JP2001506269A5 - - Google Patents

Download PDF

Info

Publication number
JP2001506269A5
JP2001506269A5 JP1998528048A JP52804898A JP2001506269A5 JP 2001506269 A5 JP2001506269 A5 JP 2001506269A5 JP 1998528048 A JP1998528048 A JP 1998528048A JP 52804898 A JP52804898 A JP 52804898A JP 2001506269 A5 JP2001506269 A5 JP 2001506269A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998528048A
Other languages
English (en)
Japanese (ja)
Other versions
JP4222632B2 (ja
JP2001506269A (ja
Filing date
Publication date
Priority claimed from IL11985396A external-priority patent/IL119853A0/xx
Priority claimed from IL12051097A external-priority patent/IL120510A0/xx
Application filed filed Critical
Priority claimed from PCT/US1997/024155 external-priority patent/WO1998027055A1/en
Publication of JP2001506269A publication Critical patent/JP2001506269A/ja
Publication of JP2001506269A5 publication Critical patent/JP2001506269A5/ja
Application granted granted Critical
Publication of JP4222632B2 publication Critical patent/JP4222632B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP52804898A 1996-12-18 1997-12-18 アミノインダン誘導体 Expired - Fee Related JP4222632B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL11985396A IL119853A0 (en) 1996-12-18 1996-12-18 Aminoindan derivatives
IL119853 1996-12-18
IL12051097A IL120510A0 (en) 1997-03-24 1997-03-24 Phenylethylamine derivatives
IL120510 1997-03-24
PCT/US1997/024155 WO1998027055A1 (en) 1996-12-18 1997-12-18 Aminoindan derivatives

Publications (3)

Publication Number Publication Date
JP2001506269A JP2001506269A (ja) 2001-05-15
JP2001506269A5 true JP2001506269A5 (enExample) 2006-05-18
JP4222632B2 JP4222632B2 (ja) 2009-02-12

Family

ID=26323338

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52804898A Expired - Fee Related JP4222632B2 (ja) 1996-12-18 1997-12-18 アミノインダン誘導体

Country Status (13)

