JP2002503674A - βシート模倣物およびその使用に関する方法 - Google Patents

βシート模倣物およびその使用に関する方法

Info

Publication number
JP2002503674A
JP2002503674A JP2000531467A JP2000531467A JP2002503674A JP 2002503674 A JP2002503674 A JP 2002503674A JP 2000531467 A JP2000531467 A JP 2000531467A JP 2000531467 A JP2000531467 A JP 2000531467A JP 2002503674 A JP2002503674 A JP 2002503674A
Authority
JP
Japan
Prior art keywords
embedded image
mmol
solution
added
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000531467A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002503674A5 (enExample
Inventor
マハー エヌ． クァバー，
マイケル ケイ． マクミリアン，
マイケル エス． カーン，
ジョン イー． トゥリンスキー，
ジェシーモル マシュー，
Original Assignee
モレキュメティックス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モレキュメティックス リミテッド filed Critical モレキュメティックス リミテッド
Publication of JP2002503674A publication Critical patent/JP2002503674A/ja
Publication of JP2002503674A5 publication Critical patent/JP2002503674A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000531467A 1998-02-12 1998-02-12 βシート模倣物およびその使用に関する方法 Pending JP2002503674A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/002891 WO1999041276A1 (en) 1998-02-12 1998-02-12 β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF

Publications (2)

Publication Number Publication Date
JP2002503674A true JP2002503674A (ja) 2002-02-05
JP2002503674A5 JP2002503674A5 (enExample) 2005-12-22

Family

ID=22266392

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000531467A Pending JP2002503674A (ja) 1998-02-12 1998-02-12 βシート模倣物およびその使用に関する方法

Country Status (9)

Country Link
EP (1) EP1053246B1 (enExample)
JP (1) JP2002503674A (enExample)
KR (1) KR20010040939A (enExample)
AT (1) ATE230414T1 (enExample)
AU (1) AU748887B2 (enExample)
CA (1) CA2319766A1 (enExample)
DE (1) DE69810513T2 (enExample)
ES (1) ES2192764T3 (enExample)
WO (1) WO1999041276A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005526722A (ja) * 2002-02-14 2005-09-08 ミリアド・ジェネティックス・インコーポレイテッド β−シートミメティックならびにそれに関連する組成物および方法
JP2011525927A (ja) * 2008-06-25 2011-09-29 シェーリング コーポレイション 複素環式抗菌剤の合成および使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699855B2 (en) * 2000-02-29 2004-03-02 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus NS3 protease
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US20060276497A1 (en) 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
PT3486242T (pt) 2016-08-31 2022-01-06 Jiangsu Hengrui Medicine Co Derivado de oxopicolinamida, método de preparação para esse fim e utilização farmacêutica do mesmo
PE20190473A1 (es) 2016-09-16 2019-04-04 Cortexyme Inc Inhibidores cetonicos de gingipain de lisina
WO2020007256A1 (zh) 2018-07-02 2020-01-09 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
MX2022003649A (es) 2019-09-27 2022-06-08 Shenzhen Salubris Pharm Co Ltd Inhibidores del fxia y metodo de preparacion de los mismos y uso farmaceutico de los mismos.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06340691A (ja) * 1993-03-08 1994-12-13 Sandoz Ag ペプチド類
WO1996019483A1 (en) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
WO1996030035A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS
JPH08325152A (ja) * 1995-05-17 1996-12-10 Bristol Myers Squibb Co Ａｃｅおよびｎｅｐの抑制に有用なベンゾ縮合アゼピノンおよびピペリジノン化合物
WO1997005160A1 (en) * 1995-08-01 1997-02-13 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Bicyclic lactam derivatives as thrombin inhibitors
JP2001524931A (ja) * 1996-08-05 2001-12-04 モレキュメティクス リミテッド プロテアーゼおよびキナーゼのインヒビターとしてならびに転写因子のインヒビターとしてのβシート模倣物の使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
CA2133963C (en) * 1992-05-15 1998-07-07 Gary A. Flynn Novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a][1,2]diazepine and pyrazolo[1,2-a][1,2]diazepine derivatives useful as inhibitors of enkephalinase and ace

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06340691A (ja) * 1993-03-08 1994-12-13 Sandoz Ag ペプチド類
WO1996019483A1 (en) * 1994-12-22 1996-06-27 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
WO1996030035A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS
JPH08325152A (ja) * 1995-05-17 1996-12-10 Bristol Myers Squibb Co Ａｃｅおよびｎｅｐの抑制に有用なベンゾ縮合アゼピノンおよびピペリジノン化合物
WO1997005160A1 (en) * 1995-08-01 1997-02-13 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Bicyclic lactam derivatives as thrombin inhibitors
JP2001524931A (ja) * 1996-08-05 2001-12-04 モレキュメティクス リミテッド プロテアーゼおよびキナーゼのインヒビターとしてならびに転写因子のインヒビターとしてのβシート模倣物の使用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ADAM, W. ET AL., J. ORG. CHEM., vol. 58, no. 6, JPN6009008779, 1993, pages 1477 - 1482, ISSN: 0001259947 *
BALDWIN, J.E. ET AL., HETEROCYCLES, vol. 34, no. 5, JPN6009008787, 1992, pages 903 - 906, ISSN: 0001259951 *
BERNABEU, M.C. ET AL., TETRAHEDRON LETT., vol. 37, no. 20, JPN6009008789, 1996, pages 3595 - 3598, ISSN: 0001259952 *
HANESSIAN, S. ET AL., BIOORG. MED. CHEM. LETT., vol. 4, no. 11, JPN6009008781, 1994, pages 1397 - 1400, ISSN: 0001259948 *
NAKANISHI, H. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, JPN6009008785, March 1992 (1992-03-01), pages 1705 - 1709, ISSN: 0001259950 *
SALIMBENI, A. ET AL., BIOORG. MED. CHEM. LETT., vol. 7, no. 17, JPN6009008783, 1997, pages 2205 - 2210, ISSN: 0001259949 *
SLOMCZYNSKA, U. ET AL., J. ORG. CHEM., vol. 61, no. 4, JPN6009008777, 1996, pages 1198 - 1204, ISSN: 0001259946 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005526722A (ja) * 2002-02-14 2005-09-08 ミリアド・ジェネティックス・インコーポレイテッド β−シートミメティックならびにそれに関連する組成物および方法
JP2011525927A (ja) * 2008-06-25 2011-09-29 シェーリング コーポレイション 複素環式抗菌剤の合成および使用

Also Published As

Publication number Publication date
EP1053246B1 (en) 2003-01-02
DE69810513T2 (de) 2004-03-18
CA2319766A1 (en) 1999-08-19
AU6655798A (en) 1999-08-30
DE69810513D1 (de) 2003-02-06
WO1999041276A1 (en) 1999-08-19
EP1053246A1 (en) 2000-11-22
KR20010040939A (ko) 2001-05-15
AU748887B2 (en) 2002-06-13
ATE230414T1 (de) 2003-01-15
ES2192764T3 (es) 2003-10-16

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