ITRM960867A0 - Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fat tore nf-kb - Google Patents

Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fat tore nf-kb

Info

Publication number
ITRM960867A0
ITRM960867A0 IT96RM000867A ITRM960867A ITRM960867A0 IT RM960867 A0 ITRM960867 A0 IT RM960867A0 IT 96RM000867 A IT96RM000867 A IT 96RM000867A IT RM960867 A ITRM960867 A IT RM960867A IT RM960867 A0 ITRM960867 A0 IT RM960867A0
Authority
IT
Italy
Prior art keywords
ciclopenten
inhibitors
derivatives
factor
Prior art date
Application number
IT96RM000867A
Other languages
English (en)
Inventor
Maria Gabriella Santoro
Antonio Rossi
Giuliano Elia
Original Assignee
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche
Publication of ITRM960867A0 publication Critical patent/ITRM960867A0/it
Priority to IT96RM000867A priority Critical patent/IT1289250B1/it
Priority to ES97954382T priority patent/ES2268739T3/es
Priority to EP97954382A priority patent/EP0951281B9/en
Priority to PT97954382T priority patent/PT951281E/pt
Priority to AU58557/98A priority patent/AU5855798A/en
Priority to DE69736243T priority patent/DE69736243T2/de
Priority to CA2274108A priority patent/CA2274108C/en
Priority to JP52622798A priority patent/JP2001505900A/ja
Priority to PCT/EP1997/006930 priority patent/WO1998025593A2/en
Priority to AT97954382T priority patent/ATE331504T1/de
Priority to DK97954382T priority patent/DK0951281T3/da
Priority to EP06116132A priority patent/EP1704855A3/en
Priority to US09/319,743 priority patent/US6392100B1/en
Publication of ITRM960867A1 publication Critical patent/ITRM960867A1/it
Application granted granted Critical
Publication of IT1289250B1 publication Critical patent/IT1289250B1/it
Priority to US10/142,813 priority patent/US6696498B2/en
Priority to US10/742,523 priority patent/US20050020687A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT96RM000867A 1996-01-14 1996-12-13 Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb IT1289250B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT96RM000867A IT1289250B1 (it) 1996-12-13 1996-12-13 Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
PCT/EP1997/006930 WO1998025593A2 (en) 1996-12-13 1997-12-11 2-CYCLOPENTEN-1-ONE AND ITS DERIVATIVES AS INHIBITORS OF THE NF-kB FACTOR
DK97954382T DK0951281T3 (da) 1996-12-13 1997-12-11 2-cyclopenten-1-on og derivater heraf som inhibitorer af NF-kappaB-faktoren
PT97954382T PT951281E (pt) 1996-12-13 1997-12-11 2-ciclopenten-1-ona e seus derivados como inibidores do factor nf-kb
AU58557/98A AU5855798A (en) 1996-12-13 1997-12-11 2-cyclopenten-1-one and its derivatives as inhibitors of the nf-(k)b factor
DE69736243T DE69736243T2 (de) 1996-12-13 1997-12-11 2-CYCLOPENTEN-1-ON UND SEINE DERIVATE ALS INHIBITOREN VON NF-kappa B
CA2274108A CA2274108C (en) 1996-12-13 1997-12-11 2-cyclopenten-1-one and its derivatives as inhibitors of the nf-kb factor
JP52622798A JP2001505900A (ja) 1996-12-13 1997-12-11 ＮＦ−κＢ因子の抑制剤としての２−シクロペンテン−１−オンおよびその誘導体
ES97954382T ES2268739T3 (es) 1996-12-13 1997-12-11 2-ciclopenten-1-ona y sus derivados como inhibidores del factor nf-kappa b.
AT97954382T ATE331504T1 (de) 1996-12-13 1997-12-11 2-cyclopenten-1one und seine derivate als inhibitoren von nf-kappa b
EP97954382A EP0951281B9 (en) 1996-12-13 1997-12-11 2-CYCLOPENTEN-1-ONE AND ITS DERIVATIVES AS INHIBITORS OF THE NF-kappa B FACTOR
EP06116132A EP1704855A3 (en) 1996-12-13 1997-12-11 2-Cyclopenten-1-one and its Derivatives as Inhibitors of the NF-kappa B Factor
US09/319,743 US6392100B1 (en) 1996-12-13 1997-12-11 2-Cyclopenten-1-one as inhibitors of the NF-KB factor
US10/142,813 US6696498B2 (en) 1996-12-13 2002-05-10 2-cyclopenten-1-one and its derivatives as inhibitors of the NF-kB factor
US10/742,523 US20050020687A1 (en) 1996-01-14 2003-12-19 Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96RM000867A IT1289250B1 (it) 1996-12-13 1996-12-13 Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb

