JOP20190183B1 - معدِلات مستقبلات الاستروجين - Google Patents
معدِلات مستقبلات الاستروجينInfo
- Publication number
- JOP20190183B1 JOP20190183B1 JOP/2019/0183A JOP20190183A JOP20190183B1 JO P20190183 B1 JOP20190183 B1 JO P20190183B1 JO P20190183 A JOP20190183 A JO P20190183A JO P20190183 B1 JOP20190183 B1 JO P20190183B1
- Authority
- JO
- Jordan
- Prior art keywords
- estrogen receptor
- receptor modulators
- compounds
- processes
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451971P | 2017-01-30 | 2017-01-30 | |
| US201762523695P | 2017-06-22 | 2017-06-22 | |
| US201762560304P | 2017-09-19 | 2017-09-19 | |
| US201762592485P | 2017-11-30 | 2017-11-30 | |
| PCT/EP2018/052040 WO2018138303A1 (fr) | 2017-01-30 | 2018-01-29 | Modulateurs du récepteur des œstrogènes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JOP20190183A1 JOP20190183A1 (ar) | 2019-07-28 |
| JOP20190183B1 true JOP20190183B1 (ar) | 2022-09-15 |
Family
ID=61223883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2019/0183A JOP20190183B1 (ar) | 2017-01-30 | 2018-01-29 | معدِلات مستقبلات الاستروجين |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US10221173B2 (fr) |
| EP (2) | EP3494116B1 (fr) |
| JP (1) | JP6951451B2 (fr) |
| KR (1) | KR102246668B1 (fr) |
| CN (1) | CN110214140B (fr) |
| AU (1) | AU2018211495B2 (fr) |
| BR (1) | BR112019015389A2 (fr) |
| CA (1) | CA3050337A1 (fr) |
| CL (1) | CL2019001991A1 (fr) |
| CO (1) | CO2019008941A2 (fr) |
| CR (1) | CR20190379A (fr) |
| CY (1) | CY1122731T1 (fr) |
| DK (1) | DK3494116T3 (fr) |
| DO (1) | DOP2019000183A (fr) |
| EC (1) | ECSP19062381A (fr) |
| ES (2) | ES2931320T3 (fr) |
| HU (1) | HUE047761T2 (fr) |
| IL (1) | IL268263B (fr) |
| JO (1) | JOP20190183B1 (fr) |
| LT (1) | LT3494116T (fr) |
| MA (1) | MA52555A (fr) |
| MX (1) | MX2019008438A (fr) |
| MY (1) | MY196317A (fr) |
| NI (1) | NI201900080A (fr) |
| PE (1) | PE20191500A1 (fr) |
| PH (1) | PH12019501724A1 (fr) |
| PL (1) | PL3494116T3 (fr) |
| PT (1) | PT3494116T (fr) |
| RS (1) | RS59770B1 (fr) |
| SG (1) | SG11201906767XA (fr) |
| SI (1) | SI3494116T1 (fr) |
| TN (1) | TN2020000009A1 (fr) |
| TW (1) | TWI794205B (fr) |
| UA (1) | UA125043C2 (fr) |
| WO (1) | WO2018138303A1 (fr) |
| ZA (1) | ZA201904696B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018009496A (es) | 2016-02-05 | 2018-12-11 | Inventisbio Inc | Degradadores selectivos del receptor de estrogeno y sus usos. |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| CA3046965A1 (fr) | 2016-12-16 | 2018-06-21 | Janssen Pharmaceutica Nv | Inhibiteurs a petites molecules de la famille jak des kinases |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| WO2021055749A1 (fr) * | 2019-09-19 | 2021-03-25 | Totus Medicines Inc. | Conjugués thérapeutiques |
| CN115557920B (zh) * | 2022-09-22 | 2024-02-20 | 吉林奥来德光电材料股份有限公司 | 一种发光辅助材料、其制备方法及有机电致发光器件 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| JP4555547B2 (ja) | 2000-08-10 | 2010-10-06 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物 |
| US8008076B2 (en) * | 2004-04-27 | 2011-08-30 | Chugai Seiyaku Kabushiki Kaisha | Method of producing a nucleic acid encoding an antibody |
