CA2285610A1 - Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 - Google Patents

Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 Download PDF

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Publication number
CA2285610A1
CA2285610A1 CA002285610A CA2285610A CA2285610A1 CA 2285610 A1 CA2285610 A1 CA 2285610A1 CA 002285610 A CA002285610 A CA 002285610A CA 2285610 A CA2285610 A CA 2285610A CA 2285610 A1 CA2285610 A1 CA 2285610A1
Authority
CA
Canada
Prior art keywords
dosage range
compounds
alpha
compound
subject compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002285610A
Other languages
English (en)
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Glen Edward Mieling
Nick Nikolaides
Raymond Todd Henry
Russell James Sheldon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2285610A1 publication Critical patent/CA2285610A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés ayant la structure (I) telle qu'elle est décrite dans les revendications, et ses énantiomères, isomères optiques, stéréo-isomères, diastéréomères, tautomères, sels d'addition, amides biologiquement hydrolysables et leurs esters, ainsi que des compositions pharmaceutiques comprenant ces nouveaux composés. L'invention se rapporte également à l'utilisation de ces composés dans la prévention ou le traitement des troubles modulés par les adrénorécepteurs alpha-2
CA002285610A 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 Abandoned CA2285610A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4231697P 1997-04-15 1997-04-15
US60/042,316 1997-04-15
PCT/IB1998/000540 WO1998046595A1 (fr) 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Publications (1)

Publication Number Publication Date
CA2285610A1 true CA2285610A1 (fr) 1998-10-22

Family

ID=21921202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285610A Abandoned CA2285610A1 (fr) 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Country Status (12)

Country Link
EP (1) EP0975627A1 (fr)
JP (1) JP2001519828A (fr)
KR (1) KR20010006440A (fr)
CN (1) CN1256691A (fr)
AU (1) AU6514498A (fr)
BR (1) BR9808904A (fr)
CA (1) CA2285610A1 (fr)
HU (1) HUP0002242A2 (fr)
ID (1) ID24081A (fr)
IL (1) IL132384A0 (fr)
NO (1) NO995030L (fr)
WO (1) WO1998046595A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004270A1 (fr) 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Nouveaux derives de benzimidazole
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
WO1999026942A1 (fr) * 1997-11-24 1999-06-03 The Procter & Gamble Company 5-(2-imidazolinylamino)-benzimidazole, derives et procedes de preparation et d'utilisation de ces derniers en tant qu'agonistes du recepteur alpha-adrenergique ayant une meilleure stabilite metabolique
US20040167194A1 (en) * 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN110540523B (zh) * 2018-07-05 2021-02-19 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
WO1996004270A1 (fr) * 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Nouveaux derives de benzimidazole

Also Published As

Publication number Publication date
JP2001519828A (ja) 2001-10-23
NO995030D0 (no) 1999-10-15
HUP0002242A2 (hu) 2001-04-28
WO1998046595A1 (fr) 1998-10-22
BR9808904A (pt) 2005-02-22
NO995030L (no) 1999-12-15
IL132384A0 (en) 2001-03-19
EP0975627A1 (fr) 2000-02-02
AU6514498A (en) 1998-11-11
CN1256691A (zh) 2000-06-14
KR20010006440A (ko) 2001-01-26
ID24081A (id) 2000-07-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued