JP2001509378A5 - - Google Patents

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Publication number
JP2001509378A5
JP2001509378A5 JP2000502165A JP2000502165A JP2001509378A5 JP 2001509378 A5 JP2001509378 A5 JP 2001509378A5 JP 2000502165 A JP2000502165 A JP 2000502165A JP 2000502165 A JP2000502165 A JP 2000502165A JP 2001509378 A5 JP2001509378 A5 JP 2001509378A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000502165A
Other languages
Japanese (ja)
Other versions
JP4368522B2 (ja
JP2001509378A (ja
Filing date
Publication date
Priority claimed from US08/891,789 external-priority patent/US6103466A/en
Application filed filed Critical
Priority claimed from PCT/IB1998/001197 external-priority patent/WO1999002667A1/en
Publication of JP2001509378A publication Critical patent/JP2001509378A/ja
Publication of JP2001509378A5 publication Critical patent/JP2001509378A5/ja
Application granted granted Critical
Publication of JP4368522B2 publication Critical patent/JP4368522B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000502165A 1997-07-14 1998-07-14 哺乳動物におけるダブルマスル化を引き起こすミオスタチン遺伝子の変異 Expired - Lifetime JP4368522B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/891,789 1997-07-14
US08/891,789 US6103466A (en) 1997-07-14 1997-07-14 Double-muscling in mammals
US776198A 1998-01-15 1998-01-15
US09/007,761 1998-01-15
PCT/IB1998/001197 WO1999002667A1 (en) 1997-07-14 1998-07-14 Mutations in the myostation gene cause double-muscling in mammals

Publications (3)

Publication Number Publication Date
JP2001509378A JP2001509378A (ja) 2001-07-24
JP2001509378A5 true JP2001509378A5 (enExample) 2005-12-22
JP4368522B2 JP4368522B2 (ja) 2009-11-18

Family

ID=26677351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000502165A Expired - Lifetime JP4368522B2 (ja) 1997-07-14 1998-07-14 哺乳動物におけるダブルマスル化を引き起こすミオスタチン遺伝子の変異

Country Status (13)

Country Link
US (1) US20030129171A1 (enExample)
EP (2) EP1002068B1 (enExample)
JP (1) JP4368522B2 (enExample)
AT (1) ATE442436T1 (enExample)
AU (1) AU756620B2 (enExample)
CA (1) CA2296434C (enExample)
CY (1) CY1116682T1 (enExample)
DE (1) DE69841139D1 (enExample)
DK (1) DK2045322T3 (enExample)
ES (1) ES2547858T3 (enExample)
NZ (1) NZ502523A (enExample)
PT (1) PT2045322E (enExample)
WO (1) WO1999002667A1 (enExample)

