Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
  • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
  • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

• the subject invention relates to 5-(2-imidazolinylamino)benzimidazole compounds.
• the compounds have been found to be alpha-2 adrenoceptor agonists and are useful for treatment of disorders modulated by alpha-2 adrenoceptors.
• alpha-2 adrenoceptor agonists have been discussed in the literature: Ruffolo, R.R., A.J. Nichols, J.M. Stadel, & J.P. Hieble, "Pharmacologic and Therapeutic Applications of Alpha-2 Adrenoceptor Subtypes", Annual Review of Pharmacology & Toxicology, Vol. 32 (1993) pp. 243-279.
• This need relates to all disorders modulated by alpha adrenoceptors.
• the invention meets this need by providing selective alpha 2 agonists, without the undesired side effects.
• COPD chronic obstructive pulmonary disease
• diseases and disorders associated with sympathetic nervous system activity including benign prostatic hypertrophy, cardiovascular disorders comprising myocardial ischemia, cardiac reperfusion injury, angina, cardiac arrhythmia, heart failure and hypertension.
• gastrointestinal disorders such as diarrhea, irritable bowel syndrome, hyperchlorhydria (hyperacidity) and peptic ulcer (ulcer).
• This invention relates to compounds having the following structure:
• the subject invention relates compounds having the following structure:
• is hydrogen, C1-C3 alkanyl or alkenyl, cyclopropyl or halo;
• R2 is halo or C1-C3 alkanyl or alkenyl
• R3 is hydrogen; C1-C3 alkanyl, alkenyl or alkynyl; cyclopropyl, cycloalkenyl; C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo;
• R4 is hydrogen or C-1-C3 alkanyl
• R5 is selected from hydrogen and methyl; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters, and pharmaceutical compositions containing such novel compounds, and the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.
• alkanyl means a saturated hydrocarbon substituent, straight or branched chain, unsubstituted or substituted.
• Preferred alkanyl includes methyl and ethyl.
• alkenyl means a hydrocarbon substituent with one double bond, straight or branched chain, unsubstituted or substituted.
• alkylthio means a substituent having the structure Q-S-, where Q is alkanyl or alkenyl.
• alkoxy means a substituent having the structure Q-O-, where Q is alkanyl or alkenyl.
• alkylamino means a substituent having the structure Q-NH-, where Q is alkanyl or alkenyl.
• dialkylamino means a substituent having the structure Ql-N(Q2)-, where each Q is independently alkanyl or alkenyl.
• Halo is a chloro, bromo, fluoro or iodo.
• a "pharmaceutically-acceptable salt” is a cationic salt formed at any acidic (e.g., carboxyl) group, or an anionic salt formed at any basic (e.g., amino) group.
• Preferred cationic salts include the alkali metal salts (such as sodium and potassium), alkaline earth metal salts (such as magnesium and calcium) and organic salts.
• Preferred anionic salts include halides, sulfonates, carboxylates, phosphates, and the like.
• addition salts that may provide an optical center, where once there was none.
• a chiral tartrate salt may be prepared from the compounds of the invention, and this definition includes such chiral salts.
• the compounds of the invention are sufficiently basic to form acid- addition salts.
• the compounds are useful both in the free base form and the form of acid-addition salts, and both forms are within the purview of the invention.
• the acid-addition salts are in some cases a more convenient form for use. In practice, the use of the salt form inherently amounts to the use of the base form of the active.
• Acids used to prepare acid-addition salts include preferably those which produce, when combined with the free base, medicinally acceptable salts. These salts have anions that are relatively innocuous to the animal organism, such as a mammal, in medicinal doses of the salts so that the beneficial property inherent in the free base are not vitiated by any side effects ascribable to the acid's anions.
• acids-addition salts include, but at not limited to hydrochloride, hydrobromide, hydroiodiode, sulfate, hydrogensulfate, acetate, trifluoroacetate, nitrate, maleate, citrate, fumarate, formate, stearate, succinate, mallate, malonate, adipate, glutarate, lactate, propionate, butyrate, tartrate, methanesulfonate, trifluoromethanesulfonate, p-toluenesulfonate, dodecyl sulfate, cyclohexanesulfamate, and the like.
• salts within the scope of the invention are those derived from other mineral acids and organic acids.
• the acid-addition salts of the basic compounds are prepared by several methods.
• the free base can be dissolved in an aqueous alcohol solution containing the appropriate acid and the salt is isolated by evaporation of the solution.
• they may be prepared by reacting the free base with an acid in an organic solvent so that the salt separates directly. Where separation of the salt is difficult, it can be precipitated with a second organic solvent, or can be obtained by concentration of the solution.
• all acid-addition salts are within the scope of the present invention. All acid-addition salts are useful as sources of the free base form, even if the particular salt per se is desired only as an intermediate product. For example, when the salt is formed only for purposes of purification or identification, or when it is used as an intermediate in preparing a medicinally acceptable salt by ion exchange procedures, these salts are clearly contemplated to be a part of this invention.
• Biohydrolyzable amide refers to an amide of the compound of the invention that is readily converted in vivo by a mammal subject to yield an active compound of the invention.
• a “biohydrolyzable ester” refers to an ester of the compound of the invention that is readily converted by a mammal subject to yield an active compound of the invention.
