JP2001510791A - 半透性プラグを備えた浸透投与系 - Google Patents
半透性プラグを備えた浸透投与系Info
- Publication number
- JP2001510791A JP2001510791A JP2000503827A JP2000503827A JP2001510791A JP 2001510791 A JP2001510791 A JP 2001510791A JP 2000503827 A JP2000503827 A JP 2000503827A JP 2000503827 A JP2000503827 A JP 2000503827A JP 2001510791 A JP2001510791 A JP 2001510791A
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- Prior art keywords
- semi
- osmotic
- liquid
- permeable body
- enclosure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Closures For Containers (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5368997P | 1997-07-25 | 1997-07-25 | |
| US60/053,689 | 1997-07-25 | ||
| PCT/US1998/014812 WO1999004767A2 (en) | 1997-07-25 | 1998-07-24 | Osmotic delivery system with semipermeable plug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005204469A Division JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510791A true JP2001510791A (ja) | 2001-08-07 |
| JP2001510791A5 JP2001510791A5 (https=) | 2009-04-09 |
Family
ID=21985896
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000503827A Pending JP2001510791A (ja) | 1997-07-25 | 1998-07-24 | 半透性プラグを備えた浸透投与系 |
| JP2005204469A Withdrawn JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005204469A Withdrawn JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6287295B1 (https=) |
| EP (1) | EP1011642B1 (https=) |
| JP (2) | JP2001510791A (https=) |
| KR (1) | KR100600462B1 (https=) |
| CN (1) | CN1198602C (https=) |
| AR (1) | AR016543A1 (https=) |
| AT (2) | ATE357911T1 (https=) |
| AU (1) | AU8658998A (https=) |
| CA (1) | CA2297801C (https=) |
| CO (1) | CO4970812A1 (https=) |
| DE (2) | DE69840679D1 (https=) |
| MY (1) | MY125849A (https=) |
| TW (1) | TW450817B (https=) |
| WO (1) | WO1999004767A2 (https=) |
| ZA (1) | ZA986631B (https=) |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| WO1999033449A1 (en) | 1997-12-30 | 1999-07-08 | Alza Corporation | Beneficial agent delivery system with membrane plug |
| JP4383674B2 (ja) | 1998-12-31 | 2009-12-16 | インターシア セラピューティクス，インコーポレイティド | 空間効率のよいピストンを有する浸透圧送達システム |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US7258869B1 (en) * | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6436091B1 (en) * | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US7074803B2 (en) * | 2001-03-02 | 2006-07-11 | Durect Corporation | Opioid formulations |
| US6491684B1 (en) * | 2001-05-22 | 2002-12-10 | Durect Corporation | Fluid delivery device having a water generating electrochemical/chemical pump and associated method |
| US7163688B2 (en) * | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
| US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| WO2004000284A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| CA2477923C (en) | 2002-03-01 | 2021-02-23 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| US7470267B2 (en) * | 2002-05-01 | 2008-12-30 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method |
| US7896867B2 (en) * | 2002-05-01 | 2011-03-01 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| US7458965B2 (en) * | 2002-05-01 | 2008-12-02 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| WO2007005565A2 (en) * | 2002-05-01 | 2007-01-11 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| US20060116663A1 (en) * | 2002-05-01 | 2006-06-01 | Joshi Ashok V | Electro-osmotic fluid delivery device and method |
| TW200420306A (en) * | 2002-06-17 | 2004-10-16 | Alza Corp | Osmotic delivery system with early zero order push power engine |
| MXPA05000224A (es) * | 2002-06-26 | 2005-06-03 | Alza Corp | Piston de volumen eficiente, minimamente deformable, para sistemas de suministro osmotico de farmacos. |
