JP2000501744A5 - - Google Patents
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- Publication number
- JP2000501744A5 JP2000501744A5 JP1997526303A JP52630397A JP2000501744A5 JP 2000501744 A5 JP2000501744 A5 JP 2000501744A5 JP 1997526303 A JP1997526303 A JP 1997526303A JP 52630397 A JP52630397 A JP 52630397A JP 2000501744 A5 JP2000501744 A5 JP 2000501744A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Description
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58955296A | 1996-01-22 | 1996-01-22 | |
US08/589,552 | 1996-01-22 | ||
PCT/US1997/001071 WO1997026277A2 (en) | 1996-01-22 | 1997-01-22 | Morphogen analogs and methods for producing them |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000501744A JP2000501744A (ja) | 2000-02-15 |
JP2000501744A5 true JP2000501744A5 (ja) | 2004-11-11 |
Family
ID=24358486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9526303A Ceased JP2000501744A (ja) | 1996-01-22 | 1997-01-22 | モルホゲン類似体およびその製法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US6273598B1 (ja) |
EP (1) | EP0876401B1 (ja) |
JP (1) | JP2000501744A (ja) |
AT (1) | ATE364629T1 (ja) |
AU (1) | AU725295B2 (ja) |
CA (1) | CA2244228A1 (ja) |
DE (1) | DE69737809T2 (ja) |
WO (1) | WO1997026277A2 (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
US20020168761A1 (en) * | 2000-01-24 | 2002-11-14 | Gour Barbara J. | Peptidomimetic modulators of cell adhesion |
US7122623B2 (en) | 1996-07-12 | 2006-10-17 | Adherex Technologies, Inc. | Compounds and methods for modulating cell adhesion |
US20040006011A1 (en) * | 1996-07-12 | 2004-01-08 | Gour Barbara J. | Peptidomimetic modulators of cell adhesion |
US5922558A (en) * | 1997-09-12 | 1999-07-13 | Lumigen, Inc. | Methods and compositions for generating chemiluminescence with a peroxidase |
DE19831758A1 (de) * | 1998-07-15 | 2000-02-03 | Jerini Bio Tools Gmbh | Ligandenbestimmung für Proteine |
US7629309B2 (en) * | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
ATE384736T1 (de) * | 2001-04-30 | 2008-02-15 | Zystor Therapeutics Inc | Subzelluläres targeting von therapeutischen proteinen |
US20030072761A1 (en) * | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
CA2472472A1 (en) * | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
EP2801616A1 (en) * | 2002-06-17 | 2014-11-12 | Thrasos Innovation, Inc. | Single domain TDF-related compounds and analogs thereof |
AU2002950183A0 (en) * | 2002-07-12 | 2002-09-12 | The Council Of The Queensland Institute Of Medical Research | Expression of hydrophobic proteins |
US20040093164A1 (en) * | 2002-11-08 | 2004-05-13 | Carlson William D. | Computer system and methods for producing morphogen analogs of human TDF-1 |
EP1593060A2 (en) * | 2003-01-21 | 2005-11-09 | The Trustees Of The University Of Pennsylvania | Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel kcsa |
US20040204862A1 (en) * | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
US20050009877A1 (en) * | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
CN1922313B (zh) * | 2004-02-10 | 2011-10-26 | 生物马林医药公司 | 酸性α-糖苷酶及其片段 |
AU2005230854A1 (en) * | 2004-03-31 | 2005-10-20 | Xencor, Inc | BMP-7 variants with improved properties |
CA2571218C (en) * | 2004-06-17 | 2015-11-03 | William D. Carlson | Tdf-related compounds and analogs thereof |
AU2012201060B2 (en) * | 2005-09-20 | 2015-01-22 | Thrasos Innovation, Inc. | TDF-related compounds and analogs thereof |
HUE026634T2 (en) | 2005-09-20 | 2016-07-28 | Thrasos Innovation Inc | TDF-related compounds and analogues thereof |
EP1978994B1 (en) * | 2005-12-22 | 2012-02-01 | Janssen Biotech, Inc. | Bmp-7 variant compositions, methods and uses |
US7659250B2 (en) * | 2005-12-22 | 2010-02-09 | Centocor, Inc. | BMP-7 variant compositions, methods and uses |
JP2010509344A (ja) * | 2006-11-13 | 2010-03-25 | ザイストール セラピューティクス, インコーポレイテッド | ポンペ病を治療するための方法 |
ES2474194T3 (es) | 2008-02-13 | 2014-07-08 | Keith Hruska | PMO-7 para su uso en el tratamiento de la hiperplasia de la neo�ntima |
US20090291967A1 (en) * | 2008-03-05 | 2009-11-26 | Adherex Technologies, Inc. | Small molecule modulators of cell adhesion |
ES2629853T3 (es) | 2008-05-07 | 2017-08-16 | Biomarin Pharmaceutical Inc. | Péptidos de dirección lisosómica y usos de los mismos |
EP3075386B1 (en) | 2009-06-17 | 2019-10-16 | BioMarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
US9721070B2 (en) | 2013-12-19 | 2017-08-01 | Chevron Phillips Chemical Company Lp | Selective oligomerization catalysts and methods of identifying same |
