IT1292426B1 - Sali nitrati di ace-inibitori - Google Patents

Sali nitrati di ace-inibitori

Info

Publication number
IT1292426B1
IT1292426B1 IT97MI001523A ITMI971523A IT1292426B1 IT 1292426 B1 IT1292426 B1 IT 1292426B1 IT 97MI001523 A IT97MI001523 A IT 97MI001523A IT MI971523 A ITMI971523 A IT MI971523A IT 1292426 B1 IT1292426 B1 IT 1292426B1
Authority
IT
Italy
Prior art keywords
nitrated
ace
inhibitors
salts
activity
Prior art date
Application number
IT97MI001523A
Other languages
English (en)
Italian (it)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ITMI971523A0 publication Critical patent/ITMI971523A0/it
Priority to IT97MI001523A priority Critical patent/IT1292426B1/it
Priority to ES98938668T priority patent/ES2190095T3/es
Priority to PCT/EP1998/003946 priority patent/WO1999000361A1/en
Priority to IL13269198A priority patent/IL132691A/en
Priority to CA002292794A priority patent/CA2292794A1/en
Priority to AU87300/98A priority patent/AU740411B2/en
Priority to EP98938668A priority patent/EP1019370B1/en
Priority to CNB988062763A priority patent/CN1205186C/zh
Priority to JP50529499A priority patent/JP2002506456A/ja
Priority to SI9830175T priority patent/SI1019370T1/xx
Priority to AT98938668T priority patent/ATE230393T1/de
Priority to DE69810498T priority patent/DE69810498T2/de
Priority to DK98938668T priority patent/DK1019370T3/da
Priority to BRPI9810459-4A priority patent/BR9810459A/pt
Priority to KR10-1999-7011984A priority patent/KR100512892B1/ko
Priority to US09/423,287 priority patent/US6218417B1/en
Priority to RU2000100825/04A priority patent/RU2194037C2/ru
Priority to HU0003133A priority patent/HUP0003133A3/hu
Publication of ITMI971523A1 publication Critical patent/ITMI971523A1/it
Application granted granted Critical
Publication of IT1292426B1 publication Critical patent/IT1292426B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT97MI001523A 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori IT1292426B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori
JP50529499A JP2002506456A (ja) 1997-06-27 1998-06-24 Ａｃｅ（アンギオテンシン変換酵素）阻害剤硝酸塩
AT98938668T ATE230393T1 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
IL13269198A IL132691A (en) 1997-06-27 1998-06-24 Ace-inhibitor nitrate salts and pharmaceutical compositions containing them
CA002292794A CA2292794A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
AU87300/98A AU740411B2 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
EP98938668A EP1019370B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
CNB988062763A CN1205186C (zh) 1997-06-27 1998-06-24 Ace－抑制剂硝酸盐
ES98938668T ES2190095T3 (es) 1997-06-27 1998-06-24 Sales nitricas de inhibidores del enzima de conversion.
SI9830175T SI1019370T1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
PCT/EP1998/003946 WO1999000361A1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
DE69810498T DE69810498T2 (de) 1997-06-27 1998-06-24 Ace-inhibitoren stickstoffsalze
DK98938668T DK1019370T3 (da) 1997-06-27 1998-06-24 Nitratsalte af ACE-inhibitorer
BRPI9810459-4A BR9810459A (pt) 1997-06-27 1998-06-24 sais nìtricos dos inibidores de ace
KR10-1999-7011984A KR100512892B1 (ko) 1997-06-27 1998-06-24 에이스저해제 질산염
US09/423,287 US6218417B1 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts
RU2000100825/04A RU2194037C2 (ru) 1997-06-27 1998-06-24 Нитрат асе-ингибитора
HU0003133A HUP0003133A3 (en) 1997-06-27 1998-06-24 Ace-inhibitor nitric salts and use of them for producing pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Publications (3)

Publication Number Publication Date
ITMI971523A0 ITMI971523A0 (enExample) 1997-06-27
ITMI971523A1 ITMI971523A1 (it) 1998-12-27
IT1292426B1 true IT1292426B1 (it) 1999-02-08

Family

ID=11377450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001523A IT1292426B1 (it) 1997-06-27 1997-06-27 Sali nitrati di ace-inibitori

Country Status (17)

