KR100600462B1 - 삼투 전달 시스템 플러그, 삼투 전달 시스템, 삼투 약제 전달 시스템으로부터 이로운 약제의 전달율을 제어하는 방법, 및 삼투 전달 시스템의 반투과체를 통한 액체 투과율을 변화시키는 방법 - Google Patents

삼투 전달 시스템 플러그, 삼투 전달 시스템, 삼투 약제 전달 시스템으로부터 이로운 약제의 전달율을 제어하는 방법, 및 삼투 전달 시스템의 반투과체를 통한 액체 투과율을 변화시키는 방법 Download PDF

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KR100600462B1
KR100600462B1 KR1020007000797A KR20007000797A KR100600462B1 KR 100600462 B1 KR100600462 B1 KR 100600462B1 KR 1020007000797 A KR1020007000797 A KR 1020007000797A KR 20007000797 A KR20007000797 A KR 20007000797A KR 100600462 B1 KR100600462 B1 KR 100600462B1
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liquid
delivery system
delete delete
semipermeable
osmotic
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Korean (ko)
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KR20010022224A (ko
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첸구오화
디오네케이쓰이
라우텐바흐스코트디
조단스코트디
베리스테펜에이
로덴버거크레이그아이
아예르루팔
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알자 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Closures For Containers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
KR1020007000797A 1997-07-25 1998-07-24 삼투 전달 시스템 플러그, 삼투 전달 시스템, 삼투 약제 전달 시스템으로부터 이로운 약제의 전달율을 제어하는 방법, 및 삼투 전달 시스템의 반투과체를 통한 액체 투과율을 변화시키는 방법 Expired - Fee Related KR100600462B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5368997P 1997-07-25 1997-07-25
US60/053,689 1997-07-25
PCT/US1998/014812 WO1999004767A2 (en) 1997-07-25 1998-07-24 Osmotic delivery system with semipermeable plug

Publications (2)

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KR20010022224A KR20010022224A (ko) 2001-03-15
KR100600462B1 true KR100600462B1 (ko) 2006-07-13

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KR1020007000797A Expired - Fee Related KR100600462B1 (ko) 1997-07-25 1998-07-24 삼투 전달 시스템 플러그, 삼투 전달 시스템, 삼투 약제 전달 시스템으로부터 이로운 약제의 전달율을 제어하는 방법, 및 삼투 전달 시스템의 반투과체를 통한 액체 투과율을 변화시키는 방법