| DE10233622A1 (de) * | 2002-07-24 | 2004-02-12 | Disetronic Licensing Ag | Infusionspumpe, Verfahren, Steuerprogramm und Halbleiterbauelement zur dosierten Verabreichung einer medizinischen Flüssigkeit |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| EP1578398A2 (en) * | 2002-12-19 | 2005-09-28 | ALZA Corporation | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| EP2339328A3 (en) | 2002-12-30 | 2011-07-13 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of celecoxib |
| ATE550022T1 (de) | 2003-02-28 | 2012-04-15 | Mcneil Ppc Inc | Pharmazeutische mischkristalle von celecoxib- nicotinamid |
| ATE387236T1 (de) * | 2003-03-31 | 2008-03-15 | Alza Corp | Osmotische pumpe mit mitteln zum ableiten des innendrucks |
| CA2520766A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| WO2004091278A2 (en) * | 2003-04-11 | 2004-10-28 | Transform Pharmaceuticals, Inc. | Gabapentin compositions |
| WO2005000786A1 (en) | 2003-05-23 | 2005-01-06 | Transform Pharmaceuticals, Inc. | Sertraline compositions |
| US7858110B2 (en) | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| CA2437639C (en) * | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US20090208540A1 (en) * | 2003-08-11 | 2009-08-20 | Indevus Pharmaceuticals, Inc. | Implantable device for the delivery of naltrexone and methods of use thereof |
| US7632245B1 (en) * | 2003-08-18 | 2009-12-15 | Medrad, Inc. | Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure |
| US7217351B2 (en) * | 2003-08-29 | 2007-05-15 | Beta Micropump Partners Llc | Valve for controlling flow of a fluid |
| US7927599B2 (en) | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| NZ546182A (en) * | 2003-09-26 | 2009-08-28 | Alza Corp | Controlled release formulations of opioid and nonopioid analgesics such as hydrocodone and acetaminophen |
| JP2007506775A (ja) | 2003-09-26 | 2007-03-22 | アルザ・コーポレーシヨン | 漸増する放出速度を表す制御放出製剤 |
| KR20060092255A (ko) | 2003-09-26 | 2006-08-22 | 알자 코포레이션 | 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법 |
| MXPA06002967A (es) | 2003-09-30 | 2006-06-14 | Alza Corp | Aparato de suministro de agente activo de conduccion osmotica que proporciona perfil de liberacion ascendente. |
| CN1905861A (zh) | 2003-10-31 | 2007-01-31 | 阿尔扎公司 | 具有自保持、快启动薄膜插塞的渗透泵 |
| US20050113410A1 (en) * | 2003-11-03 | 2005-05-26 | Mark Tawa | Pharmaceutical salts of zafirlukast |
| JP2007526792A (ja) * | 2003-11-06 | 2007-09-20 | アルザ・コーポレーシヨン | 移植可能な浸透ポンプと一緒の使用のためのモジュール型の吸入速度低下器 |
| CN1882327A (zh) | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
| WO2005092065A2 (en) * | 2004-03-25 | 2005-10-06 | Transform Pharmaceuticals, Inc. | Novel tricyclic compounds and related methods of treatment |
| US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| WO2006007448A2 (en) * | 2004-06-17 | 2006-01-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
| US20060020253A1 (en) * | 2004-07-26 | 2006-01-26 | Prescott Anthony D | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
| US8541026B2 (en) * | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
| EP1827385B1 (en) | 2004-11-23 | 2013-03-27 | Adamas Pharmaceuticals, Inc. | Pharmaceutical composition comprising memantine in an extended dosage release form for use in the treatment of dementias |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| US8389578B2 (en) | 2004-11-24 | 2013-03-05 | Adamas Pharmaceuticals, Inc | Composition and method for treating neurological disease |
| US20060160783A1 (en) * | 2004-12-30 | 2006-07-20 | Transform Pharmaceuticals, Inc. | Novel omeprazole forms and related methods |
