AU5779690A - Mutation of the rhinovirus system - Google Patents

Mutation of the rhinovirus system

Info

Publication number
AU5779690A
AU5779690A AU57796/90A AU5779690A AU5779690A AU 5779690 A AU5779690 A AU 5779690A AU 57796/90 A AU57796/90 A AU 57796/90A AU 5779690 A AU5779690 A AU 5779690A AU 5779690 A AU5779690 A AU 5779690A
Authority
AU
Australia
Prior art keywords
mutation
protease
trans
oligopeptides
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU57796/90A
Other versions
AU644078B2 (en
Inventor
Herbert Auer
Dieter Blaas
Friederike Fessl
Ernst Kuechler
Ingrid Maurer-Fogy
Timothy Skern
Wolfgang Sommergruber
Peter Volkmann
Manfred Zorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU5779690A publication Critical patent/AU5779690A/en
Application granted granted Critical
Publication of AU644078B2 publication Critical patent/AU644078B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1009—Picornaviridae, e.g. hepatitis A virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to systems which make it possible to introduce mutations in the VP1/2A and in the complete coding region of the 2A protease, to test systems with which the "cis" and "trans" activity can be investigated, to oligonucleotides which encode the mutations, and to the oligopeptides derived therefrom and to the use thereof, furthermore oligopeptides which are cleaved by the 2A protease into trans with different efficiency, and to the use thereof.
AU57796/90A 1989-06-25 1990-06-25 Mutation of the rhinovirus system Ceased AU644078B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3920860 1989-06-25
DE3920860 1989-06-25
DE4018376 1990-06-08
DE4018376 1990-06-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU35245/93A Division AU657205B2 (en) 1989-06-25 1993-03-16 Mutation of the rhinovirus system

Publications (2)

Publication Number Publication Date
AU5779690A true AU5779690A (en) 1991-01-03
AU644078B2 AU644078B2 (en) 1993-12-02

Family

ID=25882343

Family Applications (2)

Application Number Title Priority Date Filing Date
AU57796/90A Ceased AU644078B2 (en) 1989-06-25 1990-06-25 Mutation of the rhinovirus system
AU35245/93A Ceased AU657205B2 (en) 1989-06-25 1993-03-16 Mutation of the rhinovirus system

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU35245/93A Ceased AU657205B2 (en) 1989-06-25 1993-03-16 Mutation of the rhinovirus system

Country Status (16)

Country Link
EP (2) EP0410147B1 (en)
JP (1) JPH04503608A (en)
KR (1) KR920701439A (en)
AT (1) ATE114717T1 (en)
AU (2) AU644078B2 (en)
CA (1) CA2019661A1 (en)
DE (2) DE59007818D1 (en)
DK (1) DK0410147T3 (en)
ES (1) ES2064537T3 (en)
FI (1) FI903144A0 (en)
GR (1) GR3015192T3 (en)
IE (2) IE950434L (en)
IL (2) IL94841A0 (en)
NO (1) NO902789L (en)
NZ (1) NZ234212A (en)
PT (1) PT94458B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318423B2 (en) 2004-07-06 2012-11-27 Focus Diagnostics, Inc. Methods and compositions for detecting rhinoviruses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263903A1 (en) * 1986-10-10 1988-04-20 E.I. Du Pont De Nemours And Company Method for preparing specific inhibitors of virus-specified proteases
EP0321973B1 (en) * 1987-12-23 1993-11-03 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Expression of the virally encoded protease P2A of HRV2

Also Published As

Publication number Publication date
IE66395B1 (en) 1995-12-27
DK0410147T3 (en) 1995-03-13
DE4020211A1 (en) 1991-01-17
IE950434L (en) 1990-12-25
IL94841A0 (en) 1991-04-15
FI903144A0 (en) 1990-06-21
IE902270L (en) 1990-12-25
WO1991000348A1 (en) 1991-01-10
PT94458A (en) 1991-02-08
NZ234212A (en) 1993-03-26
JPH04503608A (en) 1992-07-02
DE59007818D1 (en) 1995-01-12
WO1991000348A3 (en) 2004-04-29
NO902789L (en) 1990-12-27
EP0602687A1 (en) 1994-06-22
AU3524593A (en) 1993-05-27
GR3015192T3 (en) 1995-05-31
ES2064537T3 (en) 1995-02-01
AU644078B2 (en) 1993-12-02
EP0410147B1 (en) 1994-11-30
IL112507A0 (en) 1995-05-26
IE902270A1 (en) 1991-01-16
AU657205B2 (en) 1995-03-02
PT94458B (en) 1997-02-28
NO902789D0 (en) 1990-06-22
EP0410147A1 (en) 1991-01-30
ATE114717T1 (en) 1994-12-15
CA2019661A1 (en) 1990-12-25
KR920701439A (en) 1992-08-11

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