EP1473292A1
(en)
*
|
1997-11-03 |
2004-11-03 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
ATE300299T1
(de)
*
|
1997-12-22 |
2005-08-15 |
Bayer Pharmaceuticals Corp |
Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
|
ES2155817T3
(es)
*
|
1997-12-22 |
2007-06-16 |
Bayer Pharmaceuticals Corp. |
Inhibicion de la actividad de la quinasa p38 utilizando ureas heterociclicas sustituidas con arilo y heteroarilo.
|
AU2006201959B2
(en)
*
|
1997-12-22 |
2008-09-04 |
Bayer Healthcare Llc |
Inhibition of Raf Kinase using Substituted Heterocyclic Ureas
|
EP1041982B1
(en)
*
|
1997-12-22 |
2011-10-19 |
Bayer HealthCare LLC |
INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
|
US7928239B2
(en)
*
|
1999-01-13 |
2011-04-19 |
Bayer Healthcare Llc |
Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
|
ATE556713T1
(de)
|
1999-01-13 |
2012-05-15 |
Bayer Healthcare Llc |
Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
UA73492C2
(en)
|
1999-01-19 |
2005-08-15 |
|
Aromatic heterocyclic compounds as antiinflammatory agents
|
EP1157026A1
(en)
|
1999-02-22 |
2001-11-28 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Polycyclo heterocyclic derivatives as antiinflammatory agents
|
WO2000051998A1
(en)
|
1999-03-02 |
2000-09-08 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as reversible inhibitors of cathepsin s
|
KR100709497B1
(ko)
|
1999-03-12 |
2007-04-20 |
베링거 인겔하임 파마슈티칼즈, 인코포레이티드 |
소염제로서 유용한 화합물 및 이의 제조방법
|
JP2002539206A
(ja)
|
1999-03-12 |
2002-11-19 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
抗炎症剤としての芳香族複素環化合物
|
DE60024830T2
(de)
|
1999-07-09 |
2006-06-14 |
Boehringer Ingelheim Pharma |
Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
|
AP2002002442A0
(en)
*
|
1999-08-12 |
2002-03-31 |
Pharmacia Italia Spa |
3(5)-Amino-pyrazole derivatives, process for their preparation and their preparation and their use as antitumor agents.
|
US6420364B1
(en)
|
1999-09-13 |
2002-07-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compound useful as reversible inhibitors of cysteine proteases
|
TR200201364T2
(tr)
*
|
1999-11-22 |
2002-10-21 |
Smithkline Beecham P. L. C. |
Yeni bileşikler.
|
US6525046B1
(en)
|
2000-01-18 |
2003-02-25 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as antiinflammatory agents
|
US6608052B2
(en)
|
2000-02-16 |
2003-08-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as anti-inflammatory agents
|
AU2001287654B2
(en)
*
|
2000-08-10 |
2006-12-14 |
Pfizer Italia S.R.I. |
Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
US6645990B2
(en)
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
EP1341771A2
(en)
|
2000-11-29 |
2003-09-10 |
Glaxo Group Limited |
Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
|
CA2445003A1
(en)
|
2001-05-16 |
2002-11-21 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Diarylurea derivatives useful as anti-inflammatory agents
|
WO2002096876A1
(en)
|
2001-05-25 |
2002-12-05 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Carbamate and oxamide compounds as inhibitors of cytokine production
|
EP1709965A3
(en)
*
|
2001-07-11 |
2006-12-27 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Methods of treating cytokine mediate diseases
|
ES2309207T3
(es)
*
|
2001-09-05 |
2008-12-16 |
Smithkline Beecham Plc |
Derivados furanicos sustituidos con piridina como inhibidores de quinasa raf.