• Optical isomer "stereoisomer”, “enantiomer,” “diastereomer,” as referred to herein have the standard art recognized meanings (Cf., Hawlevs Condensed Chemical Dictionary. 11th Ed.).
• an addition salt may provide an optical center, where once there was none.
• a chiral tartrate salt may be prepared from the compounds of the invention, and this definition includes such chiral salts. It will be apparent to the skilled artisan that disclosure of the racemic mixture alone discloses any enantiomers therein. Thus by one disclosure, more than one compound is taught.
• animal includes “mammals” which includes “humans”.
• This invention includes compounds of the structure of formula I.
• Preferred compounds include:
• substituents may be incorporated at the 2- position for example, by treating a 1 ,2 phenyl diamine with a acyl halide or the like in the presence of a dehydrating agent.
• This material is purified further via flash column chromatography on silica gel (95:5 hexane:ethyl acetate) to give rise to 6.2 g of 5-chloro-2,4-dinitro-m-xylene as a white crystalline solid.
• 5-Azido-2,4-dinitro-m-xylene To a 100 mL round bottom flask are added 10 mL of N,N-dimethylformamide, 707 mg of 5-chloro-2,4-dinitro-m-xylene, and 219 mg of sodium azide. The resulting mixture is heated at 80°C for 45 minutes then cooled to room temperature and poured into ice/water and extracted with ethyl acetate (3 x 50 mL). The combined organics are dried over magnesium sulfate, filtered, and concentrated via rotary evaporation to provide 650 mg of 5- azido-2,4-dinitro-t77-xylene as a yellow/brown solid.
• 5-Amino-4,6-dimethylbenzimidazole A heterogeneous mixture of 410 mg of 4,6-dimethyl-5-nitrobenzimidazole and 50 mg of 10% palladium-on-carbon in 25 mL of methanol is treated with hydrogen (1 atm, balloon) for 16 hours. The resulting mixture is filtered through Celite and concentrated via rotary evaporation to give rise to a yellow residue. This residue is purified via flash chromatography on silica gel (95:5 methylene chloride:methanol) to give rise to 265 mg of 5-amino-4,6-dimethylbenzimidazole as a white solid. 4,6-Dimethyl-5-isothiocyanatobenzimidazole.
• compositions which comprise a safe and effective amount of a subject compound, or a pharmaceutically-acceptable salt thereof, and a pharmaceutically-acceptable carrier.
• safe and effective amount means an amount of the subject compound sufficient to significantly induce a positive modification in the condition to be treated, but low enough to avoid serious side effects (at a reasonable benefit/risk ratio), within the scope of sound medical judgment.
• a safe and effective amount of the subject compound will vary with the age and physical condition of the patient being treated, the severity of the condition, the duration of the treatment, the nature of concurrent therapy, the particular pharmaceutically-acceptable carrier utilized, and like factors within the knowledge and expertise of the attending physician.
• a dosage form is within the purview of the skilled artisan. Examples are provided for the skilled artisan, but are non-limiting, and it is contemplated that the skilled artisan can prepare variations of the compositions claimed.
• compositions of this invention preferably comprise from about 0.0001 % to about 99% by weight of the subject compound, more preferably from about 0.01% to about 90% of the compound of the invention.
• the dosage form has preferably from about 10% to about 50%, also preferably from about 5% to about 10%, also preferably from about 1% to about 5%, and also preferably from about 0.01% to about 1 % of the subject compound.
• the frequency of dosing of the subject compound is dependent upon the pharmacokinetic properties of each specific agent (for example, biological half-life) and can be determined by the skilled artisan.
• compositions of this invention contain a pharmaceutically-acceptable carrier.
• pharmaceutically-acceptable carrier means one or more compatible solid or liquid filler diluents or encapsulating substances which are suitable for administration to a mammal.
• compatible means that the components of the composition are capable of being commingled with the subject compound, and with each other, in a manner such that there is no interaction which would substantially reduce the pharmaceutical efficacy of the composition under ordinary use situations.
• the compounds of the invention are soluble in the components of the composition.
• Pharmaceutically-acceptable carriers must, of course, be of sufficiently high purity and sufficiently low toxicity to render them suitable for administration to the mammal being treated.
• substances which can serve as pharmaceutically- acceptable carriers or components thereof are sugars, such as lactose, glucose and sucrose; starches, such as corn starch and potato starch; cellulose and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose, and methyl cellulose; powdered tragacanth; malt; gelatin; talc; solid lubricants, such as stearic acid and magnesium stearate; calcium sulfate; vegetable oils, such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil and oil of theobroma; polyols such as propylene glycol, glycerine, sorbitol, mannitol, and polyethylene glycol; alginic acid; emulsifiers, such as the Tweens®; wetting agents, such sodium lauryl sulfate; coloring agents; flavoring agents; tableting agents, stabilizers; antioxidants; preservatives; pyrogen-free water
• the preferred unit dosage form is therefore tablets, capsules, lozenges, chewable tablets, and the like.
• Such unit dosage forms comprise a safe and effective amount of the subject compound, which is preferably from about 0.01 mg to about 350 mg, more preferably from about 0.1 mg to about 35 mg, based on a 70 kg person.
• the pharmaceutically-acceptable carrier suitable for the preparation of unit dosage forms for peroral administration are well-known in the art.
