DK0410147T3 - Modified VP1 / P2A regions from rhinoviral systems - Google Patents

Modified VP1 / P2A regions from rhinoviral systems

Info

Publication number
DK0410147T3
DK0410147T3 DK90112064.2T DK90112064T DK0410147T3 DK 0410147 T3 DK0410147 T3 DK 0410147T3 DK 90112064 T DK90112064 T DK 90112064T DK 0410147 T3 DK0410147 T3 DK 0410147T3
Authority
DK
Denmark
Prior art keywords
systems
rhinoviral
regions
modified
protease
Prior art date
Application number
DK90112064.2T
Other languages
Danish (da)
Inventor
Ingrid Dr Maurer-Fogy
Dieter Dipl-Ing Dr Blaas
Wolfgang Dr Bioch Sommergruber
Peter Dr Biol Volkmann
Friederike Dipl-Ing Fessl
Ernst Dr Kuechler
Timothy Dr Biochem Skern
Manfred Zorn
Herbert Auer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK0410147T3 publication Critical patent/DK0410147T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1009—Picornaviridae, e.g. hepatitis A virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to systems which make it possible to introduce mutations in the VP1/2A and in the complete coding region of the 2A protease, to test systems with which the "cis" and "trans" activity can be investigated, to oligonucleotides which encode the mutations, and to the oligopeptides derived therefrom and to the use thereof, furthermore oligopeptides which are cleaved by the 2A protease into trans with different efficiency, and to the use thereof.
DK90112064.2T 1989-06-25 1990-06-25 Modified VP1 / P2A regions from rhinoviral systems DK0410147T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3920860 1989-06-25
DE4018376 1990-06-08

Publications (1)

Publication Number Publication Date
DK0410147T3 true DK0410147T3 (en) 1995-03-13

Family

ID=25882343

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90112064.2T DK0410147T3 (en) 1989-06-25 1990-06-25 Modified VP1 / P2A regions from rhinoviral systems

Country Status (17)

Country Link
EP (2) EP0410147B1 (en)
JP (1) JPH04503608A (en)
KR (1) KR920701439A (en)
AT (1) ATE114717T1 (en)
AU (2) AU644078B2 (en)
CA (1) CA2019661A1 (en)
DE (2) DE59007818D1 (en)
DK (1) DK0410147T3 (en)
ES (1) ES2064537T3 (en)
FI (1) FI903144A0 (en)
GR (1) GR3015192T3 (en)
IE (2) IE66395B1 (en)
IL (2) IL94841A0 (en)
NO (1) NO902789L (en)
NZ (1) NZ234212A (en)
PT (1) PT94458B (en)
WO (1) WO1991000348A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4136443A1 (en) * 1991-11-06 1993-05-13 Boehringer Ingelheim Int EXPRESSION OF THE TIRE PROTEINASE 2A, ITS PARTIAL CLEANING AND PROVISION OF COMPETITIVE SUBSTRATES
US8318423B2 (en) 2004-07-06 2012-11-27 Focus Diagnostics, Inc. Methods and compositions for detecting rhinoviruses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0263903A1 (en) * 1986-10-10 1988-04-20 E.I. Du Pont De Nemours And Company Method for preparing specific inhibitors of virus-specified proteases
DE3885431D1 (en) * 1987-12-23 1993-12-09 Boehringer Ingelheim Int Expression of the virally encoded protease P2A of HRV2.

Also Published As

Publication number Publication date
KR920701439A (en) 1992-08-11
DE59007818D1 (en) 1995-01-12
ATE114717T1 (en) 1994-12-15
CA2019661A1 (en) 1990-12-25
IE902270A1 (en) 1991-01-16
IL112507A0 (en) 1995-05-26
EP0602687A1 (en) 1994-06-22
AU657205B2 (en) 1995-03-02
AU644078B2 (en) 1993-12-02
IL94841A0 (en) 1991-04-15
WO1991000348A3 (en) 2004-04-29
AU3524593A (en) 1993-05-27
PT94458B (en) 1997-02-28
DE4020211A1 (en) 1991-01-17
AU5779690A (en) 1991-01-03
NZ234212A (en) 1993-03-26
NO902789D0 (en) 1990-06-22
ES2064537T3 (en) 1995-02-01
EP0410147B1 (en) 1994-11-30
JPH04503608A (en) 1992-07-02
PT94458A (en) 1991-02-08
EP0410147A1 (en) 1991-01-30
GR3015192T3 (en) 1995-05-31
NO902789L (en) 1990-12-27
IE950434L (en) 1990-12-25
IE66395B1 (en) 1995-12-27
IE902270L (en) 1990-12-25
WO1991000348A1 (en) 1991-01-10
FI903144A0 (en) 1990-06-21

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