CY1116682T1 - Διπλασιασμος-μυϊκης μαζας σε θηλαστικα - Google Patents

Διπλασιασμος-μυϊκης μαζας σε θηλαστικα

Info

Publication number
CY1116682T1
CY1116682T1 CY20151100796T CY151100796T CY1116682T1 CY 1116682 T1 CY1116682 T1 CY 1116682T1 CY 20151100796 T CY20151100796 T CY 20151100796T CY 151100796 T CY151100796 T CY 151100796T CY 1116682 T1 CY1116682 T1 CY 1116682T1
Authority
CY
Cyprus
Prior art keywords
sequence
protein
seq
myostatin
activity
Prior art date
Application number
CY20151100796T
Other languages
English (en)
Inventor
Luc Grobet
Michel Georges
Dominique Poncelet
Original Assignee
Université de Liège
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/891,789 external-priority patent/US6103466A/en
Application filed by Université de Liège filed Critical Université de Liège
Publication of CY1116682T1 publication Critical patent/CY1116682T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/124—Animal traits, i.e. production traits, including athletic performance or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Γονίδιο (cDNA) που κωδικοποιεί πρωτεΐνη βόειας μυοστατίνης. Η αλληλουχία που κωδικοποιεί νουκλεϊνικό οξύ πιστοποιείται ως SEQ ID ΝΟ:1 και η αλληλουχία πρωτεΐνης πιστοποιείται ως SEQ ID ΝΟ:2. Έχει αλληλουχηθεί ένα μεταλλακτικό γονίδιο (SEQ ID NO: 3) όπου η κωδικοποιητική αλληλουχία έχει έλλειψη μιας διαδοχικής αλληλουχίας 11-ζευγών βάσης (SEQ ID NO: 11) της αλληλουχίας που κωδικοποιεί βόεια πρωτεΐνη που έχει δραστικότητα μυοστατίνης. Έχει δειχθεί ότι βοοειδή της ράτσας Belgian Blue, τα οποία είναι ομόζυγα προς το μεταλλακτικό γονίδιο που έχει έλλειψη δραστικότητας μυοστατίνης έχουν διπλή-μυϊκή μάζα. Περιγράφεται μια μέθοδος για προσδιορισμό της παρουσίας μυϊκής υπερπλασίας σε ένα θηλαστικό- η μέθοδος περιλαμβάνει λήψη ενός δείγματος υλικού που περιέχει DNA από το θηλαστικό και εξακρίβωση του κατά πόσο μια αλληλουχία του DNA που κωδικοποιεί (a) πρωτεΐνη με βιολογική δραστικότητα μυοστατίνης υπάρχει και κατά πόσο μια αλληλουχία του DNA που κωδικοποιεί (b) αλληλική πρωτεΐνη που έχει έλλειψη της δραστικότητας του (a) υπάρχει. Η απουσία του (a) και η παρουσία του (b) δεικνύει την παρουσία μυϊκής υπερπλασίας στο θηλαστικό.
CY20151100796T 1997-07-14 2015-09-14 Διπλασιασμος-μυϊκης μαζας σε θηλαστικα CY1116682T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/891,789 US6103466A (en) 1997-07-14 1997-07-14 Double-muscling in mammals
US776198A 1998-01-15 1998-01-15
EP08006554.3A EP2045322B1 (en) 1997-07-14 1998-07-14 Double-muscling in mammals

Publications (1)

Publication Number Publication Date
CY1116682T1 true CY1116682T1 (el) 2017-03-15

Family

ID=26677351

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100796T CY1116682T1 (el) 1997-07-14 2015-09-14 Διπλασιασμος-μυϊκης μαζας σε θηλαστικα

Country Status (13)

