JP2000516933A5 - - Google Patents

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Publication number
JP2000516933A5
JP2000516933A5 JP1998510497A JP51049798A JP2000516933A5 JP 2000516933 A5 JP2000516933 A5 JP 2000516933A5 JP 1998510497 A JP1998510497 A JP 1998510497A JP 51049798 A JP51049798 A JP 51049798A JP 2000516933 A5 JP2000516933 A5 JP 2000516933A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP1998510497A
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English (en)
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JP2000516933A (ja
JP4364305B2 (ja
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Priority claimed from PCT/GB1997/002205 external-priority patent/WO1998007727A1/en
Publication of JP2000516933A publication Critical patent/JP2000516933A/ja
Publication of JP2000516933A5 publication Critical patent/JP2000516933A5/ja
Application granted granted Critical
Publication of JP4364305B2 publication Critical patent/JP4364305B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Figure 2000516933
Figure 2000516933
Figure 2000516933
JP51049798A 1996-08-19 1997-08-15 極めて脂肪親和性のカンプトテシン誘導体 Expired - Lifetime JP4364305B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2417196P 1996-08-19 1996-08-19
US60/024,171 1996-08-19
PCT/GB1997/002205 WO1998007727A1 (en) 1996-08-19 1997-08-15 Highly lipophilic camptothecin derivatives

Publications (3)

Publication Number Publication Date
JP2000516933A JP2000516933A (ja) 2000-12-19
JP2000516933A5 true JP2000516933A5 (ja) 2005-04-07
JP4364305B2 JP4364305B2 (ja) 2009-11-18

Family

ID=21819224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51049798A Expired - Lifetime JP4364305B2 (ja) 1996-08-19 1997-08-15 極めて脂肪親和性のカンプトテシン誘導体

Country Status (17)

Country Link
US (3) US5910491A (ja)
EP (1) EP0925301B1 (ja)
JP (1) JP4364305B2 (ja)
KR (1) KR100516593B1 (ja)
CN (1) CN1107678C (ja)
AT (1) ATE261974T1 (ja)
AU (1) AU718799C (ja)
BR (1) BR9711319B1 (ja)
CA (1) CA2262745C (ja)
DE (1) DE69728152T2 (ja)
DK (1) DK0925301T3 (ja)
ES (1) ES2214634T3 (ja)
IL (1) IL127800A (ja)
NZ (1) NZ334240A (ja)
PT (1) PT925301E (ja)
WO (1) WO1998007727A1 (ja)
ZA (1) ZA977437B (ja)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136978A (en) 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6743917B2 (en) 1993-06-30 2004-06-01 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) * 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
WO1998007727A1 (en) * 1996-08-19 1998-02-26 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6169080B1 (en) * 1997-02-13 2001-01-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US7105492B2 (en) 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
PT1044977E (pt) * 1999-03-09 2002-09-30 Sigma Tau Ind Farmaceuti Derivados de camptotecina com actividade antitumoral
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU4822500A (en) * 1999-05-04 2000-11-17 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US7332550B2 (en) * 2000-10-06 2008-02-19 Carnegie Mellon University Stabilization of transition metal complexes for catalysis in diverse environments
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US20040034050A1 (en) * 2002-06-03 2004-02-19 Yang Li-Xi Homo-camptothecin derivatives
US6723849B1 (en) * 2002-10-25 2004-04-20 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
WO2005060871A1 (en) * 2003-12-17 2005-07-07 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
WO2005061517A1 (en) 2003-12-17 2005-07-07 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US20060094692A1 (en) * 2004-10-28 2006-05-04 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
US7030243B1 (en) 2004-10-28 2006-04-18 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
AU2007240737B2 (en) * 2006-04-19 2011-12-08 Crown Bioscience, Inc. Camptothecin-analog with a novel, "flipped" lactone-stable, E-ring and methods for making and using same
WO2008021549A2 (en) * 2006-08-18 2008-02-21 Sidney Kimmel Cancer Center Methods and compositions for topoisomerase i modulated tumor suppression
US8883190B2 (en) * 2006-12-01 2014-11-11 Wake Forest University Health Sciences Urologic devices incorporating collagen inhibitors
US7687496B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
CA2700904C (en) * 2007-10-16 2014-10-14 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
WO2009051580A1 (en) * 2007-10-16 2009-04-23 Bionumerik Pharmaceuticals, Inc. C7-substituted camptothecin analogs
US7687497B2 (en) 2007-10-16 2010-03-30 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US20140073793A1 (en) * 2012-09-07 2014-03-13 BioNumeric Pharmaceuticals, Inc. Germanium-containing camptothecin analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
DE2150234A1 (de) * 1971-10-08 1973-04-12 Basf Ag Verfahren zur herstellung von camptothecin und camptothecin-derivaten
DE2534601A1 (de) * 1975-08-02 1977-02-17 Basf Ag Verfahren zur herstellung von camptothecin-aehnlichen verbindungen
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US5405963A (en) * 1993-06-10 1995-04-11 Smithkline Beecham Corporation Process for asymmetric total synthesis of camptothecin analogues
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
WO1998007727A1 (en) * 1996-08-19 1998-02-26 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

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