EP0975627A1 - Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 - Google Patents

Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Info

Publication number
EP0975627A1
EP0975627A1 EP98910927A EP98910927A EP0975627A1 EP 0975627 A1 EP0975627 A1 EP 0975627A1 EP 98910927 A EP98910927 A EP 98910927A EP 98910927 A EP98910927 A EP 98910927A EP 0975627 A1 EP0975627 A1 EP 0975627A1
Authority
EP
European Patent Office
Prior art keywords
dosage range
compounds
alpha
compound
subject compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98910927A
Other languages
German (de)
English (en)
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Glen Edward Mieling
Nick Nikolaides
Raymond Todd Henry
Russell James Sheldon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP0975627A1 publication Critical patent/EP0975627A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne des composés ayant la structure (I) telle qu'elle est décrite dans les revendications, et ses énantiomères, isomères optiques, stéréo-isomères, diastéréomères, tautomères, sels d'addition, amides biologiquement hydrolysables et leurs esters, ainsi que des compositions pharmaceutiques comprenant ces nouveaux composés. L'invention se rapporte également à l'utilisation de ces composés dans la prévention ou le traitement des troubles modulés par les adrénorécepteurs alpha-2
EP98910927A 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 Withdrawn EP0975627A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4231697P 1997-04-15 1997-04-15
US42316P 1997-04-15
PCT/IB1998/000540 WO1998046595A1 (fr) 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Publications (1)

Publication Number Publication Date
EP0975627A1 true EP0975627A1 (fr) 2000-02-02

Family

ID=21921202

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98910927A Withdrawn EP0975627A1 (fr) 1997-04-15 1998-04-09 Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2

Country Status (12)

Country Link
EP (1) EP0975627A1 (fr)
JP (1) JP2001519828A (fr)
KR (1) KR20010006440A (fr)
CN (1) CN1256691A (fr)
AU (1) AU6514498A (fr)
BR (1) BR9808904A (fr)
CA (1) CA2285610A1 (fr)
HU (1) HUP0002242A2 (fr)
ID (1) ID24081A (fr)
IL (1) IL132384A0 (fr)
NO (1) NO995030L (fr)
WO (1) WO1998046595A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2196792A1 (fr) 1994-08-04 1996-02-15 Yoon T. Jeon Nouveaux derives de benzimidazole
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
CN1284073A (zh) * 1997-11-24 2001-02-14 宝洁公司 5－(2－咪唑啉基氨基)－苯并咪唑衍生物,其制备和作为具有改进的代谢稳定性的a－肾上腺素能受体激动剂的应用
US20040167194A1 (en) 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN110540523B (zh) * 2018-07-05 2021-02-19 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
CA2196792A1 (fr) * 1994-08-04 1996-02-15 Yoon T. Jeon Nouveaux derives de benzimidazole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9846595A1 *

Also Published As

Publication number Publication date
JP2001519828A (ja) 2001-10-23
NO995030L (no) 1999-12-15
IL132384A0 (en) 2001-03-19
CN1256691A (zh) 2000-06-14
BR9808904A (pt) 2005-02-22
KR20010006440A (ko) 2001-01-26
CA2285610A1 (fr) 1998-10-22
WO1998046595A1 (fr) 1998-10-22
AU6514498A (en) 1998-11-11
HUP0002242A2 (hu) 2001-04-28
NO995030D0 (no) 1999-10-15
ID24081A (id) 2000-07-06

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