| US20100113502A1 (en) | 2005-03-22 | 2010-05-06 | Astrazeneca Ab | Novel Tetrahydro-1H-Pyrido[4,3-b] Indole Derivatives as CB1 Receptor Ligands |
| FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
| AR058223A1 (es) | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
| EP2223925A1 (fr) | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Inhibiteurs de kinase |
| CA3080983C (fr) | 2009-05-27 | 2023-02-28 | Pct Therapeutics, Inc. | Procede limitant et reduisant une infection virale |
| WO2010138659A1 (fr) * | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Procédés pour traiter des tumeurs cérébrales |
| US20120157401A1 (en) | 2009-05-27 | 2012-06-21 | Ptc Therapeutics, Inc. | Methods for treating neurofibromatosis |
| ES2627692T3 (es) | 2010-06-10 | 2017-07-31 | Aragon Pharmaceuticals, Inc. | Moduladores de receptores de estrógenos y usos de los mismos |
| WO2011159769A2 (fr) | 2010-06-17 | 2011-12-22 | Aragon Pharmaceuticals, Inc. | Modulateurs de récepteur d'œstrogène d'indane et utilisations de ceux-ci |
| WO2013090829A1 (fr) | 2011-12-14 | 2013-06-20 | Aragon Pharmaceuticals, Inc. | Modulateurs des récepteurs des œstrogènes et ses utilisations |
| WO2014191726A1 (fr) * | 2013-05-28 | 2014-12-04 | Astrazeneca Ab | Composés chimiques |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| RU2015152171A (ru) | 2013-06-19 | 2017-07-25 | Серагон Фармасьютикалз, Инк. | Азетидиновые модуляторы эстрогеновых рецепторов и их применения |
| WO2015092634A1 (fr) | 2013-12-16 | 2015-06-25 | Novartis Ag | Composés et compositions de 1,2,3,4-tétrahydroisoquinoléine en tant qu'antagonistes et agents de dégradation sélectifs des récepteurs des œstrogènes |
| JP6807841B2 (ja) | 2014-12-18 | 2021-01-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エストロゲン受容体モジュレーター及びその使用 |
| BR112017007662B1 (pt) * | 2014-12-18 | 2021-11-03 | F. Hoffmann-La Roche Ag | Composto, composição farmacêutica e uso de um composto |
| EP3233818A1 (fr) | 2014-12-18 | 2017-10-25 | F. Hoffmann-La Roche AG | Dérivés de 2,3-di(phénylchromène) utiles pour le traitement du cancer |
| WO2016174551A1 (fr) | 2015-04-27 | 2016-11-03 | Pfizer Inc. | Composés anti-œstrogéniques |
| CN107531722B (zh) | 2015-05-26 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 杂环雌激素受体调节剂及其用途 |
| US10087191B2 (en) | 2015-06-16 | 2018-10-02 | Jiangsu Hengrui Medicine Co., Ltd. | Piperidine derivative and preparation method and pharmaceutical use thereof |
| CN106518768B (zh) | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
| UA122346C2 (uk) | 2015-10-01 | 2020-10-26 | Олема Фармасьютикалз, Інк. | ТЕТРАГІДРО-1H-ПІРИДО[3,4-b]ІНДОЛЬНІ АНТИЕСТРОГЕННІ ЛІКАРСЬКІ ПРЕПАРАТИ |
| US10399939B2 (en) | 2015-11-09 | 2019-09-03 | Genentech, Inc. | Tetrahydronaphthalene estrogen receptor modulators and uses thereof |
| CN107428758B (zh) | 2015-11-12 | 2020-08-04 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的用途 |
| US10398689B2 (en) | 2015-12-22 | 2019-09-03 | Jiangsu Hengrui Medicine Co., Ltd. | Benzopiperidine derivative, preparation method thereof and medical use thereof |
