HUP0002242A2 - Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok - Google Patents
Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékokInfo
- Publication number
- HUP0002242A2 HUP0002242A2 HU0002242A HUP0002242A HUP0002242A2 HU P0002242 A2 HUP0002242 A2 HU P0002242A2 HU 0002242 A HU0002242 A HU 0002242A HU P0002242 A HUP0002242 A HU P0002242A HU P0002242 A2 HUP0002242 A2 HU P0002242A2
- Authority
- HU
- Hungary
- Prior art keywords
- alpha
- alkyl
- hydrogen
- alkenyl
- imidazolinylamino
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title 1
- JYQSIEABODGLIB-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-3h-benzimidazol-5-amine Chemical class C1=NCCN1NC1=CC=C(N=CN2)C2=C1 JYQSIEABODGLIB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 hydroxy, mercapto Chemical group 0.000 abstract 2
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002889 sympathetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4231697P | 1997-04-15 | 1997-04-15 | |
| PCT/IB1998/000540 WO1998046595A1 (fr) | 1997-04-15 | 1998-04-09 | Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0002242A2 true HUP0002242A2 (hu) | 2001-04-28 |
Family
ID=21921202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002242A HUP0002242A2 (hu) | 1997-04-15 | 1998-04-09 | Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0975627A1 (fr) |
| JP (1) | JP2001519828A (fr) |
| KR (1) | KR20010006440A (fr) |
| CN (1) | CN1256691A (fr) |
| AU (1) | AU6514498A (fr) |
| BR (1) | BR9808904A (fr) |
| CA (1) | CA2285610A1 (fr) |
| HU (1) | HUP0002242A2 (fr) |
| ID (1) | ID24081A (fr) |
| IL (1) | IL132384A0 (fr) |
| NO (1) | NO995030L (fr) |
| WO (1) | WO1998046595A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU704972B2 (en) | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| JP2001524478A (ja) * | 1997-11-24 | 2001-12-04 | ザ プロクター アンド ギャンブル カンパニー | ５−（２−イミダゾリニルアミノ）−ベンゾイミダゾール誘導体類、それらの調製および改良された代謝安定性を有するアルファアドレナリン受容体作動薬としてのそれらの使用 |
| US20040167194A1 (en) * | 2003-02-20 | 2004-08-26 | Randall Jared Lynn | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
| WO2010074753A1 (fr) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs |
| CN110540523B (zh) * | 2018-07-05 | 2021-02-19 | 安徽圣诺贝化学科技有限公司 | 一种制备磺基取代苯并咪唑及其衍生物的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| AU704972B2 (en) * | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
-
1998
- 1998-04-04 ID IDW991378A patent/ID24081A/id unknown
- 1998-04-09 EP EP98910927A patent/EP0975627A1/fr not_active Withdrawn
- 1998-04-09 IL IL13238498A patent/IL132384A0/xx unknown
- 1998-04-09 JP JP54366398A patent/JP2001519828A/ja active Pending
- 1998-04-09 AU AU65144/98A patent/AU6514498A/en not_active Abandoned
- 1998-04-09 CA CA002285610A patent/CA2285610A1/fr not_active Abandoned
- 1998-04-09 WO PCT/IB1998/000540 patent/WO1998046595A1/fr not_active Application Discontinuation
- 1998-04-09 CN CN98805130A patent/CN1256691A/zh active Pending
- 1998-04-09 BR BR9808904-8A patent/BR9808904A/pt not_active IP Right Cessation
- 1998-04-09 KR KR1019997009530A patent/KR20010006440A/ko not_active Application Discontinuation
- 1998-04-09 HU HU0002242A patent/HUP0002242A2/hu unknown
-
1999
- 1999-10-15 NO NO995030A patent/NO995030L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001519828A (ja) | 2001-10-23 |
| NO995030D0 (no) | 1999-10-15 |
| NO995030L (no) | 1999-12-15 |
| EP0975627A1 (fr) | 2000-02-02 |
| CA2285610A1 (fr) | 1998-10-22 |
| BR9808904A (pt) | 2005-02-22 |
| IL132384A0 (en) | 2001-03-19 |
| ID24081A (id) | 2000-07-06 |
| KR20010006440A (ko) | 2001-01-26 |
| AU6514498A (en) | 1998-11-11 |
| CN1256691A (zh) | 2000-06-14 |
| WO1998046595A1 (fr) | 1998-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0301493A2 (hu) | Indolszármazékok, eljárás előállításukra és alkalmazásuk | |
| PT1251848E (pt) | Inibidores de girase e as sua utilizacoes | |
| HUP0202001A2 (hu) | DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok | |
| DE69327438D1 (de) | Therapeutische Mittel für die Parkinsonsche Krankheit | |
| HUP9904215A2 (hu) | Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-indol-származékok | |
| HUP0402150A2 (hu) | A CB1 jelzésű kannabinoid receptorra nézve agonista, parciális agonista vagy antagonista hatású 1H-imidazol-származékok, eljárás az előállításukra, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására | |
| PL356252A1 (en) | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist | |
| HUP0402352A2 (hu) | Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
| HUP0200804A2 (hu) | 4-H-1-benzopirán-4-on-származékokat tartalmazó gyógyászati készítmények alkalmazása simaizomsejt proliferáció gátlására | |
| HUP0202623A2 (hu) | MEK-gátló vegyületek alkalmazása gyógyászati készítmények előállítására | |
| TR200102237T2 (tr) | N²-fenil amidin türevleri. | |
| NZ507144A (en) | Benzamide derivatives useful for the treatment of diseases mediated by cytokines | |
| HUP9801599A2 (hu) | Alfa1L-agonista imidazolinszármazékok alkalmazása inkontinencia kezelésére szolgáló gyógyszerkészítmények előállítására, új imidazolin-származékok és eljárás ezek előállítására | |
| PE20070829A1 (es) | Inhibidores cetp heterociclicos | |
| EE9700282A (et) | Bensimidasooli ühendid, nimetatud ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine | |
| PE20071034A1 (es) | Compuestos heterociclicos como inhibidores de cetp | |
| HUP0202934A2 (hu) | [(Aril-szulfonil)-amino]-szubsztituált hidroxámsav-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| DE69317439T2 (de) | Azoxycyanbenzol-Derivate | |
| HUP0002242A2 (hu) | Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok | |
| HUP0002966A2 (hu) | Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-benzoxazol-származékok és az ezeket tartalmazó gyógyszerkészítmények | |
| TW200611693A (en) | GPR35 and modulators thereof for the treatment of metabolic-related disorders | |
| HUP0004330A2 (hu) | Szinergetikus fungicid hatóanyag-keverék amidvegyületek és benzimidazolok vagy ezeket leadó elővegyületek alapján és alkalmazása | |
| HUP0203767A2 (hu) | Új indolszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| ATE269851T1 (de) | Benzimidazole derivate | |
| PT982305E (pt) | Novos derivados do indano-1-ol proceso para a sua preparacao e as composicoes farmaceuticas que os contem |