Publications (3)

Publication Number Publication Date
ITRM960867A0 true ITRM960867A0 (it) 1996-12-13
ITRM960867A1 ITRM960867A1 (it) 1998-06-13
IT1289250B1 IT1289250B1 (it) 1998-09-29

Family

ID=11404593

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96RM000867A IT1289250B1 (it) 1996-01-14 1996-12-13 Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb

Country Status (12)

Country Link
US (2) US6392100B1 (it)
EP (2) EP0951281B9 (it)
JP (1) JP2001505900A (it)
AT (1) ATE331504T1 (it)
AU (1) AU5855798A (it)
CA (1) CA2274108C (it)
DE (1) DE69736243T2 (it)
DK (1) DK0951281T3 (it)
ES (1) ES2268739T3 (it)
IT (1) IT1289250B1 (it)
PT (1) PT951281E (it)
WO (1) WO1998025593A2 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020687A1 (en) * 1996-01-14 2005-01-27 Consiglio Nazionale Ricerche Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds
IT1289250B1 (it) 1996-12-13 1998-09-29 Consiglio Nazionale Ricerche Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
AU5195799A (en) * 1998-08-18 2000-03-14 Takara Shuzo Co., Ltd. Remedies or preventives containing cyclopentenone compounds as the active ingredient
WO2000056341A1 (en) * 1999-03-22 2000-09-28 Charterhouse Therapeutics Ltd. Chemical compounds and their uses
GB9929702D0 (en) * 1999-12-16 2000-02-09 Charterhouse Therapeutics Ltd Chemical compounds and their uses
JPWO2002036547A1 (ja) * 2000-11-01 2004-03-11 味の素株式会社 シクロプロパンカルボン酸アミド化合物及びその医薬用途
DE10300222A1 (de) * 2003-01-03 2004-07-15 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen
US8129345B2 (en) * 2006-07-20 2012-03-06 Dana-Farber Cancer Institute, Inc. MUC1-IκB kinase complexes and their activities
US20080287532A1 (en) * 2007-05-18 2008-11-20 Joseph Schwarz Oxacyclopentene-2 derivatives
WO2017165170A1 (en) * 2016-03-21 2017-09-28 William Marsh Rice University Electron withdrawing group substituted and macrocyclic pgj3 analogs and methods of treatment thereof
CN116874362B (zh) * 2023-06-27 2024-08-16 东海实验室 一类环戊烯酮类化合物及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0131441B1 (en) * 1983-07-06 1989-10-18 Teijin Limited 5-alkylidene-2-halo-4-substituted-2-cyclopentenone and process for production thereof
JPS6097926A (ja) * 1983-11-04 1985-05-31 Teijin Ltd 新規な４−ヒドロキシ−２−シクロペンテノン類およびその製造方法
JPS6147437A (ja) * 1984-08-15 1986-03-07 Teijin Ltd ５―アルキリデン―２―ハロ―４―置換―２―シクロペンテノン類
US4954519A (en) 1987-04-28 1990-09-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
US4711895A (en) 1984-10-22 1987-12-08 Teijin Limited 4-hydroxy-2-cyclopentenone, process for production thereof, pharmaceutical composition comprising it
