ATE230414T1 - Mimetika von beta-faltblatt und verfahren zur verwendung davon - Google Patents

Mimetika von beta-faltblatt und verfahren zur verwendung davon

Info

Publication number
ATE230414T1
ATE230414T1 AT98908551T AT98908551T ATE230414T1 AT E230414 T1 ATE230414 T1 AT E230414T1 AT 98908551 T AT98908551 T AT 98908551T AT 98908551 T AT98908551 T AT 98908551T AT E230414 T1 ATE230414 T1 AT E230414T1
Authority
AT
Austria
Prior art keywords
beta
protein
sheet mimetics
beta sheet
sheet
Prior art date
Application number
AT98908551T
Other languages
German (de)
English (en)
Inventor
Maher N Qaber
Michael K Mcmillian
Michael S Kahn
John E Tulinsky
Jessymol Mathew
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Application granted granted Critical
Publication of ATE230414T1 publication Critical patent/ATE230414T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98908551T 1998-02-12 1998-02-12 Mimetika von beta-faltblatt und verfahren zur verwendung davon ATE230414T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/002891 WO1999041276A1 (en) 1998-02-12 1998-02-12 β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF

Publications (1)

Publication Number Publication Date
ATE230414T1 true ATE230414T1 (de) 2003-01-15

Family

ID=22266392

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98908551T ATE230414T1 (de) 1998-02-12 1998-02-12 Mimetika von beta-faltblatt und verfahren zur verwendung davon

Country Status (9)

Country Link
EP (1) EP1053246B1 (enExample)
JP (1) JP2002503674A (enExample)
KR (1) KR20010040939A (enExample)
AT (1) ATE230414T1 (enExample)
AU (1) AU748887B2 (enExample)
CA (1) CA2319766A1 (enExample)
DE (1) DE69810513T2 (enExample)
ES (1) ES2192764T3 (enExample)
WO (1) WO1999041276A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699855B2 (en) * 2000-02-29 2004-03-02 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus NS3 protease
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US20060276497A1 (en) 2000-05-09 2006-12-07 Cephalon, Inc. Novel multicyclic compounds and the use thereof
AU2003219809A1 (en) * 2002-02-14 2003-09-04 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
US20110212078A1 (en) 2008-06-25 2011-09-01 Reddy Panduranga Adulla P Synthesis and use of heterocyclic antibacterial agents
RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
PT3486242T (pt) 2016-08-31 2022-01-06 Jiangsu Hengrui Medicine Co Derivado de oxopicolinamida, método de preparação para esse fim e utilização farmacêutica do mesmo
PE20190473A1 (es) 2016-09-16 2019-04-04 Cortexyme Inc Inhibidores cetonicos de gingipain de lisina
WO2020007256A1 (zh) 2018-07-02 2020-01-09 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
MX2022003649A (es) 2019-09-27 2022-06-08 Shenzhen Salubris Pharm Co Ltd Inhibidores del fxia y metodo de preparacion de los mismos y uso farmaceutico de los mismos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
CA2133963C (en) * 1992-05-15 1998-07-07 Gary A. Flynn Novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a][1,2]diazepine and pyrazolo[1,2-a][1,2]diazepine derivatives useful as inhibitors of enkephalinase and ace
EP0618223A3 (en) * 1993-03-08 1996-06-12 Sandoz Ltd Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
NZ297360A (en) * 1994-12-22 2000-03-27 Iaf Biochem Int 5-oxo-5H-thiazolo[3,2-a]pyridine, 5-oxo-2-thia-4a,7-diaza-naphthalene, 4-oxo-octahydro-pyrrolo[1,2-a]pyrazine or 6-oxo-octahydro-pyrido-[2,1-c][1,4]thiazine derivatives and medicaments
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
EP0817642A1 (en) * 1995-03-24 1998-01-14 Molecumetics, Ltd. $g(b)-SHEET MIMETICS AND USE THEREOF AS INHIBITORS OF BIOLOGICALLY ACTIVE PEPTIDES OR PROTEINS
US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
CA2262900A1 (en) * 1996-08-05 1998-02-12 Molecumetics Ltd. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors

Also Published As

Publication number Publication date
EP1053246B1 (en) 2003-01-02
DE69810513T2 (de) 2004-03-18
CA2319766A1 (en) 1999-08-19
AU6655798A (en) 1999-08-30
DE69810513D1 (de) 2003-02-06
WO1999041276A1 (en) 1999-08-19
JP2002503674A (ja) 2002-02-05
EP1053246A1 (en) 2000-11-22
KR20010040939A (ko) 2001-05-15
AU748887B2 (en) 2002-06-13
ES2192764T3 (es) 2003-10-16

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