|
SI1450799T1
(sl)
*
|
2001-12-03 |
2007-02-28 |
Bayer Pharmaceuticals Corp |
Aril secninske spojine v kombinaciji z drugimi citostaticnimi ali citotoksicnimi sredstvi za zdravljenje cloveskih rakov
|
ATE529406T1
(de)
|
2002-02-11 |
2011-11-15 |
Bayer Healthcare Llc |
Aryl-harnstoffe als kinase inhibitoren
|
WO2003068223A1
(en)
*
|
2002-02-11 |
2003-08-21 |
Bayer Corporation |
Aryl ureas with raf kinase and angiogenesis inhibiting activity
|
US10653684B2
(en)
|
2002-02-11 |
2020-05-19 |
Bayer Healthcare Llc |
Aryl ureas with angiogenisis inhibiting activity
|
AU2003209116A1
(en)
|
2002-02-11 |
2003-09-04 |
Bayer Pharmaceuticals Corporation |
Aryl ureas with angiogenesis inhibiting activity
|
ATE386030T1
(de)
|
2002-02-25 |
2008-03-15 |
Boehringer Ingelheim Pharma |
1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
|
JP2005537290A
(ja)
*
|
2002-07-25 |
2005-12-08 |
ファルマシア・イタリア・エス・ピー・エー |
キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
US7202257B2
(en)
|
2003-12-24 |
2007-04-10 |
Deciphera Pharmaceuticals, Llc |
Anti-inflammatory medicaments
|
CA2516931C
(en)
|
2003-02-28 |
2014-09-09 |
Bayer Pharmaceuticals Corporation |
Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
|
US7557129B2
(en)
|
2003-02-28 |
2009-07-07 |
Bayer Healthcare Llc |
Cyanopyridine derivatives useful in the treatment of cancer and other disorders
|
CA2526285A1
(en)
|
2003-05-15 |
2004-12-23 |
Arqule, Inc. |
Inhibitors of p38 and methods of using the same
|
JP4860474B2
(ja)
|
2003-05-20 |
2012-01-25 |
バイエル、ファーマシューテイカルズ、コーポレイション |
Pdgfrによって仲介される病気のためのジアリール尿素
|
DK1663978T3
(da)
|
2003-07-23 |
2008-04-07 |
Bayer Pharmaceuticals Corp |
Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
|
US20050148605A1
(en)
*
|
2003-11-13 |
2005-07-07 |
Ambit Biosciences Corporation |
Amide derivatives as ABL modulators
|
TW200530236A
(en)
|
2004-02-23 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Heteroaryl phenylurea
|
US20060211752A1
(en)
|
2004-03-16 |
2006-09-21 |
Kohn Leonard D |
Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
|
EP1730129B1
(en)
*
|
2004-03-19 |
2011-01-19 |
Dipharma Francis S.r.l. |
Intermediates for the preparation of pramipexole
|
WO2005110994A2
(en)
|
2004-04-30 |
2005-11-24 |
Bayer Pharmaceuticals Corporation |
Substituted pyrazolyl urea derivatives useful in the treatment of cancer
|
US7829560B2
(en)
|
2004-07-08 |
2010-11-09 |
Arqule, Inc. |
1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase
|
MY191349A
(en)
*
|
2004-08-27 |
2022-06-17 |
Bayer Pharmaceuticals Corp |
New pharmaceutical compositions for the treatment of hyper-proliferative disorders
|
EP1809636A1
(en)
|
2004-10-19 |
2007-07-25 |
Arqule, Inc. |
Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
|
GB0423554D0
(en)
*
|
2004-10-22 |
2004-11-24 |
Cancer Rec Tech Ltd |
Therapeutic compounds
|
AU2005321946B2
(en)
*
|
2004-12-23 |
2012-08-16 |
Deciphera Pharmaceuticals, Llc |
Enzyme modulators and treatments
|
GB0500435D0
(en)
*
|
2005-01-10 |
2005-02-16 |
Novartis Ag |
Organic compounds
|
UA93673C2
(ru)
|
2005-03-07 |
2011-03-10 |
Баер Шеринг Фарма Акциенгезельшафт |
Фармацевтическая композиция, которая содержит омега-карбоксиарилзамещенную дифенилмочевину, для лечения paka
|
JP5072595B2
(ja)
|
2005-08-05 |
2012-11-14 |
中外製薬株式会社 |
マルチキナーゼ阻害剤
|
DE102005037499A1
(de)
|
2005-08-09 |
2007-02-15 |
Merck Patent Gmbh |
Pyrazolderivate
|
CA2629468A1
(en)
*
|
2005-11-15 |
2007-05-24 |
Bayer Pharmaceuticals Corporation |
Pyrazolyl urea derivatives useful in the treatment of cancer
|
US8580798B2
(en)
|
2005-12-21 |
2013-11-12 |
Bayer Intellectual Property Gmbh |
Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders
|
EP2338488A1
(en)
|
2006-05-26 |
2011-06-29 |
Bayer HealthCare, LLC |
Drug combinations with substituted diaryl ureas for the treatment of cancer
|
US7897762B2
(en)
|
2006-09-14 |
2011-03-01 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of proliferative diseases
|
CA2672951A1
(en)
|
2006-12-20 |
2008-07-03 |
Bayer Healthcare Llc |
Hydroxy methyl phenyl pyrazolyl urea compound useful in the treatment of cancer
|
US7737149B2
(en)
*
|
2006-12-21 |
2010-06-15 |
Astrazeneca Ab |
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
|
JP5396379B2
(ja)
|
2007-04-02 |
2014-01-22 |
エボテック・アーゲー |
ピリド−2−イル縮合複素環式化合物ならびにその組成物および使用
|
EP2146718A4
(en)
|
2007-04-20 |
2010-08-11 |
Deciphera Pharmaceuticals Llc |
KINASEHEMMER FOR THE TREATMENT OF MYELOPROLIFERATIVE AND OTHER PROLIFERATIVE DISEASES
|
CL2009000448A1
(es)
|
2008-02-29 |
2009-11-27 |
Genentech Inc |
Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros.