WO2017032853A2 (en) * | 2015-08-25 | 2017-03-02 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4908773A (en) | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
ATE231523T1 (de) | 1988-04-08 | 2003-02-15 | Stryker Corp | Osteogene vorrichtungen |
US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
US5061786A (en) | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
US5118791A (en) | 1989-05-25 | 1992-06-02 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
GB8914122D0 (en) * | 1989-06-20 | 1989-08-09 | Wellcome Found | Polypeptide expression |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5688678A (en) * | 1990-05-16 | 1997-11-18 | Genetics Institute, Inc. | DNA encoding and methods for producing BMP-8 proteins |
WO1992001933A1 (en) | 1990-07-20 | 1992-02-06 | E.I. Du Pont De Nemours And Company | Generation of a complete set of structural coordinates of a molecule from a set of partial coordinates |
EP0551440B1 (en) | 1990-09-14 | 2002-12-18 | The Trustees Of The University Of Pennsylvania | Design of bioactive peptides based on immunoglobulin structure |
JPH07500487A (ja) * | 1990-10-18 | 1995-01-19 | ストライカー コーポレイション | 骨形成ペプチド |
US5824647A (en) * | 1990-12-12 | 1998-10-20 | Postlethwaite; Arnold E. | Chemotactic wound healing peptides |
US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
JPH06508623A (ja) * | 1991-06-19 | 1994-09-29 | エス・アール・アイ・インターナシヨナル | 抗ウィルス剤としてのインフルエンザウィルスのm−蛋白質ペプチド |
AU3320193A (en) | 1991-07-22 | 1993-02-23 | Regents Of The University Of California, The | Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex |
JPH05262788A (ja) | 1991-09-03 | 1993-10-12 | Hitachi Chem Co Ltd | ペプチド類、その設計方法及び製造方法並びに受容体上の生理活性ペプチドの結合部位の決定方法 |
US5353236A (en) | 1992-04-23 | 1994-10-04 | The Board Of Trustees Of The Leland Stanford University | High-resolution crystallographic modelling of a macromolecule |
US5322933A (en) | 1992-05-07 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Crystal structure of TGF-β-2 |
CA2141600A1 (en) * | 1992-08-03 | 1994-02-17 | Richard U. Margolis | Cloning, expression and uses for neurocan as a chondroitin sulfate proteoglycan |
JP3645258B2 (ja) * | 1993-01-12 | 2005-05-11 | ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−5 |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
WO1994018236A1 (en) | 1993-02-03 | 1994-08-18 | Amrad Corporation Limited | Receptor-binding determinant from leukaemia inhibitory factor |
US5453937A (en) | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
US5637480A (en) * | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
EP0788370A4 (en) | 1993-07-09 | 1998-07-08 | Smithkline Beecham Corp | CYCLIC, PARTIAL RANDOM PEPTIDE LIBRARIES |
GB9317120D0 (en) | 1993-08-17 | 1993-09-29 | Royal Postgrad Med School | Human serum amyloid p component |
US5856122A (en) | 1993-08-24 | 1999-01-05 | University Of Alberta | Modification of pertussis toxin |
US5652334A (en) | 1993-09-08 | 1997-07-29 | City Of Hope | Method for design of substances that enhance memory and improve the quality of life |
US5565352A (en) * | 1993-11-24 | 1996-10-15 | Arch Development Corporation | Deubiquitinating enzyme: compositions and methods |
WO1995014791A1 (en) | 1993-11-26 | 1995-06-01 | Hendry Lawrence B | Design of drugs involving receptor-ligand-dna interactions |
US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
US5932716A (en) * | 1995-07-26 | 1999-08-03 | Creative Biomolecules, Inc. | Morphogen-responsive regulatory elements |
US6677432B1 (en) * | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
JP3786533B2 (ja) * | 1998-11-12 | 2006-06-14 | 善彦 西村 | ペプチド及び骨形成促進剤 |
DE60033576T2 (de) * | 2000-11-06 | 2007-10-31 | Thrasos, Inc., Waltham | Methoden zum screening knochenmorphogenetishemimetika |
-
1997
- 1997-01-22 AU AU22449/97A patent/AU725295B2/en not_active Ceased
- 1997-01-22 EP EP97905604A patent/EP0876401B1/en not_active Expired - Lifetime
- 1997-01-22 US US08/786,284 patent/US6273598B1/en not_active Expired - Lifetime
- 1997-01-22 DE DE69737809T patent/DE69737809T2/de not_active Expired - Lifetime
- 1997-01-22 AT AT97905604T patent/ATE364629T1/de not_active IP Right Cessation
- 1997-01-22 WO PCT/US1997/001071 patent/WO1997026277A2/en active IP Right Grant
- 1997-01-22 JP JP9526303A patent/JP2000501744A/ja not_active Ceased
- 1997-01-22 CA CA002244228A patent/CA2244228A1/en not_active Abandoned
-
2001
- 2001-02-22 US US09/791,946 patent/US20020028453A1/en not_active Abandoned