JP2002505336A5 - - Google Patents
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- Publication number
- JP2002505336A5 JP2002505336A5 JP2000534566A JP2000534566A JP2002505336A5 JP 2002505336 A5 JP2002505336 A5 JP 2002505336A5 JP 2000534566 A JP2000534566 A JP 2000534566A JP 2000534566 A JP2000534566 A JP 2000534566A JP 2002505336 A5 JP2002505336 A5 JP 2002505336A5
- Authority
- JP
- Japan
- Prior art keywords
- enoic acid
- group
- formula
- compound
- epi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 description 17
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- -1 polymethylene groups Polymers 0.000 description 4
- WCFIGQHNBJXROP-IHMUCKAYSA-N (R)-4-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(O)=O)C)[C@@]1(C)CC2 WCFIGQHNBJXROP-IHMUCKAYSA-N 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 2
- PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 2
- ZKWFSTHEYLJLEL-UHFFFAOYSA-N morpholine-4-carboxamide Chemical compound NC(=O)N1CCOCC1 ZKWFSTHEYLJLEL-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 201000009623 Myopathy Diseases 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9804861.4 | 1998-03-06 | ||
| GBGB9804861.4A GB9804861D0 (en) | 1998-03-06 | 1998-03-06 | Chemical compounds |
| PCT/GB1999/000681 WO1999045024A1 (en) | 1998-03-06 | 1999-03-08 | Cholenic acid amides and pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002505336A JP2002505336A (ja) | 2002-02-19 |
| JP2002505336A5 true JP2002505336A5 (enExample) | 2006-05-11 |
Family
ID=10828156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534566A Pending JP2002505336A (ja) | 1998-03-06 | 1999-03-08 | コレン酸アミドおよびその医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7235552B1 (enExample) |
| EP (1) | EP1060188A1 (enExample) |
| JP (1) | JP2002505336A (enExample) |
| KR (1) | KR100690037B1 (enExample) |
| CN (1) | CN1177860C (enExample) |
| AU (1) | AU752992B2 (enExample) |
| CA (1) | CA2319763C (enExample) |
| CZ (1) | CZ298478B6 (enExample) |
| GB (1) | GB9804861D0 (enExample) |
| HU (1) | HUP0100854A3 (enExample) |
| IL (1) | IL138137A (enExample) |
| NO (1) | NO317378B1 (enExample) |
| NZ (1) | NZ506139A (enExample) |
| WO (1) | WO1999045024A1 (enExample) |
| ZA (1) | ZA991841B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ523042A (en) * | 2000-05-11 | 2004-05-28 | Res Inst Medicine Chem | 2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity |
| EP1514874A1 (en) * | 2003-07-28 | 2005-03-16 | Schering Aktiengesellschaft | Thiomorpholino steroid compounds, the use thereof for the preparation of meiosis regulating medicaments and method for the preparation thereof |
| WO2009059239A2 (en) * | 2007-11-02 | 2009-05-07 | Mayo Foundation For Medical Education And Research | REDUCING Aβ42 LEVELS AND Aβ AGGREGATION |
| WO2010065936A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
| US8987235B2 (en) | 2011-05-17 | 2015-03-24 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses |
| CA2842462C (en) | 2011-07-20 | 2020-01-28 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
| RU2669800C2 (ru) | 2013-03-15 | 2018-10-16 | Брихэм Янг Юниверсити | Способы лечения воспаления, аутоиммунных расстройств и боли |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| EP3275888B1 (en) * | 2016-07-28 | 2019-09-25 | Council of Scientific & Industrial Research | Progesterone-cationic lipid hybrid as anticancer agent and the process of synthesis thereof |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| US12186328B2 (en) | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| WO2023205801A2 (en) | 2022-04-22 | 2023-10-26 | Asteroid Therapeutics | Steroidal compositions and methods of treating lipogenic cancers |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1512326A (fr) * | 1964-03-27 | 1968-02-09 | Roussel Uclaf | Nouveaux stéroïdes azotés et procédé de préparation |
| US4217288A (en) * | 1977-03-24 | 1980-08-12 | Wisconsin Alumni Research Foundation | Anti-vitamin D compounds |
| US4172076A (en) * | 1977-04-04 | 1979-10-23 | Diamond Shamrock Corporation | Process for preparing steroidal acids and their intermediate derivatives |
| DE2920092A1 (de) * | 1978-05-19 | 1979-11-29 | Wisconsin Alumni Res Found | Antivitamin d-verbindungen und diese enthaltende pharmazeutische zusammensetzungen |
| GB8505862D0 (en) * | 1985-03-07 | 1985-04-11 | Erba Farmitalia | Steroidic 5alpha-reductase inhibitors |
| US5494905A (en) * | 1991-11-07 | 1996-02-27 | Research Institute For Medicine And Chemistry | Vitamin D amide derivatives |
| JP3493037B2 (ja) * | 1991-12-18 | 2004-02-03 | 中外製薬株式会社 | ２２−オキサコレカルシフェロール誘導体とその製造方法 |
| IL105050A0 (en) * | 1992-03-27 | 1993-07-08 | Lilly Co Eli | Steroid derivatives |
| GB9309422D0 (en) * | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| WO1997042215A1 (en) * | 1996-05-06 | 1997-11-13 | Bionumerik Pharmaceuticals, Inc. | Process for preparing 27-hydroxy cholesterol and related derivatives |
| PL334840A1 (en) * | 1997-01-24 | 2000-03-27 | Univ California | Application of fxr, pparalpha and lxralpha activators in order to restore the barrier function, to stimulate epithelium differentation and to inhibit proliferation |
-
1998
- 1998-03-06 GB GBGB9804861.4A patent/GB9804861D0/en not_active Ceased
-
1999
- 1999-03-08 IL IL13813799A patent/IL138137A/xx not_active IP Right Cessation
- 1999-03-08 ZA ZA9901841A patent/ZA991841B/xx unknown
- 1999-03-08 HU HU0100854A patent/HUP0100854A3/hu unknown
- 1999-03-08 NZ NZ506139A patent/NZ506139A/xx unknown
- 1999-03-08 AU AU32675/99A patent/AU752992B2/en not_active Ceased
- 1999-03-08 CA CA002319763A patent/CA2319763C/en not_active Expired - Fee Related
- 1999-03-08 CN CNB998036935A patent/CN1177860C/zh not_active Expired - Fee Related
- 1999-03-08 KR KR1020007009596A patent/KR100690037B1/ko not_active Expired - Fee Related
- 1999-03-08 EP EP99937931A patent/EP1060188A1/en not_active Withdrawn
- 1999-03-08 CZ CZ20003253A patent/CZ298478B6/cs not_active IP Right Cessation
- 1999-03-08 JP JP2000534566A patent/JP2002505336A/ja active Pending
- 1999-03-08 WO PCT/GB1999/000681 patent/WO1999045024A1/en not_active Ceased
-
2000
- 2000-08-01 US US09/630,546 patent/US7235552B1/en not_active Expired - Fee Related
- 2000-09-04 NO NO20004399A patent/NO317378B1/no not_active IP Right Cessation
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