JP2000502571A - ペプチド免疫原 - Google Patents
ペプチド免疫原Info
- Publication number
- JP2000502571A JP2000502571A JP9530632A JP53063297A JP2000502571A JP 2000502571 A JP2000502571 A JP 2000502571A JP 9530632 A JP9530632 A JP 9530632A JP 53063297 A JP53063297 A JP 53063297A JP 2000502571 A JP2000502571 A JP 2000502571A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- bsw17
- ige
- mimotope
- immunogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
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- 229940070741 purified protein derivative of tuberculin Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/528—CH4 domain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(a)BSW17ミモトープペプチドの少なくとも一部分と (b)そのペプチドに対する免疫応答を誘導する能力のある部分 とを含む、免疫原性分子。 2.BSW17ミモトープペプチドが環状であるため、その各末端はジスルフィ ドブリッジを形成する更に2つのシステイン残基よって結合しているか、または 各末端は化学的に架橋しているか、またはBSW17ミモトープペプチドが直鎖 状であるため、カルボキシ末端アミノ酸をアミド化により適宜ブロックでき、お よび/またはアミノ末端アミノ酸をアセチル化により適宜ブロックできる、請求 の範囲第1項に記載の免疫原性分子。 3.ポリマーペプチドまたは組換え融合タンパク質の形態であるため、ポリマー ペプチドの1つのモノマー化合物または融合タンパク質の片方がBSW17ミモ トープペプチドの部分を構成しており、かつポリマーペプチドまたは融合タンパ ク質の残りの部分が免疫応答誘導部分を構成している、請求の範囲第1項に記載 の免疫原性分子。 4.BSW17ミモトープペプチドと免疫原性キャリアーのコンジュゲートの形 態である、請求の範囲第1項に記載の免疫原性分子。 5.BSW17ミモトープペプチド部分が、実質的に、 から選択されるアミノ酸配列から成るか、またはそれらを含有する、請求の範囲 第1項に記載の免疫原性分子。 6.請求の範囲第1項ないし5項のいずれか1項に記載の免疫原性分子とアジュ バントを含む、医薬組成物。 7.請求の範囲第1項ないし5項のいずれか1項に定義したBSW17ミモトー プペプチドの一部分に特異的であるため、BSW17により認識される天然エピ トープを含むIgEの重鎖上のアミノ酸配列と反応性である抗体ドメインを含む 、リガンド。 8.モノクローナル抗体またはそのFab'またはF(ab')2フラグメントの形態で ある、請求の範囲第7項に記載のリガンド。 9.(a)BSW17ミモトープペプチドの一部分と(b)そのペプチドに対する免 疫応答を誘導する能力のある部分とを適切に結合させることを含む、請求の範囲 第1項に記載の免疫原性分子の製法。 10.IgE媒介疾患の処置における医薬として使用するための、請求の範囲第 1項ないし5項のいずれか1項に定義した免疫原性分子。 11.アレルギーに対するワクチンの製造における、請求の範囲第1項ないし5 項のいずれか1項に定義した免疫原性分子の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9604412.8 | 1996-03-01 | ||
GBGB9604412.8A GB9604412D0 (en) | 1996-03-01 | 1996-03-01 | Organic compounds |
GBGB9617702.7A GB9617702D0 (en) | 1996-08-22 | 1996-08-22 | Organic compounds |
GB9617702.7 | 1996-08-22 | ||
PCT/EP1997/001013 WO1997031948A1 (en) | 1996-03-01 | 1997-02-28 | Peptide immunogens for vaccination against and treatment of allergy |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002377664A Division JP2003231696A (ja) | 1996-03-01 | 2002-12-26 | ペプチド免疫原 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000502571A true JP2000502571A (ja) | 2000-03-07 |
JP3421970B2 JP3421970B2 (ja) | 2003-06-30 |
Family
ID=26308839
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53063297A Expired - Fee Related JP3421970B2 (ja) | 1996-03-01 | 1997-02-28 | ペプチド免疫原 |
JP2002377664A Pending JP2003231696A (ja) | 1996-03-01 | 2002-12-26 | ペプチド免疫原 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002377664A Pending JP2003231696A (ja) | 1996-03-01 | 2002-12-26 | ペプチド免疫原 |
Country Status (25)
Country | Link |
---|---|
US (1) | US6610297B1 (ja) |
EP (1) | EP0885244B2 (ja) |
JP (2) | JP3421970B2 (ja) |
KR (2) | KR100498198B1 (ja) |
CN (1) | CN1174998C (ja) |
AT (1) | ATE230417T1 (ja) |
AU (1) | AU719609B2 (ja) |
BR (1) | BR9707819A (ja) |
CA (1) | CA2245497C (ja) |
