ES2192764T3 - Mimeticos de lamina beta y metodos relacionados con el uso de los mismos. - Google Patents
Mimeticos de lamina beta y metodos relacionados con el uso de los mismos.Info
- Publication number
- ES2192764T3 ES2192764T3 ES98908551T ES98908551T ES2192764T3 ES 2192764 T3 ES2192764 T3 ES 2192764T3 ES 98908551 T ES98908551 T ES 98908551T ES 98908551 T ES98908551 T ES 98908551T ES 2192764 T3 ES2192764 T3 ES 2192764T3
- Authority
- ES
- Spain
- Prior art keywords
- beta
- same
- mimetics
- lamina
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención está dirigida a miméticos de lámina beta y al uso de los mismos, incluyendo el uso para la preparación de un medicamento para conseguir efectos terapéuticos en un animal de sangre caliente, a través de una o más de: inhibición de proteasa, inhibición de cinasa, regulación de un factor de transcripción y/o inhibición de interacciones de fijación proteína-proteína. Los efectos terapéuticos son originados por la administración al animal de sangre caliente de una cantidad terapéuticamente eficaz de un mimético de lámina beta que tiene la estructura general indicada en la reivindicación 1. Esta estructura incluye un sistema anular bicíclico, de estructura general (I) (incluyendo las sales farmacéuticamente aceptables del mismo):
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1998/002891 WO1999041276A1 (en) | 1998-02-12 | 1998-02-12 | β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2192764T3 true ES2192764T3 (es) | 2003-10-16 |
Family
ID=22266392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98908551T Expired - Lifetime ES2192764T3 (es) | 1998-02-12 | 1998-02-12 | Mimeticos de lamina beta y metodos relacionados con el uso de los mismos. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1053246B1 (es) |
JP (1) | JP2002503674A (es) |
KR (1) | KR20010040939A (es) |
AT (1) | ATE230414T1 (es) |
AU (1) | AU748887B2 (es) |
CA (1) | CA2319766A1 (es) |
DE (1) | DE69810513T2 (es) |
ES (1) | ES2192764T3 (es) |
WO (1) | WO1999041276A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003525294A (ja) * | 2000-02-29 | 2003-08-26 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | C型肝炎ウイルスns3プロテアーゼの阻害剤 |
US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
US20060276497A1 (en) | 2000-05-09 | 2006-12-07 | Cephalon, Inc. | Novel multicyclic compounds and the use thereof |
WO2003068237A1 (en) * | 2002-02-14 | 2003-08-21 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
JP2011525927A (ja) * | 2008-06-25 | 2011-09-29 | シェーリング コーポレイション | 複素環式抗菌剤の合成および使用 |
WO2016057413A2 (en) | 2014-10-06 | 2016-04-14 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
WO2017083433A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
RU2742771C2 (ru) | 2016-08-31 | 2021-02-10 | Цзянсу Хэнжуй Медицин Ко., Лтд. | Производное оксопиколинамида, способ его получения и его фармацевтическое применение |
MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
US11225462B2 (en) | 2018-07-02 | 2022-01-18 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal forms of oxypyridine amide derivative and preparation method therefor |
JP7450024B2 (ja) | 2019-09-27 | 2024-03-14 | シェンヅェン サルブリス ファーマシューティカルズ カンパニー リミテッド | FXIa阻害剤及びその調製方法と医薬用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2117123T3 (es) * | 1992-02-14 | 1998-08-01 | Merrell Pharma Inc | Derivados de aminocetilmercaptoacetilamida utilizados como inhibidores de la encefalinasa y del enzima de conversion de angiotensina. |
NZ251930A (en) * | 1992-05-15 | 1996-02-27 | Merrell Dow Pharma | Mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a]diazepine and pyrazolo[1,2-a]diazepine derivatives, pharmaceutical compositions and preparatory methods |
EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
AU4250596A (en) * | 1994-12-22 | 1996-07-10 | Biochem Pharma Inc. | Low molecular weight bicyclic thrombin inhibitors |
WO1996030396A1 (en) * | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
ES2161354T3 (es) * | 1995-03-24 | 2001-12-01 | Molecumetics Ltd | Compuestos mimeticos de la hoja beta y su uso como inhibidores de proteasas. |
US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
ES2262184T3 (es) * | 1996-08-05 | 2006-11-16 | Myriad Genetics, Inc. | Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion. |
-
1998
- 1998-02-12 AU AU66557/98A patent/AU748887B2/en not_active Ceased
- 1998-02-12 KR KR1020007008856A patent/KR20010040939A/ko not_active Application Discontinuation
- 1998-02-12 WO PCT/US1998/002891 patent/WO1999041276A1/en not_active Application Discontinuation
- 1998-02-12 EP EP98908551A patent/EP1053246B1/en not_active Expired - Lifetime
- 1998-02-12 DE DE69810513T patent/DE69810513T2/de not_active Expired - Lifetime
- 1998-02-12 JP JP2000531467A patent/JP2002503674A/ja active Pending
- 1998-02-12 AT AT98908551T patent/ATE230414T1/de not_active IP Right Cessation
- 1998-02-12 ES ES98908551T patent/ES2192764T3/es not_active Expired - Lifetime
- 1998-02-12 CA CA002319766A patent/CA2319766A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE230414T1 (de) | 2003-01-15 |
JP2002503674A (ja) | 2002-02-05 |
WO1999041276A1 (en) | 1999-08-19 |
KR20010040939A (ko) | 2001-05-15 |
DE69810513T2 (de) | 2004-03-18 |
EP1053246B1 (en) | 2003-01-02 |
AU6655798A (en) | 1999-08-30 |
CA2319766A1 (en) | 1999-08-19 |
AU748887B2 (en) | 2002-06-13 |
EP1053246A1 (en) | 2000-11-22 |
DE69810513D1 (de) | 2003-02-06 |
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