JOP20180121A1 - أجسام مضادة ضد عامل التخثر xi - Google Patents

أجسام مضادة ضد عامل التخثر xi

Info

Publication number
JOP20180121A1
JOP20180121A1 JOP/2018/0121A JOP20180121A JOP20180121A1 JO P20180121 A1 JOP20180121 A1 JO P20180121A1 JO P20180121 A JOP20180121 A JO P20180121A JO P20180121 A1 JOP20180121 A1 JO P20180121A1
Authority
JO
Jordan
Prior art keywords
coagulation factor
antibodies
activation
fxia
apl
Prior art date
Application number
JOP/2018/0121A
Other languages
Arabic (ar)
English (en)
Inventor
Oldham Elizabeth
Ganti Vaishnavi
Tabrizifard Mohammad
P Ellsworth Kenneth
Seiffert Dietmar
Prinz Bianka
Chen Zhu
Milligan James
Original Assignee
Adimab Llc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adimab Llc, Merck Sharp & Dohme filed Critical Adimab Llc
Publication of JOP20180121A1 publication Critical patent/JOP20180121A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JOP/2018/0121A 2016-06-14 2017-06-16 أجسام مضادة ضد عامل التخثر xi JOP20180121A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662349888P 2016-06-14 2016-06-14
PCT/US2017/036940 WO2017218371A1 (en) 2016-06-14 2017-06-12 Anti-coagulation factor xi antibodies

Publications (1)

Publication Number Publication Date
JOP20180121A1 true JOP20180121A1 (ar) 2018-12-12

Family

ID=59078269

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2018/0121A JOP20180121A1 (ar) 2016-06-14 2017-06-16 أجسام مضادة ضد عامل التخثر xi

Country Status (29)

Country Link
US (6) US10676536B2 (https=)
EP (1) EP3469002A1 (https=)
JP (2) JP7022081B2 (https=)
KR (2) KR102218714B1 (https=)
CN (2) CN109476758B (https=)
AR (1) AR108717A1 (https=)
AU (3) AU2017286432B2 (https=)
BR (1) BR112018075858A2 (https=)
CA (2) CA3025869C (https=)
CL (2) CL2018003565A1 (https=)
CO (1) CO2018013434A2 (https=)
CR (1) CR20180583A (https=)
DO (1) DOP2018000284A (https=)
EA (1) EA201892716A1 (https=)
EC (1) ECSP18091593A (https=)
GE (2) GEP20227382B (https=)
IL (2) IL263272B2 (https=)
JO (1) JOP20180121A1 (https=)
MA (1) MA45234A (https=)
MX (2) MX2018015757A (https=)
MY (1) MY201852A (https=)
NI (1) NI201800134A (https=)
PE (1) PE20190416A1 (https=)
PH (1) PH12018502586A1 (https=)
SG (2) SG11201810763TA (https=)
TN (1) TN2018000417A1 (https=)
TW (2) TWI802193B (https=)
UA (1) UA129793C2 (https=)
WO (1) WO2017218371A1 (https=)

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IL267538B2 (en) 2016-12-23 2024-05-01 Novartis Ag Antibodies against factor XI and methods for use in preventing, treating, managing or reducing the risk of thromboembolic disorder or stroke in a patient
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
EP4177274A4 (en) * 2020-07-02 2024-04-03 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Anti-fxi/fxia antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
CA3188566A1 (en) * 2020-07-03 2022-01-06 Suzhou Alphamab Co., Ltd. Coagulation factor xi (fxi) binding protein
IL304971A (en) 2021-02-09 2023-10-01 Arxx Therapeutics As Humanized anti-S100A4 antibody, uses and methods
US20250034277A1 (en) * 2021-11-30 2025-01-30 Suzhou Alphamab Co., Ltd. Method for preventing and/or treating thromboembolic diseases
EP4644426A1 (en) * 2022-12-30 2025-11-05 Gan & Lee Pharmaceuticals Co., Ltd. Antibody against coagulation factor xi and/or activated form factor xia thereof, and use thereof
WO2025130748A1 (zh) * 2023-12-22 2025-06-26 四川科伦博泰生物医药股份有限公司 一种抗凝血因子XI/XIa抗体制剂

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Also Published As

Publication number Publication date
JP7022081B2 (ja) 2022-02-17
EA201892716A1 (ru) 2019-05-31
TW201802120A (zh) 2018-01-16
CA3025869C (en) 2025-10-07
US11485794B2 (en) 2022-11-01
DOP2018000284A (es) 2019-01-31
IL315266A (en) 2024-10-01
PE20190416A1 (es) 2019-03-19
US11661460B2 (en) 2023-05-30
IL263272A (en) 2018-12-31
GEAP202114983A (en) 2021-12-10
US20200270364A1 (en) 2020-08-27
GEP20227382B (en) 2022-05-25
AU2020210233A1 (en) 2020-08-20
US20170355780A1 (en) 2017-12-14
WO2017218371A1 (en) 2017-12-21
ECSP18091593A (es) 2019-01-31
AR108717A1 (es) 2018-09-19
AU2017286432A1 (en) 2018-12-06
IL263272B1 (en) 2025-03-01
CL2018003565A1 (es) 2019-03-22
US10676536B2 (en) 2020-06-09
US20230287141A1 (en) 2023-09-14
KR20210021124A (ko) 2021-02-24
MX2023012740A (es) 2024-02-23
CA3025869A1 (en) 2017-12-21
CN116425879A (zh) 2023-07-14
CO2018013434A2 (es) 2018-12-28
JP7277500B2 (ja) 2023-05-19
TN2018000417A1 (en) 2020-06-15
SG10202103120UA (en) 2021-05-28
PH12018502586A1 (en) 2019-10-07
MA45234A (fr) 2019-04-17
US20200255542A1 (en) 2020-08-13
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BR112018075858A2 (pt) 2019-04-02
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NI201800134A (es) 2019-03-05
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US11479615B2 (en) 2022-10-25
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CR20180583A (es) 2019-07-02
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CL2024000367A1 (es) 2024-08-23
UA129793C2 (uk) 2025-08-06
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