• Tablets typically comprise conventional pharmaceutically-compatible adjuvants as inert diluents, such as calcium carbonate, sodium carbonate, mannitol, lactose and cellulose; binders such as starch, gelatin and sucrose; disintegrants such as starch, alginic acid and croscarmelose; lubricants such as magnesium stearate, stearic acid and talc. Glidants such as silicon dioxide can be used to improve flow characteristics of the powder mixture. Coloring agents, such as the FD&C dyes, can be added for appearance. Sweeteners and flavoring agents, such as aspartame, saccharin, menthol, peppermint, and fruit flavors, are useful adjuvants for chewable tablets.
• inert diluents such as calcium carbonate, sodium carbonate, mannitol, lactose and cellulose
• binders such as starch, gelatin and sucrose
• disintegrants such as starch, alginic acid and croscar
• Capsules typically comprise one or more solid diluents disclosed above.
• the selection of carrier components depends on secondary considerations like taste, cost, and shelf stability, which are not critical for the purposes of this invention, and can be readily made by a person skilled in the art.
• Peroral compositions also include liquid solutions, emulsions, suspensions, and the like.
• the pharmaceutically-acceptable carriers suitable for preparation of such compositions are well known in the art.
• Such liquid oral compositions preferably comprise from about 0.001% to about 5% of the subject compound, more preferably from about 0.01% to about 0.5%.
• Typical components of carriers for syrups, elixirs, emulsions and suspensions include ethanol, glycerol, propylene glycol, polyethylene glycol, liquid sucrose, sorbitol and water.
• typical suspending agents include methyl cellulose, sodium carboxymethyl cellulose, Avicel® RC-591 , tragacanth and sodium alginate; typical wetting agents include lecithin and polysorbate 80; and typical preservatives include methyl paraben and sodium benzoate.
• Peroral liquid compositions may also contain one or more components such as sweeteners, flavoring agents and colorants disclosed above.
• compositions useful for attaining systemic delivery of the subject compounds include sublingual and buccal dosage forms.
• Such compositions typically comprise one or more of soluble filler substances such as sucrose, sorbitol and mannitol; and binders such as acacia, microcrystalline cellulose, carboxymethyl cellulose and hydroxypropyl methyl cellulose. Glidants, lubricants, sweeteners, colorants, antioxidants and flavoring agents disclosed above may also be included.
• compositions can also be used to deliver the compound to the site where activity is desired: intranasal doses for nasal decongestion, inhalants for asthma, and eye drops, gels and creams for ocular disorders.
• compositions of this invention include solutions or emulsions, preferably aqueous solutions or emulsions comprising a safe and effective amount of a subject compound intended for topical intranasal administration.
• Such compositions preferably comprise from about 0.001% to about 25% of a subject compound, more preferably from about 0.01% to about 10%.
• Similar compositions are preferred for systemic delivery of subject compounds by the intranasal route.
• Compositions intended to deliver the compound systemically by intranasal dosing preferably comprise similar amounts of a subject compound as are determined to be safe and effective by peroral or parenteral administration.
• compositions used for intranasal dosing also typically include safe and effective amounts of preservatives, such as benzalkonium chloride and thimerosal and the like; chelating agents, such as edetate sodium and others; buffers such as phosphate, citrate and acetate; tonicity agents such as sodium chloride, potassium chloride, glycerin, mannitol and others; antioxidants such as ascorbic acid, acetylcystine, sodium metabisulfate and others; aromatic agents; viscosity adjustors, such as polymers, including cellulose and derivatives thereof, and polyvinyl alcohol and acids and bases to adjust the pH of these aqueous compositions as needed.
• the compositions may also comprise local anesthetics or other actives. These compositions can be used as sprays, mists, drops, and the like.
• compositions of this invention include aqueous solutions, suspensions, and dry powders comprising a safe and effective amount of a subject compound intended for atomization and inhalation administration.
• Such compositions preferably comprise from about 0.1% to about 50% of a subject compound, more preferably from about 1% to about 20%; of course, the amount can be altered to fit the circumstance of the patient contemplated and the package.
• Such compositions are typically contained in a container with attached atomizing means.
• compositions also typically include propellants such as chlorofluorocarbons 12/11 and 12/114, and more environmentally friendly fluorocarbons, or other nontoxic volatiles; solvents such as water, glycerol and ethanol, these include cosolvents as needed to solvate or suspend the active; stabilizers such as ascorbic acid, sodium metabisulfite; preservatives such as cetylpyridinium chloride and benzalkonium chloride; tonicity adjustors such as sodium chloride; buffers; and flavoring agents such as sodium saccharin.
• propellants such as chlorofluorocarbons 12/11 and 12/114, and more environmentally friendly fluorocarbons, or other nontoxic volatiles
• solvents such as water, glycerol and ethanol, these include cosolvents as needed to solvate or suspend the active
• stabilizers such as ascorbic acid, sodium metabisulfite
• preservatives such as cetylpyridinium chloride and benzalkonium chloride
• compositions of this invention include aqueous solutions comprising a safe and effective amount of a subject compound intended for topical intraocular administration.
• Such compositions preferably comprise from about 0.0001% to about 5% of a subject compound, more preferably from about 0.01% to about 0.5%.