| CA2596966A1 (en) * | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc. | Implantable osmotic device for continuous delivery of suspension formulations |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| EP2314614B1 (en) | 2005-02-28 | 2015-11-25 | Sangamo BioSciences, Inc. | Anti-angiogenic methods and compositions |
| US7959938B2 (en) * | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| JP5666087B2 (ja) | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Ｃｎｓ関連疾患の治療のための方法及び組成物 |
| US8348930B2 (en) * | 2005-07-01 | 2013-01-08 | Microlin, Llc | Fluid delivery device with a diffusion membrane and electrochemical pump |
| WO2007044910A1 (en) * | 2005-10-13 | 2007-04-19 | Duke University | Compositions for the treatment and prevention of heart disease and methods of using same |
| US20070179613A1 (en) * | 2006-01-30 | 2007-08-02 | Sdgi Holdings, Inc. | Passive lubricating prosthetic joint |
| EP2319558B1 (en) | 2006-03-14 | 2014-05-21 | University Of Southern California | Mems device for delivery of therapeutic agents |
| MX2008014870A (es) | 2006-05-30 | 2009-02-12 | Intarcia Therapeutics Inc | Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas. |
| CN101505694B (zh) * | 2006-06-21 | 2012-02-22 | 庄臣及庄臣视力保护公司 | 用于递送活性试剂的泪点塞 |
| US9474645B2 (en) * | 2006-06-21 | 2016-10-25 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
| EP2049081B1 (en) | 2006-08-09 | 2012-11-14 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| US9114133B2 (en) | 2006-08-25 | 2015-08-25 | U.S. Dept. Of Veterans Affairs | Method of improving diastolic dysfunction |
| US20080152510A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Valve for controlling flow of a primary fluid |
| US20080154242A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| US20080154243A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| KR20190126460A (ko) | 2007-02-09 | 2019-11-11 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
| HRP20130259T1 (hr) | 2007-04-23 | 2013-04-30 | Intarcia Therapeutics, Inc. | Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe |
| WO2009023718A2 (en) | 2007-08-13 | 2009-02-19 | Metabasis Therapeutics, Inc. | Novel activators of glucokinase |
| ES2425769T5 (es) | 2007-12-20 | 2017-07-28 | University Of Southern California | Aparato para la administración de agentes terapéuticos |
| US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| US8061280B2 (en) * | 2008-04-10 | 2011-11-22 | Microlin, Llc | Apparatus and method for delivering beneficial liquids at steady rate |
| US9849238B2 (en) | 2008-05-08 | 2017-12-26 | Minipumps, Llc | Drug-delivery pump with intelligent control |
| EP2320989B1 (en) | 2008-05-08 | 2015-03-11 | MiniPumps, LLC | Implantable pumps and cannulas therefor |
| ES2534865T3 (es) | 2008-05-08 | 2015-04-29 | Minipumps, Llc | Bombas de administración de fármacos |
| CA2770298C (en) | 2008-08-13 | 2017-06-20 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
| US20110236456A1 (en) * | 2008-09-30 | 2011-09-29 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of histrelin and methods of use thereof |
| CA2739181C (en) | 2008-09-30 | 2017-03-14 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of risperidone and methods of use thereof |
| JP5643762B2 (ja) * | 2008-10-15 | 2014-12-17 | インターシア セラピューティクス，インコーポレイティド | 高濃度薬物粒子、製剤、懸濁液、及びこれらの使用 |
| KR20120017030A (ko) * | 2009-04-07 | 2012-02-27 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 무밸브 약제 전달 장치 |
| EP2467797B1 (en) | 2009-08-18 | 2017-07-19 | MiniPumps, LLC | Electrolytic drug-delivery pump with adaptive control |
| US8808257B2 (en) * | 2009-08-31 | 2014-08-19 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus for pulsatile release of medicaments from a punctal plug |
