|
DE19819023A1
(de)
*
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
US6974838B2
(en)
|
1998-08-24 |
2005-12-13 |
Sepracor Inc. |
Methods of treating or preventing pain using sibutramine metabolites
|
|
US6331571B1
(en)
|
1998-08-24 |
2001-12-18 |
Sepracor, Inc. |
Methods of treating and preventing attention deficit disorders
|
|
US6476078B2
(en)
|
1999-08-11 |
2002-11-05 |
Sepracor, Inc. |
Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
|
|
US6339106B1
(en)
|
1999-08-11 |
2002-01-15 |
Sepracor, Inc. |
Methods and compositions for the treatment and prevention of sexual dysfunction
|
|
EP1167367A4
(en)
|
1999-03-30 |
2002-04-24 |
Nippon Soda Co |
THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
|
|
US6399826B1
(en)
|
1999-08-11 |
2002-06-04 |
Sepracor Inc. |
Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
|
|
DE19950647A1
(de)
*
|
1999-10-21 |
2001-04-26 |
Merck Patent Gmbh |
Imidazolderivate als Phosphodiesterase VII-Hemmer
|
|
DE10031585A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
|
AU2001290311A1
(en)
*
|
2000-09-29 |
2002-04-08 |
Nippon Soda Co., Ltd. |
Thienopyrimidine compounds and their salts and process for preparation of both
|
|
WO2002062343A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Merck Patent Gmbh |
PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS
|
|
US6610887B2
(en)
|
2001-04-13 |
2003-08-26 |
Sepracor Inc. |
Methods of preparing didesmethylsibutramine and other sibutramine derivatives
|
|
CN101100472A
(zh)
*
|
2001-04-30 |
2008-01-09 |
美国拜尔公司 |
4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
|
|
CN1261437C
(zh)
*
|
2001-09-04 |
2006-06-28 |
阿克佐诺贝尔公司 |
具有LH与FSH联合激动活性的甘氨酸-取代的噻吩并[2,3-d]嘧啶
|
|
WO2003035653A1
(en)
*
|
2001-10-26 |
2003-05-01 |
Nippon Soda Co.,Ltd. |
Pyridothienopyrimidine compound and salt thereof
|
|
US7153412B2
(en)
|
2001-12-28 |
2006-12-26 |
Kabushiki Kaisha Toyota Chuo Kenkyusho |
Electrodes, electrochemical elements, gas sensors, and gas measurement methods
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
AR044743A1
(es)
*
|
2002-09-26 |
2005-10-05 |
Nihon Nohyaku Co Ltd |
Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
|
|
GB0320300D0
(en)
*
|
2003-08-29 |
2003-10-01 |
Cancer Rec Tech Ltd |
Pyrimidothiophene compounds
|
|
DE10351436A1
(de)
*
|
2003-11-04 |
2005-06-09 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
|
GB0420719D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
GB0420722D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
TWI417095B
(zh)
*
|
2006-03-15 |
2013-12-01 |
Janssen Pharmaceuticals Inc |
1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
|
|
TW200845978A
(en)
*
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
|
TW200900065A
(en)
*
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
|
US9603848B2
(en)
|
2007-06-08 |
2017-03-28 |
Senomyx, Inc. |
Modulation of chemosensory receptors and ligands associated therewith
|
|
TWI445532B
(zh)
|
2007-09-14 |
2014-07-21 |
Janssen Pharmaceuticals Inc |
1’,3’-二取代-4-苯基-3,4,5,6-四氫-2h,1’h-〔1,4’〕聯吡啶基-2’-酮化物
|
|
AU2008297877C1
(en)
*
|
2007-09-14 |
2013-11-07 |
Addex Pharma S.A. |
1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
|
|
CN101848893B
(zh)
|
2007-09-14 |
2012-06-06 |
奥梅-杨森制药有限公司 |
1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮
|
|
CA2704436C
(en)
*
|
2007-11-14 |
2016-01-05 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
US20100227853A1
(en)
*
|
2008-04-18 |
2010-09-09 |
Trustees Of Boston College |
Inhibitors of cyclic amp phosphodiesterases
|
|
KR101523126B1
(ko)
|
2008-07-31 |
2015-05-26 |
세노믹스, 인코포레이티드 |
단맛 향상제의 제조 방법 및 중간체
|
|
ES2439291T3
(es)
|
2008-09-02 |
2014-01-22 |
Janssen Pharmaceuticals, Inc. |
Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
|
|
CN102186477B
(zh)
|
2008-10-16 |
2013-07-17 |
奥梅-杨森制药有限公司 |
作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
|
|
CA2744138C
(en)
|
2008-11-28 |
2015-08-11 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
|
SI2430022T1
(sl)
|
2009-05-12 |
2014-04-30 |
Janssen Pharmaceuticals, Inc. |
1,2,3-triazolo(4,3-a)piridin derivati in njihova uporaba za zdravljenje ali prepreäśevanje nevroloĺ kih in psihiatriäśnih nepravilnosti
|
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
BRPI1010831A2
(pt)
|
2009-05-12 |
2016-04-05 |
Addex Pharmaceuticals Sa |
derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
|
|
WO2012062751A1
(en)
|
2010-11-08 |
2012-05-18 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
|
ES2552455T3
(es)
|
2010-11-08 |
2015-11-30 |
Janssen Pharmaceuticals, Inc. |
Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
|
|
WO2012062759A1
(en)
|
2010-11-08 |
2012-05-18 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
|
HK1198475A1
(en)
|
2011-07-19 |
2015-05-08 |
无限药品股份有限公司 |
Heterocyclic compounds and uses thereof
|
|
WO2013106547A1
(en)
|
2012-01-10 |
2013-07-18 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
KR20150041040A
(ko)
|
2012-08-06 |
2015-04-15 |
세노믹스, 인코포레이티드 |
단맛 향미 개질제
|
|
JO3155B1
(ar)
|
2013-02-19 |
2017-09-20 |
Senomyx Inc |
معدِّل نكهة حلوة
|
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
|
KR20220051273A
(ko)
|
2014-01-21 |
2022-04-26 |
얀센 파마슈티카 엔.브이. |
대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
|
|
IL279202B2
(en)
|
2014-01-21 |
2023-09-01 |
Janssen Pharmaceutica Nv |
Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
|
|
US10300042B2
(en)
|
2014-06-23 |
2019-05-28 |
Celgene Corporation |
Apremilast for the treatment of a liver disease or a liver function abnormality
|
|
CN109311868B
(zh)
|
2015-12-22 |
2022-04-01 |
尚医治疗有限责任公司 |
用于治疗癌症和炎性疾病的化合物
|
|
BR112019027640A2
(pt)
|
2017-06-21 |
2020-07-07 |
SHY Therapeutics LLC |
composto, método para testar a capacidade de um ou mais compostos, método para inibir a função de ras, método para inibir a função de rho, método para inibir a função de rac, composição farmacêutica
|
|
BR112021002261A2
(pt)
|
2018-08-07 |
2021-05-04 |
Firmenich Incorporated |
2,2-dióxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-substituídos e formulações e usos dos mesmos
|
|
US12391705B2
(en)
|
2018-12-19 |
2025-08-19 |
Shy Therapeutics, Llc |
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
CN116178374B
(zh)
*
|
2023-01-13 |
2024-10-08 |
河北医科大学 |
小电导钙激活钾离子通道激动剂及其合成和应用
|