JP2002503673A5 - - Google Patents
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- Publication number
- JP2002503673A5 JP2002503673A5 JP2000531466A JP2000531466A JP2002503673A5 JP 2002503673 A5 JP2002503673 A5 JP 2002503673A5 JP 2000531466 A JP2000531466 A JP 2000531466A JP 2000531466 A JP2000531466 A JP 2000531466A JP 2002503673 A5 JP2002503673 A5 JP 2002503673A5
- Authority
- JP
- Japan
- Prior art keywords
- valyloxy
- isoleucyloxy
- propionyl
- formula
- embedded image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 aliphatic L-amino acids Chemical class 0.000 description 11
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800452A SE9800452D0 (sv) | 1998-02-13 | 1998-02-13 | Antivirals |
| SE9800452-6 | 1998-02-13 | ||
| SE9800469-0 | 1998-02-16 | ||
| SE9800469A SE9800469D0 (sv) | 1998-02-16 | 1998-02-16 | Pharmaceuticals |
| SE9801216-4 | 1998-04-03 | ||
| SE9801216A SE9801216D0 (sv) | 1998-04-03 | 1998-04-03 | Pharmaceuticals |
| ZA987267A ZA987267B (en) | 1997-08-15 | 1998-08-13 | Nucleosides |
| SE9801467 | 1998-08-14 | ||
| SE98/7267 | 1998-08-14 | ||
| PCT/SE1998/001467 WO1999009031A1 (en) | 1997-08-15 | 1998-08-14 | Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv) |
| SE9803438-2 | 1998-10-07 | ||
| SE9803438A SE9803438D0 (sv) | 1998-10-07 | 1998-10-07 | Antivirals |
| PCT/SE1999/000194 WO1999041275A1 (en) | 1998-02-13 | 1999-02-15 | Prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002503673A JP2002503673A (ja) | 2002-02-05 |
| JP2002503673A5 true JP2002503673A5 (enExample) | 2006-04-06 |
Family
ID=56289887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000531466A Pending JP2002503673A (ja) | 1998-02-13 | 1999-02-15 | プロドラッグ群 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6458772B1 (enExample) |
| EP (1) | EP1054891A1 (enExample) |
| JP (1) | JP2002503673A (enExample) |
| AU (1) | AU754733B2 (enExample) |
| CA (1) | CA2318978A1 (enExample) |
| EA (1) | EA002647B1 (enExample) |
| WO (1) | WO1999041275A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
| WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| CZ301182B6 (cs) * | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| US7527807B2 (en) * | 2000-06-21 | 2009-05-05 | Cubist Pharmaceuticals, Inc. | Compositions and methods for increasing the oral absorption of antimicrobials |
| AU2001271259A1 (en) * | 2000-06-28 | 2002-01-08 | Intertainer, Inc. | Intelligent media targeting system and method |
| US7144877B2 (en) | 2000-10-06 | 2006-12-05 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| IL142535A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
| US20050019399A1 (en) * | 2001-09-21 | 2005-01-27 | Gina Fischer | Controlled release solid dispersions |
| EP1429739A1 (en) * | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
| WO2004002422A2 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| ZA200502613B (en) * | 2002-10-10 | 2006-10-25 | Yeda Res & Dev | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
| US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
| ES2624353T3 (es) | 2002-11-15 | 2017-07-13 | Idenix Pharmaceuticals Llc | 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae |
| RU2005121904A (ru) | 2002-12-12 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | Способ получения 2`-разветвленных нуклеозидов |
| GB0301938D0 (en) * | 2003-01-28 | 2003-02-26 | Biochemie Gmbh | Organic compounds |
| DE602004031096D1 (de) | 2003-03-26 | 2011-03-03 | Egalet As | Morphin-system mit kontrollierter freisetzung |
| WO2004087169A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of nevirapine and a further antiretroviral compound |
| WO2005075655A2 (en) | 2004-02-02 | 2005-08-18 | Pioneer Hi-Bred International, Inc. | Ap2 domain transcription factor odp2 (ovule development protein 2) and methods of use |
| EP2974718A1 (en) * | 2005-04-29 | 2016-01-20 | Cubist Pharmaceuticals, Inc. | Therapeutic compositions |
| JP5254033B2 (ja) | 2005-12-23 | 2013-08-07 | イデニク プハルマセウティカルス,インコーポレイテッド | 分岐型ヌクレオシドを調製するための合成中間体の製造方法 |
| WO2007084548A2 (en) * | 2006-01-18 | 2007-07-26 | Fil-Am Tech., Inc. | Viral treatment |
| WO2008106091A1 (en) * | 2007-02-26 | 2008-09-04 | Yeda Research And Development Co. Ltd. | Use of long-chain alcohol derivatives for the treatment of alopecia areata |
| US7964751B2 (en) * | 2007-02-26 | 2011-06-21 | Yeda Research And Development Co. Ltd. | Enantiomers of amino-phenyl-acetic acid octadec-9-(Z) enyl ester, their salts and their uses |