• compositions also typically include one or more of preservatives, such as benzalkonium chloride, thimerosal, phenylmercuric acetate; vehicles, such as poloxamers, modified celluloses, povidone and purified water; tonicity adjustors, such as sodium chloride, mannitol and glycerin; buffers such as acetate, citrate, phosphate and borate; antioxidants such as sodium metabisulfite, butylated hydroxy toluene and acetyl cysteine; acids and bases may be used to adjust the pH of these formulations as needed.
• preservatives such as benzalkonium chloride, thimerosal, phenylmercuric acetate
• vehicles such as poloxamers, modified celluloses, povidone and purified water
• tonicity adjustors such as sodium chloride, mannitol and glycerin
• buffers such as acetate, citrate, phosphate and borate
• compositions of this invention useful for peroral administration include solids, such as tablets and capsules, and liquids, such as solutions, suspensions and emulsions (preferably in soft gelatin capsules), comprising a safe and effective amount of a subject compound.
• Such compositions preferably comprise from about 0.01 mg to about 350 mg per dose, more preferably from about 0.1 mg to about 35 mg per dose.
• Such compositions can be coated by conventional methods, typically with pH or time- dependent coatings, such that the subject compound is released in the gastrointestinal tract at various times to extend the desired action.
• Such dosage forms typically include, but are not limited to, one or more of cellulose acetate phthalate, polyvinylacetate phthalate, hydroxypropyl methyl cellulose phthalate, ethyl cellulose, Eudragit® coatings, waxes and shellac.
• compositions of this invention may optionally include other drug actives.
• drug actives include: Antihistamines, including;
• Hydroxyzine preferably at a dosage range of from about 25 to about 400 mg; Doxylamine, preferably at a dosage range of from about 3 to about 75 mg; Pyrilamine, preferably at a dosage range of from about 6.25 to about 200 mg; Chlorpheniramine, preferably at a dosage range of from about 1 to about 24 mg; Phenindamine, preferably at a dosage range of from about 6.25 to about 150 mg; Dexchlorpheniramine, preferably at a dosage range of from about 0.5 to about 12 mg; Dexbrompheniramine, preferably at a dosage range of from about 0.5 to about 12 mg; Clemastine, preferably at a dosage range of from about 1 to about 9 mg; Diphenhydramine, preferably at a dosage range of from about 6.25 to about 300 mg; Azelastine, preferably at a dosage range of from about 140 to about 1 ,680 ⁇ g (when dosed intranasally); 1 to about 8 mg (when dosed orally); Acri
• Codeine preferably at a dosage range of from about 2.5 to about 120 mg; Hydrocodone, preferably at a dosage range of from about 2.5 to about 40 mg; Dextromethorphan, preferably at a dosage range of from about 2.5 to about 120 mg; Noscapine, preferably at a dosage range of from about 3 to about 180 mg; Benzonatate, preferably at a dosage range of from about 100 to about 600 mg; Diphenhydramine, preferably at a dosage range of from about 12.5 to about 150 mg; Chlophedianol, preferably at a dosage range of from about 12.5 to about 100 mg; Clobutinol, preferably at a dosage range of from about 20 to about 240 mg; Fominoben, preferably at a dosage range of from about 80 to about 480 mg; Glaucine; Pholcodine, preferably at a dosage range of from about 1 to about 40 mg; Zipeprol, preferably at a dosage range of from about 75 to about 300 mg; Hydromorphone, preferably at a dosage
• Antiinflammatories preferably Non-Steroidal Anti-inflammatories. (NSAIDS) including;
• Ibuprofen preferably at a dosage range of from about 50 to about 3,200 mg; Naproxen, preferably at a dosage range of from about 62.5 to about 1 ,500 mg; Sodium naproxen, preferably at a dosage range of from about 110 to about 1 ,650 mg; Ketoprofen, preferably at a dosage range of from about 25 to about 300 mg; Indoprofen, preferably at a dosage range of from about 25 to about 200 mg; Indomethacin, preferably at a dosage range of from about 25 to about 200 mg; Sulindac, preferably at a dosage range of from about 75 to about 400 mg; Diflunisal, preferably at a dosage range of from about 125 to about 1 ,500 mg; Ketorolac, preferably at a dosage range of from about 10 to about 120 mg; Piroxicam, preferably at a dosage range of from about 10 to about 40 mg; Aspirin, preferably at a dosage range of from about 80 to about 4,000 mg; Meclofenamate,
• Acetaminophen preferably at a dosage range of from about 80 to about 4,000 mg; and others:
• Guaifenesin preferably at a dosage range of from about 50 to about 2,400 mg; N-Acetylcysteine, preferably at a dosage range of from about 100 to about 600 mg; Ambroxol, preferably at a dosage range of from about 15 to about 120 mg; Bromhexine, preferably at a dosage range of from about 4 to about 64 mg; Terpin hydrate, preferably at a dosage range of from about 100 to about 1 ,200 mg; Potassium iodide, preferably at a dosage range of from about 50 to about 250 mg and others;
• Anticholinergics e.g.. Atropinics
• atropinics preferably intranasally or orally administered anticholinergics.