Country Link
US (4) US6303650B1 (enExample)
EP (2) EP0966435B1 (enExample)
JP (1) JP4222632B2 (enExample)
AT (2) ATE292619T1 (enExample)
AU (1) AU5726898A (enExample)
CA (1) CA2275425C (enExample)
DE (2) DE69732984T2 (enExample)
DK (1) DK0966435T3 (enExample)
ES (1) ES2241064T3 (enExample)
HU (1) HU229507B1 (enExample)
IL (1) IL130528A (enExample)
PT (1) PT966435E (enExample)
WO (1) WO1998027055A1 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69732984T2 (de) 1996-12-18 2006-02-16 Teva Pharmaceutical Industries Ltd. Aminoindanderivate
AU3959099A (en) * 1998-06-03 1999-12-20 Nissan Chemical Industries Ltd. Indan derivatives
EP1242066B1 (en) 1999-10-27 2006-06-28 Teva Pharmaceutical Industries Ltd. Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
CA2477218A1 (en) * 2002-02-27 2003-09-04 Teva Pharmaceutical Industries, Ltd. Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors
EP1565185A4 (en) * 2002-11-07 2011-01-05 Technion Res & Dev Foundation NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
US8097608B2 (en) 2003-11-25 2012-01-17 Technion Research And Development Foundation Ltd. Methods for treatment of cardiovascular disorders and diseases
EP1686973A4 (en) * 2003-11-25 2009-03-25 Technion Res & Dev Foundation COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISEASES
JP2005232148A (ja) * 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd 神経保護剤としてプロパルギルアミンの使用
EP1574498A1 (en) * 2004-02-19 2005-09-14 PPG-Sipsy Process for the synthesis of substituted alpha-aminoindan derivatives
EP1778196A4 (en) * 2004-07-26 2008-12-17 Teva Pharma PHARMACEUTICAL DOSAGES CONTAINING RASAGILINE
WO2006014968A2 (en) * 2004-07-27 2006-02-09 Teva Pharmaceutical Industries, Ltd. Propargyl nitroxydes and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
WO2006029135A1 (en) * 2004-09-08 2006-03-16 Teva Pharmaceutical Usa, Inc Improved process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
CA2596664A1 (en) * 2005-02-17 2006-08-24 Teva Pharmaceutical Industries Ltd. Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
CA2600008A1 (en) 2005-02-22 2006-11-16 Teva Pharmaceutical Industries Ltd. Improved process for the synthesis of enantiomeric indanylamine derivatives
KR20140103356A (ko) 2005-02-23 2014-08-26 테바 파마슈티컬 인더스트리즈 리미티드 함량 균일성이 개선된 라사길린 제형
CA2600603A1 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Formulations of ladostigil tartrate
EP1848689A1 (en) * 2005-02-24 2007-10-31 Teva Pharmaceutical Industries Ltd. Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof
US20060276537A1 (en) * 2005-06-01 2006-12-07 Tamar Goren Use of ladostigil for the treatment of multiple sclerosis
EP1890690A4 (en) * 2005-06-02 2010-06-02 Jenrin Discovery MAO-B INHIBITORS FOR TREATING OBESITY
US7539261B2 (en) * 2005-08-22 2009-05-26 Nec Laboratories America, Inc. Multi-layer coded modulation for non-ergodic block fading channels
WO2007038677A2 (en) * 2005-09-28 2007-04-05 Teva Pharmaceutical Industries Ltd. Methods for preparation of ladostigil tartrate crystalline form a1
WO2007038676A2 (en) * 2005-09-28 2007-04-05 Teva Pharmaceutical Industries Ltd. Polymorphic forms of ladostigil tartrate
US8263655B2 (en) * 2005-10-06 2012-09-11 Technion Research And Development Foundation Ltd Methods for treatment of renal failure
WO2007056403A2 (en) * 2005-11-04 2007-05-18 Teva Pharmaceutical Industries Ltd. Asymmetric hydrogenation of acyl enamides
WO2007056455A2 (en) * 2005-11-07 2007-05-18 Teva Pharmaceutical Industries Ltd. N-protected aminoindanes and methods of their preparation
EP1954667B1 (en) * 2005-11-17 2017-02-08 Teva Pharmaceutical Industries Ltd Methods for isolating propargylated aminoindans
US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
US20070135518A1 (en) * 2005-12-09 2007-06-14 Marta Weinstock-Rosin Use of low-dose ladostigil for neuroprotection
EP1956904B1 (en) * 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
EP1991214B1 (en) 2006-02-21 2015-08-05 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of multiple system atrophy
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
US20070232691A1 (en) * 2006-03-31 2007-10-04 Tamar Goren Use of ladostigil for the treatment of schizophrenia
EP2007369A4 (en) 2006-04-03 2009-07-01 Teva Pharma USE OF RASAGILINE FOR THE TREATMENT OF LEG SYNDROME WITHOUT REST
EP1892233A1 (de) * 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
EA016820B1 (ru) * 2006-12-14 2012-07-30 Тева Фармасьютикал Индастриз, Лтд. Кристаллическое твердое основание разагилина
WO2008076315A1 (en) 2006-12-14 2008-06-26 Teva Pharmaceutical Industries, Ltd. Tannate salt of rasagiline
EP1987816A1 (de) * 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
NZ586025A (en) * 2008-01-11 2012-08-31 Teva Pharma Rasagiline mesylate tablet coated with a composisiton comprising methacrylic acid - ethyl acrylate copolymer and triethyl citrate
ES2389353T3 (es) * 2008-06-10 2012-10-25 Teva Pharmaceutical Industries Ltd. Cápsulas de gelatina blanda de rasagilina
JP2011522892A (ja) * 2008-06-13 2011-08-04 テバ ファーマシューティカル インダストリーズ リミティド パーキンソン病緩和のためのラサギリン
WO2009154777A2 (en) 2008-06-19 2009-12-23 Teva Pharmaceutical Industries, Ltd. Process for preparing and drying solid rasagiline base
CA2727021A1 (en) * 2008-06-19 2009-12-23 Teva Pharmaceutical Industries Ltd. Process for purifying rasagiline base
US8080584B2 (en) * 2009-01-23 2011-12-20 Teva Pharmaceuticals Industries, Ltd. Delayed release rasagiline citrate formulation
RS53504B1 (sr) 2009-07-09 2015-02-27 Ratiopharm Gmbh Soli razagilina i njihovi farmaceutski preparati
RU2734632C2 (ru) 2010-02-03 2020-10-21 Фарма Ту Б Лтд. Составы разагилина с пролонгированным высвобождением и их применение
AU2011282720B2 (en) 2010-07-27 2016-12-22 Teva Pharmaceutical Industries Ltd. Use of rasagiline for the treatment of olfactory dysfunction
AU2011282716A1 (en) 2010-07-27 2013-03-14 Teva Pharmaceutical Industries Ltd. Dispersions of rasagiline citrate
KR20140090996A (ko) 2011-10-10 2014-07-18 테바 파마슈티컬 인더스트리즈 리미티드 R(+)-n-폼일-프로파길-아미노인단
AU2012323351A1 (en) 2011-10-10 2014-05-22 Teva Pharmaceutical Industries Ltd. R(+)-N-methyl-propargyl-aminoindan
EP2811995B1 (en) 2012-02-12 2017-08-09 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Ladostigil therapy for immunomodulation
JP2015529196A (ja) 2012-08-17 2015-10-05 テバ ファーマシューティカル インダストリーズ リミティド ラサギリンの非経口製剤
KR20250149173A (ko) * 2023-03-31 2025-10-15 미쓰이 가가쿠 가부시키가이샤 카바메이트 화합물

