JP2001507676A5 - - Google Patents

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Publication number
JP2001507676A5
JP2001507676A5 JP1998522179A JP52217998A JP2001507676A5 JP 2001507676 A5 JP2001507676 A5 JP 2001507676A5 JP 1998522179 A JP1998522179 A JP 1998522179A JP 52217998 A JP52217998 A JP 52217998A JP 2001507676 A5 JP2001507676 A5 JP 2001507676A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998522179A
Other languages
English (en)
Japanese (ja)
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JP2001507676A (ja
JP4264137B2 (ja
Filing date
Publication date
Priority claimed from IT96MI002368A external-priority patent/IT1295694B1/it
Application filed filed Critical
Publication of JP2001507676A publication Critical patent/JP2001507676A/ja
Publication of JP2001507676A5 publication Critical patent/JP2001507676A5/ja
Application granted granted Critical
Publication of JP4264137B2 publication Critical patent/JP4264137B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP52217998A 1996-11-14 1997-11-12 抗血栓性有機硝酸塩 Expired - Fee Related JP4264137B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT96A002368 1996-11-14
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
PCT/EP1997/006311 WO1998021193A1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates

Publications (3)

Publication Number Publication Date
JP2001507676A JP2001507676A (ja) 2001-06-12
JP2001507676A5 true JP2001507676A5 (enExample) 2005-07-14
JP4264137B2 JP4264137B2 (ja) 2009-05-13

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52217998A Expired - Fee Related JP4264137B2 (ja) 1996-11-14 1997-11-12 抗血栓性有機硝酸塩

Country Status (18)

Country Link
US (1) US6242432B1 (enExample)
EP (1) EP0941218B1 (enExample)
JP (1) JP4264137B2 (enExample)
KR (1) KR100504122B1 (enExample)
CN (1) CN1094931C (enExample)
AT (1) ATE226199T1 (enExample)
AU (1) AU729423B2 (enExample)
BR (1) BR9712959B1 (enExample)
CA (1) CA2272063C (enExample)
DE (1) DE69716461T2 (enExample)
DK (1) DK0941218T3 (enExample)
ES (1) ES2186013T3 (enExample)
HU (1) HUP0000667A3 (enExample)
IL (1) IL129768A (enExample)
IT (1) IT1295694B1 (enExample)
PT (1) PT941218E (enExample)
RU (1) RU2190594C2 (enExample)
WO (1) WO1998021193A1 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IE20000052A1 (en) * 1999-04-29 2000-11-29 Russinsky Ltd Nitric acid salts of B-blockers
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
EP1212053A4 (en) 1999-09-08 2004-08-11 Nitromed Inc METHODS FOR THE TREATMENT AND PROPHYLAXIS OF CONGESTIVE HEART FAILURE BY HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
AU780261B2 (en) 1999-10-29 2005-03-10 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
IL150368A0 (en) * 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
AU3838901A (en) 2000-02-16 2001-08-27 Illumina Inc Parallel genotyping of multiple patient samples
AU7007001A (en) 2000-06-22 2002-01-02 Nitromed Inc Nitrosated and nitrosylated taxanes, compositions and methods of use
JP2004521083A (ja) * 2000-10-27 2004-07-15 ニトロメッド,インク. 酸化窒素不足によって特徴づけられる血管疾患の治療方法
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP2042181A1 (en) 2002-02-04 2009-04-01 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
CA2487414A1 (en) * 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20060258652A1 (en) * 2002-11-22 2006-11-16 Haj-Yehia Abdullah I Beta-blockers having antioxidant and no-donor activity
EP1578413A2 (en) * 2002-11-29 2005-09-28 Yissum Research Development Company of The Hebrew University of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
PL379197A1 (pl) * 2003-06-19 2006-07-24 Nicox S.A. Nitroksylowe pochodne enalaprilu i pokrewne związki jako inhibitory ACE do leczenia chorób sercowo-naczyniowych
CA2536173A1 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
AU2004294297A1 (en) * 2003-12-02 2005-06-16 Nicox S.A. Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs
AP2006003622A0 (en) * 2003-12-02 2006-06-30 Nicox Sa Nitrooxyderivatives of antihypertensive drugs
OA13356A (en) 2004-01-05 2007-04-13 Nicox Sa Prostaglandin nitrooxyderivatives.
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS RELATED TO HEART ERROR
JP2008510755A (ja) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
US20080300292A1 (en) * 2004-11-08 2008-12-04 Nitromed, Inc Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders
EP1846380A4 (en) * 2005-01-21 2010-02-17 Nicox Sa HETEROCYCLIC NITROGEN MONOXIDE DONOR COMPOSITIONS CONTAINING CARDIOVASCULAR COMPOUNDS, AND METHODS OF USING THE SAME
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
US20080274171A1 (en) * 2005-10-18 2008-11-06 Nicoletta Almirante Renin Inhibitors Nitroderivatives
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
AU2007210813A1 (en) 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
WO2007097951A2 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
AU2007224368A1 (en) * 2006-03-08 2007-09-13 Actelion Pharmaceuticals Ltd New amines
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
WO2007136626A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
RU2322972C1 (ru) * 2006-09-12 2008-04-27 Илья Николаевич Медведев Способ профилактики тромбозов у больных артериальной гипертонией с метаболическим синдромом
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
FR2921365B1 (fr) * 2007-09-21 2012-10-12 Servier Lab Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG192543A1 (en) 2008-05-05 2013-08-30 Merck Canada Inc 3, 4 - substituted piperidine derivatives as renin inhibitors
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
US9163044B2 (en) 2011-04-19 2015-10-20 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドAlfama,Inc. 一酸化ルテニウム放出分子およびその使用
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
WO2018087092A1 (en) 2016-11-08 2018-05-17 Bausch & Lomb Incorporated Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma
JP7775080B2 (ja) 2019-07-01 2025-11-25 トニックス ファーマ リミテッド 抗cd154抗体およびその使用
US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
CN118146175A (zh) * 2024-02-07 2024-06-07 广州楷石生物科技有限公司 右旋噻吗洛尔衍生物及其制备方法和应用
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
HU218923B (hu) 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
WO1997031896A1 (en) * 1996-03-01 1997-09-04 Sankyo Company, Limited Thiazolidine derivatives

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