Country Link
US (1) US20030129171A1 (el)
EP (2) EP1002068B1 (el)
JP (1) JP4368522B2 (el)
AT (1) ATE442436T1 (el)
AU (1) AU756620B2 (el)
CA (1) CA2296434C (el)
CY (1) CY1116682T1 (el)
DE (1) DE69841139D1 (el)
DK (1) DK2045322T3 (el)
ES (1) ES2547858T3 (el)
NZ (1) NZ502523A (el)
PT (1) PT2045322E (el)
WO (1) WO1999002667A1 (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7566768B1 (en) 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
US7393682B1 (en) * 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
DE69432815T2 (de) 1993-03-19 2003-12-11 The Johns Hopkins University School Of Medicine, Baltimore Wachstumsfaktor-8
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
US6008434A (en) 1994-07-08 1999-12-28 Johns Hopkins University School Of Medicine Growth differentiation factor-11 transgenic mice
GB2333706A (en) * 1998-02-02 1999-08-04 Merck & Co Inc Method for increasing muscle mass in animals
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
AU5483599A (en) * 1998-08-14 2000-03-06 Board Of Regents, The University Of Texas System Calcineurin-dependent control of skeletal muscle fiber type
BR0008188A (pt) * 1999-01-21 2002-02-13 Metamorphix Inc Inibidores de fator de diferenciação de crescimento e usos para os mesmos
TR200200133T2 (tr) * 1999-07-20 2002-05-21 Pharmexa A/S GDF-8 aktivitesinin aşağı doğru düzenlenmesi için bir yöntem.
ZA200003786B (en) * 1999-07-30 2002-01-21 Pfizer Prod Inc Myostatin regulatory region, nucleotide sequence determination and methods for its use.
US7011943B2 (en) 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
KR20020065509A (ko) * 2000-09-06 2002-08-13 티모시 에이. 호지 유전자이식 및 표적 돌연변이유발 스크리닝을 위한시스템, 방법 및 장치
US7037501B2 (en) 2001-01-04 2006-05-02 Regents Of The University Of Minnesota Myostatin immnoconjugate
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
SI1581649T1 (sl) 2002-12-20 2011-09-30 Amgen Inc Vezna sredstva, ki zavirajo miostatin
ZA200506094B (en) 2002-12-31 2006-11-29 Mmi Genomics Inc Compositions, methods and systems for inferring bovine traits
CN1829532A (zh) 2003-06-02 2006-09-06 惠氏公司 肌肉抑制素（gdf8）抑制剂和皮质类固醇联合用于治疗神经肌肉紊乱的用途
WO2006086667A2 (en) 2005-02-09 2006-08-17 Avi Bio Pharma, Inc. Antisense composition and method for treating muscle atrophy
ES2659114T3 (es) 2005-08-19 2018-03-13 Wyeth Llc Anticuerpos antagonistas contra GDF-8 y usos en el tratamiento de ALS y otros trastornos asociados con GDF-8
KR100872042B1 (ko) * 2005-09-14 2008-12-05 주식회사 바이오리더스 마이오스타틴을 발현하는 세포표면 발현벡터 및 상기벡터에 의해 형질전환된 미생물
GB2433320B (en) * 2005-12-16 2009-10-07 Norwegian University Of Life S Diagnostic method
AU2006345724B2 (en) * 2006-06-30 2013-11-21 Lakewood-Amedex, Inc. Compositions and methods for the treatment of muscle wasting
KR100857861B1 (ko) * 2007-10-15 2008-09-11 주식회사 바이오리더스 Ｍｙｏ－２ 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물
US9528124B2 (en) 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
KR20140046408A (ko) * 2011-02-25 2014-04-18 리컴비네틱스 인코포레이티드 유전자 변형 동물 및 이의 생산방법
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
CA2876397C (en) 2012-06-15 2019-08-06 Pfizer Inc. Improved antagonist antibodies against gdf-8 and uses therefor
AR091482A1 (es) * 2012-06-21 2015-02-04 Recombinetics Inc Celulas modificadas geneticamente y metodos par su obtencion
PT2981822T (pt) 2013-05-06 2020-12-07 Scholar Rock Inc Composições e métodos para modulação do fator de crescimento
EP2960653A1 (en) * 2014-06-24 2015-12-30 Stichting Kwaliteitsgarantie Vleeskalversector Diagnostic kit and method for the identification of the manipulation of muscle mass in a domestic animal
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
CN108699555A (zh) * 2015-10-09 2018-10-23 萨勒普塔医疗公司 用于治疗杜兴肌营养不良和相关病症的组合物和方法
CN106472430A (zh) * 2016-10-21 2017-03-08 延边朝鲜族自治州农业科学院（延边特产研究所） 一种寒冷地区烟蚜茧蜂冬季保种方法
US20210015844A1 (en) * 2018-03-14 2021-01-21 Beacon Medcare (Hk) Limited Composition for purification of biofluids
CN110157818B (zh) * 2019-07-08 2023-04-25 云南东恒经贸集团猪育种有限公司 一种与猪眼肌高产性状相关的分子标记及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5264558A (en) 1987-06-19 1993-11-23 The Regents Of The University Of California Single-chain monellin analog as a low calorie protein sweetner
WO1989005823A1 (en) 1987-12-23 1989-06-29 The Upjohn Company Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
GB9021679D0 (en) 1990-10-05 1990-11-21 Gorman Scott David Antibody preparation
US5162209A (en) * 1991-01-18 1992-11-10 Beth Israel Hospital Association Synthesis of full-length, double-stranded dna from a single-stranded linear dna template
US5962316A (en) * 1992-10-16 1999-10-05 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
DE69432815T2 (de) * 1993-03-19 2003-12-11 The Johns Hopkins University School Of Medicine, Baltimore Wachstumsfaktor-8
ES2233936T3 (es) * 1994-02-04 2005-06-16 Bio Merieux Virus msrv1 asociado a la esclerosis en placas, sus constituyentes nucleicos y sus aplicaciones.
AU6274298A (en) * 1997-02-05 1998-08-25 Johns Hopkins University School Of Medicine, The Growth differentiation factor-8