| CA2687192C (en) | 2007-06-04 | 2015-11-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| BRPI0813237B8 (pt) | 2007-06-18 | 2021-05-25 | Sunshine Lake Pharma Co Ltd | composto, método para preparar o composto, medicamento, e, uso do composto |
| NZ594207A (en) | 2009-02-06 | 2013-03-28 | Egalet Ltd | Immediate release composition resistant to abuse by intake of alcohol |
| NZ597283A (en) | 2009-06-24 | 2013-07-26 | Egalet Ltd | Controlled release formulations |
| AU2010339481B2 (en) | 2009-12-30 | 2016-02-04 | Pioneer Hi-Bred International, Inc. | Methods and compositions for targeted polynucleotide modification |
| EP2529018B1 (en) | 2009-12-30 | 2016-06-22 | Pioneer Hi-Bred International, Inc. | Methods and compositions for the introduction and regulated expression of genes in plants |
| US8530444B2 (en) * | 2010-06-01 | 2013-09-10 | Aposense Ltd. | Pharmaceutical compounds |
| US9192680B2 (en) | 2010-06-01 | 2015-11-24 | Aposense Ltd. | Pharmaceutical compounds |
| JP2014506593A (ja) * | 2011-02-21 | 2014-03-17 | メディヴィル・アクチエボラーグ | Flgの合成 |
| CA3207643A1 (en) * | 2015-09-23 | 2017-03-30 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| KR102378845B1 (ko) | 2017-03-30 | 2022-03-24 | 엑스더블유파마 리미티드 | 이환형 헤테로아릴 유도체 및 이의 제조 및 용도 |
| CN112004802B (zh) | 2018-09-30 | 2021-12-28 | 凯瑞康宁生物工程(武汉)有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| CN115244028A (zh) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | 4-缬氨酰氧基丁酸的合成方法 |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| AU2021293941B2 (en) | 2020-06-18 | 2024-03-28 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| CN115666527B (zh) | 2020-10-05 | 2025-03-07 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的修饰释放组合物 |
| TW202300139A (zh) | 2021-03-19 | 2023-01-01 | 凱瑞康寧生技股份有限公司 | γ-羟基丁酸衍生物的聯合釋放製劑的藥代動力學 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458772B1 (en) * | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
| IE34948B1 (en) | 1970-03-12 | 1975-10-01 | Leo Pharm Prod Ltd | New penicillin esters |
| US3705191A (en) | 1970-04-13 | 1972-12-05 | Monsanto Co | Substituted ethane diphosphonic acids and salts and esters thereof |
| US4168267A (en) | 1978-10-23 | 1979-09-18 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl prolines |
| GB2043072B (en) | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
| US4486425A (en) | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
| US4337201A (en) | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4760057A (en) | 1983-06-23 | 1988-07-26 | Merck & Co., Inc. | (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| US4594199A (en) | 1983-09-19 | 1986-06-10 | E. R. Squibb & Sons, Inc. | Method for making phosphinic acid intermediates |
| GB8421112D0 (en) | 1984-08-20 | 1984-09-26 | Unilever Plc | Pyroglutamic acid esters |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| SE8602981D0 (sv) | 1986-07-04 | 1986-07-04 | Astra Laekemedel Ab | Novel medicinal use |
| DE3623397A1 (de) | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DD279407A1 (de) | 1986-07-24 | 1990-06-06 | Akad Wissenschaften Ddr | Verfahren zur herstellung eines mittels gegen aids |
| DK406686D0 (da) | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
| GB8719367D0 (en) | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
| CA1321994C (en) | 1987-10-28 | 1993-09-07 | Reid Von Borstel | Acylated uridine and cytidine and uses thereof |
| US5198539A (en) | 1988-08-19 | 1993-03-30 | Burroughs Wellcome Co. | 5'-esters of 2',3'-dideoxy-3'-fluoro-5-ethynyluridine |
| ZA898567B (en) | 1988-11-15 | 1990-08-29 | Merrell Dow Pharma | Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives |
| AU618436B2 (en) | 1988-12-19 | 1991-12-19 | Wellcome Foundation Limited, The | Antiviral cytosine and guanine derivatives |
| DK24089D0 (da) | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
| US5001115A (en) | 1989-05-17 | 1991-03-19 | University Of Florida | Prodrugs of biologically active hydroxyaromatic compounds |
| FI83421C (fi) | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat. |
| US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5227506A (en) | 1989-09-06 | 1993-07-13 | Merck & Co., Inc. | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors |
| AU636678B2 (en) * | 1989-11-06 | 1993-05-06 | Nycomed Imaging As | Nucleoside derivatives |