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US (3) US6287295B1 (https=)
EP (1) EP1011642B1 (https=)
JP (2) JP2001510791A (https=)
KR (1) KR100600462B1 (https=)
CN (1) CN1198602C (https=)
AR (1) AR016543A1 (https=)
AT (2) ATE357911T1 (https=)
AU (1) AU8658998A (https=)
CA (1) CA2297801C (https=)
CO (1) CO4970812A1 (https=)
DE (2) DE69840679D1 (https=)
MY (1) MY125849A (https=)
TW (1) TW450817B (https=)
WO (1) WO1999004767A2 (https=)
ZA (1) ZA986631B (https=)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
WO1999033449A1 (en) 1997-12-30 1999-07-08 Alza Corporation Beneficial agent delivery system with membrane plug
JP4383674B2 (ja) 1998-12-31 2009-12-16 インターシア セラピューティクス，インコーポレイティド 空間効率のよいピストンを有する浸透圧送達システム
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6436091B1 (en) * 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US6491684B1 (en) * 2001-05-22 2002-12-10 Durect Corporation Fluid delivery device having a water generating electrochemical/chemical pump and associated method
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
US8061006B2 (en) * 2001-07-26 2011-11-22 Powderject Research Limited Particle cassette, method and kit therefor
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
WO2004000284A1 (en) * 2002-06-21 2003-12-31 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
CA2477923C (en) 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7470267B2 (en) * 2002-05-01 2008-12-30 Microlin, Llc Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method
US7896867B2 (en) * 2002-05-01 2011-03-01 Microlin, Llc Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US7458965B2 (en) * 2002-05-01 2008-12-02 Microlin, Llc Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
WO2007005565A2 (en) * 2002-05-01 2007-01-11 Microlin, Llc Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US20060116663A1 (en) * 2002-05-01 2006-06-01 Joshi Ashok V Electro-osmotic fluid delivery device and method
TW200420306A (en) * 2002-06-17 2004-10-16 Alza Corp Osmotic delivery system with early zero order push power engine
MXPA05000224A (es) * 2002-06-26 2005-06-03 Alza Corp Piston de volumen eficiente, minimamente deformable, para sistemas de suministro osmotico de farmacos.
DE10233622A1 (de) * 2002-07-24 2004-02-12 Disetronic Licensing Ag Infusionspumpe, Verfahren, Steuerprogramm und Halbleiterbauelement zur dosierten Verabreichung einer medizinischen Flüssigkeit
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
EP1578398A2 (en) * 2002-12-19 2005-09-28 ALZA Corporation Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
ATE550022T1 (de) 2003-02-28 2012-04-15 Mcneil Ppc Inc Pharmazeutische mischkristalle von celecoxib- nicotinamid
ATE387236T1 (de) * 2003-03-31 2008-03-15 Alza Corp Osmotische pumpe mit mitteln zum ableiten des innendrucks
CA2520766A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
WO2004091278A2 (en) * 2003-04-11 2004-10-28 Transform Pharmaceuticals, Inc. Gabapentin compositions
WO2005000786A1 (en) 2003-05-23 2005-01-06 Transform Pharmaceuticals, Inc. Sertraline compositions
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (en) * 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US20090208540A1 (en) * 2003-08-11 2009-08-20 Indevus Pharmaceuticals, Inc. Implantable device for the delivery of naltrexone and methods of use thereof
US7632245B1 (en) * 2003-08-18 2009-12-15 Medrad, Inc. Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure
US7217351B2 (en) * 2003-08-29 2007-05-15 Beta Micropump Partners Llc Valve for controlling flow of a fluid
US7927599B2 (en) 2003-09-08 2011-04-19 Ethicon, Inc. Chondrocyte therapeutic delivery system
US8257963B2 (en) * 2007-06-01 2012-09-04 Depuy Mitek, Inc. Chondrocyte container and method of use
US7897384B2 (en) * 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
NZ546182A (en) * 2003-09-26 2009-08-28 Alza Corp Controlled release formulations of opioid and nonopioid analgesics such as hydrocodone and acetaminophen
JP2007506775A (ja) 2003-09-26 2007-03-22 アルザ・コーポレーシヨン 漸増する放出速度を表す制御放出製剤
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
MXPA06002967A (es) 2003-09-30 2006-06-14 Alza Corp Aparato de suministro de agente activo de conduccion osmotica que proporciona perfil de liberacion ascendente.
CN1905861A (zh) 2003-10-31 2007-01-31 阿尔扎公司 具有自保持、快启动薄膜插塞的渗透泵
US20050113410A1 (en) * 2003-11-03 2005-05-26 Mark Tawa Pharmaceutical salts of zafirlukast
JP2007526792A (ja) * 2003-11-06 2007-09-20 アルザ・コーポレーシヨン 移植可能な浸透ポンプと一緒の使用のためのモジュール型の吸入速度低下器
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
WO2005092065A2 (en) * 2004-03-25 2005-10-06 Transform Pharmaceuticals, Inc. Novel tricyclic compounds and related methods of treatment
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
WO2006007448A2 (en) * 2004-06-17 2006-01-19 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