• Ipratroprium preferably intranasally, preferably at a dosage range of from about 42 to about 252 ⁇ g
• Atropine sulfate preferably oral
• Belladonna preferably as an extract
• Scopolamine preferably at a dosage range of from about 400 to about 3,200 ⁇ g
• Scopolamine methobromide preferably at a dosage range of from about 2.5 to about 20 mg
• Homatropine methobromide preferably at a dosage range of from about 2.5 to about 40 mg
• Hyoscyamine preferably oral), preferably at a dosage range of from about 125 to about 1 ,000 ⁇ g
• Hyoscyamine preferably oral
• Isopropramide preferably oral, preferably at a dosage range of from about 5 to about 20 mg
• Orphenadrine preferably oral, preferably at a dosage range of from about 50 to about 400 mg
• Benzalkonium chloride preferably intranasally preferably a 0.005 to about 0.1% solution and others;
• Mast Cell Stabilizers preferably intranasally, or orally administered mast cell stabilizers, including;
• Cromalyn preferably at a dosage range of from about 10 to about 60 mg;
• Nedocromil preferably at a dosage range of from about 10 to about 60 mg;
• Oxatamide preferably at a dosage range of from about 15 to about 120 mg;
• Ketotifen preferably at a dosage range of from about 1 to about 4 mg;
• Lodoxamide preferably at a dosage range of from about 100 to about 3,000 ⁇ g and others;
• Leukotriene Antagonists including Zileuton and others
• Methylxanthines including;
• Caffeine preferably at a dosage range of from about 65 to about 600 mg;
• Theophylline preferably at a dosage range of from about 25 to about 1 ,200 mg;
• Antioxidants or radical inhibitors including;
• Ascorbic acid preferably at a dosage range of from about 50 to about 10,000 mg; Tocopherol, preferably at a dosage range of from about 50 to about 2,000 mg; Ethanol, preferably at a dosage range of from about 500 to about 10,000 mg and others;
• Steroids preferably intranasally administered steroids, including:
• Beclomethasone preferably at a dosage range of from about 84 to about 336 ⁇ g; Fluticasone, preferably at a dosage range of from about 50 to about 400 ⁇ g;
• Budesonide preferably at a dosage range of from about 64 to about 256 ⁇ g;
• Mometasone preferably at a dosage range of from about 50 to about 300 mg;
• Triamcinolone preferably at a dosage range of from about 110 to about 440 ⁇ g;
• Dexamethasone preferably at a dosage range of from about 168 to about 1 ,008 ⁇ g
• Flunisolide preferably at a dosage range of from about 50 to about 300 ⁇ g
• Prednisone preferably oral
• Hydrocortisone preferably oral
• Bronchodilators preferably for inhalation, including;
• Albuterol preferably at a dosage range of from about 90 to about 1 ,080 ⁇ g; 2 to about 16 mg (if dosed orally); Epinephrine, preferably at a dosage range of from about 220 to about 1 ,320 ⁇ g; Ephedrine, preferably at a dosage range of from about 15 to about 240 mg (if dosed orally); 250 to about 1 ,000 ⁇ g (if dosed intranasally); Metaproterenol, preferably at a dosage range of from about 65 to about 780 ⁇ g or 10 to about 80 mg if dosed orally; Terbutaline, preferably at a dosage range of from about 200 to about 2,400 ⁇ g; 2.5 to about 20 mg (if dosed orally); Isoetharine, preferably at a dosage range of from about 340 to about 1 ,360 ⁇ g; Pirbuterol, preferably at a dosage range of from about 200 to about 2,400 ⁇ g; Bitolterol, preferably at a dosage
• Amantadine preferably at a dosage range of from about 50 to about 200 mg; Rimantadine, preferably at a dosage range of from about 50 to about 200 mg; Enviroxime; Nonoxinols, preferably at a dosage range of from about 2 to about 20 mg (preferably an intranasal form); Acyclovir, preferably at a dosage range of from about 200 to about 2,000 mg (oral); 1 to about 10 mg (preferably an intranasal form); Alpha-lnterferon, preferably at a dosage range of from about 3 to about 36 MIU; Beta-lnterferon, preferably at a dosage range of from about 3 to about 36 MIU and others;
• Ocular Drug actives acetylcholinesterase inhibitors, e.g., echothiophate from about 0.03% to about 0.25% in topical solution and others; and Gastrointestinal actives: antidiarrheals, e.g., loperamide from about 0.1 mg to about 1.0 mg per dose, and bismuth subsalicylate from about 25 mg to about 300 mg per dose and others.
• acetylcholinesterase inhibitors e.g., echothiophate from about 0.03% to about 0.25% in topical solution and others
• Gastrointestinal actives antidiarrheals, e.g., loperamide from about 0.1 mg to about 1.0 mg per dose, and bismuth subsalicylate from about 25 mg to about 300 mg per dose and others.
• alpha-2 agonists provide efficacy is by intervening in the biological cascade responsible for disorder(s) and/or manifestation(s) thereof. It may be that there is no deficit in alpha-2 adrenoceptor activity: such activity may be normal. However, administration of an alpha-2 agonist may be a useful way of rectifying a disorder, condition or manifestation thereof.
• the terms “disease,” “disorder” and “condition” are used interchangeably to refer to maladies related to or modulated by alpha-2 adrenoceptor activity.