| SMT201700583T1 (it) | 2009-09-28 | 2018-01-11 | Intarcia Therapeutics Inc | Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario |
| CA2776173A1 (en) | 2009-09-30 | 2011-04-07 | Nicholas Marini | Cofactors and methods of use for individuals |
| MX365650B (es) | 2009-12-02 | 2019-06-10 | Adamas Pharmaceuticals Inc | Composiciones de amantadina y metodos para su uso. |
| US8038650B2 (en) * | 2010-02-22 | 2011-10-18 | Microsert Ltd. | Slow release liquid drug delivery device |
| CA2794565C (en) | 2010-04-08 | 2018-08-21 | Emory University | Substituted androst-4-ene diones |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9585930B2 (en) | 2011-03-20 | 2017-03-07 | Trustees Of Boston University | Therapeutic agent for emphysema and COPD |
| US20140227293A1 (en) | 2011-06-30 | 2014-08-14 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
| US8623924B2 (en) | 2011-07-15 | 2014-01-07 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| MX2015006023A (es) | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
| CN105101958B (zh) | 2013-01-15 | 2019-05-17 | 纽斯尔特科学公司 | 治疗肺病状 |
| CN104001261A (zh) * | 2013-02-27 | 2014-08-27 | 重庆市北碚区精神卫生中心 | 一种皮下给药装置 |
| JP2016508842A (ja) * | 2013-03-05 | 2016-03-24 | タリス バイオメディカル エルエルシー | 装置の開口部を通じて制御された薬物放出のための薬物送達装置及び方法 |
| US9486573B2 (en) | 2013-03-14 | 2016-11-08 | Bayer Healthcare Llc | Fluid delivery system and method of fluid delivery to a patient |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| CN105358115A (zh) | 2013-07-17 | 2016-02-24 | 拜耳医疗保健股份有限公司 | 基于卡匣的膛孔内输液器 |
| CA2924141C (en) | 2013-08-22 | 2022-06-07 | The General Hospital Corporation | 5-amino 4-cyano substituted oxazole and thiazole derivatives as inhibitors of human 12/15-lipoxygenase |
| EP3110507B1 (en) | 2014-02-27 | 2020-11-18 | NuSirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| MX2018005689A (es) | 2015-11-05 | 2018-08-01 | Massachusetts Gen Hospital | Administracion intratecal de secuencias de acido nucleico que codifican abcd1 para el tratamiento de la adrenomieloneuropatia. |
| MA43532A (fr) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals Inc | Méthodes et compositions destinés au traitement de troubles liés à des crises épileptiques |
| RU2760007C2 (ru) | 2016-05-16 | 2021-11-22 | Интарсия Терапьютикс, Инк. | Полипептиды, селективные к рецепторам глюкагона, и способы их применения |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10406336B2 (en) * | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| CN110191717A (zh) | 2016-10-20 | 2019-08-30 | 佩特通公司 | 向中枢神经系统递送神经保护性多肽的方法 |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| CN110545838A (zh) | 2017-03-08 | 2019-12-06 | 因塔西亚制药公司 | 用于从药物递送装置施用致恶心化合物的设备和方法 |
| WO2018200885A1 (en) | 2017-04-26 | 2018-11-01 | Neurocentria, Inc. | Magnesium compositions and methods of use |
| CN109583550A (zh) * | 2017-09-28 | 2019-04-05 | 振锋企业股份有限公司 | 非接触式数据载体 |
| WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| AR116632A1 (es) | 2018-10-11 | 2021-05-26 | Intarcia Therapeutics Inc | Polipéptidos análogos de la amilina humana y sus métodos de uso |
| CN110613888B (zh) * | 2019-07-24 | 2022-03-08 | 南京中医药大学 | 耳塞式鼓室给药装置 |
| ES1247524Y (es) * | 2019-12-20 | 2020-08-28 | Probodelt S L | Dispositivo atrayente para dipteros |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
| US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4490256A (en) * | 1982-11-26 | 1984-12-25 | Sartorius Gmbh | Apparatus for static membrane filtration |
| US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
| US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4610686A (en) * | 1983-11-02 | 1986-09-09 | Alza Corporation | Controlled delivery of haloperidol by an osmotic delivery system |