US20060020253A1 (en) * 2004-07-26 2006-01-26 Prescott Anthony D Implantable device having reservoir with controlled release of medication and method of manufacturing the same
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
EP1827385B1 (en) 2004-11-23 2013-03-27 Adamas Pharmaceuticals, Inc. Pharmaceutical composition comprising memantine in an extended dosage release form for use in the treatment of dementias
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
US8389578B2 (en) 2004-11-24 2013-03-05 Adamas Pharmaceuticals, Inc Composition and method for treating neurological disease
US20060160783A1 (en) * 2004-12-30 2006-07-20 Transform Pharmaceuticals, Inc. Novel omeprazole forms and related methods
CA2596966A1 (en) * 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc. Implantable osmotic device for continuous delivery of suspension formulations
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
EP2314614B1 (en) 2005-02-28 2015-11-25 Sangamo BioSciences, Inc. Anti-angiogenic methods and compositions
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
JP5666087B2 (ja) 2005-04-06 2015-02-12 アダマス・ファーマシューティカルズ・インコーポレーテッド Ｃｎｓ関連疾患の治療のための方法及び組成物
US8348930B2 (en) * 2005-07-01 2013-01-08 Microlin, Llc Fluid delivery device with a diffusion membrane and electrochemical pump
WO2007044910A1 (en) * 2005-10-13 2007-04-19 Duke University Compositions for the treatment and prevention of heart disease and methods of using same
US20070179613A1 (en) * 2006-01-30 2007-08-02 Sdgi Holdings, Inc. Passive lubricating prosthetic joint
EP2319558B1 (en) 2006-03-14 2014-05-21 University Of Southern California Mems device for delivery of therapeutic agents
MX2008014870A (es) 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
CN101505694B (zh) * 2006-06-21 2012-02-22 庄臣及庄臣视力保护公司 用于递送活性试剂的泪点塞
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
EP2049081B1 (en) 2006-08-09 2012-11-14 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
US9114133B2 (en) 2006-08-25 2015-08-25 U.S. Dept. Of Veterans Affairs Method of improving diastolic dysfunction
US20080152510A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Valve for controlling flow of a primary fluid
US20080154242A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Delivery device for a fluid
US20080154243A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Delivery device for a fluid
KR20190126460A (ko) 2007-02-09 2019-11-11 메타베이시스 테라퓨틱스, 인크. 글루카곤 수용체의 길항제
HRP20130259T1 (hr) 2007-04-23 2013-04-30 Intarcia Therapeutics, Inc. Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
WO2009023718A2 (en) 2007-08-13 2009-02-19 Metabasis Therapeutics, Inc. Novel activators of glucokinase
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US8061280B2 (en) * 2008-04-10 2011-11-22 Microlin, Llc Apparatus and method for delivering beneficial liquids at steady rate
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2320989B1 (en) 2008-05-08 2015-03-11 MiniPumps, LLC Implantable pumps and cannulas therefor
ES2534865T3 (es) 2008-05-08 2015-04-29 Minipumps, Llc Bombas de administración de fármacos
CA2770298C (en) 2008-08-13 2017-06-20 Metabasis Therapeutics, Inc. Glucagon antagonists
US20110236456A1 (en) * 2008-09-30 2011-09-29 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of histrelin and methods of use thereof
CA2739181C (en) 2008-09-30 2017-03-14 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of risperidone and methods of use thereof
JP5643762B2 (ja) * 2008-10-15 2014-12-17 インターシア セラピューティクス，インコーポレイティド 高濃度薬物粒子、製剤、懸濁液、及びこれらの使用
KR20120017030A (ko) * 2009-04-07 2012-02-27 코닌클리케 필립스 일렉트로닉스 엔.브이. 무밸브 약제 전달 장치
EP2467797B1 (en) 2009-08-18 2017-07-19 MiniPumps, LLC Electrolytic drug-delivery pump with adaptive control
US8808257B2 (en) * 2009-08-31 2014-08-19 Johnson & Johnson Vision Care, Inc. Methods and apparatus for pulsatile release of medicaments from a punctal plug
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
CA2776173A1 (en) 2009-09-30 2011-04-07 Nicholas Marini Cofactors and methods of use for individuals
MX365650B (es) 2009-12-02 2019-06-10 Adamas Pharmaceuticals Inc Composiciones de amantadina y metodos para su uso.
US8038650B2 (en) * 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device
CA2794565C (en) 2010-04-08 2018-08-21 Emory University Substituted androst-4-ene diones
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9585930B2 (en) 2011-03-20 2017-03-07 Trustees Of Boston University Therapeutic agent for emphysema and COPD
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
US8623924B2 (en) 2011-07-15 2014-01-07 Nusirt Sciences, Inc. Compositions and methods for modulating metabolic pathways
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
