JP2000515866A5 - - Google Patents

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Publication number
JP2000515866A5
JP2000515866A5 JP1998508318A JP50831898A JP2000515866A5 JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5 JP 1998508318 A JP1998508318 A JP 1998508318A JP 50831898 A JP50831898 A JP 50831898A JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998508318A
Other languages
English (en)
Japanese (ja)
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JP2000515866A (ja
JP4033494B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/013244 external-priority patent/WO1998004569A1/en
Publication of JP2000515866A publication Critical patent/JP2000515866A/ja
Publication of JP2000515866A5 publication Critical patent/JP2000515866A5/ja
Application granted granted Critical
Publication of JP4033494B2 publication Critical patent/JP4033494B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP50831898A 1996-07-26 1997-07-25 ヌクレオチドアナログ Expired - Lifetime JP4033494B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2270896P 1996-07-26 1996-07-26
US68683896A 1996-07-26 1996-07-26
US60/022,708 1996-07-26
US08/686,838 1996-07-26
PCT/US1997/013244 WO1998004569A1 (en) 1996-07-26 1997-07-25 Nucleotide analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007180398A Division JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ

Publications (3)

Publication Number Publication Date
JP2000515866A JP2000515866A (ja) 2000-11-28
JP2000515866A5 true JP2000515866A5 (enExample) 2004-08-19
JP4033494B2 JP4033494B2 (ja) 2008-01-16

Family

ID=26696272

Family Applications (6)

Application Number Title Priority Date Filing Date
JP50831898A Expired - Lifetime JP4033494B2 (ja) 1996-07-26 1997-07-25 ヌクレオチドアナログ
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Country Status (4)

Country Link
JP (6) JP4033494B2 (enExample)
CA (1) CA2261619C (enExample)
TW (2) TW444020B (enExample)
WO (1) WO1998004569A1 (enExample)

Families Citing this family (44)

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WO1998004569A1 (en) * 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
ES2187991T3 (es) * 1997-07-25 2003-06-16 Gilead Sciences Inc Composiciones de analogo de nucleotido.
PT1243590E (pt) * 1997-07-25 2005-05-31 Gilead Sciences Inc Composicao de analogos nuclotidicos e metodo de sintese
DK1243590T3 (da) * 1997-07-25 2005-07-25 Gilead Sciences Inc Nukleotid-analog sammensætning og syntesemetode
US6194391B1 (en) * 1998-06-24 2001-02-27 Emory University 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol
HRP20030047B1 (hr) * 2000-07-21 2016-02-26 Gilead Sciences, Inc. Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava
TW200408645A (en) 2002-04-26 2004-06-01 Gilead Sciences Inc Non nucleoside reverse transcriptase inhibitors
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
SG182849A1 (en) 2003-04-25 2012-08-30 Gilead Sciences Inc Antiviral phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
EP1620109A2 (en) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
WO2005042773A1 (en) 2003-10-24 2005-05-12 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
BRPI0417988A (pt) 2003-12-22 2007-04-27 Gilead Sciences Inc análogos de fosfonato antivirais
MXPA06007095A (es) * 2003-12-22 2006-09-04 Gilead Sciences Inc Conjugados de fosfonato inhibidores de cinasa.
PT2258376T (pt) 2004-07-27 2019-05-31 Gilead Sciences Inc Análogos fosfonatados de compostos inibidores do vih
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2006133632A1 (fr) * 2005-06-13 2006-12-21 Brightgene Bio-Medical Technology Co., Ltd. Promedicament analogue nucleotidique et sa preparation
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2161023A3 (en) 2007-04-13 2010-12-29 Southern Research Institute Anti-angiogenic agents and methods of use.
EP2160394A1 (en) * 2007-05-22 2010-03-10 Ultimorphix Technologies B.v. Tenofovir disoproxil hemi-fumaric acid co-crystal
WO2009064174A1 (en) * 2007-11-14 2009-05-22 Ultimorphix Technologies B.V. Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
EP2291386B1 (en) * 2008-04-25 2016-01-13 Cipla Limited Crystalline form of tenofovir disoproxil and a process for its preparation
BRPI0915878A2 (pt) 2008-07-08 2015-11-03 Gilead Sciences Inc sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
CN102093422B (zh) * 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
US20140073607A1 (en) * 2011-05-10 2014-03-13 Okapi Sciences Nv Compounds for use in the treatment of feline retroviral infections
AP3639A (en) 2011-08-16 2016-03-13 Gilead Sciences Inc Tenofovir alafenamide hemifumarate
CN103626802A (zh) * 2012-08-23 2014-03-12 重庆药友制药有限责任公司 一种制备替诺福韦的新方法
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
EP2860185A1 (en) 2013-10-09 2015-04-15 Zentiva, k.s. An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
PT2860184T (pt) 2013-10-09 2018-11-20 Zentiva Ks Sal de di-hidrogenofosfato de tenofovir disoproxil
TWI660965B (zh) * 2014-01-15 2019-06-01 美商基利科學股份有限公司 泰諾福韋之固體形式
PT3661937T (pt) 2017-08-01 2021-09-24 Gilead Sciences Inc Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法

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IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
DK0481214T3 (da) * 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
GB9026164D0 (en) * 1990-12-01 1991-01-16 Beecham Group Plc Pharmaceuticals
ATE486882T1 (de) * 1993-09-17 2010-11-15 Gilead Sciences Inc Nukleotidanaloge
WO1998004569A1 (en) * 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs

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