JP2001505782A5 - - Google Patents
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- Publication number
- JP2001505782A5 JP2001505782A5 JP1998526956A JP52695698A JP2001505782A5 JP 2001505782 A5 JP2001505782 A5 JP 2001505782A5 JP 1998526956 A JP1998526956 A JP 1998526956A JP 52695698 A JP52695698 A JP 52695698A JP 2001505782 A5 JP2001505782 A5 JP 2001505782A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Description
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3214596P | 1996-12-09 | 1996-12-09 | |
US60/032,145 | 1996-12-09 | ||
US08/982,272 US7070771B1 (en) | 1996-12-09 | 1997-12-01 | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
US08/982,272 | 1997-12-01 | ||
PCT/US1997/022740 WO1998026061A2 (en) | 1996-12-09 | 1997-12-08 | Expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001505782A JP2001505782A (ja) | 2001-05-08 |
JP2001505782A5 true JP2001505782A5 (ja) | 2005-08-11 |
JP4015201B2 JP4015201B2 (ja) | 2007-11-28 |
Family
ID=26708033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52695698A Expired - Fee Related JP4015201B2 (ja) | 1996-12-09 | 1997-12-08 | 補助分子リガンド遺伝子を含む新規な発現ベクター、ならびに免疫調節のためのならびに悪性腫瘍および自己免疫疾患の処置のためのその用途 |
Country Status (16)
Country | Link |
---|---|
US (3) | US7070771B1 (ja) |
EP (4) | EP0948614B1 (ja) |
JP (1) | JP4015201B2 (ja) |
CN (1) | CN1221662C (ja) |
AT (2) | ATE547524T1 (ja) |
AU (1) | AU5795798A (ja) |
BR (1) | BR9714004A (ja) |
CA (2) | CA2274498C (ja) |
DE (1) | DE69739220D1 (ja) |
DK (1) | DK0948614T3 (ja) |
ES (1) | ES2321246T3 (ja) |
IL (3) | IL130247A0 (ja) |
NO (2) | NO327411B1 (ja) |
NZ (1) | NZ336092A (ja) |
PT (1) | PT948614E (ja) |
WO (1) | WO1998026061A2 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
JP2003508016A (ja) * | 1999-04-16 | 2003-03-04 | エフ.ホフマン−ラ ロシュ アーゲー | Cd40/cd40lキメラポリペプチドをコードする核酸、それらの生成方法及びそれらの使用 |
GB9917180D0 (en) * | 1999-07-23 | 1999-09-22 | Univ Sheffield | Cell surface receptor |
GB0025307D0 (en) * | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
AU2002221780A1 (en) * | 2000-10-31 | 2002-05-15 | F.Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
US7786282B2 (en) * | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
WO2003070271A2 (en) * | 2002-02-25 | 2003-08-28 | Isis Innovation Limted | Novel complexes for inducing an immune response |
US7495090B2 (en) * | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
US20080044393A1 (en) * | 2004-07-16 | 2008-02-21 | White Robert L | Retinal dystrophin transgene and methods of use thereof |
EP2139913A4 (en) * | 2007-03-08 | 2011-09-21 | Mayo Foundation | INDUCTION OF TUMOR CELL DEATH THROUGH IMMUNE |
US20100050276A1 (en) * | 2008-08-22 | 2010-02-25 | Brown University | Transgenic non-human animal models of apoptosis-mediated conditions |
EP2788021B1 (en) | 2011-12-09 | 2017-01-18 | Bavarian Nordic A/S | Poxvirus vector for the expression of bacterial antigens linked to tetanus toxin fragment c |
RS58122B1 (sr) * | 2012-10-17 | 2019-02-28 | Vascular Biogenics Ltd | Adenovirus koji eksprimira fas-himer i njegova upotreba u postupcima lečenja kancera |
WO2015148879A1 (en) * | 2014-03-27 | 2015-10-01 | The Regents Of The University Of Michigan | Cancer immunotherapy compositions and methods |
AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
CN105567679B (zh) * | 2014-10-10 | 2019-07-05 | 深圳市北科生物科技有限公司 | 可分泌型trail蛋白构建物和表达载体 |
WO2017079297A1 (en) | 2015-11-02 | 2017-05-11 | Memgen Llc | Methods for treatment of cancer |
US11298420B2 (en) | 2016-12-21 | 2022-04-12 | Memgen, Llc | Armed oncolytic viruses |
CN117384929A (zh) | 2017-03-27 | 2024-01-12 | 新加坡国立大学 | 一种编码由细胞表达的嵌合受体的多核苷酸 |
CN113766956B (zh) | 2019-03-05 | 2024-05-07 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
CN112725379B (zh) * | 2021-01-27 | 2024-08-13 | 上海南方模式生物科技股份有限公司 | 人源化cd40基因改造动物模型的构建方法及应用 |
US11585330B1 (en) * | 2021-09-29 | 2023-02-21 | Halliburton Energy Services, Inc. | Flow control for geothermal well |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3750056T2 (de) | 1986-06-20 | 1995-04-06 | Dainippon Pharmaceutical Co | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. |
EP0317641B1 (en) | 1987-05-29 | 1993-03-17 | Sagami Chemical Research Center | Fused protein containing lymphotoxin |
JP2930713B2 (ja) | 1989-08-16 | 1999-08-03 | カイロン コーポレイション | タンパク質ホルモン形成の抑制用の組成物およびその使用法 |
US5519119A (en) | 1990-09-21 | 1996-05-21 | Ishihara Sangyo Kaisha Ltd. | Muteins of TNF pharmaceutical compositions and a method of making |
CA2055168A1 (en) | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
DK0667901T4 (da) | 1991-10-25 | 2008-11-10 | Immunex Corp | Hidtil ukendt cytokin |
EP0670730B1 (en) | 1992-03-30 | 2003-06-04 | Immunex Corporation | Fusion protein comprising two tumor necrosis factor receptors |
SK376492A3 (en) | 1992-04-02 | 1995-06-07 | Hoffmann La Roche | Tnf - muteins and method of their production |
DK0615451T3 (da) | 1992-05-26 | 2006-04-24 | Immunex Corp | Hidtil ukendt cytokin der binder til CD30 |
AU5098493A (en) | 1992-08-21 | 1994-03-15 | Schering Corporation | Cd40 ligand, anti cd40 antibodies, and soluble cd40 |
JPH07508179A (ja) | 1992-08-21 | 1995-09-14 | シェリング・コーポレーション | ヒトインターロイキン−13 |
US5540926A (en) | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
US5573924A (en) | 1992-09-08 | 1996-11-12 | Immunex Corporation | CD27 ligand |
US5565321A (en) | 1993-01-22 | 1996-10-15 | Immunex Corporation | Detection of mutations in a CD40 ligand gene |
ES2211876T3 (es) | 1993-01-22 | 2004-07-16 | Immunex Corporation | Deteccion y tratamiento de mutaciones en un gel del ligando de cd40. |
US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
US5861310A (en) * | 1993-11-03 | 1999-01-19 | Dana-Farber Cancer Institute | Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor |
JPH08127594A (ja) | 1993-11-10 | 1996-05-21 | Mochida Pharmaceut Co Ltd | Fas抗原に結合する新規蛋白質およびそれをコードするDNA |
AU1059095A (en) * | 1993-11-24 | 1995-06-13 | Australian National University, The | Treatment of viral disease with cd40l peptide |
PT751781E (pt) | 1993-12-23 | 2004-09-30 | Nat Inst Of Health As Repr By | Utilizacao de anticorpos monoclonais ou ligandos oligomericos soluveis no fabrico de um medicamento para a prevencao ou tratamento de desordens neoplasicas |
EP0739350B1 (en) | 1994-01-07 | 2008-02-27 | Mochida Pharmaceutical Co., Ltd. | Ligand that binds fas antigen |
DK0763057T3 (da) | 1994-04-28 | 2006-03-27 | Boehringer Ingelheim Pharma | Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf |
US5606023A (en) | 1994-05-24 | 1997-02-25 | Thomas Jefferson University | Mutant tumor necrosis factor proteins |
US5759536A (en) | 1994-05-27 | 1998-06-02 | University Technology Corporation | Use of fas ligand to supress T-lymphocyte-mediated immune responses |
BR9508419A (pt) | 1994-07-22 | 1997-11-18 | Hoffmann La Roche | Composições farmacêuticas compreendendo uma proteina de ligação de tnf quinerica |
GB9425060D0 (en) | 1994-12-13 | 1995-02-08 | Univ Birmingham | Carcinoma treatment |
US5888764A (en) * | 1995-01-20 | 1999-03-30 | Uab Research Foundation | Human fas gene promoter region |
US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
US6016832A (en) * | 1997-04-16 | 2000-01-25 | Woodward Governor Company | Valve for controlling gas mass flow |
JP4162849B2 (ja) | 1997-09-17 | 2008-10-08 | 持田製薬株式会社 | 新規Fasリガンド誘導体 |
US7786282B2 (en) * | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
US7495090B2 (en) * | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
-
1997
- 1997-12-01 US US08/982,272 patent/US7070771B1/en not_active Expired - Fee Related
- 1997-12-08 AT AT09164341T patent/ATE547524T1/de active
- 1997-12-08 EP EP97954089A patent/EP0948614B1/en not_active Expired - Lifetime
- 1997-12-08 EP EP06125424A patent/EP1806360A3/en not_active Ceased
- 1997-12-08 EP EP09164341A patent/EP2145958B1/en not_active Expired - Lifetime
- 1997-12-08 IL IL13024797A patent/IL130247A0/xx active IP Right Grant
- 1997-12-08 AU AU57957/98A patent/AU5795798A/en not_active Abandoned
- 1997-12-08 BR BR9714004-0A patent/BR9714004A/pt not_active IP Right Cessation
- 1997-12-08 DE DE69739220T patent/DE69739220D1/de not_active Expired - Lifetime
- 1997-12-08 DK DK97954089T patent/DK0948614T3/da active
- 1997-12-08 JP JP52695698A patent/JP4015201B2/ja not_active Expired - Fee Related
- 1997-12-08 NZ NZ336092A patent/NZ336092A/en not_active IP Right Cessation
- 1997-12-08 CA CA2274498A patent/CA2274498C/en not_active Expired - Fee Related
- 1997-12-08 EP EP10184082A patent/EP2287309A1/en not_active Withdrawn
- 1997-12-08 WO PCT/US1997/022740 patent/WO1998026061A2/en active Application Filing
- 1997-12-08 CN CNB971816743A patent/CN1221662C/zh not_active Expired - Fee Related
- 1997-12-08 AT AT97954089T patent/ATE420956T1/de not_active IP Right Cessation
- 1997-12-08 CA CA2707726A patent/CA2707726C/en not_active Expired - Fee Related
- 1997-12-08 ES ES97954089T patent/ES2321246T3/es not_active Expired - Lifetime
- 1997-12-08 PT PT97954089T patent/PT948614E/pt unknown
-
1999
- 1999-06-02 IL IL130247A patent/IL130247A/en not_active IP Right Cessation
- 1999-06-07 NO NO19992756A patent/NO327411B1/no not_active IP Right Cessation
-
2004
- 2004-12-17 US US11/015,117 patent/US7524944B2/en not_active Expired - Fee Related
-
2006
- 2006-09-26 IL IL178306A patent/IL178306A0/en not_active IP Right Cessation
-
2007
- 2007-09-27 NO NO20074906A patent/NO331434B1/no not_active IP Right Cessation
-
2009
- 2009-02-13 US US12/371,188 patent/US7906638B2/en not_active Expired - Fee Related