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2982783A (en) 1961-05-02 Amevoevdanes
US2916490A (en) 1959-12-08 Ocjhs
US3201470A (en) 1965-08-17 Chsx c cech
US3123642A (en) 1964-03-03 Indanyl and tetrahydronaphthyl
SE371190B (enExample) 1972-03-24 1974-11-11 Kabi Ab
US2573645A (en) 1949-05-25 1951-10-30 Smith Kline French Lab N-hydroxyethyl aminoindanes
GB852735A (en) 1956-04-13 1960-11-02 Schering Ag Manufacture of 1-aminoindanes
US3178478A (en) 1961-02-13 1965-04-13 Ciba Geigy Corp 2-amino-5-halo-indanes
US3060091A (en) 1961-02-13 1962-10-23 Ciba Geigy Corp Analgesic composition consisting of morphines and amino-indanes
US3253037A (en) 1962-06-19 1966-05-24 Ciba Geigy Corp N-2-alkynyl-amino-benzocylo-alkanes
US3709996A (en) 1963-08-02 1973-01-09 Aspro Nicholas Ltd Pharmaceutical compositions containing n-cyclopropyl-1-aminoindane compounds and adapted for administration to obtain inhibition of monoamine oxidase enzyme and process
GB1187017A (en) 1966-07-16 1970-04-08 Aspro Nicholas Ltd Substituted 1-Amino Indanes and Tetrahydronaphthalens
NL6408165A (enExample) 1964-07-17 1966-01-18
US3308157A (en) 1964-08-07 1967-03-07 Colgate Palmolive Co N-(benzocyclobutene-1-loweralkyl)-carboxylic acid amides
US3637740A (en) 1969-04-21 1972-01-25 Pfizer Aminobenzocycloalkane compounds
US3507962A (en) 1969-05-09 1970-04-21 Thompson Chem Co Hayward Controlling leafminer insects with selected carbamate insecticides,including 3,5-dimethyl-4-dimethylamino-methyl phenyl-n-methylcarbamate
US3704323A (en) 1969-12-23 1972-11-28 Squibb & Sons Inc Indane derivatives
NL7011683A (enExample) 1970-08-07 1972-02-09
US3991207A (en) 1971-03-18 1976-11-09 Pfizer Inc. Combination therapy for Parkinson's disease
US3751420A (en) 1971-04-01 1973-08-07 Squibb & Sons Inc Monoolmonoene amines
BE786748A (fr) 1971-07-26 1973-01-26 Basf Ag 1-aminomethyl-indanes-n-substitues
US4029731A (en) 1974-11-06 1977-06-14 Pfizer Inc. Aminophenyltetralin compounds
US4134997A (en) 1977-03-01 1979-01-16 University Of Iowa Research Foundation Effect of an aminotetralin derivative on coronary blood flow in infarcted hearts
US4096173A (en) 1977-03-28 1978-06-20 Eli Lilly And Company Chlorinated 1-aminoindane N-methyl transferase inhibitors
US4128666A (en) 1977-08-18 1978-12-05 Smithkline Corporation 4 AND 5-Halo substituted 2-indanamine compounds
US4132737A (en) 1978-02-27 1979-01-02 Eli Lilly And Company Trifluoromethyl substituted 1-aminoindanes
US5286747A (en) 1981-05-08 1994-02-15 Per A. E. Carlsson 1-alkyl-2-aminotetralin derivatives
SE464194B (sv) 1983-03-04 1991-03-18 Otsuka Pharma Co Ltd Indanderivat, foerfarande foer framstaellning daerav samt farmaceutiska kompositioner
US4529723A (en) 1983-04-29 1985-07-16 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
JPS6169747A (ja) 1984-08-31 1986-04-10 Otsuka Pharmaceut Co Ltd 2,3―ジヒドロ―1h―インデン誘導体及びその製造法
US5242919A (en) 1984-08-31 1993-09-07 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-1H-indene derivatives
US5378729A (en) 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5654301A (en) 1985-02-15 1997-08-05 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
IL74497A (en) 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
US4632939A (en) 1985-03-15 1986-12-30 Eli Lilly And Company Anticonvulsant agents
US4833273A (en) 1986-02-03 1989-05-23 Warner-Lambert Company Process for the resolution of 1-aminoindanes
