JP2001518081A5 - - Google Patents

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Publication number
JP2001518081A5
JP2001518081A5 JP1998538799A JP53879998A JP2001518081A5 JP 2001518081 A5 JP2001518081 A5 JP 2001518081A5 JP 1998538799 A JP1998538799 A JP 1998538799A JP 53879998 A JP53879998 A JP 53879998A JP 2001518081 A5 JP2001518081 A5 JP 2001518081A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1998538799A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001518081A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/004300 external-priority patent/WO1998038859A1/en
Publication of JP2001518081A publication Critical patent/JP2001518081A/ja
Publication of JP2001518081A5 publication Critical patent/JP2001518081A5/ja
Abandoned legal-status Critical Current

Links

JP53879998A 1997-03-04 1998-03-04 スルホニル２価アリールまたはヘテロアリールヒドロキサム酸化合物 Abandoned JP2001518081A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3518297P 1997-03-04 1997-03-04
US60/035,182 1997-03-04
PCT/US1998/004300 WO1998038859A1 (en) 1997-03-04 1998-03-04 Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds

Publications (2)

Publication Number Publication Date
JP2001518081A JP2001518081A (ja) 2001-10-09
JP2001518081A5 true JP2001518081A5 (enExample) 2005-11-10

Family

ID=21881145

Family Applications (4)

Application Number Title Priority Date Filing Date
JP53878098A Abandoned JP2002515901A (ja) 1997-03-04 1998-03-04 芳香族スルホニルα−シクロアミノヒドロキサム酸化合物
JP53879998A Abandoned JP2001518081A (ja) 1997-03-04 1998-03-04 スルホニル２価アリールまたはヘテロアリールヒドロキサム酸化合物
JP53879698A Abandoned JP2002513407A (ja) 1997-03-04 1998-03-04 Ｎ−ヒドロキシ４−スルホニルブタンアミド化合物
JP53798598A Abandoned JP2002515900A (ja) 1997-03-04 1998-03-04 芳香族スルホニルアルファ−ヒドロキシヒドロキサム酸化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP53878098A Abandoned JP2002515901A (ja) 1997-03-04 1998-03-04 芳香族スルホニルα−シクロアミノヒドロキサム酸化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP53879698A Abandoned JP2002513407A (ja) 1997-03-04 1998-03-04 Ｎ−ヒドロキシ４−スルホニルブタンアミド化合物
JP53798598A Abandoned JP2002515900A (ja) 1997-03-04 1998-03-04 芳香族スルホニルアルファ−ヒドロキシヒドロキサム酸化合物

Country Status (19)