| US4615698A (en) * | 1984-03-23 | 1986-10-07 | Alza Corporation | Total agent osmotic delivery system |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4874388A (en) | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5180591A (en) * | 1990-07-11 | 1993-01-19 | Alza Corporation | Delivery device with a protective sleeve |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| GB9027422D0 (en) * | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) * | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| AU688776B2 (en) * | 1993-06-23 | 1998-03-19 | Brown University Research Foundation | Method and apparatus for sealing implantable, membrane encapsulation devices |
| US5458888A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| US5678999A (en) * | 1994-08-08 | 1997-10-21 | Cicare; Augusto Ulderico | System for training helicopter pilots |
| US5690952A (en) * | 1995-06-07 | 1997-11-25 | Judy A. Magruder et al. | Implantable system for delivery of fluid-sensitive agents to animals |
| ES2233768T3 (es) | 1996-02-02 | 2005-06-16 | Alza Corporation | Liberacion prolongada de un agente activo utilizando un sistema implantable. |
-
1998
- 1998-07-23 MY MYPI98003363A patent/MY125849A/en unknown
- 1998-07-24 WO PCT/US1998/014812 patent/WO1999004767A2/en not_active Ceased
- 1998-07-24 TW TW087112143A patent/TW450817B/zh not_active IP Right Cessation
- 1998-07-24 AR ARP980103662A patent/AR016543A1/es unknown
- 1998-07-24 CO CO98042276A patent/CO4970812A1/es unknown
- 1998-07-24 JP JP2000503827A patent/JP2001510791A/ja active Pending
- 1998-07-24 US US09/121,878 patent/US6287295B1/en not_active Expired - Lifetime
- 1998-07-24 DE DE69840679T patent/DE69840679D1/de not_active Expired - Lifetime
- 1998-07-24 CN CNB988075237A patent/CN1198602C/zh not_active Expired - Fee Related
- 1998-07-24 AT AT98937963T patent/ATE357911T1/de not_active IP Right Cessation
- 1998-07-24 CA CA002297801A patent/CA2297801C/en not_active Expired - Fee Related
- 1998-07-24 EP EP98937963A patent/EP1011642B1/en not_active Expired - Lifetime
- 1998-07-24 KR KR1020007000797A patent/KR100600462B1/ko not_active Expired - Fee Related
- 1998-07-24 DE DE69837439T patent/DE69837439D1/de not_active Expired - Lifetime
- 1998-07-24 AT AT07003466T patent/ATE425739T1/de not_active IP Right Cessation
- 1998-07-24 AU AU86589/98A patent/AU8658998A/en not_active Abandoned
- 1998-07-24 ZA ZA986631A patent/ZA986631B/xx unknown
-
2001
- 2001-05-18 US US09/859,428 patent/US6923800B2/en not_active Expired - Lifetime
-
2005
- 2005-07-13 JP JP2005204469A patent/JP2005306885A/ja not_active Withdrawn
- 2005-08-02 US US11/196,758 patent/US20050281877A1/en not_active Abandoned
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| ATE425739T1 (de) | 2009-04-15 |
| US20050281877A1 (en) | 2005-12-22 |
| EP1011642A2 (en) | 2000-06-28 |
| HK1028739A1 (en) | 2001-03-02 |
| CA2297801A1 (en) | 1999-02-04 |
| WO1999004767A3 (en) | 1999-04-22 |
| DE69840679D1 (de) | 2009-04-30 |
| US6923800B2 (en) | 2005-08-02 |
| AR016543A1 (es) | 2001-07-25 |
| WO1999004767A2 (en) | 1999-02-04 |
| TW450817B (en) | 2001-08-21 |
| JP2005306885A (ja) | 2005-11-04 |
| CA2297801C (en) | 2009-10-27 |
| DE69837439D1 (de) | 2007-05-10 |
| CO4970812A1 (es) | 2000-11-07 |
| US6287295B1 (en) | 2001-09-11 |
| KR100600462B1 (ko) | 2006-07-13 |
| ATE357911T1 (de) | 2007-04-15 |
| CN1265031A (zh) | 2000-08-30 |
| KR20010022224A (ko) | 2001-03-15 |
| ZA986631B (en) | 1999-02-10 |
| EP1011642B1 (en) | 2007-03-28 |
| AU8658998A (en) | 1999-02-16 |
| CN1198602C (zh) | 2005-04-27 |
| US20010027311A1 (en) | 2001-10-04 |
| MY125849A (en) | 2006-08-30 |
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