JP2001519769A - N―(アリール/ヘテロアリール)アミノ酸誘導体、その医薬組成物および該化合物を用いたβ―アミロイドペプチドの放出および/またはその合成を阻害する方法 - Google Patents
N―(アリール/ヘテロアリール)アミノ酸誘導体、その医薬組成物および該化合物を用いたβ―アミロイドペプチドの放出および/またはその合成を阻害する方法Info
- Publication number
- JP2001519769A JP2001519769A JP52364998A JP52364998A JP2001519769A JP 2001519769 A JP2001519769 A JP 2001519769A JP 52364998 A JP52364998 A JP 52364998A JP 52364998 A JP52364998 A JP 52364998A JP 2001519769 A JP2001519769 A JP 2001519769A
- Authority
- JP
- Japan
- Prior art keywords
- dichlorophenyl
- alanyl
- group
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75533496A | 1996-11-22 | 1996-11-22 | |
US08/755,334 | 1996-11-22 | ||
PCT/US1997/018704 WO1998022493A2 (fr) | 1996-11-22 | 1997-11-20 | DERIVES DE N-(ARYL/HETEROARYL) AMINOACIDE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET PROCEDES PERMETTANT D'INHIBER LA LIBERATION DE PEPTIDE β AMYLOIDE ET/OU SA SYNTHESE A L'AIDE DE CES COMPOSES |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001519769A true JP2001519769A (ja) | 2001-10-23 |
Family
ID=25038718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52364998A Pending JP2001519769A (ja) | 1996-11-22 | 1997-11-20 | N―(アリール/ヘテロアリール)アミノ酸誘導体、その医薬組成物および該化合物を用いたβ―アミロイドペプチドの放出および/またはその合成を阻害する方法 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0942923A2 (fr) |
JP (1) | JP2001519769A (fr) |
CN (1) | CN1237978A (fr) |
AU (1) | AU5354398A (fr) |
BR (1) | BR9714358A (fr) |
CA (1) | CA2270876A1 (fr) |
HU (1) | HUP0001383A3 (fr) |
ID (1) | ID22275A (fr) |
IL (1) | IL129477A0 (fr) |
NO (1) | NO992426L (fr) |
NZ (1) | NZ335157A (fr) |
TR (1) | TR199901132T2 (fr) |
WO (1) | WO1998022493A2 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
AU6278099A (en) | 1998-09-30 | 2000-04-17 | Elan Pharmaceuticals, Inc. | Biological reagents and methods for determining the mechanism in the generation of beta-amyloid peptide |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
IL142816A0 (en) | 1998-12-24 | 2002-03-10 | Du Pont Pharm Co | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
EP1218377A1 (fr) | 1999-10-08 | 2002-07-03 | Bristol-Myers Squibb Pharma Company | AMINO SULFONAMIDES DE LACTAME UTILISES COMME INHIBITEURS DE LA PRODUCTION DE PROTEINE A$g(b) |
US6525044B2 (en) | 2000-02-17 | 2003-02-25 | Bristol-Myers Squibb Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production |
BR0107532A (pt) | 2000-04-03 | 2004-11-03 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica |
CA2403550A1 (fr) | 2000-04-03 | 2001-10-11 | Hong Liu | Lactames cycliques utiles en tant qu'inhibiteurs de la production de proteine a-beta |
US6632812B2 (en) | 2000-04-11 | 2003-10-14 | Dupont Pharmaceuticals Company | Substituted lactams as inhibitors of Aβ protein production |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
BR0106717A (pt) | 2000-06-01 | 2002-04-16 | Bristol Myers Squibb Pharma Co | Compostos, composição farmacêutica e usos dos compostos de lactama inovadora |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
BRPI0113470B8 (pt) | 2000-08-24 | 2021-05-25 | Univ Pittsburgh | composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
CA2436526C (fr) | 2000-12-13 | 2010-10-19 | Wyeth | Inhibiteurs sulfonamides heterocycliques de la production de beta-amyloide |
CH698246B1 (de) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test zur Identifizierung von Inhibitoren von Beta-Sekretasen. |
DE10306202A1 (de) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen |
RU2440995C2 (ru) * | 2003-03-14 | 2012-01-27 | Юнивесити Оф Питсбэг | Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего |
NZ542468A (en) | 2003-03-31 | 2009-01-31 | Wyeth Corp | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
EP1633350B1 (fr) | 2003-06-05 | 2012-10-03 | Elan Pharmaceuticals, Inc. | Amino acide amidyle pyrazoles acyles et composes relatifs |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
CN1910158A (zh) | 2004-01-16 | 2007-02-07 | 惠氏公司 | 含有氮杂环的β淀粉样蛋白生成的杂环磺酰胺抑制剂 |
WO2005085185A1 (fr) * | 2004-03-03 | 2005-09-15 | Smithkline Beecham Corporation | Derives d'aniline utilises comme modulateurs du recepteur selectif de l'androgene |
EP1871379A4 (fr) * | 2005-04-15 | 2010-06-02 | Glaxosmithkline Llc | Cyanoarylamines |
CN100999546B (zh) * | 2007-01-11 | 2010-08-11 | 清华大学 | 具有含氮杂环修饰的多肽类化合物及其应用 |
WO2012172449A1 (fr) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactames convenant comme inhibiteurs des bêta-sécrétases |
CN111777571B (zh) * | 2020-06-28 | 2023-07-11 | 武汉药明康德新药开发有限公司 | 一种手性2-氨基-3 -(1,3-苯并噻唑-2-基)丙酸盐酸盐的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ274074A (en) * | 1993-10-01 | 1997-11-24 | Merrell Pharma Inc | Various dipeptide derivatives having a reduced carboxy group, the aldehyde being optionally substituted; pharmaceutical compositions |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
-
1997
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 ID IDW990395A patent/ID22275A/id unknown
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/xx unknown
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/hu unknown
- 1997-11-20 CN CN97199776A patent/CN1237978A/zh active Pending
- 1997-11-20 CA CA002270876A patent/CA2270876A1/fr not_active Abandoned
- 1997-11-20 JP JP52364998A patent/JP2001519769A/ja active Pending
- 1997-11-20 EP EP97950576A patent/EP0942923A2/fr not_active Withdrawn
- 1997-11-20 IL IL12947797A patent/IL129477A0/xx unknown
- 1997-11-20 BR BR9714358A patent/BR9714358A/pt not_active IP Right Cessation
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/fr not_active Application Discontinuation
- 1997-11-20 NZ NZ335157A patent/NZ335157A/xx unknown
-
1999
- 1999-05-20 NO NO992426A patent/NO992426L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ID22275A (id) | 1999-09-23 |
AU5354398A (en) | 1998-06-10 |
EP0942923A2 (fr) | 1999-09-22 |
IL129477A0 (en) | 2000-02-29 |
WO1998022493A3 (fr) | 1998-07-23 |
TR199901132T2 (xx) | 1999-08-23 |
NO992426L (no) | 1999-06-30 |
BR9714358A (pt) | 2000-03-21 |
CA2270876A1 (fr) | 1998-05-28 |
HUP0001383A1 (hu) | 2001-05-28 |
CN1237978A (zh) | 1999-12-08 |
NZ335157A (en) | 2001-01-26 |
WO1998022493A2 (fr) | 1998-05-28 |
NO992426D0 (no) | 1999-05-20 |
HUP0001383A3 (en) | 2001-11-28 |
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