| US9969732B2 (en) | 2016-04-08 | 2018-05-15 | Genentech, Inc. | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof |
| US10125135B2 (en) | 2016-04-20 | 2018-11-13 | Astrazeneca Ab | Chemical compounds |
| JP7064772B2 (ja) | 2016-05-06 | 2022-05-11 | ザビエル・ユニバーシティ・オブ・ルイジアナ | 選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ） |
| CN109415361B (zh) | 2016-06-29 | 2022-03-08 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物及其制备方法和其在医药上的用途 |
| WO2018019793A1 (fr) * | 2016-07-25 | 2018-02-01 | Astrazeneca Ab | Dérivés n-(2-(4-((1r,3r)-3-méthyl-2,3,4,9-tétrahydro-1h-pyrido [3,4-b]indol-1-yl)phénoxy) éthyl)propan-1-amine et composés associés en tant que régulateurs négatifs sélectifs du récepteur d'oestrogène pour le traitement du cancer |
| CN107814798B (zh) | 2016-09-14 | 2020-11-03 | 四川科伦博泰生物医药股份有限公司 | 3-取代丙烯酸类化合物及其制备方法和用途 |
| EP3512842B1 (fr) | 2016-09-15 | 2024-01-17 | Arvinas, Inc. | Dérivés d'indole en tant qu'agents de dégradation des récepteurs de l'estrogène |
| BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
| US10131663B2 (en) | 2016-10-24 | 2018-11-20 | Astrazeneca Ab | Chemical compounds |
| CN110291072A (zh) | 2016-12-16 | 2019-09-27 | 巴斯夫欧洲公司 | 农药化合物 |
| EP3763717B1 (fr) | 2016-12-16 | 2023-03-08 | Eli Lilly And Co. | Dérivés de pyrido[4,3-d][1,3]oxazin-2-one en tant qu'inhibiteurs de la forme mutée des protéines idh1 et idh2 |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| PL3555064T3 (pl) | 2016-12-16 | 2023-03-06 | Pfizer Inc. | Agoności receptora GLP-1 i ich zastosowania |
| CA3046965A1 (fr) | 2016-12-16 | 2018-06-21 | Janssen Pharmaceutica Nv | Inhibiteurs a petites molecules de la famille jak des kinases |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| CA3047212A1 (fr) | 2017-01-30 | 2018-08-02 | Chiesi Farmaceutici S.P.A. | Derives de tyrosine amide utilises en tant qu'inhibiteurs de la rho-kinase |
-
2018
- 2018-01-29 DK DK18705097.6T patent/DK3494116T3/da active
- 2018-01-29 AU AU2018211495A patent/AU2018211495B2/en active Active
- 2018-01-29 JO JOP/2019/0183A patent/JOP20190183B1/ar active
- 2018-01-29 CN CN201880008715.8A patent/CN110214140B/zh active Active
- 2018-01-29 ES ES19203383T patent/ES2931320T3/es active Active
- 2018-01-29 MX MX2019008438A patent/MX2019008438A/es unknown
- 2018-01-29 BR BR112019015389-6A patent/BR112019015389A2/pt active Search and Examination
- 2018-01-29 HU HUE18705097A patent/HUE047761T2/hu unknown
- 2018-01-29 RS RS20200018A patent/RS59770B1/sr unknown
- 2018-01-29 US US15/881,962 patent/US10221173B2/en active Active
- 2018-01-29 CR CR20190379A patent/CR20190379A/es unknown
- 2018-01-29 EP EP18705097.6A patent/EP3494116B1/fr active Active
- 2018-01-29 EP EP19203383.5A patent/EP3689873B1/fr active Active
- 2018-01-29 KR KR1020197025253A patent/KR102246668B1/ko active IP Right Grant
- 2018-01-29 TW TW107103088A patent/TWI794205B/zh active
- 2018-01-29 PE PE2019001434A patent/PE20191500A1/es unknown
- 2018-01-29 WO PCT/EP2018/052040 patent/WO2018138303A1/fr unknown
- 2018-01-29 ES ES18705097T patent/ES2766249T3/es active Active
