JP2001522836A5 - - Google Patents
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- Publication number
- JP2001522836A5 JP2001522836A5 JP2000520420A JP2000520420A JP2001522836A5 JP 2001522836 A5 JP2001522836 A5 JP 2001522836A5 JP 2000520420 A JP2000520420 A JP 2000520420A JP 2000520420 A JP2000520420 A JP 2000520420A JP 2001522836 A5 JP2001522836 A5 JP 2001522836A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- phenyl
- substituted
- group
- trihalomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000004953 trihalomethyl group Chemical group 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 125000000623 heterocyclic group Chemical group 0.000 description 4
- 0 *CCNC(C=Cc1ccc(Cc2c[n]cn2)cc1)=O Chemical compound *CCNC(C=Cc1ccc(Cc2c[n]cn2)cc1)=O 0.000 description 3
- -1 3, 5-dimethylphenyl Chemical group 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- QIJFEZANWQTHRK-UHFFFAOYSA-N CC1(CC(C=C2)=CCC2=C=CC(C)=O)N=CNC1 Chemical compound CC1(CC(C=C2)=CCC2=C=CC(C)=O)N=CNC1 QIJFEZANWQTHRK-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96626497A | 1997-11-07 | 1997-11-07 | |
| US08/966,264 | 1997-11-07 | ||
| PCT/US1998/023225 WO1999024406A1 (en) | 1997-11-07 | 1998-11-05 | Phenyl-alkyl-imidazoles as h3 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522836A JP2001522836A (ja) | 2001-11-20 |
| JP2001522836A5 true JP2001522836A5 (https=) | 2006-01-05 |
Family
ID=25511129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520420A Pending JP2001522836A (ja) | 1997-11-07 | 1998-11-05 | Ｈ３レセプターアンタゴニストとしてのフェニル−アルキル−イミダゾール |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1028948B1 (https=) |
| JP (1) | JP2001522836A (https=) |
| CN (1) | CN1285823A (https=) |
| AR (1) | AR016416A1 (https=) |
| AT (1) | ATE231841T1 (https=) |
| AU (1) | AU1296899A (https=) |
| CA (1) | CA2309121A1 (https=) |
| DE (1) | DE69811110T2 (https=) |
| ES (1) | ES2188029T3 (https=) |
| PE (1) | PE130799A1 (https=) |
| WO (1) | WO1999024406A1 (https=) |
| ZA (1) | ZA9810184B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230030B1 (hu) * | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| WO2004066960A2 (en) * | 2003-01-28 | 2004-08-12 | Schering Corporation | Combination of h1, h3 and h4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| ATE547404T1 (de) | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
| WO2005063697A2 (en) * | 2003-12-23 | 2005-07-14 | Schering Corporation | Substituted n-aryl amidines as selective d1 dopamine receptor antagonists for the treatment of obesity and cns disorders |
| AU2006204724A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| JPH09505298A (ja) * | 1993-11-15 | 1997-05-27 | シェーリング コーポレイション | Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール |
| FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| KR20000029975A (ko) * | 1996-08-16 | 2000-05-25 | 둘락 노먼 씨. | 히스타민수용체길항제의배합물을사용한상부기도알레르기반응의치료 |
-
1998
- 1998-11-05 EP EP98956444A patent/EP1028948B1/en not_active Expired - Lifetime
- 1998-11-05 CA CA002309121A patent/CA2309121A1/en not_active Abandoned
- 1998-11-05 AU AU12968/99A patent/AU1296899A/en not_active Abandoned
- 1998-11-05 DE DE69811110T patent/DE69811110T2/de not_active Expired - Fee Related
- 1998-11-05 CN CN98812982A patent/CN1285823A/zh active Pending
- 1998-11-05 ES ES98956444T patent/ES2188029T3/es not_active Expired - Lifetime
- 1998-11-05 AT AT98956444T patent/ATE231841T1/de not_active IP Right Cessation
- 1998-11-05 WO PCT/US1998/023225 patent/WO1999024406A1/en not_active Ceased
- 1998-11-05 JP JP2000520420A patent/JP2001522836A/ja active Pending
- 1998-11-06 AR ARP980105621A patent/AR016416A1/es unknown
- 1998-11-06 PE PE1998001071A patent/PE130799A1/es not_active Application Discontinuation
- 1998-11-06 ZA ZA9810184A patent/ZA9810184B/xx unknown
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