JP2001513370A5 - - Google Patents

Info

Publication number

JP2001513370A5

JP2001513370A5 JP2000507005A JP2000507005A JP2001513370A5 JP 2001513370 A5 JP2001513370 A5 JP 2001513370A5 JP 2000507005 A JP2000507005 A JP 2000507005A JP 2000507005 A JP2000507005 A JP 2000507005A JP 2001513370 A5 JP2001513370 A5 JP 2001513370A5

Authority

JP

Japan

Prior art keywords

vitamin

dialysis solution

pharmaceutically acceptable

acceptable salt

carnitine

Prior art date

1998-08-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000385 dialysis solution Substances 0.000 description 9
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 8
• 150000003839 salts Chemical class 0.000 description 7
• PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 5
• 229960004203 carnitine Drugs 0.000 description 5
• 229930003231 vitamin Natural products 0.000 description 5
• 235000013343 vitamin Nutrition 0.000 description 5
• 239000011782 vitamin Substances 0.000 description 5
• 229940088594 vitamin Drugs 0.000 description 5
• 150000003722 vitamin derivatives Chemical class 0.000 description 5
• RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 4
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 4
• JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 4
• FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 4
• 229960000304 folic acid Drugs 0.000 description 4
• 235000019152 folic acid Nutrition 0.000 description 4
• 239000011724 folic acid Substances 0.000 description 4
• 235000019157 thiamine Nutrition 0.000 description 4
• 229960003495 thiamine Drugs 0.000 description 4
• 239000011721 thiamine Substances 0.000 description 4
• KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 4
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
• 229930003268 Vitamin C Natural products 0.000 description 2
• 235000019154 vitamin C Nutrition 0.000 description 2
• 239000011718 vitamin C Substances 0.000 description 2
• 239000000004 hemodialysis solution Substances 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 239000000243 solution Substances 0.000 description 1