Country Link
US (1) US6218417B1 (enExample)
EP (1) EP1019370B1 (enExample)
JP (1) JP2002506456A (enExample)
KR (1) KR100512892B1 (enExample)
CN (1) CN1205186C (enExample)
AT (1) ATE230393T1 (enExample)
AU (1) AU740411B2 (enExample)
BR (1) BR9810459A (enExample)
CA (1) CA2292794A1 (enExample)
DE (1) DE69810498T2 (enExample)
DK (1) DK1019370T3 (enExample)
ES (1) ES2190095T3 (enExample)
HU (1) HUP0003133A3 (enExample)
IL (1) IL132691A (enExample)
IT (1) IT1292426B1 (enExample)
RU (1) RU2194037C2 (enExample)
WO (1) WO1999000361A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
WO2001017528A1 (en) 1999-09-08 2001-03-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
JP2003514020A (ja) 1999-10-29 2003-04-15 ニトロメド インコーポレーテッド 酸化窒素不足により特徴付けられる血管疾患の治療法
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
CA2475209A1 (en) * 2002-02-04 2003-08-14 Alfama - Investigacao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS ASSOCIATED WITH HEART FAILURE
CN101010323B (zh) 2004-08-25 2010-06-16 埃科特莱茵药品有限公司 作为肾素抑制剂的双环壬烯衍生物
PL1679072T3 (pl) * 2005-01-06 2009-03-31 Ipca Laboratories Ltd Sposób syntezy pochodnych kwasu (2S, 3aS, 7aS)-1-(S)-alanylo- oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprilu
WO2006121853A1 (en) * 2005-05-05 2006-11-16 Keryx Biopharmaceuticals, Inc. Combination therapy with sulodexide and a blood pressure reducing agent in the treatment of diabetic nephropathy
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
GB0511686D0 (en) * 2005-06-08 2005-07-13 Novartis Ag Organic compounds
US20080274171A1 (en) * 2005-10-18 2008-11-06 Nicoletta Almirante Renin Inhibitors Nitroderivatives
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
NZ570828A (en) 2006-02-02 2011-07-29 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
AU2007217980A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
WO2007102127A2 (en) * 2006-03-08 2007-09-13 Actelion Pharmaceuticals Ltd New amines
CA2652135A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
MX2010012067A (es) * 2008-05-05 2010-12-06 Merck Frosst Canada Ltd Derivados de 3,4-piperidina sustituida como inhibidores de la renina.
WO2012145520A2 (en) 2011-04-19 2012-10-26 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT377496B (de) * 1981-06-19 1985-03-25 Voith Gmbh J M Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
DE69433744T2 (de) * 1993-09-17 2004-10-14 Pfizer Inc. 3-amino-5-carboxy-substituierte piperidine und 3-amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten
AU702662B2 (en) 1994-05-10 1999-02-25 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
AU4953796A (en) * 1995-03-15 1996-10-02 Sanyko Company, Limited Dipeptide compounds having ahpba structure
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
CN1141771A (zh) * 1995-08-02 1997-02-05 贾力 巯-亚硝基化合物及其医学用途

Also Published As

Publication number Publication date
EP1019370B1 (en) 2003-01-02
KR100512892B1 (ko) 2005-09-07
IL132691A (en) 2004-06-01
ITMI971523A0 (enExample) 1997-06-27
CN1205186C (zh) 2005-06-08
IL132691A0 (en) 2001-03-19
DK1019370T3 (da) 2003-05-05
WO1999000361A1 (en) 1999-01-07
BR9810459A (pt) 2006-10-03
US6218417B1 (en) 2001-04-17
JP2002506456A (ja) 2002-02-26
ES2190095T3 (es) 2003-07-16
DE69810498T2 (de) 2003-10-30
ATE230393T1 (de) 2003-01-15
HUP0003133A2 (en) 2001-03-28
ITMI971523A1 (it) 1998-12-27
AU740411B2 (en) 2001-11-01
AU8730098A (en) 1999-01-19
CA2292794A1 (en) 1999-01-07
CN1260780A (zh) 2000-07-19
EP1019370A1 (en) 2000-07-19
DE69810498D1 (de) 2003-02-06
RU2194037C2 (ru) 2002-12-10
KR20010013958A (ko) 2001-02-26
HUP0003133A3 (en) 2002-10-28

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Legal Events

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