JP2002504084A - 塗布領域の厚さが薄く柔軟性が高い経皮治療システムおよびその製造方法 - Google Patents
塗布領域の厚さが薄く柔軟性が高い経皮治療システムおよびその製造方法Info
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- JP2002504084A JP2002504084A JP53399197A JP53399197A JP2002504084A JP 2002504084 A JP2002504084 A JP 2002504084A JP 53399197 A JP53399197 A JP 53399197A JP 53399197 A JP53399197 A JP 53399197A JP 2002504084 A JP2002504084 A JP 2002504084A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.基体に活性物質を放出する経皮治療システムであり、そのシステムの構造が 分離層(2)を備えた基体(1)、活性物質含有薄膜層(3)、および非粘着仕 上げが施された保護層(4)から成り、前記分離層(2)が前記薄膜層(3)に 対するその結合力を解除できる材料からなることを特徴とする経皮治療システム 。 2.前記薄膜(3)が一つまたは複数の印刷手順によって前記基体(1)上に形 成されることを特徴とする請求項1に記載の経皮治療システム。 3.前記分離層(2)が水溶性薄膜形成物質を含むことを特徴とする請求項1に 記載の経皮治療システム。 4.前記分離層(2)が脂溶性薄膜形成物質を含むことを特徴とする請求項1に 記載の経皮治療システム。 5.前記分離層(2)が水溶性かつ脂溶性の薄膜形成物質を含むことを特徴とす る請求項1に記載の経皮治療システム。 6.前記分離層(2)が40℃以上に温度を上げることによって液化できる物質 であることを特徴とする請求項1に記載の経皮治療システム。 7.前記分離層(2)が1〜50μm、好ましくは5〜20μmの層厚を有する ことを特徴とする請求項3から6に記載の経皮治療システム。 8.前記基体(1)が多孔性材料、好ましくは紙からなることを特徴とする請求 項1に記載の経皮治療システム。 9.前記基体(1)が20〜200μm、好ましくは100〜150μmの層厚 を有することを特徴とする請求項1または8に記載の経皮治療システム。 10.前記活性物質含有薄膜(3)が積層体を示すことを特徴とする請求項1に 記載の経皮治療システム。 11.個々の層が面積、層厚、および組成のパラメーターのうち少なくとも一つ に関して異なり、また少なくとも一つの層が少なくとも一つの活性物質を含むこ とを特徴とする請求項10に記載の経皮治療システム。 12.前記薄膜層中の活性物質が互いに離れた領域に導入されていることを特徴 とする請求項11に記載の経皮治療システム。 13.前記活性物質含有薄膜層(3)が前記保護層側において自己粘着性である ことを特徴とする請求項1に記載の経皮治療システム。 14.前記薄膜層(3)が一つまたは複数の薄膜形成ポリマーを含むことを特徴 とする請求項1に記載の経皮治療システム。 15.前記薄膜層(3)が5〜50μm、好ましくは5〜20μmの層厚を有す ることを特徴とする請求項1に記載の経皮治療システム。 16.前記薄膜層(3)が基体(1)上に間隔をおいた切片として分布すること を特徴とする請求項1に記載の経皮治療システム。 17.活性物質を皮膚に放出するための、塗布厚が小さくかつ柔軟性が高い平ら な形状またはシート状のシステムの製造方法であり、一つ以上の印刷方法工程を 特徴とする製造方法。 18.最初の印刷工程がその面積に関する前記経皮治療システム(TTS)の大 きさを決定することを特徴とする請求項17に記載の方法。 19.前記システムの大きさがその後の印刷工程の一つによって決定されること を特徴とする請求項17に記載の方法。 20.前記システムの大きさを決定する印刷工程が、粘着性にされているか、ま たは可溶性または液化できる分離層が備えられた基体上において、部分的または 全面的に実施されることを特徴とする請求項17に記載の方法。 21.前記印刷媒体が完成されたTTSの裏当て層を形成することを特徴とする 請求項17に記載の方法。 22.前記印刷媒体が皮膚と接触する自己粘着性マトリクス層の形成に適してい ることを特徴とする請求項17に記載の方法。 23.前記印刷媒体が一つ以上の活性物質を含むことを特徴とする請求項17に 記載の方法。 24.前記TTSの裏当て層として形成された印刷層が、マーキング、表示また は彩色の目的で印刷されることを特徴とする請求項17に記載の方法。 25.前記TTSの裏当て層として形成された印刷層が、粘着性にされ、かつそ の粘着性が前記の印刷された基体の粘着性よりもきわだっていない支持膜を備え ることを特徴とする請求項17に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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DE19611684 | 1996-03-25 | ||
DE19611684.8 | 1996-03-25 | ||
DE19708674A DE19708674C2 (de) | 1996-03-25 | 1997-03-04 | Transdermales therapeutisches System mit einer wirkstoffhaltigen Filmschicht und einer löslichen Trennschicht, sowie ein Verfahren zu dessen Herstellung |
DE19708674.8 | 1997-03-04 | ||
PCT/EP1997/001252 WO1997035564A1 (de) | 1996-03-25 | 1997-03-12 | Transdermales therapeutisches system mit geringer applikationsdicke und hoher flexibilität sowie herstellungsverfahren |
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JP2002504084A true JP2002504084A (ja) | 2002-02-05 |
JP4086317B2 JP4086317B2 (ja) | 2008-05-14 |
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JP53399197A Expired - Lifetime JP4086317B2 (ja) | 1996-03-25 | 1997-03-12 | 塗布領域の厚さが薄く柔軟性が高い経皮治療システムおよびその製造方法 |