EP0252290B1 (en) 1986-06-10 1992-06-03 CHIESI FARMACEUTICI S.p.A. Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof
US5153225A (en) 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
HU201906B (en) 1987-03-04 1991-01-28 Sandoz Ag Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
US5011995A (en) 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
US4873241A (en) 1988-10-31 1989-10-10 Fisons Corporation 2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics
US5225596A (en) 1989-01-09 1993-07-06 The Upjohn Company Halo substituted aminotetralins
CA1335106C (en) 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
JP2725378B2 (ja) * 1989-05-29 1998-03-11 武田薬品工業株式会社 カルバミド酸エステル誘導体
IE902294A1 (en) 1989-07-06 1991-01-16 Abbott Lab Alkynyl amines that regulate cholinergic neurotransmission
US5118704A (en) 1989-08-30 1992-06-02 Whitby Research, Inc. Substituted 2-aminotetralins useful as dopaminergics
US5071875A (en) 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2654104B1 (fr) 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
JPH03176457A (ja) 1989-12-04 1991-07-31 Nippon Paint Co Ltd 新規プロパルギル化合物、その製法ならびに該化合物を含む被覆材
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
FR2662162B1 (fr) 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
TW197435B (enExample) 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
IL99759A (en) 1991-10-16 1997-06-10 Teva Pharma Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
DK0664291T3 (da) 1992-10-05 2000-10-30 Ube Industries Pyrimidinforbindelse
US5350762A (en) 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds
GB9315600D0 (en) 1993-07-28 1993-09-08 Smithkline Beecham Plc Compounds
AU7513494A (en) 1993-08-06 1995-02-28 Upjohn Company, The 2-aminoindans as selective dopamine d3 ligands
US5516943A (en) 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
US5401758A (en) 1993-10-07 1995-03-28 Bristol-Myers Squibb Company Pyridinyl cyanoguanidine compounds
IL111240A (en) 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
US5877218A (en) 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
AU1867095A (en) * 1994-01-10 1995-08-01 Technion Research & Development Foundation Ltd. 1-aminoindan derivatives and compositions thereof
FR2717175B1 (fr) 1994-03-11 1996-06-14 Adir Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271679B (it) 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5646188A (en) 1995-07-05 1997-07-08 Teva Pharmaceutical Industries, Ltd. Polyamine derivatives of 1-aminoindan
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
DE69732984T2 (de) 1996-12-18 2006-02-16 Teva Pharmaceutical Industries Ltd. Aminoindanderivate
JP3002155B2 (ja) 1997-06-25 2000-01-24 日本サーボ株式会社 景品懸吊装置
US20040010038A1 (en) 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors

Similar Documents

Publication Publication Date Title
JP2000506027A5 (enExample)
JP2000516112A5 (enExample)
JP2000505328A5 (enExample)
JP2000509608A5 (enExample)
JP2000505564A5 (enExample)
JP2001500665A5 (enExample)
JP2000506275A5 (enExample)
JP2001506453A5 (enExample)
JP2000515856A5 (enExample)
JP2001505165A5 (enExample)
JP2000507909A5 (enExample)
JP2000517347A5 (enExample)
JP2001504172A5 (enExample)
JP2001502299A5 (enExample)
JP2000503249A5 (enExample)
JP2001503038A5 (enExample)
JP2000506917A5 (enExample)
JP2000508592A5 (enExample)
JP2000506959A5 (enExample)
JP2001503879A5 (enExample)
JP2001504470A5 (enExample)
JP2001500754A5 (enExample)
JP2000506624A5 (enExample)
JP2001501612A5 (enExample)
JP2000507547A5 (enExample)