JP2000515866A5 - - Google Patents

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Publication number
JP2000515866A5
JP2000515866A5 JP1998508318A JP50831898A JP2000515866A5 JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5 JP 1998508318 A JP1998508318 A JP 1998508318A JP 50831898 A JP50831898 A JP 50831898A JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP1998508318A
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English (en)
Japanese (ja)
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JP2000515866A (ja
JP4033494B2 (ja
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Publication date
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Priority claimed from PCT/US1997/013244 external-priority patent/WO1998004569A1/en
Publication of JP2000515866A publication Critical patent/JP2000515866A/ja
Publication of JP2000515866A5 publication Critical patent/JP2000515866A5/ja
Application granted granted Critical
Publication of JP4033494B2 publication Critical patent/JP4033494B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP50831898A 1996-07-26 1997-07-25 ヌクレオチドアナログ Expired - Lifetime JP4033494B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2270896P 1996-07-26 1996-07-26
US68683896A 1996-07-26 1996-07-26
US60/022,708 1996-07-26
US08/686,838 1996-07-26
PCT/US1997/013244 WO1998004569A1 (en) 1996-07-26 1997-07-25 Nucleotide analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007180398A Division JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ

Publications (3)

Publication Number Publication Date
JP2000515866A JP2000515866A (ja) 2000-11-28
JP2000515866A5 true JP2000515866A5 (enExample) 2004-08-19
JP4033494B2 JP4033494B2 (ja) 2008-01-16

Family

ID=26696272

Family Applications (6)

Application Number Title Priority Date Filing Date
JP50831898A Expired - Lifetime JP4033494B2 (ja) 1996-07-26 1997-07-25 ヌクレオチドアナログ
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Country Status (4)

Country Link
JP (6) JP4033494B2 (enExample)
CA (1) CA2261619C (enExample)
TW (2) TW470748B (enExample)
WO (1) WO1998004569A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004569A1 (en) * 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
NZ501659A (en) * 1997-07-25 2004-12-24 Gilead Sciences Inc Methods of nucleotide analogue 9-[2[[bis[(pivaloyloxy)-methoxy]phosphinyljmethoxyjethyl] adenine ("adefovir dipivoxil" or "AD") synthesis
EP1243590B1 (en) * 1997-07-25 2005-02-09 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
PT1243590E (pt) * 1997-07-25 2005-05-31 Gilead Sciences Inc Composicao de analogos nuclotidicos e metodo de sintese
BR9911457A (pt) * 1998-06-24 2001-12-11 Univ Emory Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv
OA12393A (en) * 2000-07-21 2006-04-18 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same.
WO2003090691A2 (en) 2002-04-26 2003-11-06 Gilead Sciences, Inc. Method and compositions for identifying anti-hiv therapeutic compounds
SI1583542T1 (sl) 2003-01-14 2008-12-31 Gilead Sciences Inc Sestavki in postopki za kombinacijsko antivirusnoterapijo
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
JP2006524710A (ja) 2003-04-25 2006-11-02 ギリアード サイエンシーズ， インコーポレイテッド キナーゼインヒビターホスホネート抱合体
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
CA2523083C (en) 2003-04-25 2014-07-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
EP1644389B1 (en) 2003-06-16 2011-01-19 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US7273717B2 (en) 2003-10-24 2007-09-25 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds with GS-9005 ester hydrolase B
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
JP2007515495A (ja) 2003-12-22 2007-06-14 ギリアード サイエンシーズ， インコーポレイテッド ４’−置換カルボビル誘導体およびアバカビル誘導体ならびにｈｉｖおよびｈｃｖ抗ウイルス活性を有する関連化合物
WO2005063258A1 (en) * 2003-12-22 2005-07-14 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
PL216369B1 (pl) 2004-07-27 2014-03-31 Gilead Sciences Pochodne fosfonianowe, kompozycje farmaceutyczne zawierające te pochodne oraz zastosowanie tych pochodnych do wytwarzania leku do hamowania wirusa HIV
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
WO2006133632A1 (fr) * 2005-06-13 2006-12-21 Brightgene Bio-Medical Technology Co., Ltd. Promedicament analogue nucleotidique et sa preparation
EP2420238A3 (en) 2007-04-13 2012-03-07 Southern Research Institute Anti-angiogenic agents
AU2008253803A1 (en) * 2007-05-22 2008-11-27 Ultimorphix Technolgies B.V. Tenofovir disoproxil hemi-fumaric acid Co-crystal
WO2009064174A1 (en) * 2007-11-14 2009-05-22 Ultimorphix Technologies B.V. Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
NZ588796A (en) * 2008-04-25 2012-07-27 Cipla Ltd Crystalline form of tenofovir disoproxil and a process for its preparation
JP5620376B2 (ja) 2008-07-08 2014-11-05 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖ阻害剤化合物の塩
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
JP5847296B2 (ja) * 2011-05-10 2016-01-20 アラタナ セラピューティクス エン ヴェー ネコレトロウイルス感染症の治療に使用するための化合物
ES2608871T5 (es) 2011-08-16 2024-04-04 Gilead Sciences Inc Alafenamide hemifumarate de tenofovir
CN103626802A (zh) * 2012-08-23 2014-03-12 重庆药友制药有限责任公司 一种制备替诺福韦的新方法
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
WO2014068265A1 (en) 2012-10-29 2014-05-08 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
EP2860185A1 (en) 2013-10-09 2015-04-15 Zentiva, k.s. An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
EP2860184B1 (en) 2013-10-09 2018-08-29 Zentiva, k.s. Dihydrogenphosphate salt of Tenofovir disoproxil
TWI660965B (zh) * 2014-01-15 2019-06-01 美商基利科學股份有限公司 泰諾福韋之固體形式
EP3661937B1 (en) 2017-08-01 2021-07-28 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222553A (en) * 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
DE69129650T2 (de) * 1990-09-14 1999-03-25 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha Wirkstoffvorläufer von Phosphonaten
GB9026164D0 (en) * 1990-12-01 1991-01-16 Beecham Group Plc Pharmaceuticals
WO1995007920A1 (en) * 1993-09-17 1995-03-23 Gilead Sciences, Inc. Nucleotide analogs
WO1998004569A1 (en) * 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs

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