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US (1) | US6165499A (ja) |
EP (1) | EP0889723B1 (ja) |
JP (1) | JP4086317B2 (ja) |
CN (1) | CN1219126A (ja) |
AT (1) | ATE218328T1 (ja) |
AU (1) | AU728120B2 (ja) |
CZ (1) | CZ306398A3 (ja) |
DK (1) | DK0889723T3 (ja) |
ES (1) | ES2177962T3 (ja) |
HU (1) | HUP9902673A3 (ja) |
IL (1) | IL126251A (ja) |
NO (1) | NO984458L (ja) |
NZ (1) | NZ332033A (ja) |
PL (1) | PL329196A1 (ja) |
PT (1) | PT889723E (ja) |
SK (1) | SK130298A3 (ja) |
WO (1) | WO1997035564A1 (ja) |
Cited By (1)
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JP2017510474A (ja) * | 2013-12-31 | 2017-04-13 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド | インテグラルフィルム製品を形成するための方法 |
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US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
DE19728516C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Levonorgestrel und gegebenenfalls Estradiol |
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-
1997
- 1997-03-12 HU HU9902673A patent/HUP9902673A3/hu unknown
- 1997-03-12 SK SK1302-98A patent/SK130298A3/sk unknown
- 1997-03-12 AT AT97914228T patent/ATE218328T1/de active
- 1997-03-12 CZ CZ983063A patent/CZ306398A3/cs unknown
- 1997-03-12 DK DK97914228T patent/DK0889723T3/da active
- 1997-03-12 ES ES97914228T patent/ES2177962T3/es not_active Expired - Lifetime
- 1997-03-12 IL IL12625197A patent/IL126251A/xx not_active IP Right Cessation
- 1997-03-12 AU AU21555/97A patent/AU728120B2/en not_active Ceased
- 1997-03-12 PT PT97914228T patent/PT889723E/pt unknown
- 1997-03-12 US US09/155,334 patent/US6165499A/en not_active Expired - Lifetime
- 1997-03-12 PL PL97329196A patent/PL329196A1/xx unknown
- 1997-03-12 JP JP53399197A patent/JP4086317B2/ja not_active Expired - Lifetime
- 1997-03-12 WO PCT/EP1997/001252 patent/WO1997035564A1/de active IP Right Grant
- 1997-03-12 CN CN97194761A patent/CN1219126A/zh active Pending
- 1997-03-12 EP EP97914228A patent/EP0889723B1/de not_active Expired - Lifetime
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2017510474A (ja) * | 2013-12-31 | 2017-04-13 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド | インテグラルフィルム製品を形成するための方法 |
Also Published As
Publication number | Publication date |
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NO984458L (no) | 1998-11-24 |
US6165499A (en) | 2000-12-26 |
PT889723E (pt) | 2002-11-29 |
CZ306398A3 (cs) | 1999-01-13 |
IL126251A0 (en) | 1999-05-09 |
HUP9902673A3 (en) | 2001-04-28 |
JP4086317B2 (ja) | 2008-05-14 |
EP0889723A1 (de) | 1999-01-13 |
NO984458D0 (no) | 1998-09-24 |
ES2177962T3 (es) | 2002-12-16 |
CN1219126A (zh) | 1999-06-09 |
ATE218328T1 (de) | 2002-06-15 |
IL126251A (en) | 2003-06-24 |
HUP9902673A2 (hu) | 2000-10-28 |
AU2155597A (en) | 1997-10-17 |
EP0889723B1 (de) | 2002-06-05 |
WO1997035564A1 (de) | 1997-10-02 |
NZ332033A (en) | 1999-09-29 |
PL329196A1 (en) | 1999-03-15 |
AU728120B2 (en) | 2001-01-04 |
DK0889723T3 (da) | 2002-09-23 |
SK130298A3 (en) | 1999-03-12 |
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