- 2018-01-29 SI SI201830022T patent/SI3494116T1/sl unknown
- 2018-01-29 UA UAA201909412A patent/UA125043C2/uk unknown
- 2018-01-29 SG SG11201906767XA patent/SG11201906767XA/en unknown
- 2018-01-29 MA MA052555A patent/MA52555A/fr unknown
- 2018-01-29 CA CA3050337A patent/CA3050337A1/fr active Pending
- 2018-01-29 LT LTEP18705097.6T patent/LT3494116T/lt unknown
- 2018-01-29 JP JP2019538615A patent/JP6951451B2/ja active Active
- 2018-01-29 MY MYPI2019004298A patent/MY196317A/en unknown
- 2018-01-29 PL PL18705097T patent/PL3494116T3/pl unknown
- 2018-01-29 TN TNP/2020/000009A patent/TN2020000009A1/en unknown
- 2018-01-29 PT PT187050976T patent/PT3494116T/pt unknown
-
2019
- 2019-01-31 US US16/263,683 patent/US10590132B2/en active Active
- 2019-07-15 CL CL2019001991A patent/CL2019001991A1/es unknown
- 2019-07-16 DO DO2019000183A patent/DOP2019000183A/es unknown
- 2019-07-17 ZA ZA2019/04696A patent/ZA201904696B/en unknown
- 2019-07-25 IL IL268263A patent/IL268263B/en unknown
- 2019-07-26 NI NI201900080A patent/NI201900080A/es unknown
- 2019-07-26 PH PH12019501724A patent/PH12019501724A1/en unknown
- 2019-08-16 CO CONC2019/0008941A patent/CO2019008941A2/es unknown
- 2019-08-28 EC ECSENADI201962381A patent/ECSP19062381A/es unknown
-
2020
- 2020-01-08 CY CY20201100014T patent/CY1122731T1/el unknown
- 2020-01-29 US US16/775,781 patent/US11046689B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020551870A1 (en) | Tetracyclic heteroaryl compounds | |
| CR20210504A (es) | Compuestos tricíclicos condensados útiles como agentes anticancerígenos | |
| JOP20190183B1 (ar) | معدِلات مستقبلات الاستروجين | |
| PH12019500830A1 (en) | 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer | |
| NZ737399A (en) | Ccr2 modulators | |
| MX2019002180A (es) | Moduladores alostericos positivos del receptor m1 muscarinico. | |
| CA2912921C (fr) | Composes de pyrazole a titre de modulateurs de fshr et leurs utilisations | |
| MX2021000377A (es) | Degradadores selectivos del receptor de estrogeno. | |
| MX2020011405A (es) | Derivados de bencimidazol como moduladores del receptor gamma huerfano (rory) relacionado con retinoide y usos farmaceuticos de los mismos. | |
| ZA202400595B (en) | Spirocyclic compounds | |
| NZ763341A (en) | Polycyclic amides as muscarinic m1 receptor positive allosteric modulators | |
| MX2019011265A (es) | Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2. | |
| WO2015138276A3 (fr) | Modulateurs du récepteur orphelin lié au récepteur de l'acide rétinoïque et leurs utilisations | |
| NZ741384A (en) | Dopamine d3 receptor antagonists having a morpholine moiety | |
| NZ764004A (en) | Heteroaryl compounds as muscarinic m1 receptor positive allosteric modulators | |
| TW201613921A (en) | Serine derivatives as ghrelin receptor agonists | |
| WO2015138280A3 (fr) | Modulateurs des récepteurs orphelins associés au récepteur de l'acide rétinoïque et leurs utilisations | |
| MX2016011900A (es) | Derivados de acido azaindol-acetico y su uso como moduladores del receptor de prostaglandina d2. | |
| EA201991734A1 (ru) | Модуляторы рецептора эстрогена |