HUP0002242A2 - Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok - Google Patents
Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékokInfo
- Publication number
- HUP0002242A2 HUP0002242A2 HU0002242A HUP0002242A HUP0002242A2 HU P0002242 A2 HUP0002242 A2 HU P0002242A2 HU 0002242 A HU0002242 A HU 0002242A HU P0002242 A HUP0002242 A HU P0002242A HU P0002242 A2 HUP0002242 A2 HU P0002242A2
- Authority
- HU
- Hungary
- Prior art keywords
- alpha
- alkyl
- hydrogen
- alkenyl
- imidazolinylamino
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title 1
- JYQSIEABODGLIB-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-3h-benzimidazol-5-amine Chemical class C1=NCCN1NC1=CC=C(N=CN2)C2=C1 JYQSIEABODGLIB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 hydroxy, mercapto Chemical group 0.000 abstract 2
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002889 sympathetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4231697P | 1997-04-15 | 1997-04-15 | |
| PCT/IB1998/000540 WO1998046595A1 (fr) | 1997-04-15 | 1998-04-09 | Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0002242A2 true HUP0002242A2 (hu) | 2001-04-28 |
Family
ID=21921202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002242A HUP0002242A2 (hu) | 1997-04-15 | 1998-04-09 | Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0975627A1 (fr) |
| JP (1) | JP2001519828A (fr) |
| KR (1) | KR20010006440A (fr) |
| CN (1) | CN1256691A (fr) |
| AU (1) | AU6514498A (fr) |
| BR (1) | BR9808904A (fr) |
| CA (1) | CA2285610A1 (fr) |
| HU (1) | HUP0002242A2 (fr) |
| ID (1) | ID24081A (fr) |
| IL (1) | IL132384A0 (fr) |
| NO (1) | NO995030L (fr) |
| WO (1) | WO1998046595A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004270A1 (fr) | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Nouveaux derives de benzimidazole |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| WO1999026942A1 (fr) * | 1997-11-24 | 1999-06-03 | The Procter & Gamble Company | 5-(2-imidazolinylamino)-benzimidazole, derives et procedes de preparation et d'utilisation de ces derniers en tant qu'agonistes du recepteur alpha-adrenergique ayant une meilleure stabilite metabolique |
| US20040167194A1 (en) * | 2003-02-20 | 2004-08-26 | Randall Jared Lynn | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
| US8555875B2 (en) | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| CN110540523B (zh) * | 2018-07-05 | 2021-02-19 | 安徽圣诺贝化学科技有限公司 | 一种制备磺基取代苯并咪唑及其衍生物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| WO1996004270A1 (fr) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Nouveaux derives de benzimidazole |
-
1998
- 1998-04-04 ID IDW991378A patent/ID24081A/id unknown
- 1998-04-09 HU HU0002242A patent/HUP0002242A2/hu unknown
- 1998-04-09 WO PCT/IB1998/000540 patent/WO1998046595A1/fr not_active Application Discontinuation
- 1998-04-09 CN CN98805130A patent/CN1256691A/zh active Pending
- 1998-04-09 AU AU65144/98A patent/AU6514498A/en not_active Abandoned
- 1998-04-09 IL IL13238498A patent/IL132384A0/xx unknown
- 1998-04-09 CA CA002285610A patent/CA2285610A1/fr not_active Abandoned
- 1998-04-09 EP EP98910927A patent/EP0975627A1/fr not_active Withdrawn
- 1998-04-09 KR KR1019997009530A patent/KR20010006440A/ko not_active Application Discontinuation
- 1998-04-09 BR BR9808904-8A patent/BR9808904A/pt not_active IP Right Cessation
- 1998-04-09 JP JP54366398A patent/JP2001519828A/ja active Pending
-
1999
- 1999-10-15 NO NO995030A patent/NO995030L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001519828A (ja) | 2001-10-23 |
| NO995030D0 (no) | 1999-10-15 |
| WO1998046595A1 (fr) | 1998-10-22 |
| BR9808904A (pt) | 2005-02-22 |
| NO995030L (no) | 1999-12-15 |
| IL132384A0 (en) | 2001-03-19 |
| EP0975627A1 (fr) | 2000-02-02 |
| AU6514498A (en) | 1998-11-11 |
| CA2285610A1 (fr) | 1998-10-22 |
| CN1256691A (zh) | 2000-06-14 |
| KR20010006440A (ko) | 2001-01-26 |
| ID24081A (id) | 2000-07-06 |
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