Also Published As

Publication number Publication date
WO1999002667A1 (en) 1999-01-21
AU8457198A (en) 1999-02-08
EP2045322A1 (en) 2009-04-08
NZ502523A (en) 2003-02-28
DE69841139D1 (de) 2009-10-22
EP2045322B1 (en) 2015-07-01
JP2001509378A (ja) 2001-07-24
PT2045322E (pt) 2015-10-16
ES2547858T3 (es) 2015-10-09
ATE442436T1 (de) 2009-09-15
EP1002068A1 (en) 2000-05-24
DK2045322T3 (en) 2015-10-05
CA2296434C (en) 2013-10-15
EP1002068B1 (en) 2009-09-09
CA2296434A1 (en) 1999-01-21
US20030129171A1 (en) 2003-07-10
JP4368522B2 (ja) 2009-11-18
AU756620B2 (en) 2003-01-16

Similar Documents

Publication Publication Date Title
CY1116682T1 (el) Διπλασιασμος-μυϊκης μαζας σε θηλαστικα
EP1439230A3 (en) Human transmembrane protein TMP-2 gene
BR9710665A (pt) Compostos que promovem o desenvolvimento do tecido
ATE189607T1 (de) Dna codierend für einen menschlichen neuropeptid y/peptid yy/pankreaspolypeptid-rezeptor (y4) und seine verwendung
ES2083344T1 (es) Dna que codifica un receptor 5-ht1f humano y utilizacion del mismo.
PL299053A1 (en) Amino acid compound being a nucleic acid, vector, host cell, genomic zyme clone, method of diagnozing the alzheimer disease, method of determining and expressing a nucleic acid sequence
EP1541686A4 (en) CONSTRUCTION OF ANTIBODY USING A MRL / LPR MOUSE
ATE398626T1 (de) Thyroid natrium/jodid symporter und dafür kodierende nukleinsäure
ATE432287T1 (de) Peptidfragmente mit den zelltod verhindernder aktivität
ATE512217T1 (de) 5-substituerte hydantoin racemase, dafür kodierende dna, und verfahren zur herstellung optisch aktiver aminosäure
DE69816987D1 (de) Verfahren und zusammenstellungen zur identifiezierung von genetisch resistenten schweinen gegen f18 e. coli assozierte krankheiten
DK1129191T3 (da) Fremgangsmåder til diagnosticering eller behandling af neurologiske sygdomme
MXPA02000293A (es) Isoformas de la amp ciclico fosfodiesterasa y metodos de uso.
Heilmann et al. Proteolytic processing of the vitellogenin precursor in the boll weevil, Anthonomus grandis
ATE452903T1 (de) Modifizierte peptide und deren verwendung zur behandlung von autoimmunkrankheiten
ATE312914T1 (de) Rdgb-proteine
EP1065269A4 (en) GENE CODING FOR HM1.24 AND PROMOTOR THEREOF
WO2003044170A3 (en) Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
DE69943149D1 (en) Serinprotease bssp2
SE9701344D0 (sv) Transgenic, non-human animal with protein deficiency, cells derived therefrom, use of said animal and cells, and method of producing said transgenic animal
WO2000068433A3 (en) Autism gene
ATE301199T1 (de) Beta-primeverosidase gen
AU5779690A (en) Mutation of the rhinovirus system
JP2003189884A5 (el)