MX2015006023A (es) 2012-11-13 2016-03-31 Nusirt Sciences Inc Composiciones y metodos para incrementar el metabolismo energetico.
CN105101958B (zh) 2013-01-15 2019-05-17 纽斯尔特科学公司 治疗肺病状
CN104001261A (zh) * 2013-02-27 2014-08-27 重庆市北碚区精神卫生中心 一种皮下给药装置
JP2016508842A (ja) * 2013-03-05 2016-03-24 タリス バイオメディカル エルエルシー 装置の開口部を通じて制御された薬物放出のための薬物送達装置及び方法
US9486573B2 (en) 2013-03-14 2016-11-08 Bayer Healthcare Llc Fluid delivery system and method of fluid delivery to a patient
CN105228627B (zh) 2013-03-15 2018-07-13 纽斯尔特科学公司 亮氨酸和烟酸降低脂质水平
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
CN105358115A (zh) 2013-07-17 2016-02-24 拜耳医疗保健股份有限公司 基于卡匣的膛孔内输液器
CA2924141C (en) 2013-08-22 2022-06-07 The General Hospital Corporation 5-amino 4-cyano substituted oxazole and thiazole derivatives as inhibitors of human 12/15-lipoxygenase
EP3110507B1 (en) 2014-02-27 2020-11-18 NuSirt Sciences, Inc. Compositions and methods for the reduction or prevention of hepatic steatosis
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
MX2018005689A (es) 2015-11-05 2018-08-01 Massachusetts Gen Hospital Administracion intratecal de secuencias de acido nucleico que codifican abcd1 para el tratamiento de la adrenomieloneuropatia.
MA43532A (fr) 2015-12-30 2018-11-07 Adamas Pharmaceuticals Inc Méthodes et compositions destinés au traitement de troubles liés à des crises épileptiques
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
CN110191717A (zh) 2016-10-20 2019-08-30 佩特通公司 向中枢神经系统递送神经保护性多肽的方法
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
CN110545838A (zh) 2017-03-08 2019-12-06 因塔西亚制药公司 用于从药物递送装置施用致恶心化合物的设备和方法
WO2018200885A1 (en) 2017-04-26 2018-11-01 Neurocentria, Inc. Magnesium compositions and methods of use
CN109583550A (zh) * 2017-09-28 2019-04-05 振锋企业股份有限公司 非接触式数据载体
WO2019160940A1 (en) 2018-02-13 2019-08-22 Ligand Pharmaceuticals Incorporated Glucagon receptor antagonists
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
AR116632A1 (es) 2018-10-11 2021-05-26 Intarcia Therapeutics Inc Polipéptidos análogos de la amilina humana y sus métodos de uso
CN110613888B (zh) * 2019-07-24 2022-03-08 南京中医药大学 耳塞式鼓室给药装置
ES1247524Y (es) * 2019-12-20 2020-08-28 Probodelt S L Dispositivo atrayente para dipteros
WO2025160155A1 (en) 2024-01-22 2025-07-31 The Broad Institute, Inc. Epigenetic targeting of prion diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3732865A (en) 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3995632A (en) 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4243030A (en) 1978-08-18 1981-01-06 Massachusetts Institute Of Technology Implantable programmed microinfusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4340054A (en) 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4490256A (en) * 1982-11-26 1984-12-25 Sartorius Gmbh Apparatus for static membrane filtration
US4552561A (en) 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4610686A (en) * 1983-11-02 1986-09-09 Alza Corporation Controlled delivery of haloperidol by an osmotic delivery system
US4615698A (en) * 1984-03-23 1986-10-07 Alza Corporation Total agent osmotic delivery system
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4874388A (en) 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5180591A (en) * 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5223265A (en) 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) * 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
AU688776B2 (en) * 1993-06-23 1998-03-19 Brown University Research Foundation Method and apparatus for sealing implantable, membrane encapsulation devices
US5458888A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5678999A (en) * 1994-08-08 1997-10-21 Cicare; Augusto Ulderico System for training helicopter pilots
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
ES2233768T3 (es) 1996-02-02 2005-06-16 Alza Corporation Liberacion prolongada de un agente activo utilizando un sistema implantable.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system

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ATE425739T1 (de) 2009-04-15
US20050281877A1 (en) 2005-12-22
EP1011642A2 (en) 2000-06-28
HK1028739A1 (en) 2001-03-02
JP2001510791A (ja) 2001-08-07
CA2297801A1 (en) 1999-02-04
WO1999004767A3 (en) 1999-04-22
DE69840679D1 (de) 2009-04-30
US6923800B2 (en) 2005-08-02
AR016543A1 (es) 2001-07-25
WO1999004767A2 (en) 1999-02-04
TW450817B (en) 2001-08-21
JP2005306885A (ja) 2005-11-04
CA2297801C (en) 2009-10-27
DE69837439D1 (de) 2007-05-10
CO4970812A1 (es) 2000-11-07
US6287295B1 (en) 2001-09-11
ATE357911T1 (de) 2007-04-15
CN1265031A (zh) 2000-08-30
KR20010022224A (ko) 2001-03-15
ZA986631B (en) 1999-02-10
EP1011642B1 (en) 2007-03-28
AU8658998A (en) 1999-02-16
CN1198602C (zh) 2005-04-27
US20010027311A1 (en) 2001-10-04
MY125849A (en) 2006-08-30

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