|
CN102015707A
(zh)
|
2008-02-29 |
2011-04-13 |
阵列生物制药公司 |
Raf抑制剂化合物及其使用方法
|
GB0818033D0
(en)
|
2008-10-02 |
2008-11-05 |
Respivert Ltd |
Novel compound
|
WO2010038086A2
(en)
|
2008-10-02 |
2010-04-08 |
Respivert Limited |
Novel compounds
|
CN102333770B
(zh)
|
2008-12-11 |
2015-01-28 |
瑞斯比维特有限公司 |
P38map激酶抑制剂
|
GB0905955D0
(en)
|
2009-04-06 |
2009-05-20 |
Respivert Ltd |
Novel compounds
|
EP2556067B1
(en)
|
2010-04-08 |
2016-02-24 |
Respivert Limited |
Pyrazolyl ureas as p38 map kinase inhibitors
|
CN103003262A
(zh)
|
2010-07-16 |
2013-03-27 |
协和发酵麒麟株式会社 |
含氮芳香族杂环衍生物
|
WO2012012404A1
(en)
|
2010-07-19 |
2012-01-26 |
Bayer Healthcare Llc |
Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
|
EP2578582A1
(en)
|
2011-10-03 |
2013-04-10 |
Respivert Limited |
1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
|
BR112014007694B1
(pt)
|
2011-10-03 |
2022-09-27 |
Respivert Limited |
Compostos de 1-(3-(tert-butil)-1-(p-tolil)-1h-pirazol-5-il)-3-(4-((2-(fenilamino) pirimidin-4-il)óxi) naftalen-1-il)ureia, seus usos, composição e formulação farmacêutica compreendendo os mesmos
|
US8461179B1
(en)
|
2012-06-07 |
2013-06-11 |
Deciphera Pharmaceuticals, Llc |
Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
KR20140011780A
(ko)
*
|
2012-07-19 |
2014-01-29 |
한미약품 주식회사 |
단백질 키나아제 저해활성을 갖는 이소퀴놀린-5-카복스아미드 유도체
|
GB201214750D0
(en)
|
2012-08-17 |
2012-10-03 |
Respivert Ltd |
Compounds
|
GB201215357D0
(en)
|
2012-08-29 |
2012-10-10 |
Respivert Ltd |
Compounds
|
US20160016934A1
(en)
|
2013-03-14 |
2016-01-21 |
Respivert Limited |
Kinase inhibitors
|
US9750723B2
(en)
|
2013-10-31 |
2017-09-05 |
Ohio University |
Prevention and treatment of non-alcoholic fatty liver disease
|
TWI751099B
(zh)
|
2014-02-14 |
2022-01-01 |
英商瑞斯比維特有限公司 |
作為激酶抑制劑之吡唑基脲,包含其之製藥組成物及其用途
|
US20170202818A1
(en)
|
2014-07-18 |
2017-07-20 |
Ohio University |
Methods and compositions to modify gsk-3 activity
|
SG11202007198WA
(en)
|
2018-01-31 |
2020-08-28 |
Deciphera Pharmaceuticals Llc |
Combination therapy for the treatment of gastrointestinal stromal tumors
|
PT3762368T
(pt)
|
2018-03-08 |
2022-05-06 |
Incyte Corp |
Compostos de aminopirazina diol como inibidores de pi3k-y
|
CN108484587A
(zh)
*
|
2018-06-03 |
2018-09-04 |
刘思良 |
一种Raf激酶抑制剂及其在癌症治疗中的应用
|
WO2020010003A1
(en)
|
2018-07-02 |
2020-01-09 |
Incyte Corporation |
AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
|
BR112022002609A2
(pt)
|
2019-08-12 |
2022-08-09 |
Deciphera Pharmaceuticals Llc |
Métodos de tratamento de tumores estromais gastrointestinais
|
TW202122082A
(zh)
|
2019-08-12 |
2021-06-16 |
美商迪賽孚爾製藥有限公司 |
治療胃腸道基質瘤方法
|
KR20220123058A
(ko)
|
2019-12-30 |
2022-09-05 |
데시페라 파마슈티칼스, 엘엘씨. |
1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
|
IL293866A
(en)
|
2019-12-30 |
2022-08-01 |
Deciphera Pharmaceuticals Llc |
Compositions of amorphous kinase inhibitors and methods of using them
|
US11779572B1
(en)
|
2022-09-02 |
2023-10-10 |
Deciphera Pharmaceuticals, Llc |
Methods of treating gastrointestinal stromal tumors
|