• a disorder described by the terms “modulated by alpha-2 adrenoceptors,” or “modulated by alpha-2 adrenoceptor activity” refers to a disorder, condition or disease where alpha-2 adrenoceptor activity is an effective means of alleviating the disorder or one or more of the biological manifestations of the disease or disorder; or interferes with one or more points in the biological cascade either leading to the disorder or responsible for the underlying disorder; or alleviates one or more symptoms of the disorder.
• disorders subject to "modulation” include those for which:
• the lack of alpha-2 activity is a "cause" of the disorder or one or more of the biological manifestations, whether the activity was altered genetically, by infection, by irritation, by internal stimulus or by some other cause;
• the disease or disorder or the observable manifestation or manifestations of the disease or disorder are alleviated by alpha-2 activity.
• the lack of alpha-2 activity need not be causally related to the disease or disorder or the observable manifestations thereof;
• Alpha-2 activity interferes with part of the biochemical or cellular cascade that results in or relates to the disease or disorder.
• the alpha-2 activity alters the cascade, and thus controls the disease, condition or disorder.
• the compounds of this invention are particularly useful for the treatment of nasal congestion associated with allergies, colds, and other nasal disorders, as well as the sequelae of congestion of the mucous membranes (for example, sinusitis and otitis media). At effective doses, it has been found that undesired side effects can be avoided.
• the subject compounds are believed to provide advantages in the treatment of nasal decongestion over related compounds through their ability to interact with alpha- 2 adrenoceptors.
• the subject compounds have been found to be alpha-2 adrenoceptor agonists which cause constriction of peripheral vascular beds in the nasal turbinates.
• Alpha-2 adrenoceptors are distributed both inside and outside of the central nervous system. Thus, though not essential for activity or efficacy, certain disorders preferably are treated with compounds that act on alpha-2 adrenoceptors in only one of these regions.
• Compounds of this invention vary in their ability to penetrate into the central nervous system and, thus, to produce effects mediated through central alpha-2 adrenoceptors. Thus, for example, a compound which displays a higher degree of central nervous system activity is preferred for central nervous system indications over other compounds as described below. However, even for compounds that exhibit primarily peripheral activity, central nervous system actions can be evoked by an increase in the dose of the compound. Further specificity of action of these compounds can be achieved by delivering the agent to the region where activity is desired (for example, topical administration to the eye, nasal mucosa or respiratory tract).
• Compounds preferred for, but not limited to, the treatment of certain cardiovascular disorders, pain, substance abuse and/or withdrawal, ulcer and hyperacidity include those compounds that are centrally acting.
• centrally acting what is meant is that they have some action on the alpha-2 adrenoceptors in the central nervous system in addition to their action at peripheral alpha-2 adrenoceptors.
• peripherally acting what is meant is that these compounds act primarily on alpha-2 adrenoceptors in the periphery, rather than those in the central nervous system. Methods are available in the art to determine which compounds are primarily peripherally acting and which are primarily centrally acting.
• compounds of the subject invention are also useful for the treatment of ocular disorders such as ocular hypertension, glaucoma, hyperemia, conjunctivitis, and uveitis.
• the compounds are administered either perorally, or topically as drops, sprays, mists, gels or creams directly to the surface of the mammalian eye.
• the compounds of this invention are also useful for controlling gastrointestinal disorders, such as diarrhea, irritable bowel syndrome, hyperchlorhydria and peptic ulcer.
• the compounds of this invention are also useful for diseases and disorders associated with sympathetic nervous system activity, including hypertension, myocardial ischemia, cardiac reperfusion injury, angina, cardiac arrhythmia, heart failure and benign prostatic hypertrophy. Due to their sympatholytic effect, compounds are also useful as an adjunct to anesthesia during surgical procedures.
• the compounds of this invention are also useful for relieving pain associated with various disorders.
• the compounds are administered perorally, parenterally, and/or by direct injection into the cerebrospinal fluid.
• the compounds of this invention are also useful for the prophylactic or acute treatment of migraine.
• the compounds are administered perorally, parenterally or intranasally.
• the compounds of this invention are also useful for treatment of substance abuse, in particular abuse of alcohol and opiates, and alleviating the abstinence syndromes evoked by withdrawal of these substances.
• the compounds of this invention are also useful for other diseases and disorders where vasoconstriction, particularly of veins, would provide a benefit, including septic or cardiogenic shock, elevated intracranial pressure, hemmorhoids, venous insufficiency, varicose veins, and menopausal flushing.
• the compounds of this invention are also useful for neurologic diseases and disorders, including spasticity, epilepsy, attention deficit hyperactive disorder, Tourette's syndrome, and cognitive disorders.
• the pharmacological activity and selectivity of these compounds can be determined using published test procedures.
• the alpha-2 selectivity of the compounds is determined by measuring receptor binding affinities and in vitro functional potencies in a variety of tissues known to possess alpha-2 and/or alpha-1 receptors. (See, e.g., The Alpha-2 Adrenergic Receptors. L.E. Limbird, ed., Humana Press, Clifton, NJ.)
• the following in vivo assays are typically conducted in rodents or other species.
• Central nervous system activity is determined by measuring locomotor activity as an index of sedation. (See, e.g., Spyraki, C. & H.
