JP2001507215A - 組換え糖タンパク質のインビトロでの実用的なシアリル化 - Google Patents

組換え糖タンパク質のインビトロでの実用的なシアリル化

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Publication number
JP2001507215A
JP2001507215A JP51870998A JP51870998A JP2001507215A JP 2001507215 A JP2001507215 A JP 2001507215A JP 51870998 A JP51870998 A JP 51870998A JP 51870998 A JP51870998 A JP 51870998A JP 2001507215 A JP2001507215 A JP 2001507215A
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Prior art keywords
sialyltransferase
amino acid
acid sequence
recombinant
sialic acid
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JP51870998A
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Japanese (ja)
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JP2001507215A5 (enExample
Inventor
シー． ポールソン，ジェイムス
ジェイ． ベイヤー，ロバート
スジョバーグ，エリック
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サイテル コーポレイション
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Publication of JP2001507215A publication Critical patent/JP2001507215A/ja
Publication of JP2001507215A5 publication Critical patent/JP2001507215A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP51870998A 1997-01-16 1998-01-15 組換え糖タンパク質のインビトロでの実用的なシアリル化 Withdrawn JP2001507215A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3571097P 1997-01-16 1997-01-16
US60/035,710 1997-01-16
PCT/US1998/000835 WO1998031826A1 (en) 1997-01-16 1998-01-15 Practical in vitro sialylation of recombinant glycoproteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010229044A Division JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Publications (2)

Publication Number Publication Date
JP2001507215A true JP2001507215A (ja) 2001-06-05
JP2001507215A5 JP2001507215A5 (enExample) 2005-09-08

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ID=21884346

Family Applications (2)

Application Number Title Priority Date Filing Date
JP51870998A Withdrawn JP2001507215A (ja) 1997-01-16 1998-01-15 組換え糖タンパク質のインビトロでの実用的なシアリル化
JP2010229044A Withdrawn JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Family Applications After (1)

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JP2010229044A Withdrawn JP2011024597A (ja) 1997-01-16 2010-10-08 組換え糖タンパク質のインビトロでの実用的なシアリル化

Country Status (12)

Country Link
US (5) US6399336B1 (enExample)
EP (1) EP1015622B1 (enExample)
JP (2) JP2001507215A (enExample)
AT (1) ATE263841T1 (enExample)
AU (1) AU736993B2 (enExample)
CA (1) CA2278178C (enExample)
DE (1) DE69823046T2 (enExample)
DK (1) DK1015622T3 (enExample)
ES (1) ES2218806T3 (enExample)
IL (2) IL130964A0 (enExample)
NZ (1) NZ336780A (enExample)
WO (1) WO1998031826A1 (enExample)

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JP2005515974A (ja) * 2001-10-22 2005-06-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 卵胞形成のためのゴナドドロピン
JP2006503091A (ja) * 2002-10-17 2006-01-26 ファーミング・インテレクチュアル・プロパティー・ビー．ブイ． タンパク質の修飾
JP2009545575A (ja) * 2006-08-01 2009-12-24 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換ｆｖｉｉの組成物
JP2010512306A (ja) * 2006-10-27 2010-04-22 ザ ロックフェラー ユニバーシティー 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
JP4812625B2 (ja) * 2004-10-18 2011-11-09 日本たばこ産業株式会社 糖転移酵素の酵素活性を向上させる方法
JP2018515125A (ja) * 2015-05-22 2018-06-14 ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト 改変フォン・ヴィルブランド因子を製造するための方法

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US6689604B1 (en) 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
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US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
ATE365219T1 (de) 1999-10-26 2007-07-15 Plant Res Int Bv Glykolisierung des säugetiertyps in pflanzen
NZ522320A (en) * 2000-05-12 2007-03-30 Neose Technologies Inc In vitro modification of glycosylation patterns of recombinant glycopeptides
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
CN100385006C (zh) 2001-01-19 2008-04-30 陶氏化学公司 利用植物细胞分泌性生产具有人型糖链的糖蛋白的方法
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7439043B2 (en) 2001-10-10 2008-10-21 Neose Technologies, Inc. Galactosyl nucleotide sugars
US7297511B2 (en) 2001-10-10 2007-11-20 Neose Technologies, Inc. Interferon alpha: remodeling and glycoconjugation of interferon alpha
EP2292273A3 (en) 2001-10-10 2011-11-23 BioGeneriX AG Remodeling and glycoconjugation of peptides
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
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US7265084B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7179617B2 (en) 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7265085B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycoconjugation methods and proteins/peptides produced by the methods
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7473680B2 (en) 2001-11-28 2009-01-06 Neose Technologies, Inc. Remodeling and glycoconjugation of peptides
JP2005535280A (ja) 2001-11-28 2005-11-24 ネオーズ テクノロジーズ， インコーポレイテッド エンドグリカナーゼを用いる糖タンパク質のリモデリング
CA2478294C (en) 2002-03-19 2013-09-03 Plant Research International B.V. Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta (1,4)-n-acetylglucosaminyltransferase iii) expression in plants
CA2923247A1 (en) 2002-03-19 2003-09-25 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
ES2363205T3 (es) 2002-06-21 2011-07-26 Novo Nordisk Health Care Ag Glicoformas del factor vii pegilado.
DE60336555D1 (de) 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylierte glykoformen von faktor vii
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AR042145A1 (es) 2002-11-27 2005-06-08 Dow Agrociences Llc Produccion de inmunoglobulinas en plantas con una fucocilacion reducida
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US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
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US7932364B2 (en) * 2003-05-09 2011-04-26 Novo Nordisk A/S Compositions and methods for the preparation of human growth hormone glycosylation mutants
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US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
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NZ548123A (en) 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
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WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
WO2006020372A2 (en) * 2004-07-23 2006-02-23 Neose Technologies, Inc. Enzymatic modification of glycopeptides
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
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US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
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CA2593682C (en) * 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
JP5235657B2 (ja) * 2005-03-24 2013-07-10 バイオジェネリックス ゲーエムベーハー 原核生物における可溶性活性真核生物グリコシルトランスフェラーゼの発現
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005515974A (ja) * 2001-10-22 2005-06-02 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 卵胞形成のためのゴナドドロピン
JP2006503091A (ja) * 2002-10-17 2006-01-26 ファーミング・インテレクチュアル・プロパティー・ビー．ブイ． タンパク質の修飾
JP4812625B2 (ja) * 2004-10-18 2011-11-09 日本たばこ産業株式会社 糖転移酵素の酵素活性を向上させる方法
JP2009545575A (ja) * 2006-08-01 2009-12-24 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換ｆｖｉｉの組成物
JP2015042678A (ja) * 2006-08-01 2015-03-05 エルエフビー バイオテクノロジーズ 大部分がグリカンで二触角性バイシアリル化され、フコース化されていない形態の遺伝子組み換えプロセス及び形質転換ｆｖｉｉの組成物
JP2010512306A (ja) * 2006-10-27 2010-04-22 ザ ロックフェラー ユニバーシティー 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法
JP2018515125A (ja) * 2015-05-22 2018-06-14 ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト 改変フォン・ヴィルブランド因子を製造するための方法

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US20030124645A1 (en) 2003-07-03
NZ336780A (en) 2000-12-22
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US6399336B1 (en) 2002-06-04
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AU6242798A (en) 1998-08-07
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US20020119516A1 (en) 2002-08-29
EP1015622A4 (en) 2002-06-19
WO1998031826A1 (en) 1998-07-23
AU736993B2 (en) 2001-08-09
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DK1015622T3 (da) 2004-08-02
US20020160460A1 (en) 2002-10-31

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