JP2001506599A - アルファ−２アドレナリン受容体アゴニストとして有効な２−イミダゾリニルアミノインダゾール化合物 - Google Patents

アルファ−２アドレナリン受容体アゴニストとして有効な２−イミダゾリニルアミノインダゾール化合物

Info

Publication number
JP2001506599A
JP2001506599A JP52468698A JP52468698A JP2001506599A JP 2001506599 A JP2001506599 A JP 2001506599A JP 52468698 A JP52468698 A JP 52468698A JP 52468698 A JP52468698 A JP 52468698A JP 2001506599 A JP2001506599 A JP 2001506599A
Authority
JP
Japan
Prior art keywords
preferred
compounds
compound
hydrogen
dosage range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP52468698A
Other languages
English (en)
Japanese (ja)
Inventor
カプス，トーマス，リー．
ボグダン，ソフィー，エバ．
ヘンリー，レイモンド，トッド．
シェルダン，ラッセル，ジェイムズ．
シーベル，ウィリアム，リー．
アレス，ジェフリー，ジョーゼフ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of JP2001506599A publication Critical patent/JP2001506599A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP52468698A 1996-11-25 1997-11-21 アルファ−２アドレナリン受容体アゴニストとして有効な２−イミダゾリニルアミノインダゾール化合物 Pending JP2001506599A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3174096P 1996-11-25 1996-11-25
US60/031,740 1996-11-25
PCT/US1997/020551 WO1998023609A1 (fr) 1996-11-25 1997-11-21 Composes 2-imidazolinylamino-indazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Publications (1)

Publication Number Publication Date
JP2001506599A true JP2001506599A (ja) 2001-05-22

Family

ID=21861136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52468698A Pending JP2001506599A (ja) 1996-11-25 1997-11-21 アルファ−２アドレナリン受容体アゴニストとして有効な２−イミダゾリニルアミノインダゾール化合物

Country Status (20)

Country Link
EP (1) EP0944620A1 (fr)
JP (1) JP2001506599A (fr)
KR (1) KR20000069104A (fr)
CN (1) CN1244864A (fr)
AR (1) AR010643A1 (fr)
AU (1) AU5433998A (fr)
BR (1) BR9713535A (fr)
CA (1) CA2272644A1 (fr)
CO (1) CO4910166A1 (fr)
CZ (1) CZ183999A3 (fr)
HU (1) HUP9904660A3 (fr)
ID (1) ID22676A (fr)
IL (1) IL130067A0 (fr)
NO (1) NO992502L (fr)
NZ (1) NZ335882A (fr)
PE (1) PE47099A1 (fr)
SK (1) SK69699A3 (fr)
TR (1) TR199901542T2 (fr)
WO (1) WO1998023609A1 (fr)
ZA (1) ZA9710576B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9908175D0 (en) * 1999-04-09 1999-06-02 Lilly Co Eli Method of treating neurological disorders
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US20100311965A1 (en) 2007-12-28 2010-12-09 Carna Biosciences Inc. 2-aminoquinazoline derivative
WO2010074753A1 (fr) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs
CN112538074A (zh) * 2020-12-24 2021-03-23 艾希尔（深圳）药物研发有限公司 一种溴莫尼定脱溴杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641782A5 (en) * 1978-12-07 1984-03-15 Siegfried Ag 1H- and 2H-indazole derivatives
US4526898A (en) * 1980-09-05 1985-07-02 Siegfried Aktiengesselschaft Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
ATE194771T1 (de) * 1993-12-17 2000-08-15 Procter & Gamble 6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten

Also Published As

Publication number Publication date
CA2272644A1 (fr) 1998-06-04
CZ183999A3 (cs) 1999-11-17
NO992502L (no) 1999-07-26
PE47099A1 (es) 1999-06-12
EP0944620A1 (fr) 1999-09-29
NZ335882A (en) 2000-12-22
AU5433998A (en) 1998-06-22
IL130067A0 (en) 2000-02-29
TR199901542T2 (xx) 2000-01-21
WO1998023609A1 (fr) 1998-06-04
ID22676A (id) 1999-12-09
AR010643A1 (es) 2000-06-28
NO992502D0 (no) 1999-05-25
SK69699A3 (en) 2000-06-12
HUP9904660A3 (en) 2002-02-28
CO4910166A1 (es) 2000-04-24
ZA9710576B (en) 1998-09-16
BR9713535A (pt) 2000-03-21
KR20000069104A (ko) 2000-11-25
CN1244864A (zh) 2000-02-16
HUP9904660A2 (hu) 2000-06-28

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