• Antidiarrheal activity is determined by measuring the ability of the compounds to inhibit prostaglandin-induced diarrhea. (See, e.g., Thollander, M., P. Hellstrom & T. Svensson, "Suppression of Castor Oil-Induced Diarrhea by Alpha-2 Adrenoceptor Agonists", Alimentary Pharmacology and Therapeutics. Vol. 5 (1991), pp. 255-262).
• Efficacy in treating irritable bowel syndrome is determined by measuring the ability of compounds to reduce the stress-induced increase in fecal output. (See, e.g., Barone, F., J. Deegan, W. Price, P. Fowler, J. Fondacaro & H. Ormsbee III, "Cold-restraint stress increases rat fecal pellet output and colonic transit", American Journal of Physiology. Vol. 258 (1990), pp. G329-G337). Antiulcer and reduction of hyperchlorhydria efficacy is determined by measuring the reduction in gastric acid secretion produced by these compounds (See, e.g., Tazi-Saad, K., J. Chariot, M.
• Antiasthma activity is determined by measuring the effect of the compound on bronchoconstriction associated with pulmonary challenges such as inhaled antigens. (See, e.g., Chang, J. J. Musser & J.
• Activity in cough is determined by measuring the number and latency of the cough response to respiratory challenges such as inhaled citric acid.
• respiratory challenges such as inhaled citric acid.
• inhaled citric acid See, e.g., Callaway, J. & R. King, "Effects of Inhaled ⁇ 2- Adrenoceptor and GABA ⁇ Receptor Agonists on Citric Acid-Induced Cough and Tidal Volume Changes in Guinea Pigs", European Journal of Pharmacology. Vol. 220 (1992), pp. 187-195.
• the sympatholytic activity of these compounds is determined by measuring the reduction of plasma catecholamines (See, e.g., R. Urban, B. Szabo & K.
• hypotensive effect of these compounds is measure directly as a reduction in mean blood pressure (See, e.g., Timmermans, P. & P. Van Zwieten, "Central and peripheral ⁇ -adrenergic effects of some imidazolidines", European Journal of Pharmacology. Vol. 45 (1977), pp. 229-236).
• Clinical studies have demonstrated the beneficial effect of alpha-2 agonists in the prevention of myocardial ischemia during surgery (See, e.g., Talke, P., J. Li, U. Jain, J. Leung, K. Drasner, M. Hollenberg & D.
• vasoconstrictor activity of these compounds is demonstrated by measuring the contractile properties on isolated arteries and veins in vitro (See, e.g., Flavahan, N., T. Rimele, J. Cooke & M. Vanhoutte, "Characterization of Postjunctional Alpha-1 and Alpha-2 Adrenoceptors Activated by Exogenous or Nerve-Released Norepinephrine in the Canine Saphenous Vein", Journal of Pharmacology and Experimental Therapeutics. Vol. 230 (1984), pp. 699-705).
• the antinociceptive and pain reducing properties of these compounds is demonstrated by measuring the increase in pain threshold in the rodent writhing and hot plate antinociceptive models (See, e.g., Millan, M., K. Bervoets, J. Rivet, R. Widdowson, A. Renouard, S, Le Marouille-Girardon & A. Gobert, "Multiple Alpha-2 Adrenergic Receptor Subtypes. II. Evidence for a Role of Rat Alpha-2A Adrenergic Receptors in the Control of Nociception, Motor Behavior and Hippocampal Synthesis of Noradrenaline", Journal of Pharmacology and Experimental Therapeutics. Vol. 270 (1994), pp. 958-972).
• the antimigraine effect of these compounds is demonstrated by measuring the reduction of dural neurogenic inflammation to trigeminal ganglion stimulation in the rat (See, e.g., Matsubara, T., M. Moskowitz & Z. Huang, "UK-14,304, R(-)-alpha-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms", European Journal of Pharmacology. Vol. 224 (1992), pp. 145- 150).
• the ability of these compounds to suppress opiate withdrawal is demonstrated by measuring the suppression of enhanced sympathetic nerve activity (See, e.g., Franz, D., D. Hare & K.
• alpha-2 agonists in the management of neurologic disorders
• attention-deficit hyperactive disorder and Tourette's syndrome See, e.g., Chappell P., M. Riddle, L. Scahill, K. Lynch, R. Schultz, A. Arnsten, J. Leckman & D. Cohen, "Guanfacine treatment of comorbid attention- deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience", Journal of American Academy of Child and Adolescent Psychiatry. Vol. 34 (1995), pp. 1140-1146), cognitive disorders (See, e.g., Coull, J., "Pharmacological manipulations of the ⁇ 2-noradrenergic system.
• Another aspect of this invention involves methods for preventing or treating nasal congestion by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing nasal congestion.
• nasal congestion may be associated with human diseases or disorders which include, but are not limited to, seasonal allergic rhinitis, acute upper respiratory viral infections, sinusitis, perennial rhinitis, and vasomotor rhinitis.
• other disorders can be generally associated with mucous membrane congestion (for example, otitis media and sinusitis.)
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg.
• the frequency of administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• Such doses and frequencies are also preferred for treating other respiratory conditions, such as, cough, chronic obstructive pulmonary disease (COPD) and asthma.
• COPD chronic obstructive pulmonary disease
• Such doses and frequencies are also preferred for treating conditions that are associated with mucous membrane congestion (for example, sinusitis and otitis media).
• Another aspect of this invention involves methods for preventing or treating glaucoma by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing glaucoma.
