JP2001525325A5 - - Google Patents
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- Publication number
- JP2001525325A5 JP2001525325A5 JP2000523217A JP2000523217A JP2001525325A5 JP 2001525325 A5 JP2001525325 A5 JP 2001525325A5 JP 2000523217 A JP2000523217 A JP 2000523217A JP 2000523217 A JP2000523217 A JP 2000523217A JP 2001525325 A5 JP2001525325 A5 JP 2001525325A5
- Authority
- JP
- Japan
- Prior art keywords
- benzothieno
- pyrimidin
- tetrahydro
- chloro
- ethanolamine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002169 ethanolamines Chemical class 0.000 description 7
- OTHGDXKTNUFUKT-UHFFFAOYSA-N 2-[4-[(3-chloro-4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]propanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(C(C)C(O)=O)=NC2=C1C(CCCC1)=C1S2 OTHGDXKTNUFUKT-UHFFFAOYSA-N 0.000 description 1
- VMXOWMYGMGFXPE-UHFFFAOYSA-N 2-[4-[4-(1,3-benzodioxol-5-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=NC(NCC=2C=C3OCOC3=CC=2)=C(C2=C(CCCC2)S2)C2=N1 VMXOWMYGMGFXPE-UHFFFAOYSA-N 0.000 description 1
- PHIMOHDTSYJEJD-UHFFFAOYSA-N 2-[4-[4-[(3-chloro-4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]phenyl]acetic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(C=2C=CC(CC(O)=O)=CC=2)=NC2=C1C(CCCC1)=C1S2 PHIMOHDTSYJEJD-UHFFFAOYSA-N 0.000 description 1
- GATRUILEWKSGGZ-UHFFFAOYSA-N 4-[4-(1,3-benzodioxol-5-ylmethylamino)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylbutanoic acid Chemical compound C1CCCC2=C1C1=C(NCC=3C=C4OCOC4=CC=3)N=C(CCC(C)(C)C(O)=O)N=C1S2 GATRUILEWKSGGZ-UHFFFAOYSA-N 0.000 description 1
- ZTXNVUQKQHMFRF-UHFFFAOYSA-N 4-[4-[(3-chloro-4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylbutanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(CCC(C)(C)C(O)=O)=NC2=C1C(CCCC1)=C1S2 ZTXNVUQKQHMFRF-UHFFFAOYSA-N 0.000 description 1
- CCNIEACTJRXCHC-UHFFFAOYSA-N 5-[4-[(3,4-dichlorophenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]pentanoic acid Chemical compound C=12C=3CCCCC=3SC2=NC(CCCCC(=O)O)=NC=1NCC1=CC=C(Cl)C(Cl)=C1 CCNIEACTJRXCHC-UHFFFAOYSA-N 0.000 description 1
- WGERLWWNYCYMPT-UHFFFAOYSA-N 5-[4-[(3-chloro-4-hydroxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]pentanoic acid Chemical compound C=12C=3CCCCC=3SC2=NC(CCCCC(=O)O)=NC=1NCC1=CC=C(O)C(Cl)=C1 WGERLWWNYCYMPT-UHFFFAOYSA-N 0.000 description 1
- RGRWSSLYDHCXIK-UHFFFAOYSA-N 5-[4-[(3-chloro-4-propan-2-yloxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]pentanoic acid Chemical compound C1=C(Cl)C(OC(C)C)=CC=C1CNC1=NC(CCCCC(O)=O)=NC2=C1C(CCCC1)=C1S2 RGRWSSLYDHCXIK-UHFFFAOYSA-N 0.000 description 1
- UKFWEJPDAVFJBL-UHFFFAOYSA-N 6-[4-[(3-chloro-4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]hexanoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(CCCCCC(O)=O)=NC2=C1C(CCCC1)=C1S2 UKFWEJPDAVFJBL-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752952A DE19752952A1 (de) | 1997-11-28 | 1997-11-28 | Thienopyrimidine |
| DE19752952.6 | 1997-11-28 | ||
| PCT/EP1998/007436 WO1999028325A1 (de) | 1997-11-28 | 1998-11-19 | Thienopyrimidine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001525325A JP2001525325A (ja) | 2001-12-11 |
| JP2001525325A5 true JP2001525325A5 (https=) | 2008-12-18 |
| JP4314341B2 JP4314341B2 (ja) | 2009-08-12 |
Family
ID=7850200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000523217A Expired - Fee Related JP4314341B2 (ja) | 1997-11-28 | 1998-11-19 | チエノピリミジン類 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6420368B1 (https=) |
| EP (1) | EP1036078B1 (https=) |
| JP (1) | JP4314341B2 (https=) |
| KR (1) | KR20010032445A (https=) |
| CN (1) | CN1138780C (https=) |
| AR (1) | AR010962A1 (https=) |
| AT (1) | ATE361926T1 (https=) |
| AU (1) | AU742433B2 (https=) |
| BR (1) | BR9815409A (https=) |
| CA (1) | CA2311922C (https=) |
| CO (1) | CO4980884A1 (https=) |
| CZ (1) | CZ291068B6 (https=) |
| DE (2) | DE19752952A1 (https=) |
| ES (1) | ES2285796T3 (https=) |
| HK (1) | HK1038924A1 (https=) |
| HU (1) | HUP0100488A3 (https=) |
| ID (1) | ID24571A (https=) |
| NO (1) | NO20002702D0 (https=) |
| PL (1) | PL341156A1 (https=) |
| RU (1) | RU2217431C2 (https=) |
| SK (1) | SK7772000A3 (https=) |
| TW (1) | TW472059B (https=) |
| WO (1) | WO1999028325A1 (https=) |
| ZA (1) | ZA9810845B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
| CN1346358A (zh) | 1999-03-30 | 2002-04-24 | 日本曹达株式会社 | 噻吩并嘧啶化合物及其盐和制备方法 |
| DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| US20020006926A1 (en) | 2000-04-19 | 2002-01-17 | Roylance H. H. | Use of cyclic GMP-specific phosphodiesterase inhibitors for treatment of parkinson's disease |
| DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
| DE10031584A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
| DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
| CA2423981A1 (en) * | 2000-09-29 | 2003-03-28 | Kimiko Ichikawa | Thienopyrimidine compounds and salts thereof and process for the preparation of the same |
| DE10058663A1 (de) * | 2000-11-25 | 2002-05-29 | Merck Patent Gmbh | Verwendung von Thienopyrimidinen |
| AU2002227957A1 (en) * | 2000-12-19 | 2002-07-01 | Merck Patent Gmbh | Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives |
| DE10064994A1 (de) * | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
| DE10103647A1 (de) | 2001-01-27 | 2002-08-01 | Merck Patent Gmbh | Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates |
| HUP0302987A2 (hu) * | 2001-01-31 | 2003-12-29 | Merck Patent Gmbh | Pirazolo [4,3-d] pirimidinszármazékokat vagy tienopirimidinszármazékokat és nitrátvegyületeket tartalmazó gyógyászati készítmények |
| MXPA03009925A (es) * | 2001-04-30 | 2004-06-30 | Bayer Pharmaceuticals Corp | Nuevas tiofeno [2,3-d]pirimidinas 4-amino-5,6-sustituidas. |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| JPWO2003035653A1 (ja) * | 2001-10-26 | 2005-02-10 | 日本曹達株式会社 | ピリドチエノピリミジン化合物およびその塩 |
| OA13050A (en) | 2003-04-29 | 2006-11-10 | Pfizer Ltd | 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension. |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| CA2562251C (en) | 2004-04-07 | 2009-04-28 | Pfizer Inc. | Pyrazolo'4,3-d pyrimidines |
| GB0420719D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| ES2259891B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
| ES2259892B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
| AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
| CN109297923A (zh) * | 2018-09-19 | 2019-02-01 | 南通出入境检验检疫局检验检疫综合技术中心 | 纺织品中微量含氟整理剂的测定方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE245666C (https=) | ||||
| DD245666A1 (de) * | 1985-09-20 | 1987-05-13 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-aminosubstituierten thieno 2,3-d-pyrimidin-2-ylessigsaeureestern |
| GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| DE19644228A1 (de) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
-
1997
- 1997-11-28 DE DE19752952A patent/DE19752952A1/de not_active Withdrawn
-
1998
- 1998-11-19 HU HU0100488A patent/HUP0100488A3/hu unknown
- 1998-11-19 RU RU2000116899/04A patent/RU2217431C2/ru not_active IP Right Cessation
- 1998-11-19 HK HK02100600.0A patent/HK1038924A1/zh unknown
- 1998-11-19 BR BR9815409-5A patent/BR9815409A/pt not_active Application Discontinuation
- 1998-11-19 KR KR1020007005686A patent/KR20010032445A/ko not_active Abandoned
- 1998-11-19 ID IDW20000942A patent/ID24571A/id unknown
- 1998-11-19 CA CA002311922A patent/CA2311922C/en not_active Expired - Fee Related
- 1998-11-19 ES ES98964411T patent/ES2285796T3/es not_active Expired - Lifetime
- 1998-11-19 AU AU19625/99A patent/AU742433B2/en not_active Ceased
- 1998-11-19 CN CNB988113767A patent/CN1138780C/zh not_active Expired - Fee Related
- 1998-11-19 SK SK777-2000A patent/SK7772000A3/sk unknown
- 1998-11-19 DE DE59814003T patent/DE59814003D1/de not_active Expired - Lifetime
- 1998-11-19 PL PL98341156A patent/PL341156A1/xx not_active Application Discontinuation
- 1998-11-19 WO PCT/EP1998/007436 patent/WO1999028325A1/de not_active Ceased
- 1998-11-19 JP JP2000523217A patent/JP4314341B2/ja not_active Expired - Fee Related
- 1998-11-19 EP EP98964411A patent/EP1036078B1/de not_active Expired - Lifetime
- 1998-11-19 CZ CZ20001962A patent/CZ291068B6/cs not_active IP Right Cessation
- 1998-11-19 US US09/555,210 patent/US6420368B1/en not_active Expired - Fee Related
- 1998-11-19 AT AT98964411T patent/ATE361926T1/de not_active IP Right Cessation
- 1998-11-26 TW TW087119650A patent/TW472059B/zh not_active IP Right Cessation
- 1998-11-26 ZA ZA9810845A patent/ZA9810845B/xx unknown
- 1998-11-27 CO CO98070308A patent/CO4980884A1/es unknown
- 1998-11-27 AR ARP980106028A patent/AR010962A1/es not_active Application Discontinuation
-
2000
- 2000-05-26 NO NO20002702A patent/NO20002702D0/no not_active Application Discontinuation
-
2002
- 2002-05-16 US US10/146,028 patent/US6495554B2/en not_active Expired - Fee Related
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