JP2001522836A5 - - Google Patents
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- Publication number
- JP2001522836A5 JP2001522836A5 JP2000520420A JP2000520420A JP2001522836A5 JP 2001522836 A5 JP2001522836 A5 JP 2001522836A5 JP 2000520420 A JP2000520420 A JP 2000520420A JP 2000520420 A JP2000520420 A JP 2000520420A JP 2001522836 A5 JP2001522836 A5 JP 2001522836A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- phenyl
- substituted
- group
- trihalomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000004953 trihalomethyl group Chemical group 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 0 *CCNC(C=Cc1ccc(Cc2c[n]cn2)cc1)=O Chemical compound *CCNC(C=Cc1ccc(Cc2c[n]cn2)cc1)=O 0.000 description 3
- -1 3, 5-dimethylphenyl Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- QIJFEZANWQTHRK-UHFFFAOYSA-N CC1(CC(C=C2)=CCC2=C=CC(C)=O)N=CNC1 Chemical compound CC1(CC(C=C2)=CCC2=C=CC(C)=O)N=CNC1 QIJFEZANWQTHRK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96626497A | 1997-11-07 | 1997-11-07 | |
| US08/966,264 | 1997-11-07 | ||
| PCT/US1998/023225 WO1999024406A1 (en) | 1997-11-07 | 1998-11-05 | Phenyl-alkyl-imidazoles as h3 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522836A JP2001522836A (ja) | 2001-11-20 |
| JP2001522836A5 true JP2001522836A5 (https=) | 2006-01-05 |
Family
ID=25511129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520420A Pending JP2001522836A (ja) | 1997-11-07 | 1998-11-05 | Ｈ３レセプターアンタゴニストとしてのフェニル−アルキル−イミダゾール |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1028948B1 (https=) |
| JP (1) | JP2001522836A (https=) |
| CN (1) | CN1285823A (https=) |
| AR (1) | AR016416A1 (https=) |
| AT (1) | ATE231841T1 (https=) |
| AU (1) | AU1296899A (https=) |
| CA (1) | CA2309121A1 (https=) |
| DE (1) | DE69811110T2 (https=) |
| ES (1) | ES2188029T3 (https=) |
| PE (1) | PE130799A1 (https=) |
| WO (1) | WO1999024406A1 (https=) |
| ZA (1) | ZA9810184B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE285821T1 (de) * | 1999-10-08 | 2005-01-15 | Affinium Pharm Inc | Fab i inhibitoren |
| US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| CA2550679A1 (en) * | 2003-12-23 | 2005-07-14 | Schering Corporation | Substituted n-aryl amidines as selective d1 dopamine receptor antagonists for the treatment of obesity and cns disorders |
| AU2006204724A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| SI2861608T1 (sl) | 2012-06-19 | 2019-08-30 | Debiopharm International Sa | Derivati predzdravila (E)-N-metil-N-((3-metilbenzofuran-2-IL)metil)- 3-(7-okso-5,6,7,8-tetrahidro-1 ,8-nafthiridin-3-il)akrilamid |
| BR122023021456A2 (pt) | 2016-02-26 | 2024-02-20 | Debiopharm International S.A. | Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica |
| LT3923914T (lt) | 2019-02-14 | 2023-07-25 | Debiopharm International S.A. | Afabicino kompozicija, jos gamybos būdas |
| CN113939306B (zh) | 2019-06-14 | 2024-07-19 | 德彪药业国际股份公司 | 用于治疗涉及生物膜的细菌感染的药物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| ATE234290T1 (de) * | 1993-11-15 | 2003-03-15 | Schering Corp | Phenylalkyl-imidazole als h3-rezeptor- antagonisten |
| FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| EP0920315B1 (en) * | 1996-08-16 | 2005-12-28 | Schering Corporation | Treatment of upper airway allergic responses with a combination of histamine receptor antagonists |
-
1998
- 1998-11-05 CA CA002309121A patent/CA2309121A1/en not_active Abandoned
- 1998-11-05 WO PCT/US1998/023225 patent/WO1999024406A1/en not_active Ceased
- 1998-11-05 AT AT98956444T patent/ATE231841T1/de not_active IP Right Cessation
- 1998-11-05 EP EP98956444A patent/EP1028948B1/en not_active Expired - Lifetime
- 1998-11-05 CN CN98812982A patent/CN1285823A/zh active Pending
- 1998-11-05 AU AU12968/99A patent/AU1296899A/en not_active Abandoned
- 1998-11-05 JP JP2000520420A patent/JP2001522836A/ja active Pending
- 1998-11-05 ES ES98956444T patent/ES2188029T3/es not_active Expired - Lifetime
- 1998-11-05 DE DE69811110T patent/DE69811110T2/de not_active Expired - Fee Related
- 1998-11-06 PE PE1998001071A patent/PE130799A1/es not_active Application Discontinuation
- 1998-11-06 AR ARP980105621A patent/AR016416A1/es unknown
- 1998-11-06 ZA ZA9810184A patent/ZA9810184B/xx unknown
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