• each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg.
• intraocular dosing is used then preferably one administers a typical volume (for example, 1 or 2 drops) of a liquid composition, comprising from about 0.0001% to about 5% of a subject compound, more preferably from about 0.01% to about 0.5% of the compound.
• the frequency of administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• Another aspect of this invention involves methods for preventing or treating gastrointestinal disorders, such as diarrhea, irritable bowel syndrome, and peptic ulcer by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing gastrointestinal disorders.
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg. Peroral administration of such doses is preferred.
• the frequency of administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• Another aspect of this invention involves methods for preventing or treating migraine, by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing migraine.
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg.
• Peroral, parenteral or intranasal administration of such doses is preferred.
• the frequency of peroral administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• the frequency of parenteral dosing of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily or by infusion to the desired effect.
• the frequency of intranasal dosing of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• Another aspect of this invention involves methods for preventing or treating disorders related to sympathetic nervous system activity, such as hypertension, myocardial ischemia, cardiac reperfusion injury, angina, cardiac arrhythmia, and benign prostatic hypertrophy, by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing these diseases or disorders.
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg. Peroral and parenteral administration of such doses are preferred.
• the frequency of peroral administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• the frequency of parenteral dosing of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily or by infusion to the desired effect.
• Another aspect of this invention involves methods for preventing or treating pain, by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing pain.
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg.
• Peroral or parenteral administration of such doses is preferred.
• the frequency of peroral administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• the frequency of parenteral dosing of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily or by infusion to the desired effect.
• Another aspect of this invention involves methods for preventing or treating substance abuse and the abstinence syndrome resulting from withdrawal of these substances, such as alcohol and opiates, by administering a safe and effective amount of a subject compound to a mammal experiencing or at risk of experiencing substance abuse or withdrawal symptoms.
• Each administration of a dose of the subject compound preferably administers a dose within the range of from about 0.0001 mg/kg to about 5 mg/kg of a compound, more preferably from about 0.001 mg/kg to about 0.5 mg/kg. Peroral administration of such doses is preferred.
• the frequency of administration of a subject compound according to this invention is preferably from about once to about six times daily, more preferably from about once to about 4 times daily.
• Example A Oral Tablet Composition Ingredient Amount per tablet (mg)
• One tablet is swallowed by a patient with nasal congestion.
• the congestion is substantially diminished.
• Microcrystalline cellulose (Avicel PH 101 ®) 100.8
• One tablet is chewed and swallowed by a patient with nasal congestion.
• the congestion is substantially reduced.
• Example C Sublingual Tablet Composition Ingredient Amount per tablet (mg)
• Microcrystalline cellulose (Avicel PH 101®) 29.00
• One tablet is placed under the tongue of a patient with nasal congestion and allowed to dissolve. The congestion is rapidly and substantially diminished.
• Example D Intranasal Solution Composition
• Ingredient Composition (% w/v)
• One-tenth of a mL of the composition is sprayed from a pump actuator into each nostril of a patient with nasal congestion.
• the congestion is substantially diminished.
• Other compounds having a structure according to Formula I are used with substantially similar results.
• Example E Intranasal Gel Composition
• Ingredient Composition (% w/v)
• One-fifth of a mL of the composition is applied as drops from a dropper into each nostril of a patient with nasal congestion.
• the congestion is substantially reduced.
• Example F Inhalation Aerosol Composition
• Ingredient Composition (% w/v)
• Two-puffs of the aerosol composition is inhaled from a metered-dose inhaler by a patient with asthma.
• the asthmatic condition is effectively relieved.
• Example G Topical Ophthalmic Composition Ingredient Composition (% w/v)
• One-tenth of a mL of the composition is administered directly into each eye of a patient with glaucoma.
• the intraocular pressure is substantially reduced.
• Oral Liquid Composition Ingredient Amount/15 mL Dose
• One 15 mL dose of the alcohol-free liquid medication is swallowed by a patient with nasal congestion. The congestion is substantially diminished.
• One tablet is swallowed by a patient with migraine.
• the pain and aura of migraine is substantially diminished.
• Example Q Oral Tablet Composition Ingredient Amount per tablet (mg)
• Citric acid, anhydrous, USP 50 Citric acid, anhydrous, USP 50
• Citric acid, anhydrous, USP 50 Citric acid, anhydrous, USP 50
• composition for parenteral administration is made comprising:
• Carrier Sodium citrate buffer with (percent by weight of carrier):
• the above ingredients are mixed, forming a solution. Approximately 2.0 ml of the solution is administered, intravenously, to a human subject suffering from septic or cardiogenic shock. The symptoms subside.
• Example V Oral Tablet Composition Ingredient Amount per tablet (mg)
• combination actives are contemplated.
• medicaments which can be combined with the primary active are included in U.S. Patent No. 4,552,899 to Sunshine, et al., hereby incorporated by reference. All other references referred to throughout this specification are hereby incorporated by reference.

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• 1998
  • 1998-04-04 ID IDW991378A patent/ID24081A/id unknown
  • 1998-04-09 KR KR1019997009530A patent/KR20010006440A/ko not_active Application Discontinuation
  • 1998-04-09 EP EP98910927A patent/EP0975627A1/de not_active Withdrawn
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