DE69810513T2 - Mimetika von beta-faltblatt und verfahren zur verwendung davon - Google Patents
Mimetika von beta-faltblatt und verfahren zur verwendung davon Download PDFInfo
- Publication number
- DE69810513T2 DE69810513T2 DE69810513T DE69810513T DE69810513T2 DE 69810513 T2 DE69810513 T2 DE 69810513T2 DE 69810513 T DE69810513 T DE 69810513T DE 69810513 T DE69810513 T DE 69810513T DE 69810513 T2 DE69810513 T2 DE 69810513T2
- Authority
- DE
- Germany
- Prior art keywords
- mmol
- solution
- synthesis
- added
- stirred
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 C*(C)(*1)[*+]S(C*(*)CC2(*)I*)*2C1=O Chemical compound C*(C)(*1)[*+]S(C*(*)CC2(*)I*)*2C1=O 0.000 description 33
- NZQSSXWZMOWXQF-UHFFFAOYSA-N CC1C(C)=CC(OC)=C(C)C1C Chemical compound CC1C(C)=CC(OC)=C(C)C1C NZQSSXWZMOWXQF-UHFFFAOYSA-N 0.000 description 1
- DFEOEHRNFNHYEE-UHFFFAOYSA-N N=C(C1)C=CC1=O Chemical compound N=C(C1)C=CC1=O DFEOEHRNFNHYEE-UHFFFAOYSA-N 0.000 description 1
- DBIFEKMGESFACJ-QRIAGTGWSA-N N[C@@](Cc1ccccc1)(CC[C@@H](CC1)N2[C@@H]1C(NC(CCCNC(N)=N)C(c1nc(cccc3)c3[s]1)=O)=O)C2=O Chemical compound N[C@@](Cc1ccccc1)(CC[C@@H](CC1)N2[C@@H]1C(NC(CCCNC(N)=N)C(c1nc(cccc3)c3[s]1)=O)=O)C2=O DBIFEKMGESFACJ-QRIAGTGWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/002891 WO1999041276A1 (en) | 1998-02-12 | 1998-02-12 | β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69810513D1 DE69810513D1 (de) | 2003-02-06 |
| DE69810513T2 true DE69810513T2 (de) | 2004-03-18 |
Family
ID=22266392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69810513T Expired - Lifetime DE69810513T2 (de) | 1998-02-12 | 1998-02-12 | Mimetika von beta-faltblatt und verfahren zur verwendung davon |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1053246B1 (enExample) |
| JP (1) | JP2002503674A (enExample) |
| KR (1) | KR20010040939A (enExample) |
| AT (1) | ATE230414T1 (enExample) |
| AU (1) | AU748887B2 (enExample) |
| CA (1) | CA2319766A1 (enExample) |
| DE (1) | DE69810513T2 (enExample) |
| ES (1) | ES2192764T3 (enExample) |
| WO (1) | WO1999041276A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699855B2 (en) * | 2000-02-29 | 2004-03-02 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus NS3 protease |
| US6534651B2 (en) | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| US20060276497A1 (en) | 2000-05-09 | 2006-12-07 | Cephalon, Inc. | Novel multicyclic compounds and the use thereof |
| US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
| WO2003068237A1 (en) * | 2002-02-14 | 2003-08-21 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
| EP2307365B1 (en) * | 2008-06-25 | 2013-03-27 | Merck Sharp & Dohme Corp. | Synthesis and use of heterocyclic antibacterial agents |
| KR20170068521A (ko) | 2014-10-06 | 2017-06-19 | 코텍자임, 인코포레이티드 | 리신 진지페인의 억제제 |
| CN108602787A (zh) | 2015-11-09 | 2018-09-28 | 库特克希米公司 | 精氨酸牙龈卟啉菌蛋白酶的抑制剂 |
| CN113912586B (zh) | 2016-08-31 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
| MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
| CN112004810B (zh) | 2018-07-02 | 2022-04-08 | 江苏恒瑞医药股份有限公司 | 一种氧代吡啶酰胺类衍生物的晶型及制备方法 |
| WO2021057818A1 (zh) | 2019-09-27 | 2021-04-01 | 深圳信立泰药业股份有限公司 | FXIa抑制剂及其制备方法和医药用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100276029B1 (ko) * | 1992-02-14 | 2000-12-15 | 슈테펜엘.네스비트 | 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 |
| ES2138622T3 (es) * | 1992-05-15 | 2000-01-16 | Merrell Pharma Inc | Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca. |
| EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
| FI972466A7 (fi) * | 1994-12-22 | 1997-08-19 | Iaf Biochem Int | Pienen molekyylipainon bisyklisiä trombiini-inhibiittoreita |
| EP0817642A1 (en) * | 1995-03-24 | 1998-01-14 | Molecumetics, Ltd. | $g(b)-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS |
| WO1996030396A1 (en) * | 1995-03-24 | 1996-10-03 | Molecumetics Ltd. | β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS |
| US5877313A (en) * | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
| KR20000029838A (ko) * | 1996-08-05 | 2000-05-25 | 몰레큐메틱스 리미티드 | 프로테아제및키나제억제제로서그리고전사인자억제제로서의베타-시트유사체의용도 |
-
1998
- 1998-02-12 KR KR1020007008856A patent/KR20010040939A/ko not_active Ceased
- 1998-02-12 CA CA002319766A patent/CA2319766A1/en not_active Abandoned
- 1998-02-12 JP JP2000531467A patent/JP2002503674A/ja active Pending
- 1998-02-12 AU AU66557/98A patent/AU748887B2/en not_active Ceased
- 1998-02-12 EP EP98908551A patent/EP1053246B1/en not_active Expired - Lifetime
- 1998-02-12 ES ES98908551T patent/ES2192764T3/es not_active Expired - Lifetime
- 1998-02-12 AT AT98908551T patent/ATE230414T1/de not_active IP Right Cessation
- 1998-02-12 WO PCT/US1998/002891 patent/WO1999041276A1/en not_active Ceased
- 1998-02-12 DE DE69810513T patent/DE69810513T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE230414T1 (de) | 2003-01-15 |
| AU6655798A (en) | 1999-08-30 |
| DE69810513D1 (de) | 2003-02-06 |
| KR20010040939A (ko) | 2001-05-15 |
| CA2319766A1 (en) | 1999-08-19 |
| EP1053246A1 (en) | 2000-11-22 |
| WO1999041276A1 (en) | 1999-08-19 |
| ES2192764T3 (es) | 2003-10-16 |
| JP2002503674A (ja) | 2002-02-05 |
| AU748887B2 (en) | 2002-06-13 |
| EP1053246B1 (en) | 2003-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted |