AU3320193A - Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex - Google Patents

Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex

Info

Publication number
AU3320193A
AU3320193A AU33201/93A AU3320193A AU3320193A AU 3320193 A AU3320193 A AU 3320193A AU 33201/93 A AU33201/93 A AU 33201/93A AU 3320193 A AU3320193 A AU 3320193A AU 3320193 A AU3320193 A AU 3320193A
Authority
AU
Australia
Prior art keywords
affector
affectors
enzyme
complex
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU33201/93A
Inventor
Daniel R Knighton
Janusz M Sowadski
Susan S Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of AU3320193A publication Critical patent/AU3320193A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU33201/93A 1991-07-22 1992-07-22 Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex Abandoned AU3320193A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73561491A 1991-07-22 1991-07-22
US735614 1991-07-22

Publications (1)

Publication Number Publication Date
AU3320193A true AU3320193A (en) 1993-02-23

Family

ID=24956509

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33201/93A Abandoned AU3320193A (en) 1991-07-22 1992-07-22 Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex

Country Status (2)

Country Link
AU (1) AU3320193A (en)
WO (1) WO1993002209A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420127B1 (en) 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
US6872542B1 (en) 1993-11-18 2005-03-29 Siga Pharmaceuticals, Inc. Treatment or prophylaxis of diseases caused by pilus-forming bacteria
ATE271060T1 (en) * 1993-11-18 2004-07-15 Univ Washington COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTIONS
CA2244228A1 (en) 1996-01-22 1997-07-24 Creative Biomolecules, Inc. Morphogen analogs and methods for producing them
US6162613A (en) * 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
US7383135B1 (en) 1998-05-04 2008-06-03 Vertex Pharmaceuticals Incorporated Methods of designing inhibitors for JNK kinases
WO2001055443A1 (en) * 2000-01-31 2001-08-02 Pharmacia & Upjohn Company Crystallization and structure determination of staphylococcus aureus nad synthetase
CA2409672A1 (en) * 2000-05-10 2001-11-15 Glycodesign Inc. Designing modulators for glycosyltransferases
US7390808B2 (en) 2001-04-30 2008-06-24 Vertex Pharmaceuticals Incorporated Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
DE3827974A1 (en) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh COMBINATION PREPARATIONS OF PROTEINKINASE-C INHIBITORS WITH LIPIDS, LIPID ANALOGS, CYTOSTATICA OR INHIBITORS OF PHOSPHOLIPASES

Also Published As

Publication number Publication date
WO1993002209A1 (en) 1993-02-04

Similar Documents

Publication Publication Date Title
AU3011292A (en) Horizontal well completion methods
AU4243993A (en) New process for producing 7beta-substituted-4-aza-5alpha-androstan-3-ones
AU2358692A (en) Heat shrinkable foamed molding and process for producing same
AU597589B2 (en) Amorphous aluminosilicate and process for producing the same
AU2351492A (en) Process for the preparation of middle distillates
AU2619092A (en) Wax conversion process
AU601640B2 (en) Oxetanocin-related compounds and process for producing same
AU3320193A (en) Methods of designing specific affectors using three-dimensional conformation of enzyme/affector complex
AU8462191A (en) Process for producing stable latex
AU3146093A (en) Process for preparing thermalplastic foam
AU8799491A (en) Process for the preparation of diethers
AU8604291A (en) Process for the preparation of carebastine
AU6771890A (en) Process for the preparation of vinyl acetate
AU633102B2 (en) Process for the preparation of vinyl acetate
AU8601791A (en) Dewaxing process
EP0614853A3 (en) Method of producing zeolite beta.
AU3391993A (en) Zeolite LZ-277 and process for preparing same
AU4062189A (en) Process for forming and using microdroplets
AU1501592A (en) Process for the preparation of hydrocarbons
AU5151093A (en) Process for the preparation of alkylglycosides
AU2933792A (en) Process for producing saccharide
AU4434593A (en) Process for the preparation of imidazopyridines
AU1347392A (en) Dna -or rna- modifying enzymes immobilized to supports
GB2275266B (en) Process of preparing 2-methyl-3-aminobenzotrifluoride
AU3809689A (en) Taps