JP2000515866A5 - - Google Patents

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Publication number
JP2000515866A5
JP2000515866A5 JP1998508318A JP50831898A JP2000515866A5 JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5 JP 1998508318 A JP1998508318 A JP 1998508318A JP 50831898 A JP50831898 A JP 50831898A JP 2000515866 A5 JP2000515866 A5 JP 2000515866A5
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JP
Japan
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JP1998508318A
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JP2000515866A (ja
JP4033494B2 (ja
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Priority claimed from PCT/US1997/013244 external-priority patent/WO1998004569A1/en
Publication of JP2000515866A publication Critical patent/JP2000515866A/ja
Publication of JP2000515866A5 publication Critical patent/JP2000515866A5/ja
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Publication of JP4033494B2 publication Critical patent/JP4033494B2/ja
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Figure 2000515866
Figure 2000515866
Figure 2000515866
Figure 2000515866
Figure 2000515866
Figure 2000515866
Figure 2000515866
JP50831898A 1996-07-26 1997-07-25 ヌクレオチドアナログ Expired - Lifetime JP4033494B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68683896A 1996-07-26 1996-07-26
US2270896P 1996-07-26 1996-07-26
US60/022,708 1996-07-26
US08/686,838 1996-07-26
PCT/US1997/013244 WO1998004569A1 (en) 1996-07-26 1997-07-25 Nucleotide analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007180398A Division JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ

Publications (3)

Publication Number Publication Date
JP2000515866A JP2000515866A (ja) 2000-11-28
JP2000515866A5 true JP2000515866A5 (ja) 2004-08-19
JP4033494B2 JP4033494B2 (ja) 2008-01-16

Family

ID=26696272

Family Applications (6)

Application Number Title Priority Date Filing Date
JP50831898A Expired - Lifetime JP4033494B2 (ja) 1996-07-26 1997-07-25 ヌクレオチドアナログ
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2007180398A Withdrawn JP2007297406A (ja) 1996-07-26 2007-07-09 ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja) 1996-07-26 2010-10-15 ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja) 1996-07-26 2014-04-15 ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja) 1996-07-26 2015-04-28 ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja) 1996-07-26 2016-10-31 ヌクレオチドアナログ

Country Status (4)

Country Link
JP (6) JP4033494B2 (ja)
CA (1) CA2261619C (ja)
TW (2) TW470748B (ja)
WO (1) WO1998004569A1 (ja)

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JP4033494B2 (ja) * 1996-07-26 2008-01-16 ギリヤド サイエンシーズ, インコーポレイテッド ヌクレオチドアナログ
PT1256584E (pt) * 1997-07-25 2004-12-31 Gilead Sciences Inc Processo para a preparacao de adefovir-dipivoxil
EP1243593B1 (en) * 1997-07-25 2005-09-21 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
WO1999005150A1 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
CZ304734B6 (cs) * 2000-07-21 2014-09-10 Gilead Sciences, Inc. Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu
CA2481449A1 (en) 2002-04-26 2003-11-06 Gilead Sciences, Inc. Method and compositions for identifying anti-hiv therapeutic compounds
EP1923063A3 (en) 2003-01-14 2009-04-08 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7273716B2 (en) 2003-04-25 2007-09-25 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
EP1620109A2 (en) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
NZ542342A (en) 2003-04-25 2009-05-31 Gilead Sciences Inc Antiviral phosphonate analogs
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
ATE496056T1 (de) 2003-06-16 2011-02-15 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
WO2005044308A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
EP1715871A1 (en) * 2003-12-22 2006-11-02 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
WO2005063751A1 (en) 2003-12-22 2005-07-14 Gilead Sciences, Inc. 4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
CN102228463B (zh) * 2005-06-13 2012-12-19 博瑞生物医药技术(苏州)有限公司 泰诺福韦的晶体
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
CA2681267C (en) 2007-04-13 2013-11-19 Southern Research Institute Anti-angiogenic agents and methods of use
CN101778855A (zh) * 2007-05-22 2010-07-14 阿尔迪默菲克斯技术有限责任公司 替诺福韦酯半富马酸共晶体
WO2009064174A1 (en) * 2007-11-14 2009-05-22 Ultimorphix Technologies B.V. Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
EP2937356A1 (en) * 2008-04-25 2015-10-28 Cipla Limited Crystalline form of tenofovir disoproxil and a process for its preparation
WO2010005986A1 (en) 2008-07-08 2010-01-14 Gilead Sciences, Inc. Salts of hiv inhibitor compounds
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
WO2012152317A1 (en) * 2011-05-10 2012-11-15 Okapi Sciences Nv Compounds for use in the treatment of feline retroviral infections
CA2845553C (en) 2011-08-16 2019-05-28 Gilead Sciences, Inc. Tenofovir alafenamide hemifumarate
CN103626802A (zh) * 2012-08-23 2014-03-12 重庆药友制药有限责任公司 一种制备替诺福韦的新方法
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
WO2014068265A1 (en) 2012-10-29 2014-05-08 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
EP2860184B1 (en) 2013-10-09 2018-08-29 Zentiva, k.s. Dihydrogenphosphate salt of Tenofovir disoproxil
EP2860185A1 (en) 2013-10-09 2015-04-15 Zentiva, k.s. An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
TWI660965B (zh) * 2014-01-15 2019-06-01 美商基利科學股份有限公司 泰諾福韋之固體形式
SI3661937T1 (sl) 2017-08-01 2021-11-30 Gilead Sciences, Inc. Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法

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NZ222553A (en) * 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
GB9026164D0 (en) * 1990-12-01 1991-01-16 Beecham Group Plc Pharmaceuticals
AU691527B2 (en) * 1993-09-17 1998-05-21 Gilead Sciences, Inc. Nucleotide analogs
JP4033494B2 (ja) * 1996-07-26 2008-01-16 ギリヤド サイエンシーズ, インコーポレイテッド ヌクレオチドアナログ

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