP0988532A1 (en) | 2000-03-29 |
| US20080135420A1 (en) | 2008-06-12 |
| US7018523B2 (en) | 2006-03-28 |
| JP4929337B2 (ja) | 2012-05-09 |
| JP2010091573A (ja) | 2010-04-22 |
| US20080179196A1 (en) | 2008-07-31 |
| US6013459A (en) | 2000-01-11 |
| US6248229B1 (en) | 2001-06-19 |
| US20020033345A1 (en) | 2002-03-21 |
| CA2292696A1 (en) | 1998-12-17 |
| US20060073532A1 (en) | 2006-04-06 |
| US7579145B2 (en) | 2009-08-25 |
| WO1998057158A1 (en) | 1998-12-17 |
| EP0988532B1 (en) | 2015-12-02 |
| US6013170A (en) | 2000-01-11 |
| US20100038262A1 (en) | 2010-02-18 |
| US7514228B2 (en) | 2009-04-07 |
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