CN1256691A - 用作α－2肾上腺素能受体兴奋剂的5－(2－咪唑啉基氨基)苯并咪唑化合物 - Google Patents

用作α－2肾上腺素能受体兴奋剂的5－(2－咪唑啉基氨基)苯并咪唑化合物 Download PDF

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Publication number
CN1256691A
CN1256691A CN98805130A CN98805130A CN1256691A CN 1256691 A CN1256691 A CN 1256691A CN 98805130 A CN98805130 A CN 98805130A CN 98805130 A CN98805130 A CN 98805130A CN 1256691 A CN1256691 A CN 1256691A
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CN
China
Prior art keywords
dosage
compound
milligram
alpha
adrenergic receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98805130A
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English (en)
Chinese (zh)
Inventor
T·L·卡皮斯
S·E·波格丹
G·E·米尔林
N·尼古拉德斯
R·T·亨利
R·J·谢尔登
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of CN1256691A publication Critical patent/CN1256691A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN98805130A 1997-04-15 1998-04-09 用作α－2肾上腺素能受体兴奋剂的5－(2－咪唑啉基氨基)苯并咪唑化合物 Pending CN1256691A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4231697P 1997-04-15 1997-04-15
US60/042,316 1997-04-15

Publications (1)

Publication Number Publication Date
CN1256691A true CN1256691A (zh) 2000-06-14

Family

ID=21921202

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98805130A Pending CN1256691A (zh) 1997-04-15 1998-04-09 用作α－2肾上腺素能受体兴奋剂的5－(2－咪唑啉基氨基)苯并咪唑化合物

Country Status (12)

Country Link
EP (1) EP0975627A1 (fr)
JP (1) JP2001519828A (fr)
KR (1) KR20010006440A (fr)
CN (1) CN1256691A (fr)
AU (1) AU6514498A (fr)
BR (1) BR9808904A (fr)
CA (1) CA2285610A1 (fr)
HU (1) HUP0002242A2 (fr)
ID (1) ID24081A (fr)
IL (1) IL132384A0 (fr)
NO (1) NO995030L (fr)
WO (1) WO1998046595A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110540523A (zh) * 2018-07-05 2019-12-06 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
JP2001524478A (ja) * 1997-11-24 2001-12-04 ザ プロクター アンド ギャンブル カンパニー ５−（２−イミダゾリニルアミノ）−ベンゾイミダゾール誘導体類、それらの調製および改良された代謝安定性を有するアルファアドレナリン受容体作動薬としてのそれらの使用
US20040167194A1 (en) * 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
WO2010074753A1 (fr) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
AU704972B2 (en) * 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110540523A (zh) * 2018-07-05 2019-12-06 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法
CN110540523B (zh) * 2018-07-05 2021-02-19 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法

Also Published As

Publication number Publication date
JP2001519828A (ja) 2001-10-23
NO995030D0 (no) 1999-10-15
NO995030L (no) 1999-12-15
EP0975627A1 (fr) 2000-02-02
CA2285610A1 (fr) 1998-10-22
BR9808904A (pt) 2005-02-22
HUP0002242A2 (hu) 2001-04-28
IL132384A0 (en) 2001-03-19
ID24081A (id) 2000-07-06
KR20010006440A (ko) 2001-01-26
AU6514498A (en) 1998-11-11
WO1998046595A1 (fr) 1998-10-22

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