CY (1) | CY2457B1 (ja) |
CZ (1) | CZ299551B6 (ja) |
DE (1) | DE69718150T3 (ja) |
DK (1) | DK0885244T4 (ja) |
ES (1) | ES2190799T5 (ja) |
HK (1) | HK1014962A1 (ja) |
HU (1) | HUP9901109A3 (ja) |
IL (1) | IL125590A (ja) |
NO (1) | NO321043B1 (ja) |
NZ (1) | NZ331651A (ja) |
PL (1) | PL187209B1 (ja) |
RU (1) | RU2193413C2 (ja) |
SI (1) | SI0885244T2 (ja) |
SK (1) | SK284856B6 (ja) |
TR (1) | TR199801722T2 (ja) |
WO (1) | WO1997031948A1 (ja) |
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JP2015121536A (ja) * | 2007-05-31 | 2015-07-02 | メディジーン アーゲー | ワクチンとしての変異型パルボウイルス構造タンパク質 |
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US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
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- 1997-02-28 DE DE69718150T patent/DE69718150T3/de not_active Expired - Lifetime
- 1997-02-28 SI SI9730490T patent/SI0885244T2/sl unknown
- 1997-02-28 IL IL12559097A patent/IL125590A/xx not_active IP Right Cessation
- 1997-02-28 KR KR10-1998-0706845A patent/KR100498198B1/ko not_active IP Right Cessation
- 1997-02-28 PL PL97328858A patent/PL187209B1/pl not_active IP Right Cessation
- 1997-02-28 DK DK97905136T patent/DK0885244T4/da active
- 1997-02-28 NZ NZ331651A patent/NZ331651A/xx unknown
- 1997-02-28 HU HU9901109A patent/HUP9901109A3/hu unknown
- 1997-02-28 KR KR1020057005577A patent/KR100584051B1/ko not_active IP Right Cessation
- 1997-02-28 RU RU98118184/14A patent/RU2193413C2/ru not_active IP Right Cessation
- 1997-02-28 AU AU18796/97A patent/AU719609B2/en not_active Ceased
- 1997-02-28 CZ CZ0277198A patent/CZ299551B6/cs not_active IP Right Cessation
- 1997-02-28 CN CNB971926719A patent/CN1174998C/zh not_active Expired - Fee Related
- 1997-02-28 AT AT97905136T patent/ATE230417T1/de not_active IP Right Cessation
- 1997-02-28 SK SK1181-98A patent/SK284856B6/sk unknown
- 1997-02-28 US US09/125,641 patent/US6610297B1/en not_active Expired - Fee Related
- 1997-02-28 EP EP97905136A patent/EP0885244B2/en not_active Expired - Lifetime
- 1997-02-28 WO PCT/EP1997/001013 patent/WO1997031948A1/en active IP Right Grant
- 1997-02-28 JP JP53063297A patent/JP3421970B2/ja not_active Expired - Fee Related
- 1997-02-28 TR TR1998/01722T patent/TR199801722T2/xx unknown
- 1997-02-28 ES ES97905136T patent/ES2190799T5/es not_active Expired - Lifetime
- 1997-02-28 CA CA002245497A patent/CA2245497C/en not_active Expired - Fee Related
- 1997-02-28 BR BR9707819A patent/BR9707819A/pt not_active Application Discontinuation
-
1998
- 1998-08-31 NO NO19983999A patent/NO321043B1/no unknown
- 1998-12-31 HK HK98119259A patent/HK1014962A1/xx not_active IP Right Cessation
-
2002
- 2002-12-26 JP JP2002377664A patent/JP2003231696A/ja active Pending
-
2004
- 2004-06-04 CY CY0400044A patent/CY2457B1/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015121536A (ja) * | 2007-05-31 | 2015-07-02 | メディジーン アーゲー | ワクチンとしての変異型パルボウイルス構造タンパク質 |
JP2018109636A (ja) * | 2007-05-31 | 2018-07-12 | メディジーン アーゲー | ワクチンとしての変異型パルボウイルス構造タンパク質 |
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