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US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
US6008434A (en) 1994-07-08 1999-12-28 Johns Hopkins University School Of Medicine Growth differentiation factor-11 transgenic mice
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WO2000009667A1 (en) * 1998-08-14 2000-02-24 Board Of Regents, The University Of Texas System Calcineurin-dependent control of skeletal muscle fiber type
CA2359242C (en) * 1999-01-21 2009-12-08 Metamorphix, Inc. Growth differentiation factor inhibitors and uses therefor
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US7011943B2 (en) 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US7494817B2 (en) 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
DE60135357D1 (de) * 2000-09-06 2008-09-25 Timothy A Hodge Verfahren zum Screenen von genomischer DNS, insbesonderer bei transgener und zielgerichteter Mutagenese
US7037501B2 (en) 2001-01-04 2006-05-02 Regents Of The University Of Minnesota Myostatin immnoconjugate
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
ES2359562T3 (es) * 2002-12-20 2011-05-24 Amgen, Inc. Agentes de unión que inhiben miostatina.
EP1590471A4 (en) 2002-12-31 2009-12-09 Metamorphix Inc COMPOSITIONS, METHODS AND SYSTEMS OF INFERENCE RELATING TO CATTLE CHARACTERISTICS
KR20060026860A (ko) 2003-06-02 2006-03-24 와이어쓰 신경근 장애의 치료를 위한, 코르티코스테로이드와 조합된미오스타틴 (gdf8) 저해제의 용도
ES2852549T3 (es) * 2005-02-09 2021-09-13 Sarepta Therapeutics Inc Composición antisentido para tratamiento de la atrofia muscular
SI1915397T1 (sl) 2005-08-19 2015-05-29 Wyeth Llc Antagonistična protitelesa proti GDF-8 in uporabe pri zdravljenju ALS in drugih obolenj, povezanih z GDF-8
KR100872042B1 (ko) * 2005-09-14 2008-12-05 주식회사 바이오리더스 마이오스타틴을 발현하는 세포표면 발현벡터 및 상기벡터에 의해 형질전환된 미생물
GB2433320B (en) * 2005-12-16 2009-10-07 Norwegian University Of Life S Diagnostic method
CA2558160C (en) * 2006-06-30 2017-01-03 Oligos Etc., Inc. Antisense oligonucleotide targeting myostatin or fox01 for treatment of muscle wasting
KR100857861B1 (ko) * 2007-10-15 2008-09-11 주식회사 바이오리더스 Myo-2 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물
US9528124B2 (en) 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
WO2012116274A2 (en) * 2011-02-25 2012-08-30 Recombinetics, Inc. Genetically modified animals and methods for making the same
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
KR101704893B1 (ko) 2012-06-15 2017-02-08 화이자 인코포레이티드 Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도
AR091482A1 (es) * 2012-06-21 2015-02-04 Recombinetics Inc Celulas modificadas geneticamente y metodos par su obtencion
PL2981822T3 (pl) 2013-05-06 2021-07-12 Scholar Rock, Inc. Kompozycje i sposoby modulacji czynnika wzrostu
EP2960653A1 (en) * 2014-06-24 2015-12-30 Stichting Kwaliteitsgarantie Vleeskalversector Diagnostic kit and method for the identification of the manipulation of muscle mass in a domestic animal
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
WO2017062835A2 (en) * 2015-10-09 2017-04-13 Sarepta Therapeutics, Inc. Compositions and methods for treating duchenne muscular dystrophy and related disorders
CN106472430A (zh) * 2016-10-21 2017-03-08 延边朝鲜族自治州农业科学院(延边特产研究所) 一种寒冷地区烟蚜茧蜂冬季保种方法
WO2019174560A1 (zh) * 2018-03-14 2019-09-19 必康生技(香港)有限公司 用于生物流体净化的组合物
CN110157818B (zh) * 2019-07-08 2023-04-25 云南东恒经贸集团猪育种有限公司 一种与猪眼肌高产性状相关的分子标记及其应用
KR20230130639A (ko) * 2020-12-03 2023-09-12 (주)라트바이오 마이오스타틴 유전자가 변형된 형질전환 동물
CN120192396A (zh) * 2023-12-21 2025-06-24 江苏省农业科学院 一种肌肉生长抑制素mstn蛋白突变体及其制备方法和应用

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US5264558A (en) 1987-06-19 1993-11-23 The Regents Of The University Of California Single-chain monellin analog as a low calorie protein sweetner
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US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
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US5962316A (en) * 1992-10-16 1999-10-05 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
WO1994021681A1 (en) * 1993-03-19 1994-09-29 Johns Hopkins University School Of Medicine Growth differentiation factor-8
WO1995021256A1 (fr) * 1994-02-04 1995-08-10 Bio Merieux Virus msrv1 et agent pathogene et/ou infectant msrv2 associes a la sclerose en plaques, leurs constituants nucleiques et leurs applications
AU6274298A (en) * 1997-02-05 1998-08-25 Johns Hopkins University School Of Medicine, The Growth differentiation factor-8

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