JP2002503724A5 - - Google Patents
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- Publication number
- JP2002503724A5 JP2002503724A5 JP2000532400A JP2000532400A JP2002503724A5 JP 2002503724 A5 JP2002503724 A5 JP 2002503724A5 JP 2000532400 A JP2000532400 A JP 2000532400A JP 2000532400 A JP2000532400 A JP 2000532400A JP 2002503724 A5 JP2002503724 A5 JP 2002503724A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- substituents
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 23
- 229910052739 hydrogen Inorganic materials 0.000 description 18
- 239000001257 hydrogen Substances 0.000 description 18
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
- 125000001424 substituent group Chemical group 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 9
- 125000000217 alkyl group Chemical class 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Chemical group 0.000 description 2
- -1 C1-5Alkylsulfonyl Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 1
- 125000005129 aryl carbonyl group Chemical group 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7532198P | 1998-02-20 | 1998-02-20 | |
| US60/075,321 | 1998-02-20 | ||
| PCT/US1999/003608 WO1999042448A1 (en) | 1998-02-20 | 1999-02-19 | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002503724A JP2002503724A (ja) | 2002-02-05 |
| JP2002503724A5 true JP2002503724A5 (enExample) | 2006-03-30 |
Family
ID=22124955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000532400A Pending JP2002503724A (ja) | 1998-02-20 | 1999-02-19 | 良性前立腺過形成の治療で用いるに有用な新規な置換ピリジノアリールピペラジン類 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6218396B1 (enExample) |
| EP (1) | EP1054868B1 (enExample) |
| JP (1) | JP2002503724A (enExample) |
| KR (1) | KR100591028B1 (enExample) |
| CN (1) | CN1121390C (enExample) |
| AR (1) | AR014626A1 (enExample) |
| AT (1) | ATE250580T1 (enExample) |
| AU (1) | AU766398B2 (enExample) |
| BR (1) | BR9909647A (enExample) |
| CZ (1) | CZ294136B6 (enExample) |
| DE (1) | DE69911582T2 (enExample) |
| DK (1) | DK1054868T3 (enExample) |
| ES (1) | ES2209468T3 (enExample) |
| HU (1) | HUP0100781A3 (enExample) |
| IL (2) | IL137954A0 (enExample) |
| NO (1) | NO317103B1 (enExample) |
| NZ (1) | NZ506462A (enExample) |
| PL (1) | PL342339A1 (enExample) |
| PT (1) | PT1054868E (enExample) |
| TR (1) | TR200003220T2 (enExample) |
| TW (1) | TW565555B (enExample) |
| WO (1) | WO1999042448A1 (enExample) |
| ZA (1) | ZA991315B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269807C (zh) * | 1997-05-12 | 2006-08-16 | 奥索-麦克尼尔药品公司 | 可用于治疗良性前列腺肥大的芳基取代哌嗪 |
| ES2282279T3 (es) | 2000-08-08 | 2007-10-16 | Ortho-Mcneil Pharmaceutical, Inc. | No-imidazol ariloxipiperidina como ligandos del receptor h3. |
| JP3878178B2 (ja) * | 2001-12-28 | 2007-02-07 | 武田薬品工業株式会社 | 排尿障害予防治療剤 |
| USD545208S1 (en) | 2006-09-27 | 2007-06-26 | 001 Corporation | Perfume bottle and cap |
| EP2077262A4 (en) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | IMINOPYRIDINE DERIVATIVE AND USE THEREOF |
| MX2010011652A (es) * | 2008-04-23 | 2010-12-06 | Takeda Pharmaceutical | Derivados de iminopiridina y uso de los mismos. |
| US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| CN103980195A (zh) * | 2014-04-28 | 2014-08-13 | 广州医科大学 | 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用 |
| CN108530391B (zh) * | 2018-05-17 | 2022-05-17 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| US5403847A (en) | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| AU8130298A (en) * | 1997-07-15 | 1999-02-10 | Sankyo Company Limited | Piperazine derivatives |
-
1999
- 1999-02-18 US US09/252,313 patent/US6218396B1/en not_active Expired - Lifetime
- 1999-02-18 ZA ZA9901315A patent/ZA991315B/xx unknown
- 1999-02-19 CN CN99803027A patent/CN1121390C/zh not_active Expired - Fee Related
- 1999-02-19 KR KR1020007009156A patent/KR100591028B1/ko not_active Expired - Fee Related
- 1999-02-19 HU HU0100781A patent/HUP0100781A3/hu unknown
- 1999-02-19 AU AU33025/99A patent/AU766398B2/en not_active Ceased
- 1999-02-19 PL PL99342339A patent/PL342339A1/xx unknown
- 1999-02-19 JP JP2000532400A patent/JP2002503724A/ja active Pending
- 1999-02-19 IL IL13795499A patent/IL137954A0/xx active IP Right Grant
- 1999-02-19 WO PCT/US1999/003608 patent/WO1999042448A1/en not_active Ceased
- 1999-02-19 DK DK99934281T patent/DK1054868T3/da active
- 1999-02-19 NZ NZ506462A patent/NZ506462A/en unknown
- 1999-02-19 CZ CZ20003044A patent/CZ294136B6/cs not_active IP Right Cessation
- 1999-02-19 EP EP99934281A patent/EP1054868B1/en not_active Expired - Lifetime
- 1999-02-19 TR TR2000/03220T patent/TR200003220T2/xx unknown
- 1999-02-19 ES ES99934281T patent/ES2209468T3/es not_active Expired - Lifetime
- 1999-02-19 BR BR9909647-1A patent/BR9909647A/pt not_active Application Discontinuation
- 1999-02-19 AT AT99934281T patent/ATE250580T1/de not_active IP Right Cessation
- 1999-02-19 PT PT99934281T patent/PT1054868E/pt unknown
- 1999-02-19 DE DE69911582T patent/DE69911582T2/de not_active Expired - Fee Related
- 1999-02-23 AR ARP990100675A patent/AR014626A1/es active IP Right Grant
- 1999-04-02 TW TW088102511A patent/TW565555B/zh not_active IP Right Cessation
-
2000
- 2000-08-18 IL IL137954A patent/IL137954A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004141A patent/NO317103B1/no not_active IP Right Cessation
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