| DE69115694T2 (de) | 1990-06-13 | 1996-10-17 | Arnold Newton Mass. Glazier | Phosphorylierte prodrugs |
| US5177064A (en) | 1990-07-13 | 1993-01-05 | University Of Florida | Targeted drug delivery via phosphonate derivatives |
| WO1992013561A1 (en) | 1991-02-08 | 1992-08-20 | Pro-Neuron, Inc. | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
| JP3132167B2 (ja) | 1991-08-23 | 2001-02-05 | 藤沢薬品工業株式会社 | デプシペプチド誘導体の製造法 |
| EP0541037A3 (en) | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| DE69330114T2 (de) | 1992-07-10 | 2001-08-02 | Toray Industries, Inc. | Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel |
| US5484911A (en) | 1993-04-01 | 1996-01-16 | Health Research, Inc. | Nucleoside 5'-diphosphate conjugates of ether lipids |
| GB9515279D0 (en) | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
| DE4311801A1 (de) | 1993-04-09 | 1994-10-13 | Hoechst Ag | Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| AU5722694A (en) | 1993-11-05 | 1995-05-23 | Astra Aktiebolag | Novel amino acid derivatives |
| IL111584A0 (en) | 1993-11-18 | 1995-01-24 | Merck & Co Inc | Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them |
| DE4342907A1 (de) | 1993-12-16 | 1995-06-22 | Bayer Ag | Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten |
| DE4418690A1 (de) | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| US5441942A (en) * | 1994-05-27 | 1995-08-15 | The Scripps Research Institute | 2'3'-dideoxy-2',3'-didehydro-7,8-disubstituted guanosines and their immunostimulative effect |
| US5466811A (en) | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| US5543414A (en) | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
| PE32296A1 (es) | 1994-07-28 | 1996-08-07 | Hoffmann La Roche | Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables |
| US5696277A (en) | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
| WO1996021440A1 (en) | 1995-01-09 | 1996-07-18 | Alpha-Therapeutics, Inc. | Methods for increasing the bioavailability of biological active agents |
| BR9607492A (pt) | 1995-01-16 | 1999-06-29 | Commw Scient Ind Res Org | Conjugados de ácidos graxos de composto terapêutico |
| IL113246A (en) | 1995-04-04 | 2004-08-31 | Yissum Res Dev Co | Bisphosphonates and pharmaceutical compositions containing them |
| WO1996033201A1 (en) | 1995-04-21 | 1996-10-24 | Centre National De La Recherche Scientifique (Cnrs) | Acyclovir derivatives as antiviral agents |
| DE19529604A1 (de) | 1995-08-11 | 1997-02-13 | Bayer Ag | Endoparasitizide Mittel auf Basis von Didepsipeptiden, neue Didepsipeptide und ein Verfahren zu ihrer Herstellung |
| US5717095A (en) | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
| AU1592897A (en) | 1996-01-26 | 1997-08-20 | F. Hoffmann-La Roche Ag | Process for preparing purine derivatives |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
| JP2001503767A (ja) | 1996-11-12 | 2001-03-21 | メディヴィル・アクチボラグ | ヌクレオシド |
| ATE297904T1 (de) | 1997-04-15 | 2005-07-15 | Genentech Inc | Halo-alkoxycarbonylverbindungen |
| WO1998051692A1 (en) | 1997-05-15 | 1998-11-19 | Drug Innovation & Design, Inc. | Acyclovir diester derivatives |
| DE69800753D1 (de) * | 1997-08-15 | 2001-06-07 | Medivir Ab Huddinge | Analoge nukleoside, wie antivirale einschliesslich inhibitoren der retroviralen reverstranskriptase und der dna polymerase des hepatitis b virus |
| WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| US6974803B2 (en) * | 2001-12-06 | 2005-12-13 | Pfizer Inc | Pharmaceutical combination |
-
1999
- 1999-02-12 US US09/249,317 patent/US6458772B1/en not_active Expired - Fee Related
- 1999-02-15 WO PCT/SE1999/000194 patent/WO1999041275A1/en not_active Ceased
- 1999-02-15 CA CA002318978A patent/CA2318978A1/en not_active Abandoned
- 1999-02-15 AU AU32820/99A patent/AU754733B2/en not_active Ceased
- 1999-02-15 JP JP2000531466A patent/JP2002503673A/ja active Pending
- 1999-02-15 EP EP99932500A patent/EP1054891A1/en not_active Withdrawn
- 1999-02-15 EA EA200000838A patent/EA002647B1/ru not_active IP Right Cessation
-
2001
- 2001-11-16 US US10/015,184 patent/US6974802B2/en not_active Expired - Fee Related
-
2005
- 2005-08-12 US US11/202,682 patent/US7071173B2/en not_active Expired - Fee Related
-
2006
- 2006-01-18 US US11/335,429 patent/US7825238B2/en not_active Expired - Fee Related
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