JP2000026443A - ３―エピビタミンｄ３代謝物及び類似体の合成 - Google Patents

３―エピビタミンｄ３代謝物及び類似体の合成

Info

Publication number
JP2000026443A
JP2000026443A JP11133033A JP13303399A JP2000026443A JP 2000026443 A JP2000026443 A JP 2000026443A JP 11133033 A JP11133033 A JP 11133033A JP 13303399 A JP13303399 A JP 13303399A JP 2000026443 A JP2000026443 A JP 2000026443A
Authority
JP
Japan
Prior art keywords
formula
compound
mixture
solution
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11133033A
Other languages
English (en)
Japanese (ja)
Inventor
Andrew David Batcho
アンドリュー・ディビッド・バッチョ
Percy Sarwood Manchand
パーシー・サーウッド・マンシャンド
Milan Radoje Uskokovic
ミラン・ラドージェ・ウスココヴィック
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2000026443A publication Critical patent/JP2000026443A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/532—Cycloaliphatic phosphine oxides or thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP11133033A 1998-05-14 1999-05-13 ３―エピビタミンｄ３代謝物及び類似体の合成 Pending JP2000026443A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8552198P 1998-05-14 1998-05-14
US60/085521 1998-05-14

Publications (1)

Publication Number Publication Date
JP2000026443A true JP2000026443A (ja) 2000-01-25

Family

ID=22192175

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11133033A Pending JP2000026443A (ja) 1998-05-14 1999-05-13 ３―エピビタミンｄ３代謝物及び類似体の合成

Country Status (7)

Country Link
US (1) US6040461A (https=)
EP (1) EP0957098A1 (https=)
JP (1) JP2000026443A (https=)
KR (1) KR19990088202A (https=)
CN (1) CN1235972A (https=)
CA (1) CA2271414A1 (https=)
MX (1) MX9904401A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009508813A (ja) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア １α−フルオロー２５−ヒドロキシ−１６−２３Ｅ−ジエン−２６，２７−ビスホモ−２０−エピ−コレカルシフェロールの合成
JP2018521981A (ja) * 2015-05-29 2018-08-09 ケムボン バイオテクノロジー カンパニー，リミティド ポリエン化合物、その製造方法及びその応用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010007907A1 (en) * 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO2008091686A2 (en) * 2007-01-25 2008-07-31 Bioxell S.P.A. SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL
CN111763230A (zh) * 2020-06-23 2020-10-13 重庆华邦胜凯制药有限公司 一种卡泊三醇杂质化合物的制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US20010007907A1 (en) * 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
JP2001510183A (ja) * 1997-07-17 2001-07-31 エフ．ホフマン−ラ ロシュ アーゲー 側鎖に２つの不飽和結合を有するジホモ−セコ−コレスタン

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009508813A (ja) * 2005-08-18 2009-03-05 ビオクセル エッセ ピ ア １α−フルオロー２５−ヒドロキシ−１６−２３Ｅ−ジエン−２６，２７−ビスホモ−２０−エピ−コレカルシフェロールの合成
JP2018521981A (ja) * 2015-05-29 2018-08-09 ケムボン バイオテクノロジー カンパニー，リミティド ポリエン化合物、その製造方法及びその応用

Also Published As

Publication number Publication date
CN1235972A (zh) 1999-11-24
US6040461A (en) 2000-03-21
MX9904401A (https=) 2000-03-01
EP0957098A1 (en) 1999-11-17
KR19990088202A (ko) 1999-12-27
CA2271414A1 (en) 1999-11-14

Similar Documents

Publication Publication Date Title
JP3494637B2 (ja) １９−ノル−ビタミンｄ化合物の中間体の製造方法
JP2668759B2 (ja) １９−ノル−ビタミンｄ化合物の合成用中間体
US4772433A (en) Vitamin D analogues
CN112608361A (zh) 制备胆固醇、其衍生物及类似物的方法
US20070088007A1 (en) Method for preparing analogue of vitamin D
WO2009012955A2 (en) Process for the preparation of drospirenone
JP6440896B2 (ja) ベラプロストを作製するための方法
JP2025160437A (ja) イロプロストの製造のための方法
JP2000026443A (ja) ３―エピビタミンｄ３代謝物及び類似体の合成
EP3906228A1 (en) Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
WO2004026224A2 (en) Process for preparing prostaglandin derivatives and starting materials for the same
Haag et al. Synthesis of putative precursors of ecdysone. Part 3. Synthesis of 3β, 14α, 25-trihydroxy-5β-cholest-7-en-6-one
JPS5823660A (ja) １α―ヒドロキシビタミンＤまたは１α―ヒドロキシ―プレビタミンＤ化合物の製造方法
JPS6344743B2 (https=)
KR100697491B1 (ko) 골다공증 치료제의 제조 방법
JPH0437074B2 (https=)
CN113292630B (zh) 不对称合成Triptonide和Triptolide的方法
JP2003518089A (ja) ２４（ｓ）−ヒドロキシビタミンｄ２の製造方法
EP0387929B1 (en) Trimethylsilyl acetylene compounds, their preparation and their use in the preparation of daunomycinone derivatives
JP2975704B2 (ja) ステロイド誘導体
JP3609853B2 (ja) ビタミンｄ合成中間体の製造方法
CS266349B2 (en) Process for preparing new intermediate produts of prostaglandine
JPH047757B2 (https=)
JPS61277642A (ja) シクロペンテンアルコ−ル類およびその製造法
JPS61151166A (ja) △↑７−プロスタグランジンａ↓１エステル類及びその製造法