Country Link
US (3) US6380258B2 (enExample)
EP (4) EP0973392B1 (enExample)
JP (4) JP2002515901A (enExample)
KR (3) KR20000075954A (enExample)
CN (3) CN1253474A (enExample)
AT (1) ATE254599T1 (enExample)
AU (2) AU750130B2 (enExample)
BR (2) BR9808214A (enExample)
CA (4) CA2283275A1 (enExample)
DE (1) DE69819878T2 (enExample)
DK (1) DK0973392T3 (enExample)
EA (1) EA199900792A1 (enExample)
ES (2) ES2206903T3 (enExample)
IL (3) IL131494A (enExample)
NO (1) NO315647B1 (enExample)
NZ (1) NZ337326A (enExample)
PL (1) PL335732A1 (enExample)
PT (1) PT973392E (enExample)
WO (1) WO1998038859A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747027B1 (en) 1996-07-22 2004-06-08 Pharmacia Corporation Thiol sulfonamide metalloprotease inhibitors
DK0973392T3 (da) 1997-03-04 2004-03-29 Monsanto Co Divalente sulfonyl-aryl eller heteroarylhydroxamsyreforbindelser
US6794511B2 (en) 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6696449B2 (en) * 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
PT1037868E (pt) * 1997-11-21 2003-06-30 Upjohn Co Derivados alfa-hidroxi amino e halo de acidos beta-sulfonil-hidroxamicos como inibidores de metaloproteinases matriciais
WO2000037433A1 (en) * 1998-12-18 2000-06-29 Abbott Laboratories Inhibitors of matrix metalloproteinases
US6800646B1 (en) 1999-02-08 2004-10-05 Pharmacia Corporation Sulfamato hydroxamic acid metalloprotease inhibitor
JP2003525203A (ja) 1999-03-22 2003-08-26 ダーウィン・ディスカバリー・リミテッド ヒドロキサムおよびカルボン酸誘導体
MXPA01011481A (es) * 1999-05-12 2005-06-20 Searle & Co Derivados de acido hidroxamico como inhibidores de metaloproteasas de la matriz.
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2001038322A1 (en) 1999-11-23 2001-05-31 Methylgene, Inc. Inhibitors of histone deacetylase
US7569724B2 (en) 2000-09-29 2009-08-04 Topotarget Uk Limited Carbamic acid compounds comprising an amide linkage as HDAC inhibitors
US6888027B2 (en) 2000-09-29 2005-05-03 Topotarget Uk Limited Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
PL222211B1 (pl) 2001-06-26 2016-07-29 Amgen Fremont Inc Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza
US6683078B2 (en) * 2001-07-19 2004-01-27 Pharmacia Corporation Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
NZ536116A (en) 2002-04-03 2007-01-26 Topotarget Uk Ltd Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
AU2003221786A1 (en) 2002-04-25 2003-11-10 Pharmacia Corporation Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
GB0226855D0 (en) * 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
NZ550621A (en) * 2004-03-22 2009-11-27 Southern Res Inst Nonpeptide inhibitors of matrix metalloproteinases
US20050250789A1 (en) * 2004-04-20 2005-11-10 Burns David M Hydroxamic acid derivatives as metalloprotease inhibitors
EP1769071B1 (en) * 2004-06-01 2011-07-27 The Scripps Research Institute Proteomic analysis
US20050277897A1 (en) * 2004-06-14 2005-12-15 Ghannoum Ziad R Handpiece tip
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
CN101273013B (zh) * 2005-09-27 2013-06-12 盐野义制药株式会社 具有pgd2受体拮抗活性的磺酰胺衍生物
ES2427397T3 (es) * 2008-10-27 2013-10-30 Mitsubishi Tanabe Pharma Corporation Nuevo derivado de amida y su uso como medicina
MX337575B (es) 2009-10-09 2016-03-10 Zafgen Corp Compuestos de sulfona y métodos para lafabricación y uso de éstos.
WO2012012642A1 (en) 2010-07-22 2012-01-26 Zafgen Corporation Tricyclic compounds and methds of making and using same
CN103402989B (zh) 2011-01-26 2016-04-06 扎夫根股份有限公司 四唑化合物及其制备和使用方法
BR112013028665A2 (pt) 2011-05-06 2016-09-06 Zafgen Inc compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
KR20140040739A (ko) 2011-05-06 2014-04-03 자프겐 인크. 삼환식 피라졸 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
WO2012154676A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Partially saturated tricyclic compounds and methods of making and using same
CN104892457B (zh) * 2011-07-25 2017-07-28 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物、其药物组合物、制备方法及用途
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
BR112014017780A8 (pt) 2012-01-18 2017-07-11 Zafgen Inc Compostos de sulfona tricíclicos e métodos para fazer e usar os mesmos
MX2014008706A (es) 2012-01-18 2015-03-05 Zafgen Inc Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
US9868717B2 (en) 2012-11-05 2018-01-16 Zafgen, Inc. Tricyclic sulphonamide compounds and methods of making and using same
WO2014071363A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds and methods of making and using same
JP6169716B2 (ja) 2012-11-05 2017-07-26 ザフゲン，インコーポレイテッド 肝疾患を治療する方法
WO2014072214A1 (en) * 2012-11-09 2014-05-15 Unilever N.V. A composition and method for treating substrates
US9840520B2 (en) * 2014-05-14 2017-12-12 The Regents Of The University Of Colorado, A Body Corporate Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
WO2017158190A1 (en) * 2016-03-17 2017-09-21 Ecole polytechnique fédérale de Lausanne (EPFL) Enhancers of notch signaling and their use in the treatment of cancers and malignancies medicable by upregulation of notch
WO2020006384A1 (en) 2018-06-29 2020-01-02 Loyola University Of Chicago Carborane hydroxamic acid matrix metalloproteinase inhibitors and agents for boron neutron capture therapy
CN111217722B (zh) * 2020-03-06 2024-01-02 华东理工大学 偶氮芳基脲类衍生物及其制备方法和应用
CN116102391B (zh) * 2023-01-06 2025-01-28 湖大粤港澳大湾区创新研究院(广州增城) 二硫转移试剂及其合成与应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148801A (en) * 1978-07-03 1979-04-10 American Home Products Corporation 3-[(Chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US5103014A (en) * 1987-09-30 1992-04-07 American Home Products Corporation Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives
GB2212153B (en) 1987-11-16 1992-01-15 Squibb & Sons Inc Phenyl hydroxamic acids
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5527945A (en) * 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
EP0493925B1 (en) * 1990-12-17 1997-11-05 Sankyo Company Limited Pyrazole derivatives having herbicidal activity, their preparation and their use
JP3348725B2 (ja) * 1992-04-07 2002-11-20 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド ヒドロキサム酸ベースのコラゲナーゼとサイトカイン阻害剤
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5552419A (en) 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
WO1995029892A1 (en) 1994-04-28 1995-11-09 The Du Pont Merck Pharmaceutical Company Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
BR9509237A (pt) 1994-10-05 1997-10-21 Chiroscience Ltd Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
JP2000502330A (ja) 1995-12-08 2000-02-29 アグロン・ファーマシュウティカルズ・インコーポレーテッド メタロプロテイナーゼ阻害薬、それらを含有する薬剤組成物および薬剤としてのそれらの使用、ならびにそれらの製造に有用な方法および中間体
ES2183905T3 (es) * 1995-12-20 2003-04-01 Hoffmann La Roche Inhibidores de metaloproteasa de matriz.
WO1997024117A1 (en) * 1996-01-02 1997-07-10 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
KR20000022532A (ko) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
EP0968182B1 (en) * 1996-08-07 2004-05-06 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
DE69732571T2 (de) * 1996-09-27 2006-01-12 Pharmacia & Upjohn Co., Kalamazoo Beta-sulfonyl-hydroxamsäuren als matrix-metalloproteinaseinhibitoren
ATE205306T1 (de) * 1997-01-13 2001-09-15 Fuji Photo Film Co Ltd Wärmeentwickelbares, photoempfindliches farbmaterial
EP0966438A1 (en) * 1997-02-07 1999-12-29 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
TR199902095T2 (xx) * 1997-02-27 1999-12-21 American Cyanamid Company Matris metalloproteinaz �nleyicileri olarak amidler
DK0973392T3 (da) 1997-03-04 2004-03-29 Monsanto Co Divalente sulfonyl-aryl eller heteroarylhydroxamsyreforbindelser
US20010014688A1 (en) * 1997-11-14 2001-08-16 Thomas E. Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor

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