JPS6244A (ja) 1985-06-25 1987-01-06 Nippon Iyakuhin Kogyo Kk ２−ハロ−２−シクロペンテノン誘導体及びその製法
JPS6259258A (ja) * 1985-09-09 1987-03-14 Teijin Ltd プナグランジン類およびその製法
US6150090A (en) 1986-01-09 2000-11-21 Massachusetts Institute Of Technology Nuclear factors associated with transcriptional regulation
JPS6372672A (ja) * 1986-09-17 1988-04-02 Teijin Ltd ２−フルオロ−４−ヒドロキシ−２−シクロペンテノン類およびその製造法
AU615534B2 (en) 1988-04-19 1991-10-03 Teijin Limited 2-substituted-2-cyclopentenones
US5216183A (en) 1988-04-19 1993-06-01 Teijin Limited Cyclopentanone/cyclopentenone derivative
US5338844A (en) 1989-10-19 1994-08-16 Teijin Limited 2-substituted-2-cyclopentenone compound and anticancer agent and bone formation accelerator comprising same as active ingredient
JP3185823B2 (ja) * 1993-01-12 2001-07-11 住友電気工業株式会社 インバータ回路
DE4311835A1 (de) 1993-04-07 1994-10-13 Boehringer Ingelheim Int Verfahren zur Inhibierung der Transkription von Genen
JPH07233142A (ja) 1994-02-23 1995-09-05 Teijin Ltd ２，３，４，４，５―五置換―２―シクロペンテノン類の製造法
GB9418762D0 (en) 1994-09-16 1994-11-02 Bayer Ag Use of substituted cyclopentane-DI-and-triones
IT1293069B1 (it) 1997-07-01 1999-02-11 Consiglio Nazionale Ricerche Inibitori di nf-kb come attivatori di hsf e induttori di proteine da shock termico
IT1284853B1 (it) 1996-06-18 1998-05-22 Consiglio Nazionale Ricerche Impiego del 2-ciclopenten-1-one come induttore di hsp70.
IT1289250B1 (it) 1996-12-13 1998-09-29 Consiglio Nazionale Ricerche Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
CN1117057C (zh) 1996-09-27 2003-08-06 宝酒造株式会社 环戊烯酮及其生产方法和应用
JP2709807B2 (ja) 1996-11-01 1998-02-04 富士薬品工業株式会社 ３−クロロ−４−シリルオキシ−２−シクロペンテン−１−オン類の製造法
EA001607B1 (ru) 1997-03-17 2001-06-25 Такара Сузо Ко., Лтд. Антивирусное средство
WO1999000349A1 (en) 1997-06-30 1999-01-07 Takara Shuzo Co., Ltd. Cyclopentenone derivatives

Also Published As

Publication number Publication date
CA2274108C (en) 2010-03-16
EP1704855A2 (en) 2006-09-27
ITRM960867A1 (it) 1998-06-13
EP0951281B9 (en) 2008-02-20
JP2001505900A (ja) 2001-05-08
US20020137800A1 (en) 2002-09-26
US6392100B1 (en) 2002-05-21
DK0951281T3 (da) 2006-10-30
IT1289250B1 (it) 1998-09-29
EP1704855A3 (en) 2007-04-18
ES2268739T3 (es) 2007-03-16
WO1998025593A2 (en) 1998-06-18
US6696498B2 (en) 2004-02-24
ATE331504T1 (de) 2006-07-15
PT951281E (pt) 2006-11-30
DE69736243D1 (de) 2006-08-10
EP0951281A2 (en) 1999-10-27
AU5855798A (en) 1998-07-03
EP0951281B1 (en) 2006-06-28
DE69736243T2 (de) 2007-06-06
WO1998025593A3 (en) 1998-10-01
CA2274108A1 (en) 1998-06-18

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Legal Events

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0001 Granted